Associate Professor GALINA PAVLOVSKAYA's Outputs (26)

A molecular–mechanical link in shear-induced self-assembly of a functionalized biopolymeric fluid (2023)
Journal Article
Pavlovskaya, G. E., & Meersmann, T. (2023). A molecular–mechanical link in shear-induced self-assembly of a functionalized biopolymeric fluid. Soft Matter, 19(17), 3228-3237. https://doi.org/10.1039/d2sm01381a

23Na multiple quantum filtered (MQF) rheo-NMR methods were applied to probe the molecular foundation for flow induced self-assembly in 0.5% κ-carrageenan fluid. This method is sensitive enough to utilize an endogenous sodium ion concentration of appr... Read More about A molecular–mechanical link in shear-induced self-assembly of a functionalized biopolymeric fluid.

Novel perspectives of sodium handling in type 2 diabetes mellitus (2022)
Journal Article
Hanson, P., Arkill, K. P., Merry, C. L., Hussain, M. S., Meersmann, T., Randeva, H. S., …Barber, T. M. (2022). Novel perspectives of sodium handling in type 2 diabetes mellitus. Expert Review of Endocrinology and Metabolism, 17(4), 333-341. https://doi.org/10.1080/17446651.2022.2092094

Introduction: As a key regulator of body water, sodium homeostasis forms an essential component of human physiology. Type 2 Diabetes Mellitus (T2D)-associated sodium overload stems from chronic renal retention of sodium, contributing toward the devel... Read More about Novel perspectives of sodium handling in type 2 diabetes mellitus.

Magnetic Resonance Imaging of Sodium‐Ion Batteries (2022)
Book Chapter
Doswell, C. L., Pavlovskaya, G. E., Meersmann, T., & Britton, M. M. (2022). Magnetic Resonance Imaging of Sodium‐Ion Batteries. In S. Haber-Pohlmeier, B. Blümich, & L. Ciobanu (Eds.), Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science, and Energy Research (407-423). Wiley. https://doi.org/10.1002/9783527827244.ch18

This chapter explores the use of 2D 23 Na MRI and 23 Na nuclear magnetic resonance (NMR) spectroscopy, in combination with 3D 1 H magnetic resonance imaging (MRI) in investigating dendrite growth in a sodium metal cell and the evolution of sodium spe... Read More about Magnetic Resonance Imaging of Sodium‐Ion Batteries.

Advances in magnetic resonance tomography (2022)
Book Chapter
Pirogov, Y. A., Anisimov, N. V., Pavlova, O. S., Pavlovskaya, G. E., Sadykhov, E., Gulyaev, M. V., …Gervits, L. L. (2022). Advances in magnetic resonance tomography. In Magnetic Materials and Technologies for Medical Applications (107-152). Elsevier. https://doi.org/10.1016/B978-0-12-822532-5.00005-4

This chapter sets out the most promising modern directions of research in the field of magnetic resonance imaging. These include multinuclear studies aimed at the exploration of magnetic resonance (MR) image contrast induced by exogeneous (fluorine-1... Read More about Advances in magnetic resonance tomography.

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis (2021)
Journal Article
Keppie, S. J., Mansfield, J. C., Tang, X., Philp, C. J., Graham, H. K., Önnerfjord, P., …Vincent, T. L. (2021). Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis. Function, 2(5), Article zqab037. https://doi.org/10.1093/function/zqab037

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe t... Read More about Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis.

Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus (2021)
Journal Article
Hanson, P., Philp, C. J., Randeva, H. S., James, S., O’Hare, J. P., Meersmann, T., …Barber, T. M. (2021). Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus. JCI insight, 6(12), Article e145470. https://doi.org/10.1172/jci.insight.145470

BACKGROUND. Dietary sodium intake mismatches urinary sodium excretion over prolonged periods. Our aims were to localize and quantify electrostatically bound sodium within human skin using triple-quantum-filtered (TQF) protocols for MRI and magnetic r... Read More about Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus.

Imaging Sodium Dendrite Growth in All‐Solid‐State Sodium Batteries using 23Na T2‐weighted MRI (2020)
Journal Article
Rees, G. J., Spencer Jolly, D., Ning, Z., Marrow, T. J., Pavlovskaya, G., & Bruce, P. G. (2021). Imaging Sodium Dendrite Growth in All‐Solid‐State Sodium Batteries using 23Na T2‐weighted MRI. Angewandte Chemie, 133(4), 2138-2143. https://doi.org/10.1002/ange.202013066

Two‐dimensional, Knight‐shifted, T2‐contrasted 23Na magnetic resonance imaging of an all‐solid‐state cell with Na electrode and a ceramic electrolyte is employed to directly observe Na microstructural growth. A spalling dendritic morphology is observ... Read More about Imaging Sodium Dendrite Growth in All‐Solid‐State Sodium Batteries using 23Na T2‐weighted MRI.

Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media (2020)
Journal Article
Hill-Casey, F., Hotchkiss, T., Hardstone, K. A., Hitchcock, I., Novak, V., Schlepütz, C. M., …Rigby, S. P. (2021). Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media. Chemical Engineering Journal, 405, Article 126750. https://doi.org/10.1016/j.cej.2020.126750

© 2020 Elsevier B.V. Catalysed diesel particulate filter (DPF) monoliths are hierarchical porous solids, as demonstrated by mercury porosimetry. Establishing structure-transport relationships, including assessing the general accessibility of the cata... Read More about Hyperpolarised xenon MRI and time-resolved X-ray computed tomography studies of structure-transport relationships in hierarchical porous media.

Structural and chemical heterogeneity in ancient glass probed using gas overcondensation, X-ray tomography, and solid-state NMR (2020)
Journal Article
Rigby, S. P., Stevens, L., Meersmann, T., Pavlovskaya, G. E., Rees, G. J., Henderson, J., …Fletcher, R. S. (2020). Structural and chemical heterogeneity in ancient glass probed using gas overcondensation, X-ray tomography, and solid-state NMR. Materials Characterization, 167, Article 110467. https://doi.org/10.1016/j.matchar.2020.110467

Rare ancient glasses have complex, multi-scale structures requiring more sophisticated and non-destructive pore characterisation techniques than usual. Homotattic patch models for nitrogen adsorption gave better fits to the isotherm data, more accura... Read More about Structural and chemical heterogeneity in ancient glass probed using gas overcondensation, X-ray tomography, and solid-state NMR.

Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging (2020)
Journal Article
Kendrick, E., Bray, J. M., Doswell, C. L., Pavlovskaya, G. E., Chen, L., Kishore, B., …Britton, M. M. (2020). Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging. Nature Communications, 11(1), Article 2083. https://doi.org/10.1038/s41467-020-15938-x

© 2020, The Author(s). Sodium-ion batteries are a promising battery technology for their cost and sustainability. This has led to increasing interest in the development of new sodium-ion batteries and new analytical methods to non-invasively, directl... Read More about Operando visualisation of battery chemistry in a sodium-ion battery by 23Na magnetic resonance imaging.

Growth factor release upon cartilage injury is due to aggrecan-dependent sodium flux that is lost in osteoarthritis (2020)
Journal Article
Keppie, S., Philp, C., Wall, A., Pavlovskaya, G., & Vincent, T. (2020). Growth factor release upon cartilage injury is due to aggrecan-dependent sodium flux that is lost in osteoarthritis. Osteoarthritis and Cartilage, 28, S180. https://doi.org/10.1016/j.joca.2020.02.291

In Situ Monitoring of Heterogeneous Catalytic Hydrogenation via 129Xe NMR Spectroscopy and Proton MRI (2019)
Journal Article
Burueva, D. B., Pokochueva, E. V., Wang, X., Filkins, M., Svyatova, A., Rigby, S. P., …Koptyug, I. V. (2020). In Situ Monitoring of Heterogeneous Catalytic Hydrogenation via 129Xe NMR Spectroscopy and Proton MRI. ACS Catalysis, 10(2), 1417-1422. https://doi.org/10.1021/acscatal.9b05000

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., …Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, 1-13. https://doi.org/10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More about Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.

Magnetic resonance imaging on sodium nuclei: potential medical applications of 23Na MRI (2018)
Journal Article
Sadykhov, E., Pirogov, Y., Anisimov, N., Gulyaev, M., Pavlovskaya, G., Meersmann, T., Belyaev, V., & Fomina, D. (2018). Magnetic resonance imaging on sodium nuclei: potential medical applications of 23Na MRI. Applied Magnetic Resonance, 925-957. https://doi.org/10.1007/s00723-018-1045-7

Sodium is a key element in a living organism. The increase of its concentration is an indicator of many pathological conditions. 23Na magnetic resonance imaging (MRI) is a quantitative method that allows to determine the sodium content in tissues and... Read More about Magnetic resonance imaging on sodium nuclei: potential medical applications of 23Na MRI.

Fluid flow in a porous medium with transverse permeability discontinuity (2018)
Journal Article
Pavlovskaya, G. E., Meersmann, T., Jin, C., & Rigby, S. P. (2018). Fluid flow in a porous medium with transverse permeability discontinuity. Physical Review Fluids, 3(4), https://doi.org/10.1103/PhysRevFluids.3.044102

Magnetic Resonance Imaging (MRI) velocimetry methods were used to study fully developed axially symmetric fluid flow in a model porous medium of cylindrical symmetry with a transverse permeability discontinuity. Spatial mapping of fluid ow resulted i... Read More about Fluid flow in a porous medium with transverse permeability discontinuity.

Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents (2017)
Journal Article
Metelkina, O. N., Lodge, R. W., Rudakovskaya, P. G., Gerasimov, V. M., Lucas, C. H., Grebennikov, I. S., …Majouga, A. G. (2017). Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents. Journal of Materials Chemistry C, 5(8), 2167-2174. https://doi.org/10.1039/C6TC04141H

Magnetic nanomaterials show significant promise as contrast agents for magnetic resonance imaging (MRI). We have developed a new highly efficient one-step procedure for the synthesis of magnetically- functionalised hollow carbon nanofibres, where (i)... Read More about Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents.

Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging (2016)
Journal Article
Faas, H., Taylor, A. J., Granwehr, J., Lesbats, C., Krupa, J. L., Six, J. S., …Meersmann, T. (2016). Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging. PLoS ONE, 11(10), e0163704. https://doi.org/10.1371/journal.pone.0163704

© 2016 Taylor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging.

Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents (2016)
Journal Article
Rogers, N. J., Hill-Casey, F., Stupic, K. F., Six, J. S., Lesbats, C., Rigby, S. P., …Meersmann, T. (2016). Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents. Proceedings of the National Academy of Sciences, 113(12), 3164-3168. https://doi.org/10.1073/pnas.1600379113

Hyperpolarized (hp) 83Kr is a promising MRI contrast agent for the diagnosis of pulmonary diseases affecting the surface of the respiratory zone. However, the distinct physical properties of 83Kr that enable unique MRI contrast also complicate the pr... Read More about Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.

Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media (2016)
Journal Article
Jin, C., Langston, P. A., Pavlovskaya, G. E., Hall, M. R., & Rigby, S. P. (2016). Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media. Physical Review E, 93(1), 1-10. https://doi.org/10.1103/PhysRevE.93.013122

© 2016 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and t... Read More about Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media.

Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer (2015)
Journal Article
Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), https://doi.org/10.1002/cphc.201500367

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagn... Read More about Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer.

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema (2015)
Journal Article
Lilburn, D. M., Lesbats, C., Six, J. S., Dubuis, E., Yew-Booth, L., Shaw, D. E., …Meersmann, T. (2015). Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Interface, 12(107), Article 20150192. https://doi.org/10.1098/rsif.2015.0192

© 2015 The Authors. Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is... Read More about Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.

NMR imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129 (2015)
Journal Article
Pavlovskaya, G., Six, J. S., Meersman, T., Gopinathan, N., & Rigby, S. P. (2015). NMR imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129. AIChE Journal, 61(11), 4013-4019. https://doi.org/10.1002/aic.14929

© 2015 American Institute of Chemical Engineers. Gas-phase magnetic resonance imaging (MRI) has been used to investigate heterogeneity in mass transport in a packed bed of commercial, alumina, catalyst supports. Hyperpolarized 129Xe MRI enables study... Read More about NMR imaging of low pressure, gas-phase transport in packed beds using hyperpolarized xenon-129.

Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI (2014)
Journal Article
Pavlovskaya, G. E., & Meersmann, T. (2014). Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI. Journal of Physical Chemistry Letters, 5(15), https://doi.org/10.1021/jz501075j

Flow-induced molecular alignment was observed experimentally in a non-liquid- crystalline bioplymeric fluid during developed tubular flow. The fluid was comprised of rigid rods of the polysaccharide xanthan and exhibited shear-thinning behavior. With... Read More about Spatial mapping of flow-induced molecular alignment in a noncrystalline biopolymer fluid using double quantum filtered (DQF) 23Na MRI.

Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications (2013)
Journal Article
Hughes-Riley, T., Six, J. S., Lilburn, D., Stupic, K. F., Dorkes, A. C., Shaw, D. E., …Meersmann, T. (2013). Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications. Journal of Magnetic Resonance, 237, https://doi.org/10.1016/j.jmr.2013.09.008

As an alternative to cryogenic gas handling, hyperpolarized (hp) gas mixtures were extracted directly from the spin exchange optical pumping (SEOP) process through expansion followed by compression to ambient pressure for biomedical MRI applications.... Read More about Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications.

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr (2013)
Journal Article
Six, J. S., Hughes-Riley, T., Lilburn, D. M., Dorkes, A. C., Stupic, K. F., Shaw, D. E., …Meersmann, T. (2014). Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr. Magnetic Resonance Imaging, 32(1), 48-53. https://doi.org/10.1016/j.mri.2013.08.007

Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarizati... Read More about Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr.

Validating excised rodent lungs for functional hyperpolarized xenon-129 MRI (2013)
Journal Article
Lilburn, D. M., Hughes-Riley, T., Six, J. S., Stupic, K. F., Shaw, D. E., Pavlovskaya, G. E., & Meersmann, T. (2013). Validating excised rodent lungs for functional hyperpolarized xenon-129 MRI. PLoS ONE, 8(8), Article e73468. https://doi.org/10.1371/journal.pone.0073468

Ex vivo rodent lung models are explored for physiological measurements of respiratory function with hyperpolarized (hp) 129Xe MRI. It is shown that excised lung models allow for simplification of the technical challenges involved and provide valuable... Read More about Validating excised rodent lungs for functional hyperpolarized xenon-129 MRI.