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Dr STEPHANIE SMITH's Outputs (33)

Comparative effectiveness of various exercise interventions on central sensitisation indices: A systematic review and network meta-analysis (2025)
Journal Article
Ibrahim, A. A. E., McWilliams, D. F., Smith, S. L., Chaplin, W. J., Salimian, M., Georgopoulos, V., Kouraki, A., & Walsh, D. A. (2025). Comparative effectiveness of various exercise interventions on central sensitisation indices: A systematic review and network meta-analysis. Annals of Physical and Rehabilitation Medicine, 68(4), Article 101894. https://doi.org/10.1016/j.rehab.2024.101894

Background: Central sensitisation (CS) increases musculoskeletal pain. Quantitative sensory testing (QST) or self-report questionnaires might indicate CS. Indices of CS might be suppressed by exercise, although the optimal exercise regimen remains un... Read More about Comparative effectiveness of various exercise interventions on central sensitisation indices: A systematic review and network meta-analysis.

Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis (2024)
Journal Article
Smith, S. L., Paul, L., Steultjens, M. P. M., & Jones, R. L. (2024). Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis. Arthritis Research and Therapy, 26, Article 189. https://doi.org/10.1186/s13075-024-03419-1

Objectives: Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. Th... Read More about Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis.

Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain (2024)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Ferguson, E., Wakefield, R., Platts, D., Ledbury, S., Wilson, D., & Walsh, D. A. (2024). Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain. Arthritis Research and Therapy, 26(1), Article 175. https://doi.org/10.1186/s13075-024-03407-5

Background: Pain, the primary complaint in rheumatoid arthritis (RA), is multifaceted, and may be driven by inflammatory disease activity and central sensitisation. We aimed to ascertain what proportion of RA pain severity is explained by markers of... Read More about Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain.

Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire (2024)
Journal Article
McWilliams, D., Georgopoulos, V., Patel, J., Millar, B., Smith, S., & Walsh, D. (2024). Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire. Rheumatology, 63(12), 3306-3314. https://doi.org/10.1093/rheumatology/keae342

Background

Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnai... Read More about Validation of a questionnaire for central nervous system aspects of joint pain: the CAP questionnaire.

Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. (2023)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2024). Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. Clinical Biomechanics, 111, Article 106159. https://doi.org/10.1016/j.clinbiomech.2023.106159

Background: Knee osteoarthritis is a complex condition with established risk factors such as female sex, increasing age and body mass index, reduced quadriceps muscle strength and knee injury. Despite known associated risks, the role and behaviour of... Read More about Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis..

Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort (2023)
Journal Article
McWilliams, D. F., Yue, B., Smith, S. L., Stocks, J., Doherty, M., Valdes, A. M., Zhang, W., Sarmanova, A., Fernandes, G. S., Akin-Akinyosoye, K., Hall, M., & Walsh, D. A. (2023). Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort. Journal of Personalized Medicine, 13(10), Article 1450. https://doi.org/10.3390/jpm13101450

Knee pain is associated with lower muscle strength, and both contribute to disability. Peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help fut... Read More about Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.

P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis (2023)
Presentation / Conference Contribution
Abd Elkhabir, A. A., McWilliams, D. F., Smith, S., Chaplin, W., Salimian, M., Georgopoulos, V., Kouraki, A., & Walsh, D. A. (2023, April). P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis. Presented at British Society for Rheumatology Annual Conference 2023, Manchester

Background/Aims

Exercise has shown a promising effect in reducing central sensitisation (CS), but it is unknown which exercise type is the most effective. This review aimed to rank and compare the effectiveness of different exercise interventions... Read More about P073 Comparative effectiveness of different exercise interventions on central sensitisation indices in humans: A systematic review and network meta-analysis.

Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon (2022)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2022). Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon. Rheumatology International, 42(12), 2241-2251. https://doi.org/10.1007/s00296-022-05184-3

An advanced ultrasound imaging technique, sonoelastography (SE) is used to evaluate tissue elasticity. To determine SE potential to detect pathological-related changes, and characteristics related to tendon pathology we aimed to (1) compare quadricep... Read More about Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon.

Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review (2022)
Journal Article
Jones, R., Paul, L., Steultjens, M., & Smith, S. L. (2022). Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2791-2806. https://doi.org/10.1002/jcsm.13064

Lower limb muscle dysfunction is a key driver for impaired physical capacity and frailty status, both characteristics of sarcopenia. Sarcopenia is the key pathway between frailty and disability. Identifying biological markers for early diagnosis, tre... Read More about Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review.

An observational study of centrally facilitated pain in individuals with chronic low back pain (2022)
Journal Article
Georgopoulos, V., Akin-Akinyosoye, K., Smith, S., McWilliams, D. F., Hendrick, P., & Walsh, D. A. (2022). An observational study of centrally facilitated pain in individuals with chronic low back pain. PAIN Reports, 7(3), Article e1003. https://doi.org/10.1097/PR9.0000000000001003

Central pain facilitation can hinder recovery in people with chronic low back pain (CLBP). The aim of this observational study was to investigate whether indices of centrally facilitated pain are associated with pain outcomes in a hospital-based coho... Read More about An observational study of centrally facilitated pain in individuals with chronic low back pain.

CAN CONTINUOUS KNEE PAIN OUTCOME MEASURES BE HARMONISED? (2022)
Presentation / Conference Contribution
Georgopoulos, V., Perry, T., Smith, S., McWilliams, D., Gohir, S., Valdes, A., Steultjens, M., Woodburn, J., Vincent, T., Watt, F., & Walsh, D. CAN CONTINUOUS KNEE PAIN OUTCOME MEASURES BE HARMONISED?

Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain (2022)
Presentation / Conference Contribution
Habib, M., Smith, S., Chaplin, W., Millar, B., McWilliams, D., & Walsh, D. Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain. Presented at Osteoarthritis Research Society International (OARSI), Berlin

Purpose: Pain is the primary clinical manifestation in individuals with osteoarthritis (OA). It is an unpleasant and distressing experience, particularly during weight-bearing activities, inhibiting activity, and reducing quality of life. Two groups... Read More about Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain.

Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain (2021)
Journal Article
Yue, B., McWilliams, D., Smith, S., Stocks, J., Sarmanova, A., Fernandes, G., Swaithes, L., Frowd, N., Doherty, M., Zhang, W., Valdes, A., Hall, M., & Walsh, D. (2021). Associations of peripheral and central pain mechanisms with voluntary muscle strength in people with knee pain. Osteoarthritis and Cartilage, 29(Suppl 1), S366-S367. https://doi.org/10.1016/j.joca.2021.02.475

The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis (2021)
Presentation / Conference Contribution
Georgopoulos, V., Smith, S., McWilliams, D., Vincent, T., Watt, F., & Walsh, D. The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis. Presented at Osteoarthritis Society International World Congress, Virtual

Purpose: Knee pain is highly prevalent, most commonly attributed to osteoarthritis in older people, and in younger people often due to internal derangements. Knee pain can be measured using numerical patient-reported outcome measures (PROMs). Several... Read More about The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis.

Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons? (2021)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2021). Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons?. Knee, 28, 282-293. https://doi.org/10.1016/j.knee.2020.12.011

Objectives To explore the associations between participant characteristics and magnitudes of difference in paired elastography measures of knee tendon from different ultrasound systems, and to compare strain elastography pattern description. Material... Read More about Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons?.

Intermachine Variation of Ultrasound Strain Elastographic Measures of the Quadriceps and Patellar Tendons in Healthy Participants: Implications for Clinical Practice (2020)
Journal Article
Dickson, D. M., Fawole, H. O., Hendry, G. J., & Smith, S. L. (2020). Intermachine Variation of Ultrasound Strain Elastographic Measures of the Quadriceps and Patellar Tendons in Healthy Participants: Implications for Clinical Practice. Journal of Ultrasound in Medicine, 39(7), 1343-1353. https://doi.org/10.1002/jum.15228

Objectives
To evaluate intermachine variation and compare intraoperator and interoperator agreement and repeatability characteristics of 2 ultrasound (US) systems for measurements of quadriceps and patellar tendons by strain elastography (SE).

Me... Read More about Intermachine Variation of Ultrasound Strain Elastographic Measures of the Quadriceps and Patellar Tendons in Healthy Participants: Implications for Clinical Practice.