Susan Brown
When a test is more than just a test: Findings from patient interviews and survey in the trial of a technology to measure antidepressant medication response (the PReDicT Trial)
Brown, Susan; Ploeger, Cornelia; Guo, Boliang; Petersen, Juliana J; Petersen, Juliana J.; Beckenstrom, Amy C; Beckenstrom, Amy C.; Browning, Michael; Dawson, Gerard R; Dawson, Gerard R.; Deckert, Jürgen; Dias, Rebecca; Dourish, Colin T; Dourish, Colin T.; Gorwood, Philip; Kingslake, Jonathan; Menke, Andreas; Sola, Victor Perez; Reif, Andreas; Ruhe, Henricus; Simon, Judit; Stäblein, Michael; van Schaik, Anneke; Veltman, Dick J; Veltman, Dick J.; Morriss, Richard
Authors
Cornelia Ploeger
Dr BOLIANG GUO BOLIANG.GUO@NOTTINGHAM.AC.UK
ASSOCIATE PROFESSOR
Juliana J Petersen
Juliana J. Petersen
Amy C Beckenstrom
Amy C. Beckenstrom
Michael Browning
Gerard R Dawson
Gerard R. Dawson
Jürgen Deckert
Rebecca Dias
Colin T Dourish
Colin T. Dourish
Philip Gorwood
Jonathan Kingslake
Andreas Menke
Victor Perez Sola
Andreas Reif
Henricus Ruhe
Judit Simon
Michael Stäblein
Anneke van Schaik
Dick J Veltman
Dick J. Veltman
Professor RICHARD MORRISS richard.morriss@nottingham.ac.uk
PROFESSOR OF PSYCHIATRY AND COMMUNITY MENTAL HEALTH
Abstract
Background
A RCT of a novel intervention to detect antidepressant medication response (the PReDicT Test) took place in five European countries, accompanied by a nested study of its acceptability and implementation presented here. The RCT results indicated no effect of the intervention on depression at 8 weeks (primary outcome), although effects on anxiety at 8 weeks and functioning at 24 weeks were found.
Methods
The nested study used mixed methods. The aim was to explore patient experiences of the Test including acceptability and implementation, to inform its use within care. A bespoke survey was completed by trial participants in five countries (n = 778) at week 8. Semi-structured interviews were carried out in two countries soon after week 8 (UK n = 22, Germany n = 20). Quantitative data was analysed descriptively; for qualitative data, thematic analysis was carried out using a framework approach. Results of the two datasets were interrogated together.
Outcomes
Survey results showed the intervention was well received, with a majority of participants indicating they would use it again, and it gave them helpful extra information; a small minority indicated the Test made them feel worse. Qualitative data showed the Test had unexpected properties, including: instigating a process of reflection, giving participants feedback on progress and new understanding about their illness, and making participants feel supported and more engaged in treatment.
Interpretation
The qualitative and quantitative results are generally consistent. The Test's unexpected properties may explain why the RCT showed little effect, as properties were experienced across both trial arms. Beyond the RCT, the qualitative data sheds light on measurement reactivity, i.e., how measurements of depression can impact patients.
Citation
Brown, S., Ploeger, C., Petersen, J. J., Guo, B., Beckenstrom, A. C., Petersen, J. J., Beckenstrom, A. C., Dawson, G. R., Browning, M., Dawson, G. R., Deckert, J., Dourish, C. T., Dias, R., Dourish, C. T., Gorwood, P., Kingslake, J., Menke, A., Sola, V. P., Reif, A., Ruhe, H., …Morriss, R. (2024). When a test is more than just a test: Findings from patient interviews and survey in the trial of a technology to measure antidepressant medication response (the PReDicT Trial). Comprehensive Psychiatry, 132, Article 152467. https://doi.org/10.1016/j.comppsych.2024.152467
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 29, 2024 |
Online Publication Date | Apr 11, 2024 |
Publication Date | 2024-07 |
Deposit Date | Apr 16, 2024 |
Publicly Available Date | Apr 16, 2024 |
Journal | Comprehensive Psychiatry |
Print ISSN | 0010-440X |
Electronic ISSN | 1532-8384 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 132 |
Article Number | 152467 |
DOI | https://doi.org/10.1016/j.comppsych.2024.152467 |
Keywords | Depression; PRIMARY CARE; Digital Technology; Qualitative; Measurement reactivity |
Public URL | https://nottingham-repository.worktribe.com/output/33827894 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0010440X2400018X?via%3Dihub |
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