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Professor MATTHEW BROOKES's Outputs (99)

Source reconstruction without an MRI using optically pumped magnetometer based magnetoencephalography (2025)
Journal Article
Rhodes, N., Rier, L., Boto, E., Hill, R., & Brookes, M. J. (2025). Source reconstruction without an MRI using optically pumped magnetometer based magnetoencephalography. Imaging Neuroscience, https://doi.org/10.1162/imag.a.8

Source modelling in magnetoencephalography (MEG) infers the spatial origins of electrophysiological signals in the brain. Typically, this requires an anatomical MRI scan of the subject’s head, from which models of the magnetic fields generated by the... Read More about Source reconstruction without an MRI using optically pumped magnetometer based magnetoencephalography.

Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial (2025)
Journal Article
Acherman, Y. I. Z., Arebi, N., Arthurs, E., Bemelman, W. A., van der Bilt, J. D. W., Braat, H., Brink, M. A., Brookes, M., Brown, J. P. Y., Brown, S. R., Buskens, C. J., Consten, E. C. J., Cooney, R., Crolla, R. M. P. H., Davies, R. J., Depla, A. C. T. M., D'Haens, G. R., Dijkgraaf, M. G. W., Doherty, G., van Duijvendijk, P., …van der Zanden, E. P. M. (2025). Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial. The Lancet Gastroenterology & Hepatology, 10(6), 550-561. https://doi.org/10.1016/S2468-1253%2825%2900026-3

Background
The appendix might have an immunomodulatory role in ulcerative colitis. Appendicectomy has been suggested as a potentially therapeutic intervention to maintain remission in ulcerative colitis. We aimed to evaluate the clinical effectivene... Read More about Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial.

Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury (2025)
Journal Article
Sassani, M., Ghafari, T., Arachchige, P. R. W., Idrees, I., Gao, Y., Waitt, A., Weaver, S. R. C., Mazaheri, A., Lyons, H. S., Grech, O., Thaller, M., Witton, C., Bagshaw, A. P., Wilson, M., Park, H., Brookes, M., Novak, J., Mollan, S. P., Hill, L. J., Lucas, S. J. E., …Fernández-Espejo, D. (2025). Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury. Brain Communications, 7(2), Article fcaf120. https://doi.org/10.1093/braincomms/fcaf120

There is unmet clinical need for biomarkers to predict recovery or the development of long-term sequelae of mild traumatic brain injury, a highly prevalent condition causing a constellation of disabling symptoms. A substantial proportion of patients... Read More about Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury.

Wearable magnetoencephalography in a lightly shielded environment (2024)
Journal Article
Holmes, N., Leggett, J., Hill, R. M., Rier, L., Boto, E., Schofield, H., Hayward, T., Dawson, E., Woolger, D., Shah, V., Taulu, S., Brookes, M. J., & Bowtell, R. (2025). Wearable magnetoencephalography in a lightly shielded environment. IEEE Transactions on Biomedical Engineering, 72(2), 609-618. https://doi.org/10.1109/tbme.2024.3465654

Wearable magnetoencephalography based on optically pumped magnetometers (OPM-MEG) offers non-invasive and high-fidelity measurement of human brain electrophysiology. The flexibility of OPM-MEG also means it can be deployed in participants of all ages... Read More about Wearable magnetoencephalography in a lightly shielded environment.

A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers (2024)
Journal Article
Schofield, H., Hill, R. M., Feys, O., Holmes, N., Osborne, J., Doyle, C., Bobela, D., Corvilain, P., Wens, V., Rier, L., Bowtell, R., Ferez, M., Mullinger, K. J., Coleman, S., Rhodes, N., Rea, M., Tanner, Z., Boto, E., de Tiège, X., Shah, V., & Brookes, M. J. (2024). A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers. Imaging Neuroscience, 2, 1-22. https://doi.org/10.1162/imag_a_00283

Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; howe... Read More about A novel, robust, and portable platform for magnetoencephalography using optically-pumped magnetometers.

Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography (2024)
Journal Article
Rier, L., Rhodes, N., Pakenham, D. O., Boto, E., Holmes, N., Hill, R. M., Reina Rivero, G., Shah, V., Doyle, C., Osborne, J., Bowtell, R. W., Taylor, M., & Brookes, M. J. (2024). Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography. eLife, 13, Article RP94561. https://doi.org/10.7554/elife.94561.3

Neural oscillations mediate the coordination of activity within and between brain networks, supporting cognition and behaviour. How these processes develop throughout childhood is not only an important neuroscientific question but could also shed lig... Read More about Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography.

Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG (2024)
Journal Article
Seedat, Z. A., Pier, K. S., Holmes, N., Rea, M., Al-Hilaly, L., Tierney, T. M., Embury, C. M., Pardington, R., Mullinger, K. J., Cross, J. H., Boto, E., & Brookes, M. J. (2024). Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG. Imaging Neuroscience, 2, 1-15. https://doi.org/10.1162/imag_a_00179

Electroencephalography (EEG) and magnetoencephalography (MEG) non-invasively measure human brain electrophysiology. They differ in nature; MEG offers better performance whilst EEG (a wearable platform) is more practical. They are also complementary,... Read More about Simultaneous whole-head electrophysiological recordings using EEG and OPM-MEG.

Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics (2024)
Journal Article
Coleman, S. C., Seedat, Z. A., Pakenham, D. O., Quinn, A. J., Brookes, M. J., Woolrich, M. W., & Mullinger, K. J. (2024). Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics. Human Brain Mapping, 45(7), Article e26700. https://doi.org/10.1002/hbm.26700

The post-movement beta rebound has been studied extensively using magnetoencephalography (MEG) and is reliably modulated by various task parameters as well as illness. Our recent study showed that rebounds, which we generalise as “post-task responses... Read More about Post‐task responses following working memory and movement are driven by transient spectral bursts with similar characteristics.

The neurodevelopmental trajectory of beta band oscillations: an OPM-MEG study (2024)
Journal Article
Rier, L., Rhodes, N., Pakenham, D., Boto, E., Holmes, N., Hill, R. M., Rivero, G. R., Shah, V., Doyle, C., Osborne, J., Bowtell, R., Taylor, M. J., & Brookes, M. J. (2024). The neurodevelopmental trajectory of beta band oscillations: an OPM-MEG study. eLife, Article 94561v1. https://doi.org/10.7554/eLife.94561.1

Neural oscillations mediate coordination of activity within and between brain networks, supporting cognition and behaviour. How these processes develop throughout childhood is not only a critical neuroscientific question but could also shed light on... Read More about The neurodevelopmental trajectory of beta band oscillations: an OPM-MEG study.

Designing Optimal Loop, Saddle, and Ellipse-Based Magnetic Coils by Spherical Harmonic Mapping (2023)
Journal Article
Hobson, P. J., Hardwicke, N. L., Davis, A., Smith, T. X., Morley, C., Packer, M., Holmes, N., Weil, M. A., Brookes, M. J., Bowtell, R., & Fromhold, M. (2023). Designing Optimal Loop, Saddle, and Ellipse-Based Magnetic Coils by Spherical Harmonic Mapping. IEEE Transactions on Instrumentation and Measurement, 72, Article 1005815. https://doi.org/10.1109/TIM.2023.3284138

Adaptable, low-cost, coils designed by carefully selecting the arrangements and geometries of simple primitive units are used to generate magnetic fields for diverse applications. These extend from magnetic resonance and fundamental physics experimen... Read More about Designing Optimal Loop, Saddle, and Ellipse-Based Magnetic Coils by Spherical Harmonic Mapping.

Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study (2023)
Journal Article
Feys, O., Corvilain, P., Labyt, E., Mahmoudzadeh, M., Routier, L., Sculier, C., Holmes, N., Brookes, M., Goldman, S., Romain, R., Mitryukovskiy, S., Palacios-Laloy, A., Schwartz, D., Betrouni, N., Derambure, P., Wallois, F., Wens, V., & De Tiège, X. (2023). Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study. Frontiers in Neuroscience, 17, Article 1284262. https://doi.org/10.3389/fnins.2023.1284262

Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of... Read More about Tri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study.

Portable single-beam cesium zero-field magnetometer for magnetocardiography (2023)
Journal Article
Dawson, R., O'Dwyer, C., Mrozowski, M. S., Irwin, E., McGilligan, J. P., Burt, D. P., Hunter, D., Ingleby, S., Rea, M., Holmes, N., Brookes, M. J., Griffin, P. F., & Riis, E. (2023). Portable single-beam cesium zero-field magnetometer for magnetocardiography. Journal of Optical Microsystems, 3(4), Article 044501. https://doi.org/10.1117/1.jom.3.4.044501

Optically pumped magnetometers (OPMs) are becoming common in the realm of biomagnetic measurements. We discuss the development of a prototype zero-field cesium portable OPM and its miniaturized components. Zero-field sensors operate in a very low sta... Read More about Portable single-beam cesium zero-field magnetometer for magnetocardiography.

Test-retest reliability of the human connectome: An OPM-MEG study (2023)
Journal Article
Rier, L., Michelmann, S., Ritz, H., Shah, V., Hill, R. M., Osborne, J., Doyle, C., Holmes, N., Bowtell, R., Brookes, M. J., Norman, K. A., Hasson, U., Cohen, J. D., & Boto, E. (2023). Test-retest reliability of the human connectome: An OPM-MEG study. Imaging Neuroscience, 1, 1-20. https://doi.org/10.1162/imag_a_00020

Magnetoencephalography with optically pumped magnetometers (OPM-MEG) offers a new way to record electrophysiological brain function, with significant advantages over conventional MEG, including adaptability to head shape/size, free movement during sc... Read More about Test-retest reliability of the human connectome: An OPM-MEG study.

Benchtop magnetic shielding for benchmarking atomic magnetometers (2023)
Journal Article
Hobson, P. J., Holmes, N., Patel, P., Styles, B., Chalmers, J., Morley, C., Davis, A., Packer, M., Smith, T. X., Raudonyte, S., Holmes, D., Harrison, R., Woolger, D., Sims, D., Brookes, M. J., Bowtell, R., & Fromhold, M. (2023). Benchtop magnetic shielding for benchmarking atomic magnetometers. IEEE Transactions on Instrumentation and Measurement, 72, Article 6007309. https://doi.org/10.1109/tim.2023.3293540

Here, a benchtop hybrid magnetic shield containing four mumetal cylinders and nine internal flexible printed circuit boards is designed, constructed, tested, and operated. The shield is designed specifically as a test-bed for building and operating u... Read More about Benchtop magnetic shielding for benchmarking atomic magnetometers.

An Iterative Implementation of the Signal Space Separation Method for Magnetoencephalography Systems with Low Channel Counts (2023)
Journal Article
Holmes, N., Bowtell, R., Brookes, M. J., & Taulu, S. (2023). An Iterative Implementation of the Signal Space Separation Method for Magnetoencephalography Systems with Low Channel Counts. Sensors, 23(14), Article 6537. https://doi.org/10.3390/s23146537

The signal space separation (SSS) method is routinely employed in the analysis of multichannel magnetic field recordings (such as magnetoencephalography (MEG) data). In the SSS method, signal vectors are posed as a multipole expansion of the magnetic... Read More about An Iterative Implementation of the Signal Space Separation Method for Magnetoencephalography Systems with Low Channel Counts.

Naturalistic Hyperscanning with Wearable Magnetoencephalography (2023)
Journal Article
Holmes, N., Rea, M., Hill, R. M., Boto, E., Leggett, J., Edwards, L. J., Rhodes, N., Shah, V., Osborne, J., Fromhold, T. M., Glover, P., Montague, P. R., Brookes, M. J., & Bowtell, R. (2023). Naturalistic Hyperscanning with Wearable Magnetoencephalography. Sensors, 23(12), Article 5454. https://doi.org/10.3390/s23125454

The evolution of human cognitive function is reliant on complex social interactions which form the behavioural foundation of who we are. These social capacities are subject to dramatic change in disease and injury; yet their supporting neural substra... Read More about Naturalistic Hyperscanning with Wearable Magnetoencephalography.

Enabling ambulatory movement in wearable magnetoencephalography with matrix coil active magnetic shielding (2023)
Journal Article
Holmes, N., Rea, M., Hill, R. M., Leggett, J., Edwards, L. J., Hobson, P. J., Boto, E., Tierney, T. M., Rier, L., Rivero, G. R., Shah, V., Osborne, J., Fromhold, T. M., Glover, P., Brookes, M. J., & Bowtell, R. (2023). Enabling ambulatory movement in wearable magnetoencephalography with matrix coil active magnetic shielding. NeuroImage, 274, Article 120157. https://doi.org/10.1016/j.neuroimage.2023.120157

The ability to collect high-quality neuroimaging data during ambulatory participant movement would enable a wealth of neuroscientific paradigms. Wearable magnetoencephalography (MEG) based on optically pumped magnetometers (OPMs) has the potential to... Read More about Enabling ambulatory movement in wearable magnetoencephalography with matrix coil active magnetic shielding.

Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers (2023)
Journal Article
Hillebrand, A., Holmes, N., Sijsma, N., O’Neill, G. C., Tierney, T. M., Liberton, N., Stam, A. H., van Klink, N., Stam, C. J., Bowtell, R., Brookes, M. J., & Barnes, G. R. (2023). Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers. Scientific Reports, 13(1), Article 4623. https://doi.org/10.1038/s41598-023-31111-y

Magneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems the sensors are offset from the scalp, which limits the signal-to-noise ratio... Read More about Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers.