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Outputs (109)

Experiences and Impact of Psychiatric Inpatient Admissions Far Away from Home: A Qualitative Study with Young People, Parents/Carers and Healthcare Professionals (2024)
Journal Article
Roe, J., Holland, J., Burn, A., Hopkin, E., Wild, L., Nazir, S., …Sayal, K. (in press). Experiences and Impact of Psychiatric Inpatient Admissions Far Away from Home: A Qualitative Study with Young People, Parents/Carers and Healthcare Professionals. BMJ Mental Health,

Background There are significant clinical, policy and societal concerns about the impact on young people (YP), from admission to psychiatric wards far from home. However, research evidence is scarce. Aims To investigate the impact of at-distance admi... Read More about Experiences and Impact of Psychiatric Inpatient Admissions Far Away from Home: A Qualitative Study with Young People, Parents/Carers and Healthcare Professionals.

Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study (2024)
Journal Article
Thomas, S., Littleboy, K., Foubert, J., Nafilyan, V., Bannister, N., Routen, A., …Gordon, A. L. (in press). Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study. Age and Ageing,

Background Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID- 19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We invest... Read More about Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study.

Peer mentoring for people with acquired brain injury – a systematic review (2024)
Journal Article
De Dios Perez, B., Morris, R. P., Craven, K., & Radford, K. A. (2024). Peer mentoring for people with acquired brain injury – a systematic review. Brain Injury, https://doi.org/10.1080/02699052.2024.2310779

Introduction: Over 100 million people worldwide live with disabilities resulting from an acquired brain injury (ABI). ABI survivors experience cognitive and physical problems and require support to resume an active life. They can benefit from support... Read More about Peer mentoring for people with acquired brain injury – a systematic review.

'Far Away from Home': adolescent inpatient admissions far from home, out of area or to adult wards: a national surveillance study. (2023)
Journal Article
Holland, J., Roe, J., Guo, B., Dasilva-Ellimah, M., Burn, A., Dubicka, B., …Sayal, K. (2023). 'Far Away from Home': adolescent inpatient admissions far from home, out of area or to adult wards: a national surveillance study. BMJ Mental Health, 26(1), Article e300843. https://doi.org/10.1136/bmjment-2023-300843

Background The increasing prevalence and acuity of mental disorders among children and adolescents have placed pressure on services, including inpatient care, and resulted in young people being admitted at-distance or to adult wards. Little empirical... Read More about 'Far Away from Home': adolescent inpatient admissions far from home, out of area or to adult wards: a national surveillance study..

Specialist treatment for persistent depression in secondary care: Sustained effects from a multicentre UK study at 24 and 36 months (2023)
Journal Article
Nixon, N., Guo, B., Kaylor-Hughes, C., Simpson, S., Garland, A., Dalgleish, T., & Morriss, R. (2024). Specialist treatment for persistent depression in secondary care: Sustained effects from a multicentre UK study at 24 and 36 months. Journal of Affective Disorders, 345, 70-77. https://doi.org/10.1016/j.jad.2023.10.105

Background: Despite the known health costs of persistent depression, there is no established service framework for the treatment of this disorder and a lack of long-term outcome data to inform commissioning. To address this gap, we report the long-te... Read More about Specialist treatment for persistent depression in secondary care: Sustained effects from a multicentre UK study at 24 and 36 months.

Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting (2023)
Journal Article
Thomas, S., Machuel, P., Foubert, J., Nafilyan, V., Bannister, N., Colvin, H., …Gordon, A. (2023). Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting. BMJ Open, 13(5), Article e067786. https://doi.org/10.1136/bmjopen-2022-067786

INTRODUCTION: Older people were at particular risk of morbidity and mortality during COVID-19. Consequently, they experienced formal (externally imposed) and informal (self-imposed) periods of social isolation and quarantine. This is hypothesised to... Read More about Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting.

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study (2023)
Journal Article
Andrews, J. A., Craven, M. P., Guo, B., Weyer, J., Lees, S., Zormpas, S. I., …RADAR-CNS Consortium. (2023). Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study. JMIR Neurotechnology, 2, Article e41439. https://doi.org/10.2196/41439

Background: Multiple sclerosis (MS), epilepsy, and depression are chronic central nervous system conditions in which remote measurement technology (RMT) may offer benefits compared with usual assessment. We previously worked with clinicians, patients... Read More about Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study.

Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial (2023)
Journal Article
Morriss, R., Patel, S., Boutry, C., Patel, P., Guo, B., Briley, P. M., …Kai, J. (2023). Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial. Lancet Psychiatry, 10(3), 172-183. https://doi.org/10.1016/S2215-0366%2823%2900007-X

Background: Randomised sham-controlled trials of cranial electrostimulation with the Alpha-Stim Anxiety Insomnia and Depression (AID) device have reported improved anxiety and depression symptoms; however, no adequately powered sham-controlled trials... Read More about Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial.

Exploring self-tracking practices for those with lived experience of bipolar disorder: Learning from combined principles of Patient and Public Involvement and HCI (2022)
Conference Proceeding
Majid, S., Morriss, R., Figueredo, G., & Reeves, S. (2022). Exploring self-tracking practices for those with lived experience of bipolar disorder: Learning from combined principles of Patient and Public Involvement and HCI. In DIS '22: Designing Interactive Systems Conference (1907-1920). https://doi.org/10.1145/3532106.3533531

Bipolar Disorder (BD) is a complex, cyclical and chronic mental illness where self-tracking is central to self-management. Mobile technology is often leveraged to support this. Limited research has investigated the everyday practices of self-tracking... Read More about Exploring self-tracking practices for those with lived experience of bipolar disorder: Learning from combined principles of Patient and Public Involvement and HCI.

Resting-state functional connectivity correlates of anxiety co-morbidity in major depressive disorder (2022)
Journal Article
Briley, P. M., Webster, L., Boutry, C., Cottam, W. J., Auer, D. P., Liddle, P. F., & Morriss, R. (2022). Resting-state functional connectivity correlates of anxiety co-morbidity in major depressive disorder. Neuroscience and Biobehavioral Reviews, 138, Article 104701. https://doi.org/10.1016/j.neubiorev.2022.104701

Major depressive disorder (MDD) is frequently co-morbid with anxiety disorders. The co-morbid state has poorer functional outcomes and greater resistance to first line treatments, highlighting the need for novel treatment targets. This systematic rev... Read More about Resting-state functional connectivity correlates of anxiety co-morbidity in major depressive disorder.

Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals (2022)
Journal Article
Andrews, J. A., Craven, M. P., Lang, A. R., Guo, B., Morriss, R., Hollis, C., & RADAR-CNS Consortium. (2022). Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals. BMC Medical Informatics and Decision Making, 22(1), Article 125. https://doi.org/10.1186/s12911-022-01856-z

BACKGROUND: Epilepsy, multiple sclerosis(MS) and depression are long term, central nervous system disorders which have a significant impact on everyday life. Evaluating symptoms of these conditions is problematic and typically involves repeated visit... Read More about Making remote measurement technology work in multiple sclerosis, epilepsy and depression: survey of healthcare professionals.

A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial) (2022)
Journal Article
Patel, S., Boutry, C., Patel, P., Craven, M. P., Guo, B., Zafar, A., …Morriss, R. (2022). A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial). Trials, 23(1), Article 250. https://doi.org/10.1186/s13063-022-06192-1

Background: Major depression is the second leading cause of years lost to disability worldwide and is a leading contributor to suicide. However, first-line antidepressants are only fully effective for 33%, and only 40% of those offered psychological... Read More about A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial).

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

Service user experiences of care recommendations from the 2014 NICE guideline for bipolar disorder: a survey (2022)
Journal Article
Roe, J., Cresswell, A., Mittal, S., Al-Uzri, M., Tanner, J., Moore, M., …Morriss, R. (2022). Service user experiences of care recommendations from the 2014 NICE guideline for bipolar disorder: a survey. Journal of Mental Health, 31(5), 724-731. https://doi.org/10.1080/09638237.2021.2022614

Clinical guidelines for mental health disorders produced by the National Institute of Care Excellence (NICE) emphasise a recovery-based approach clinical care with collaborative decision-making. The aim of the study was to explore service user experi... Read More about Service user experiences of care recommendations from the 2014 NICE guideline for bipolar disorder: a survey.

Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial (2022)
Journal Article
Pszczolkowski, S., Cottam, W. J., Briley, P. M., Iwabuchi, S. J., Kaylor-Hughes, C., Shalabi, A., …Morriss, R. (2022). Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial. JMIR Research Protocols, 11(1), Article e31925. https://doi.org/10.2196/31925

Background: Depression is a substantial health and economic burden. In approximately one-third of patients, depression is resistant to first-line treatment; therefore, it is essential to find alternative treatments. Transcranial magnetic stimulation... Read More about Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial.

The Extent of User Involvement in the Design of Self-tracking Technology for Bipolar Disorder: Literature Review (2021)
Journal Article
Majid, S., Reeves, S., Figueredo, G., Brown, S., Lang, A., Moore, M., & Morriss, R. (2021). The Extent of User Involvement in the Design of Self-tracking Technology for Bipolar Disorder: Literature Review. JMIR Mental Health, 8(12), Article e27991. https://doi.org/10.2196/27991

Background: The number of self-monitoring apps for bipolar disorder (BD) is increasing. The involvement of users in human-computer interaction (HCI) research has a long history and is becoming a core concern for designers working in this space. The a... Read More about The Extent of User Involvement in the Design of Self-tracking Technology for Bipolar Disorder: Literature Review.

Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol (2021)
Journal Article
Husain, N., Lovell, K., Chew-Graham, C. A., Lunat, F., McPhillips, R., Atif, N., …Morriss, R. (2022). Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol. BJPsych Open, 8(1), Article E2. https://doi.org/10.1192/bjo.2021.1032

Background In the UK, postnatal depression is more common in British South Asian women than White Caucasion women. Cognitive-behavioural therapy (CBT) is recommended as a first-line treatment, but there is little evidence for the adaptation of CBT fo... Read More about Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol.

The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey (2021)
Journal Article
Andrews, J. A., Craven, M. P., Lang, A. R., Guo, B., Morriss, R., Hollis, C., & The RADAR-CNS Consortium. (2021). The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey. BMC Medical Informatics and Decision Making, 21, Article 282. https://doi.org/10.1186/s12911-021-01640-5

Background: A variety of smartphone apps and wearables are available both to help patients monitor their health and to support health care professionals (HCPs) in providing clinical care. As part of the RADAR-CNS consortium, we have conducted researc... Read More about The impact of data from remote measurement technology on the clinical practice of healthcare professionals in depression, epilepsy and multiple sclerosis: survey.

Design and Evaluation of Virtual Human Mediated Tasks for Assessment of Depression and Anxiety (2021)
Conference Proceeding
Egede, J. O., Jaiswal, S., Galvez Trigo, M. J., Price, D., Elliot, N., Nixon, N., …Valstar, M. (2021). Design and Evaluation of Virtual Human Mediated Tasks for Assessment of Depression and Anxiety. In IVA '21: Proceedings of the 21st ACM International Conference on Intelligent Virtual Agents (52-59). https://doi.org/10.1145/3472306.3478361

Virtual human technologies are now being widely explored as therapy tools for mental health disorders including depression and anxiety. These technologies leverage the ability of the virtual agents to engage in naturalistic social interactions with a... Read More about Design and Evaluation of Virtual Human Mediated Tasks for Assessment of Depression and Anxiety.

The predictive value of patient, therapist, and in‐session ratings of motivational factors early in remote cognitive behavioural therapy for severe health anxiety (2021)
Journal Article
Malins, S., Moghaddam, N., Morriss, R., Schröder, T., Brown, P., & Boycott, N. (2022). The predictive value of patient, therapist, and in‐session ratings of motivational factors early in remote cognitive behavioural therapy for severe health anxiety. British Journal of Clinical Psychology, 61(2), 364-384. https://doi.org/10.1111/bjc.12328

Objectives. Remote psychotherapy and the prevalence of Severe Health Anxiety (SHA) are both growing as a result of the COVID-19 pandemic. Remotely delivered Cognitive Behavioural Therapy (rCBT) for SHA is evidenced as effective, but many who seek hel... Read More about The predictive value of patient, therapist, and in‐session ratings of motivational factors early in remote cognitive behavioural therapy for severe health anxiety.

Screening male prisoners for depression and anxiety with the PHQ-9 and GAD-7 at NHS Healthcheck: patterns of symptoms and caseness threshold (2021)
Journal Article
Butcher, E., Packham, C., Williams, M., Miksza, J., Kaul, A., Khunti, K., & Morriss, R. (2021). Screening male prisoners for depression and anxiety with the PHQ-9 and GAD-7 at NHS Healthcheck: patterns of symptoms and caseness threshold. BMC Psychiatry, 21(1), Article 446. https://doi.org/10.1186/s12888-021-03453-2

Background: Screening for depression and anxiety disorders has been proposed in prison populations but little is known about caseness thresholds on commonly used self-report measures in relation to core symptoms, risk factors and symptom patterns. Me... Read More about Screening male prisoners for depression and anxiety with the PHQ-9 and GAD-7 at NHS Healthcheck: patterns of symptoms and caseness threshold.

Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study (2021)
Journal Article
Kellezi, B., Dhiman, P., Coupland, C., Whitehead, J., Morriss, R., Joseph, S., …Kendrick, D. (2022). Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study. Injury Prevention, 28(2), 131-140. https://doi.org/10.1136/injuryprev-2021-044311

Introduction: Mental health conditions are a major contributor to productivity loss and are common post-injury. This study quantifies post-injury productivity loss and its association with pre and post-injury mental health, injury, demographic, healt... Read More about Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study.

The Extent of User Involvement in the Design of Self-Tracking Technology for Bipolar Disorder: Literature Review (2021)
Working Paper
Majid, S., Reeves, S., Figueredo, G., Brown, S., Lang, A., Moore, M., & Morriss, R. The Extent of User Involvement in the Design of Self-Tracking Technology for Bipolar Disorder: Literature Review

Background: Self-monitoring applications for bipolar disorder are increasing in numbers. The application of user-centred design (UCD) is becoming standardised to optimise the reach, adoption and sustained use of this type of technology. Objectiv... Read More about The Extent of User Involvement in the Design of Self-Tracking Technology for Bipolar Disorder: Literature Review.

Correction: A Direct-to-Public Peer Support Program (Big White Wall) Versus Web-Based Information to Aid the Self-management of Depression and Anxiety: Results and Challenges of an Automated Randomized Controlled Trial (2021)
Journal Article
Morriss, R., Kaylor-Hughes, C., Rawsthorne, M., Coulson, N., Simpson, S., Guo, B., …Williams, L. (2021). Correction: A Direct-to-Public Peer Support Program (Big White Wall) Versus Web-Based Information to Aid the Self-management of Depression and Anxiety: Results and Challenges of an Automated Randomized Controlled Trial. Journal of Medical Internet Research, 23(7), Article e31543. https://doi.org/10.2196/31543

[This corrects the article DOI: 10.2196/23487.].

Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register (2021)
Journal Article
Garjani, A., Hunter, R., Law, G. R., Middleton, R. M., Tuite-Dalton, K. A., Dobson, R., …das Nair, R. (2022). Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register. Multiple Sclerosis Journal, 28(7), 1060-1071. https://doi.org/10.1177/13524585211020435

Background: People with MS (pwMS) have had higher rates of anxiety and depression than the general population before the COVID-19 pandemic, placing them at higher risk of experiencing poor psychological wellbeing during the pandemic. Objective: To as... Read More about Mental health of people with multiple sclerosis during the COVID-19 outbreak: A prospective cohort and cross-sectional case–control study of the UK MS Register.

The factor structure of the Zanarini Rating Scale for Borderline Personality Disorder: Exploratory Structural Equation Modelling and measurement invariance over time (2021)
Journal Article
Guo, B., Li, L., Crawford, M. J., & Morriss, R. (2021). The factor structure of the Zanarini Rating Scale for Borderline Personality Disorder: Exploratory Structural Equation Modelling and measurement invariance over time. International Journal of Methods in Psychiatric Research, 30(3), Article e1874. https://doi.org/10.1002/mpr.1874

Objectives There is a lack of independent longitudinal evidence on the factor structure and validity of the Zanarini Rating Scale for Borderline Personality Disorder (ZAN?BPD). This study aimed to investigate the dimensionality of ZAN?BPD and its... Read More about The factor structure of the Zanarini Rating Scale for Borderline Personality Disorder: Exploratory Structural Equation Modelling and measurement invariance over time.

A direct-to-public peer support program (Big White Wall) versus web-based information to aid the self-management of depression and anxiety: Results and challenges of an automated randomized controlled trial (2021)
Journal Article
Rawsthorne, M., Tata, L., Williams, L., Morriss, R., Guo, B., Simpson, S., …Moran, P. (2021). A direct-to-public peer support program (Big White Wall) versus web-based information to aid the self-management of depression and anxiety: Results and challenges of an automated randomized controlled trial. JMIR, 23(4), Article e23487. https://doi.org/10.2196/23487

Background: Effective help for depression and anxiety reaches a small proportion of people who might benefit from it. The scale of the problem suggests the need for effective, safe web-based public health services delivered directly to the public. On... Read More about A direct-to-public peer support program (Big White Wall) versus web-based information to aid the self-management of depression and anxiety: Results and challenges of an automated randomized controlled trial.

The Clinical Effectiveness of Using a Predictive Algorithm to Guide Antidepressant Treatment in Primary Care (PReDicT): an open-label, randomised controlled trial (2021)
Journal Article
Browning, M., Bilderbeck, A. C., Dias, R., Dourish, C. T., Kingslake, J., Deckert, J., …Dawson, G. R. (2021). The Clinical Effectiveness of Using a Predictive Algorithm to Guide Antidepressant Treatment in Primary Care (PReDicT): an open-label, randomised controlled trial. Neuropsychopharmacology, 46, 1307–1314. https://doi.org/10.1038/s41386-021-00981-z

Depressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications. Personalised medicine offers a means of reducing this delay, however the clinical effectiveness of personalised a... Read More about The Clinical Effectiveness of Using a Predictive Algorithm to Guide Antidepressant Treatment in Primary Care (PReDicT): an open-label, randomised controlled trial.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study (2021)
Journal Article
Kendrick, D., das Nair, R., Kellezi, B., Morriss, R., Kettlewell, J., Holmes, J., …Radford, K. (2021). Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study. Pilot and Feasibility Studies, 7(1), Article 29. https://doi.org/10.1186/s40814-021-00769-4

Background Traumatic injuries are common amongst working age adults. Survivors often experience physical and psychological problems, reduced quality of life and difficulty returning to work. Vocational rehabilitation improves work outcomes for a ran... Read More about Vocational rehabilitation to enhance return to work after trauma (ROWTATE): protocol for a non-randomised single-arm mixed-methods feasibility study.

Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study (2020)
Journal Article
Craven, M. P., Andrews, J., Lang, A. R., Simblett, S. K., Bruce, S., Thorpe, S., …The RADAR-CNS Consortium. (2020). Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study. JMIR Formative Research, 4(11), Article e22756. https://doi.org/10.2196/22756

Background: Epilepsy, multiple sclerosis (MS), and depression are chronic conditions where technology holds potential in clinical monitoring and self-management. Over 5 years, the Remote Assessment of Disease and Relapse-Central Nervous System (RADAR... Read More about Informing the Development of a Digital Health Platform Through Universal Points of Care: Qualitative Survey Study.

NHS Health Check Programme: a qualitative study of prison experience (2020)
Journal Article
THOMSON, L., Williams, M., Butcher, E., Morriss, R., Kunti, K., & Packham, C. (2022). NHS Health Check Programme: a qualitative study of prison experience. Journal of Public Health, 44(1), 174-183. https://doi.org/10.1093/pubmed/fdaa189

Background: NHS Health Checks began in England in 2009 and were subsequently introduced into English prisons. Uptake has been patchy and there is limited understanding about factors that may limit or enhance uptake in prison settings. Uptake of this... Read More about NHS Health Check Programme: a qualitative study of prison experience.

Outcomes of a public health campaign and automated randomised controlled trial of a direct to public peer support programme (Big White Wall) versus web-based information to aid self-management of depression and anxiety (The REBOOT study) (2020)
Working Paper
Morriss, R., Kaylor-Hughes, C., Rawsthorne, M., Coulson, N., Simpson, S., Guo, B., …Williams, L. Outcomes of a public health campaign and automated randomised controlled trial of a direct to public peer support programme (Big White Wall) versus web-based information to aid self-management of depression and anxiety (The REBOOT study)

Background: Effective help for depression and anxiety only reaches a small proportion of those who might benefit from it. The scale of the problem suggests a role for effective, safe public health online services delivered directly to the public. On... Read More about Outcomes of a public health campaign and automated randomised controlled trial of a direct to public peer support programme (Big White Wall) versus web-based information to aid self-management of depression and anxiety (The REBOOT study).

The bi-factor structure of the 17-item Hamilton Depression Rating Scale in persistent major depression; dimensional measurement of outcome (2020)
Journal Article
Nixon, N., Guo, B., Garland, A., Kaylor-Hughes, C., Nixon, E., & Morriss, R. (2020). The bi-factor structure of the 17-item Hamilton Depression Rating Scale in persistent major depression; dimensional measurement of outcome. PLoS ONE, 15(10), Article e0241370. https://doi.org/10.1371/journal.pone.0241370

Background: The 17-item Hamilton Depression Rating Scale (HDRS17) is used world-wide as an observer-rated measure of depression in randomised controlled trials (RCTs) despite continued uncertainty regarding its factor structure. This study investiga... Read More about The bi-factor structure of the 17-item Hamilton Depression Rating Scale in persistent major depression; dimensional measurement of outcome.

Preventive digital mental health interventions for children and young people: a review of the design and reporting of research (2020)
Journal Article
Bergin, A. D., Vallejos, E. P., Davies, E. B., Daley, D., Ford, T., Harold, G., …Hollis, C. (2020). Preventive digital mental health interventions for children and young people: a review of the design and reporting of research. npj Digital Medicine, 3(1), Article 133. https://doi.org/10.1038/s41746-020-00339-7

Digital health interventions (DHIs) have frequently been highlighted as one way to respond to increasing levels of mental health problems in children and young people. Whilst many are developed to address existing mental health problems, there is als... Read More about Preventive digital mental health interventions for children and young people: a review of the design and reporting of research.

Differential effects of cranial electrotherapy stimulation on changes in anxiety and depression symptoms over time in patients with generalized anxiety disorder (2020)
Journal Article
Morriss, R., & Price, L. (2020). Differential effects of cranial electrotherapy stimulation on changes in anxiety and depression symptoms over time in patients with generalized anxiety disorder. Journal of Affective Disorders, 277, 785-788. https://doi.org/10.1016/j.jad.2020.09.006

Background Cranial electrotherapy stimulation (CES) is a safe and well-tolerated 6-12 week treatment that is clinically and cost effective on both anxiety and depression symptoms resulting in sustained remission of these symptoms at 12 and 24 weeks... Read More about Differential effects of cranial electrotherapy stimulation on changes in anxiety and depression symptoms over time in patients with generalized anxiety disorder.

Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study (2020)
Journal Article
Andrews, J. A., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., Hollis, C., & The RADAR-CNS Consortium. (2020). Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study. Journal of Medical Internet Research, 22(7), Article e17414. https://doi.org/10.2196/17414

Background: Remote measurement technologies (RMT) can be used to collect data on a variety of bio-behavioral variables, which may improve the care of patients with central nervous system disorders. Although various studies have explored their potenti... Read More about Health Care Professionals’ Views on Using Remote Measurement Technology in Managing Central Nervous System Disorders: Qualitative Interview Study.

Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND) (2020)
Journal Article
Morriss, R., Webster, L., Abdelghani, M., Auer, D., Barber, S., Bates, P., …Walters, Y. (2020). Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND). BMJ Open, 10(7), Article e038430. https://doi.org/10.1136/bmjopen-2020-038430

Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost effectiveness and mechanism of action of connectivity guided intermittent Theta Burst Stimulation (cgiTBS) versus standard repetitive Transcranial Magnetic Stimulati... Read More about Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND).

The Acceptability and Usability of Digital Health Interventions for Adults with Depressive, Anxiety and Somatoform Disorders: A Qualitative Systematic Review and Meta-synthesis (2020)
Journal Article
Patel, S., Akhtar, A., Malins, S., Wright, N., Rowley, E., Young, E., …Morriss, R. (2020). The Acceptability and Usability of Digital Health Interventions for Adults with Depressive, Anxiety and Somatoform Disorders: A Qualitative Systematic Review and Meta-synthesis. Journal of Medical Internet Research, 22(7), Article e16228. https://doi.org/10.2196/16228

Background: The prevalence of mental health disorders continues to rise, with almost 4% of the world population having an anxiety disorder and almost 3.5% having depression in 2017. Despite the high prevalence, only one-third of people with depressio... Read More about The Acceptability and Usability of Digital Health Interventions for Adults with Depressive, Anxiety and Somatoform Disorders: A Qualitative Systematic Review and Meta-synthesis.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Butler, D., …Hippisley-Cox, J. (2020). Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study. PLoS Medicine, 17(7), Article e1003215. https://doi.org/10.1371/journal.pmed.1003215

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database (2020)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C., Butler, D., Hollis, C., Morriss, R., …Hippisley-Cox, J. (2020). Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database. BMC Medicine, 18(1), https://doi.org/10.1186/s12916-020-01560-7

© 2020 The Author(s). Background: Antidepressants may be used to manage a number of conditions in children and young people including depression, anxiety, and obsessive-compulsive disorder. UK guidelines for the treatment of depression in children an... Read More about Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: A descriptive study using the QResearch database.

Patient activation in psychotherapy interactions: Developing and validating the consultation interactions coding scheme (2019)
Journal Article
Malins, S., Moghaddam, N., Morriss, R., Schröder, T., Brown, P., Boycott, N., & Atha, C. (2020). Patient activation in psychotherapy interactions: Developing and validating the consultation interactions coding scheme. Journal of Clinical Psychology, 76(4), 646-658. https://doi.org/10.1002/jclp.22910

Objective We describe the development of an instrument aiming to offer interaction‐level feedback based on “patient activation”: client confidence and perceived ability to manage their health. Method Twenty‐two session‐transcripts from cogni... Read More about Patient activation in psychotherapy interactions: Developing and validating the consultation interactions coding scheme.

Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint) (2019)
Other
Andrews, J., Craven, M. P., Jamnadas-Khoda, J., Lang, A. R., Morriss, R., & Hollis, C. (in press). Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint)

Background: Remote measurement technologies (RMTs) can be used to collect data on a variety of bio-behavioural variables, which may benefit the care of people with central nervous system disorders. While various studies have explored their potential... Read More about Healthcare professional views of implementing remote measurement technology in central nervous system disorders: A qualitative interview study (Preprint).

Qualitative investigation of relatives’ and service users’ experience of mental healthcare for suicidal behaviour in bipolar disorder (2019)
Journal Article
Clements, C., Kapur, N., Jones, S. H., Morriss, R., & Peters, S. (2019). Qualitative investigation of relatives’ and service users’ experience of mental healthcare for suicidal behaviour in bipolar disorder. BMJ Open, 9(11), 1-10. https://doi.org/10.1136/bmjopen-2019-030335

Objective: People with bipolar disorder are known to be at high risk of engaging in suicidal behaviours, and those who die by suicide have often been in recent contact with mental health services. The objective of this study was to explore suicidal b... Read More about Qualitative investigation of relatives’ and service users’ experience of mental healthcare for suicidal behaviour in bipolar disorder.

Extending the use of routine outcome monitoring: Predicting long-term outcomes in cognitive behavioral therapy for severe health anxiety (2019)
Journal Article
Malins, S., Moghaddam, N., Morriss, R., & Schröder, T. (2020). Extending the use of routine outcome monitoring: Predicting long-term outcomes in cognitive behavioral therapy for severe health anxiety. Psychotherapy Research, 30(5), 662-674. https://doi.org/10.1080/10503307.2019.1657250

Objective: Routine outcome monitoring (ROM) is a well-evidenced means of improving psychotherapy’s effectiveness. However, it is unclear how meaningful ROM is for problems that span physical and mental health, such as severe health anxiety. Physical... Read More about Extending the use of routine outcome monitoring: Predicting long-term outcomes in cognitive behavioral therapy for severe health anxiety.

Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis (2019)
Journal Article
Farooqi, A., Khunti, K., Abner, S. C., Gillies, C., Morriss, R., & Seidu, S. (2019). Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 156, Article 107816. https://doi.org/10.1016/j.diabres.2019.107816

Objective: To examine the association of comorbid occurrence of diabetes and depression with risk of cardiovascular endpoints including cardiovascular mortality, coronary heart disease and stroke. Research Design and Methods: A systematic review... Read More about Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis.

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, 179(8), 1084-1093. https://doi.org/10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia. OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.

Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder (2019)
Journal Article
Morriss, R., Xydopoulos, G., Craven, M., Price, L., & Fordham, R. (2019). Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder. Journal of Affective Disorders, 253, 426-437. https://doi.org/10.1016/j.jad.2019.04.020

© 2019 Elsevier B.V. Background: Cranial electrotherapy stimulation (CES) is a well-tolerated neuromodulation treatment with demonstrated trial efficacy in anxiety disorders. The aim of the current study was to demonstrate its clinical and cost effec... Read More about Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder.

Feasibility of a randomised controlled trial of remotely delivered problem-solving cognitive behaviour therapy versus usual care for young people with depression and repeat self-harm: lessons learnt (e-DASH) (2019)
Journal Article
Sayal, K., Roe, J., Ball, H., Atha, C., Kaylor-Hughes, C., Guo, B., …Morriss, R. (2019). Feasibility of a randomised controlled trial of remotely delivered problem-solving cognitive behaviour therapy versus usual care for young people with depression and repeat self-harm: lessons learnt (e-DASH). BMC Psychiatry, 19(1), Article 42. https://doi.org/10.1186/s12888-018-2005-3

Background Self-harm and depression are strong risk factors for repeat self-harm and suicide. We aimed to investigate the feasibility of a randomised controlled trial (RCT) of remotely delivered problem-solving cognitive behaviour therapy (PSCBT)... Read More about Feasibility of a randomised controlled trial of remotely delivered problem-solving cognitive behaviour therapy versus usual care for young people with depression and repeat self-harm: lessons learnt (e-DASH).

Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multi-centre randomised controlled trial (2019)
Journal Article
Morriss, R., Patel, S., Mallins, S., Guo, B., Higton, F., James, M., …Tyrer, H. (2019). Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multi-centre randomised controlled trial. BMC Medicine, 17, 1-13. https://doi.org/10.1186/s12916-019-1253-5

Background: Repeat users of unscheduled health care with severe health anxiety are challenging to engage in psychological help and incur high service costs. We investigated whether clinical and economic outcomes were improved by offering remote cogni... Read More about Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multi-centre randomised controlled trial.

An electronic clinical decision support system for the assessment and management of suicidality in primary care (2018)
Journal Article
Horrocks, M., Michail, M., Aubeeluck, A., Wright, N., & Morriss, R. (2018). An electronic clinical decision support system for the assessment and management of suicidality in primary care. JMIR Research Protocols, 7(12), Article e11135. https://doi.org/10.2196/11135

Background: Suicide is a global public health concern, but it is preventable. Increased contact with primary care before the suicide or attempted suicide raises opportunities for intervention and prevention. However, suicide assessment and management... Read More about An electronic clinical decision support system for the assessment and management of suicidality in primary care.

Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition (2018)
Journal Article
Hidalgo-Mazzei, D., Berk, M., Cipriani, A., Cleare, A. J., Florio, A. D., Dietch, D., …Stokes, P. R. A. (2018). Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition. British Journal of Psychiatry, 214(1), 27-35. https://doi.org/10.1192/bjp.2018.257

© The Royal College of Psychiatrists 2018. Background Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to th... Read More about Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition.

An Electronic Clinical Decision Support System for the Assessment and Management of Suicidality in Primary Care: Protocol for a Mixed-Methods Study (2018)
Journal Article
Horrocks, M., Michail, M., Aubeeluck, A., Wright, N., & Morriss, R. (2018). An Electronic Clinical Decision Support System for the Assessment and Management of Suicidality in Primary Care: Protocol for a Mixed-Methods Study. JMIR Research Protocols, 17(12), https://doi.org/10.2196/11135

Background: Suicide is a global public health concern, but it is preventable. Increased contact with primary care before the suicide or attempted suicide raises opportunities for intervention and prevention. However, suicide assessment and managemen... Read More about An Electronic Clinical Decision Support System for the Assessment and Management of Suicidality in Primary Care: Protocol for a Mixed-Methods Study.

How is a specialist depression service effective for persistent moderate to severe depressive disorder?: a qualitative study of service user experience (2018)
Journal Article
Thomson, L., Barker, M., Kaylor-Hughes, C., Garland, A., Ramana, R., Morriss, R., …Simpson, S. (2018). How is a specialist depression service effective for persistent moderate to severe depressive disorder?: a qualitative study of service user experience. BMC Psychiatry, 18(1), Article 194. https://doi.org/10.1186/s12888-018-1708-9

Background. A specialist depression service (SDS) offering collaborative pharmacological and cognitive behaviour therapy treatment for persistent depressive disorder showed effectiveness against depression symptoms versus usual community based multid... Read More about How is a specialist depression service effective for persistent moderate to severe depressive disorder?: a qualitative study of service user experience.

Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study (2018)
Journal Article
Kendrick, D., Baker, R., Hill, T., Beckett, K., Coupland, C., Kellezi, B., …Morriss, R. (2018). Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study. Journal of Psychosomatic Research, 112, 15-24. https://doi.org/10.1016/j.jpsychores.2018.06.008

Objective: To quantify psychological morbidity and identify baseline factors associated with depression, anxiety and post-traumatic distress symptoms up to 12 months post-injury. Methods: Multicentre cohort study of 668 adults, aged 16 to 70,... Read More about Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study.

Lamotrigine for people with borderline personality disorder: a RCT (2018)
Journal Article
Crawford, M. J., Sanatinia, R., Barrett, B., Cunningham, G., Dale, O., Ganguli, P., …Reilly, J. G. (2018). Lamotrigine for people with borderline personality disorder: a RCT. Health Technology Assessment, 22(17), 1-68. https://doi.org/10.3310/hta22170

Background: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Pr... Read More about Lamotrigine for people with borderline personality disorder: a RCT.

The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial (2018)
Journal Article
the AQUA Trial Group, Hollis, C., Hall, C. L., Guo, B., James, M., Boadu, J., …Morriss, R. (2018). The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial. Journal of Child Psychology and Psychiatry, 59(12), 1298-1308. https://doi.org/10.1111/jcpp.12921

© 2018 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. Background: Diagnosis of attention deficit hyperactivity disorder (ADHD) relies on su... Read More about The impact of a computerised test of attention and activity (QbTest) on diagnostic decision-making in children and young people with suspected attention deficit hyperactivity disorder: single-blind randomised controlled trial.

The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial (2018)
Journal Article
Crawford, M. J., Sanatinia, R., Barrett, B., Cunningham, G., Dale, O., Ganguli, P., …Reilly, J. G. (2018). The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial. American Journal of Psychiatry, 175(8), 756-764. https://doi.org/10.1176/appi.ajp.2018.17091006

Objectives: To examine whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. Method: Multicentre, double-blind, placebo-controlled randomized trial. Between July 2013 to Novembe... Read More about The clinical effectiveness and cost effectiveness of lamotrigine for people with borderline personality disorder: a randomized, placebo-controlled trial.

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article
Coupland, C., Hill, T., Morriss, R., Moore, M., Arthur, A., & Hippisley-Cox, J. (2018). Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database. BMC Medicine, 16(1), Article 36. https://doi.org/10.1186/s12916-018-1022-x

© 2018 The Author(s). Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. Th... Read More about Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database.

Multiple-therapy-resistant major depressive disorder: a clinically important concept (2018)
Journal Article
McAllistair-Williams, R., Christmas, D. M. B., Cleare, A. J., Currie, A., Gledhill, J., Insole, L., …Young, A. H. (2018). Multiple-therapy-resistant major depressive disorder: a clinically important concept. British Journal of Psychiatry, 212(5), 274-278. https://doi.org/10.1192/bjp.2017.33

Many novel therapeutic options for depression exist which are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinicians is when it might be appropriate to consider such ‘n... Read More about Multiple-therapy-resistant major depressive disorder: a clinically important concept.

Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial (2017)
Journal Article
Kaylor-Hughes, C., Rawsthorne, M., Coulson, N. S., Simpson, S., Simons, L., Guo, B., …Morriss, R. (in press). Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial. Journal of Medical Internet Research, 6(12), Article e231. https://doi.org/10.2196/resprot.8061

Regardless of geography or income, effective help for depression and anxiety only reaches a small proportion of those who might benefit from it. The scale of the problem suggests a role for effective, safe, anonymised public health driven online serv... Read More about Direct to public peer support and e-therapy program versus information to aid self-management of depression and anxiety: protocol for a randomized controlled trial.

Direct to Public Peer Support and e-Therapy Program Versus Information to Aid Self-Management of Depression and Anxiety: Protocol for a Randomized Controlled Trial (Preprint) (2017)
Other
Kaylor-Hughes, C. J., Rawsthorne, M., Coulson, N. S., Simpson, S., Simons, L., Guo, B., …REBOOT Notts Lived Experience Advisory Panel. (2017). Direct to Public Peer Support and e-Therapy Program Versus Information to Aid Self-Management of Depression and Anxiety: Protocol for a Randomized Controlled Trial (Preprint)

The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial (2017)
Journal Article
Kingslake, J., Dias, R., Dawson, G. R., Simon, J., Goodwin, G. M., Harmer, C. J., …Browning, M. (2017). The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial. Trials, 18(1), Article 558. https://doi.org/10.1186/s13063-017-2247-2

Background Antidepressant medication is commonly used to treat depression. However, many patients do not respond to the first medication prescribed and improvements in symptoms are generally only detectable by clinicians 4–6 weeks after the medica... Read More about The effects of using the PReDicT Test to guide the antidepressant treatment of depressed patients: study protocol for a randomised controlled trial.

Users’ experiences of an online intervention for Bipolar Disorder: important lessons for design and evaluation (2017)
Journal Article
Dodd, A. L., Mallinson, S., Griffiths, M., Morriss, R., Jones, S. H., & Lobban, F. (2017). Users’ experiences of an online intervention for Bipolar Disorder: important lessons for design and evaluation. Evidence-Based Mental Health, 20(4),

Background: The evidence-base for digital interventions for physical and mental health, including severe and enduring mental health difficulties, is increasing. In a feasibility trial, web-based Enhanced Relapse Prevention (ERPonline) for bipolar dis... Read More about Users’ experiences of an online intervention for Bipolar Disorder: important lessons for design and evaluation.

National survey and analysis of barriers to the utilisation of the 2005 mental capacity act by people with bipolar disorder in England and Wales (2017)
Journal Article
Morriss, R., Mudigonda, M., Bartlett, P., Chopra, A., & Jones, S. (2017). National survey and analysis of barriers to the utilisation of the 2005 mental capacity act by people with bipolar disorder in England and Wales. Journal of Mental Health, 1-8. https://doi.org/10.1080/09638237.2017.1340613

Background: The Mental Capacity Act (2005) (MCA) provides a legal framework for advance planning for both health and welfare in England and Wales for people if they lose mental capacity e.g. through mania or severe depression. Aims: To determine the... Read More about National survey and analysis of barriers to the utilisation of the 2005 mental capacity act by people with bipolar disorder in England and Wales.

Psychological morbidity and return to work after injury: multicentre cohort study (2017)
Journal Article
Kendrick, D., Dhiman, P., Kellezi, B., Coupland, C., Whitehead, J., Beckett, K., …Morriss, R. (in press). Psychological morbidity and return to work after injury: multicentre cohort study. British Journal of General Practice, https://doi.org/10.3399/bjgp17X691673

Background: The benefits of work for physical, psychological and financial wellbeing are well documented. Return to work (RTW) after unintentional injury is often delayed, and psychological morbidity may contribute to this delay. The impact of psycho... Read More about Psychological morbidity and return to work after injury: multicentre cohort study.

Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial (2017)
Journal Article
Tyrer, P., Tyrer, H., Morriss, R., Crawford, M., Cooper, S., Yang, M., …Barrett, B. (in press). Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial. Open Heart, 4(1), Article e000582. https://doi.org/10.1136/openhrt-2016-000582

Objective: To investigate the cost-effectiveness of a modified form of cognitive behaviour therapy for recurrent non-cardiac chest pain. Methods: We tested the effectiveness and cost-effectiveness of a modified form of cognitive behaviour therapy fo... Read More about Clinical and cost-effectiveness of adapted cognitive behaviour therapy for non-cardiac chest pain: a multicentre, randomised controlled trial.

Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling (2017)
Journal Article
Guo, B., Kaylor-Hughes, C., Garland, A., Nixon, N., Sweeney, T., Simpson, S., …Morriss, R. (2017). Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling. Journal of Affective Disorders, 219, 1-8. https://doi.org/10.1016/j.jad.2017.05.020

Background: The Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument for measuring levels of depression in patients in clinical practice and academic research; its factor structure has been investigated in various samples, with limited... Read More about Factor structure and longitudinal measurement invariance of PHQ-9 for specialist mental health care patients with persistent major depressive disorder: Exploratory Structural Equation Modelling.

Assessing Feasibility and Acceptability of Web-Based Enhanced Relapse Prevention for Bipolar Disorder (ERPonline): A Randomized Controlled Trial (2017)
Journal Article
Lobban, F., Dodd, A. L., Sawczuk, A. P., Asar, O., Dagnan, D., Diggle, P. J., …Jones, S. (2017). Assessing Feasibility and Acceptability of Web-Based Enhanced Relapse Prevention for Bipolar Disorder (ERPonline): A Randomized Controlled Trial. Journal of Medical Internet Research, 19(3), Article e85. https://doi.org/10.2196/jmir.7008

Background: Interventions that teach people with bipolar disorder (BD) to recognize and respond to early warning signs (EWS) of relapse are recommended but implementation in clinical practice is poor. Objectives: The objective of this study was to te... Read More about Assessing Feasibility and Acceptability of Web-Based Enhanced Relapse Prevention for Bipolar Disorder (ERPonline): A Randomized Controlled Trial.

Cost-effectiveness of structured group psychoeducation versus unstructured group support for bipolar disorder: results from a multi-centre pragmatic randomised controlled trial (2017)
Journal Article
Camacho, E., Ntais, D., Jones, S., Riste, L., Morriss, R. K., Lobban, F., & Davies, L. (2017). Cost-effectiveness of structured group psychoeducation versus unstructured group support for bipolar disorder: results from a multi-centre pragmatic randomised controlled trial. Journal of Affective Disorders, 211, https://doi.org/10.1016/j.jad.2017.01.005

Background Bipolar disorder (BD) costs the English economy an estimated £5.2billion/year, largely through incomplete recovery. This analysis estimated the cost-effectiveness of group psychoeducation (PEd), versus group peer support (PS), for treating... Read More about Cost-effectiveness of structured group psychoeducation versus unstructured group support for bipolar disorder: results from a multi-centre pragmatic randomised controlled trial.

National survey of training of psychiatrists on advance directives to refuse treatment in relation to bipolar disorder (2017)
Journal Article
Morriss, R., Mudigonda, M., Bartlett, P., Chopra, A., & Jones, S. (2017). National survey of training of psychiatrists on advance directives to refuse treatment in relation to bipolar disorder. BJPsych Bulletin, 41(6), 320-324. https://doi.org/10.1192/pb.bp.116.055343

Aims and Methods: To determine features associated with better perceived quality of training for psychiatrists on advance decision-making in the Mental Capacity Act (MCA), and whether the quality or amount of training were associated with positive at... Read More about National survey of training of psychiatrists on advance directives to refuse treatment in relation to bipolar disorder.

Bipolar at-risk criteria: an examination of which clinical features have optimal utility for identifying youth at risk of early transition from depression to bipolar disorders (2016)
Journal Article
Scott, J., Marwaha, S., Ratheesh, A., Macmillan, I., Yung, A. R., Morriss, R. K., …Bechdolf, A. (2017). Bipolar at-risk criteria: an examination of which clinical features have optimal utility for identifying youth at risk of early transition from depression to bipolar disorders. Schizophrenia Bulletin, 43(4), 737-744. https://doi.org/10.1093/schbul/sbw154

Background: A clinical and research challenge is to identify which depressed youth are at risk of “early transition to bipolar disorders (ET-BD).” This 2-part study (1) examines the clinical utility of previously reported BD at-risk (BAR) criteria in... Read More about Bipolar at-risk criteria: an examination of which clinical features have optimal utility for identifying youth at risk of early transition from depression to bipolar disorders.

The impact of psychological factors on recovery from injury: a multicentre cohort study (2016)
Journal Article
Kellezi, B., Coupland, C., Morriss, R., Beckett, K., Joseph, S., Barnes, J., …Kendrick, D. (2016). The impact of psychological factors on recovery from injury: a multicentre cohort study. Social Psychiatry and Psychiatric Epidemiology, 52(7), https://doi.org/10.1007/s00127-016-1299-z

Purpose Unintentional injuries have a significant long-term health impact in working age adults. Depression, anxiety and post-traumatic stress disorder are common post-injury, but their impact on self-reported recovery has not been investigated in g... Read More about The impact of psychological factors on recovery from injury: a multicentre cohort study.

Psychological morbidity and health related quality of life after injury: multicentre cohort study (2016)
Journal Article
Kendrick, D., Kellezi, B., Coupland, C., Maula, A., Beckett, K., Morriss, R. K., …Christie, N. (2017). Psychological morbidity and health related quality of life after injury: multicentre cohort study. Quality of Life Research, 26(5), 1233-1250. https://doi.org/10.1007/s11136-016-1439-7

Purpose: To demonstrate the impact of psychological morbidity one month post-injury on subsequent post-injury quality of life (HRQoL) in a general injury population in the UK to inform development of trauma care and rehabilitation services. Method... Read More about Psychological morbidity and health related quality of life after injury: multicentre cohort study.

Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study (2016)
Journal Article
Malins, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. K. (2016). Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study. British Journal of General Practice, 66(651), e729-e736. https://doi.org/10.3399/bjgp16X686569

Background: Most frequent attendance in primary care is temporary. Long-term frequent attendance may be suitable for psychological intervention to address health management and service use. Aim: To explore the feasibility and acceptability of cog... Read More about Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study.

Clinical effectiveness and acceptability of structured group psychoeducation versus optimised unstructured peer support for patients with remitted bipolar disorder (PARADES): a pragmatic, multicentre, observer-blind, randomised controlled superiority trial (2016)
Journal Article
Morriss, R., Lobban, F., Riste, L., Davies, L., Holland, F., Long, R., …Jones, S. (2016). Clinical effectiveness and acceptability of structured group psychoeducation versus optimised unstructured peer support for patients with remitted bipolar disorder (PARADES): a pragmatic, multicentre, observer-blind, randomised controlled superiority trial. Lancet Psychiatry, 3(11), https://doi.org/10.1016/S2215-0366%2816%2930302-9

Background Group psychoeducation is a low-cost National Institute for Health and Care Excellence-recommended treatment for bipolar disorder. However, the clinical effectiveness and acceptability of this intervention are unclear compared with unstr... Read More about Clinical effectiveness and acceptability of structured group psychoeducation versus optimised unstructured peer support for patients with remitted bipolar disorder (PARADES): a pragmatic, multicentre, observer-blind, randomised controlled superiority trial.

Planning for incapacity by people with bipolar disorder under the Mental Capacity Act 2005 (2016)
Journal Article
Bartlett, P., Mudigonda, M., Chopra, A., Morriss, R., & Jones, S. (2016). Planning for incapacity by people with bipolar disorder under the Mental Capacity Act 2005. Journal of Social Welfare and Family Law, 38(3), 263-286. https://doi.org/10.1080/09649069.2016.1228145

© 2016 Informa UK Limited, trading as Taylor & Francis Group. The Mental Capacity Act 2005 provides a variety of legal mechanisms for people to plan for periods of incapacity for decisions relating to personal care, medical treatment, and financial... Read More about Planning for incapacity by people with bipolar disorder under the Mental Capacity Act 2005.

Efficacy and cost-effectiveness of a specialist depression service versus usual specialist mental health care to manage persistent depression: a randomised controlled trial (2016)
Journal Article
Morriss, R., Garland, A., Nixon, N., Guo, B., James, M., Kaylor-Hughes, C., …Dalgleish, T. (2016). Efficacy and cost-effectiveness of a specialist depression service versus usual specialist mental health care to manage persistent depression: a randomised controlled trial. Lancet Psychiatry, 3(9), 821-831. https://doi.org/10.1016/s2215-0366%2816%2930143-2

Background: Persistent moderate or severe unipolar depression is common and expensive to treat. Clinical guidelines recommend combined pharmacotherapy and psychotherapy. Such treatments can take up to 1 year to show an effect, but no trials of suitab... Read More about Efficacy and cost-effectiveness of a specialist depression service versus usual specialist mental health care to manage persistent depression: a randomised controlled trial.

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database (2016)
Journal Article
Coupland, C., Hill, T., Morriss, R. K., Moore, M., Arthur, A., & Hippisley-Cox, J. (2016). Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database. BMJ, 2016(352), Article i1350. https://doi.org/10.1136/bmj.i1350

© BMJ Publishing Group Ltd 2016. Objective To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depr... Read More about Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database.

Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology (2016)
Journal Article
Goodwin, G., Haddad, P., Ferrier, I., Aronson, J., Barnes, T., Cipriani, A., …Young, A. (2016). Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology, https://doi.org/10.1177/0269881116636545

The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder. The third version is based explicitly on the available evidence and presented, like previous Clinical Practice Guidelines, as r... Read More about Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology.

Psychological interventions for adults with bipolar disorder: a systematic review and meta-analysis (2016)
Journal Article
Oud, M., Mayo-Wilson, E., Braidwood, R., Schulte, P., Jones, S. H., Morriss, R. K., …Kendall, T. (2016). Psychological interventions for adults with bipolar disorder: a systematic review and meta-analysis. British Journal of Psychiatry, 208(3), 213-222. https://doi.org/10.1192/bjp.bp.114.157123

Background Psychological interventions may be beneficial for bipolar disorder. Aims Efficacy evaluation of psychological interventions for adults with bipolar disorder. Methods A systematic review of randomised controlled trials.. Outcomes were met... Read More about Psychological interventions for adults with bipolar disorder: a systematic review and meta-analysis.

An experimental study exploring the impact of vignette gender on the quality of university students’ mental health first aid for peers with symptoms of depression (2016)
Journal Article
Davies, E. B., Wardlaw, J., Morriss, R. K., & Glazebrook, C. (2016). An experimental study exploring the impact of vignette gender on the quality of university students’ mental health first aid for peers with symptoms of depression. BMC Public Health, 16, Article 187. https://doi.org/10.1186/s12889-016-2887-2

Background University students have high rates of depression, and friends are often the most commonly-used source of support for emotional distress in this population. This study aimed to explore students’ ability to provide effective support for... Read More about An experimental study exploring the impact of vignette gender on the quality of university students’ mental health first aid for peers with symptoms of depression.

Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial (2016)
Journal Article
Patel, S., Malins, S., Guo, B., James, M., Kai, J., Kaylor-Hughes, C., …Morriss, R. K. (2016). Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial. BJPsych Open, 2, https://doi.org/10.1192/bjpo.bp.115.002220

Background Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues s... Read More about Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database (2015)
Journal Article
Hill, T., Coupland, C., Morriss, R. K., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry, 15, Article 315. https://doi.org/10.1186/s12888-015-0701-9

Background: Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepres... Read More about Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database.

Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation (2015)
Journal Article
Tyrer, P., Tyrer, H., Cooper, S., Barrett, B., Kings, S., Lazarevic, V., …Crawford, M. (2015). Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation. BMC Psychology, 3(41), https://doi.org/10.1186/s40359-015-0099-7

Background Most patients with chest pain have nothing wrong with their cardiac function. Psychological forms of treatment for this condition are more likely to be successful than others. Methods/design A two-arm parallel controlled randomize... Read More about Cognitive behaviour therapy for non-cardiac pain in the chest (COPIC): a multicentre randomized controlled trial with economic evaluation.

Clinical characteristics of persistent frequent attenders in primary care: case–control study (2015)
Journal Article
Patel, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. (2015). Clinical characteristics of persistent frequent attenders in primary care: case–control study. Family Practice, cmv076. https://doi.org/10.1093/fampra/cmv076

Background. Most frequent attendance in primary care is temporary, but persistent frequent attendance is expensive and may be suitable for psychological intervention. To plan appropriate intervention and service delivery, there is a need for research... Read More about Clinical characteristics of persistent frequent attenders in primary care: case–control study.

Lamotrigine versus inert placebo in the treatment of borderline personality disorder: study protocol for a randomized controlled trial and economic evaluation (2015)
Journal Article
Crawford, M. J., Sanatinia, R., Barrett, B., Byford, S., Cunningham, G., Gakhal, K., …Reilly, J. G. (2015). Lamotrigine versus inert placebo in the treatment of borderline personality disorder: study protocol for a randomized controlled trial and economic evaluation. Trials, 16, Article 308. https://doi.org/10.1186/s13063-015-0823-x

Background: People with borderline personality disorder (BPD) experience rapid and distressing changes in mood, poor social functioning and have high rates of suicidal behaviour. Several small scale studies suggest that mood stabilizers may produce s... Read More about Lamotrigine versus inert placebo in the treatment of borderline personality disorder: study protocol for a randomized controlled trial and economic evaluation.

The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study (2015)
Journal Article
Lycett, D., Nichols, L., Ryan, R., Farley, A., Roalfe, A., Mohammed, M. A., …Aveyard, P. (2015). The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study. Lancet Diabetes and Endocrinology, 3(6), https://doi.org/10.1016/S2213-8587%2815%2900082-0

Background Smoking increases the risk of developing type 2 diabetes. However, several population studies also show a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk equates to that of... Read More about The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study.

Objective methods for reliable detection of concealed depression (2015)
Journal Article
Solomon, C., Valstar, M. F., Morriss, R. K., & Crowe, J. (2015). Objective methods for reliable detection of concealed depression. Frontiers in ICT, 2, Article 5. https://doi.org/10.3389/fict.2015.00005

Recent research has shown that it is possible to automatically detect clinical depression from audio-visual recordings. Before considering integration in a clinical pathway, a key question that must be asked is whether such systems can be easily fool... Read More about Objective methods for reliable detection of concealed depression.

Technological innovations in mental healthcare: harnessing the digital revolution (2015)
Journal Article
Hollis, C., Morriss, R., Martin, J., Amani, S., Cotton, R., Denis, M., & Lewis, S. (2015). Technological innovations in mental healthcare: harnessing the digital revolution. British Journal of Psychiatry, 206(4), https://doi.org/10.1192/bjp.bp.113.142612

Digital technology has the potential to transform mental healthcare by connecting patients, services and health data in new ways. Digital online and mobile applications can offer patients greater access to information and services and enhance clinica... Read More about Technological innovations in mental healthcare: harnessing the digital revolution.

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database (2015)
Journal Article
Coupland, C., Hill, T., Morriss, R., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database. BMJ, 350(7996), Article h517. https://doi.org/10.1136/BMJ.h517

© BMJ Publishing Group Ltd 2015. Objective To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. Design Cohort study. Setting Patients registered... Read More about Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database.

Development and usability of a website-based depression literacy intervention for university students in Nottingham (2014)
Conference Proceeding
Davies, E. B., Morriss, R. K., & Glazebrook, C. (2014). Development and usability of a website-based depression literacy intervention for university students in Nottingham.

Purpose: A large proportion of university students experience mental health difficulties, with one review reporting a 30% prevalence rate of depression in this population. Depression affects students’ quality of life and academic performance. Mental... Read More about Development and usability of a website-based depression literacy intervention for university students in Nottingham.

An analysis of the research team-service user relationship from the service user perspective: a consideration of ‘The three Rs’ (roles, relations, and responsibilities) for healthcare research organisations (2014)
Journal Article
Jordan, M., Rowley, E., Morriss, R. K., & Manning, N. (2015). An analysis of the research team-service user relationship from the service user perspective: a consideration of ‘The three Rs’ (roles, relations, and responsibilities) for healthcare research organisations. Health Expectations, 18(6), https://doi.org/10.1111/hex.12243

Background This article debates interview data from service users who engaged with the work of a Collaboration for Leadership in Applied Health Research and Care (CLAHRC). The evidence base, to date, concerning the nature of CLAHRC work at the fro... Read More about An analysis of the research team-service user relationship from the service user perspective: a consideration of ‘The three Rs’ (roles, relations, and responsibilities) for healthcare research organisations.

Computer and website-based interventions to improve common mental health problems in university students: a meta-analysis (2014)
Conference Proceeding
Davies, E. B., Morriss, R. K., & Glazebrook, C. (2014). Computer and website-based interventions to improve common mental health problems in university students: a meta-analysis.

Website-based and computer-delivered interventions could improve common mental health problems experienced by university students, as their help-seeking is limited. This review analysed RCT trials of these interventions to improve depression, anxiety... Read More about Computer and website-based interventions to improve common mental health problems in university students: a meta-analysis.

Computer-Delivered and Web-Based Interventions to Improve Depression, Anxiety, and Psychological Well-Being of University Students: A Systematic Review and Meta-Analysis (2014)
Journal Article
Davies, E. B., Morriss, R. K., & Glazebrook, C. (2014). Computer-Delivered and Web-Based Interventions to Improve Depression, Anxiety, and Psychological Well-Being of University Students: A Systematic Review and Meta-Analysis. Journal of Medical Internet Research, 16(5), Article e130. https://doi.org/10.2196/jmir.org/2014/5/e130/

Background: Depression and anxiety are common mental health difficulties experienced by university students and can impair academic and social functioning. Students are limited in seeking help from professionals. As university students are highly co... Read More about Computer-Delivered and Web-Based Interventions to Improve Depression, Anxiety, and Psychological Well-Being of University Students: A Systematic Review and Meta-Analysis.

Randomized controlled trial of computerized cognitive behavioural therapy for depressive symptoms: effectiveness and costs of a workplace intervention (2013)
Journal Article
Phillips, R., Schneider, J. M., Molosankwe, I., Leese, M., Foroushani, P. S., Grime, P., …Thornicroft, G. (2014). Randomized controlled trial of computerized cognitive behavioural therapy for depressive symptoms: effectiveness and costs of a workplace intervention. Psychological Medicine, 44(4), 741-752. https://doi.org/10.1017/S0033291713001323

Background Depression and anxiety are major causes of absence from work and underperformance in the workplace. Cognitive behavioural therapy (CBT) can be effective in treating such problems and online versions offer many practical advantages. The aim... Read More about Randomized controlled trial of computerized cognitive behavioural therapy for depressive symptoms: effectiveness and costs of a workplace intervention.

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database (2013)
Journal Article
Coupland, C., Morriss, R., Arthur, A., Moore, M., Hill, T., & Hippisley-Cox, J. (2013). Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry, 13(135), https://doi.org/10.1186/1471-244X-13-135

Background: Antidepressants are among the most commonly prescribed drugs in primary care in England and their use is increasing. This is largely due to longer durations of treatment of depression. Observational studies have shown some differences in... Read More about Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database.

Cost-effectiveness of supported self-management for CFS/ME patients in primary care (2013)
Journal Article
Richardson, G., Epstein, D., Chew-Graham, C., Dowrick, C., Bentall, R. P., Morriss, R. K., …Wearden, A. J. (2013). Cost-effectiveness of supported self-management for CFS/ME patients in primary care. BMC Family Practice, 14(Januar), Article 9. https://doi.org/10.1186/1471-2296-14-12

Background: Nurse led self-help treatments for people with chronic fatigue syndrome/myalgic encephalitis (CFS/ME) have been shown to be effective in reducing fatigue but their cost-effectiveness is unknown. Methods: Cost-effectiveness analysis... Read More about Cost-effectiveness of supported self-management for CFS/ME patients in primary care.

Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention (2012)
Journal Article
Morriss, R. K., Kai, J., Atha, C., Avery, A., Bayes, S., Franklin, M., …Yang, M. (2012). Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention. BMC Family Practice, 13(39), https://doi.org/10.1186/1471-2296-13-39

Background: The top 3% of frequent attendance in primary care is associated with 15% of all appointments in primary care, a fivefold increase in hospital expenditure, and more mental disorder and functional somatic symptoms compared to normal atte... Read More about Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention.

General practitioners' views on reattribution for patients with medically unexplained symptoms: a questionnaire and qualitative study (2008)
Journal Article
Dowrick, C., Gask, L., Hughes, J. G., Charles-Jones, H., Hogg, J. A., Peters, S., …Morriss, R. K. (2008). General practitioners' views on reattribution for patients with medically unexplained symptoms: a questionnaire and qualitative study. BMC Family Practice, 9(46), https://doi.org/10.1186/1471-2296-9-46

Background: The successful introduction of new methods for managing medically unexplained symptoms in primary care is dependent to a large degree on the attitudes, experiences and expectations of practitioners. As part of an exploratory randomised... Read More about General practitioners' views on reattribution for patients with medically unexplained symptoms: a questionnaire and qualitative study.