Outputs (46)

The critical role of technologies in neonatal care (2023)
Journal Article
Taha, S., Simpson, R. B., & Sharkey, D. (2023). The critical role of technologies in neonatal care. Early Human Development, 187, Article 105898. https://doi.org/10.1016/j.earlhumdev.2023.105898

Neonatal care has made significant advances in the last few decades. As a result, mortality and morbidity in high-risk infants, such as extremely preterm infants or those infants with birth-related brain injury, has reduced significantly. Many of the... Read More about The critical role of technologies in neonatal care.

Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study (2023)
Journal Article
Szatkowski, L., Sharkey, D., Budge, H., & Ojha, S. (2023). Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study. eClinicalMedicine, 65, Article 102296. https://doi.org/10.1016/j.eclinm.2023.102296

Background: Preterm infants often require mechanical ventilation (MV), which can be a painful experience. Opioids (such as morphine) are used to provide analgesia, despite conflicting evidence about their impact on the developing brain. We aimed to q... Read More about Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study.

Identifying Variation in the Newborn Life Support Procedure: An Automated Method (2023)
Conference Proceeding
Tan, A., Remenyte-Prescott, R., Egede, J., Valstar, M., & Sharkey, D. (2023). Identifying Variation in the Newborn Life Support Procedure: An Automated Method. In M. P. Brito, T. Aven, P. Baraldi, M. Čepin, & E. Zio (Eds.), Proceedings of the 33rd European Safety and Reliability Conference (ESREL 2023) (607-614)

This research is conducted for developing an automated method to recognize variations in the Newborn Life Support (NLS) procedure. Compliance with the NLS standard guideline is essential to prevent any adverse consequences for the newborn. Video reco... Read More about Identifying Variation in the Newborn Life Support Procedure: An Automated Method.

Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard (2023)
Journal Article
Kwok, T. C., Poulter, C., Algarni, S., Szatkowski, L., & Sharkey, D. (2023). Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard. Thorax, 78(12), 1215–1222. https://doi.org/10.1136/thorax-2023-220174

Introduction: Bronchopulmonary dysplasia (BPD) is associated with adverse long-term respiratory and neurodevelopmental outcomes. No recent studies examined the changing respiratory management and outcomes, particularly severe BPD, across a whole popu... Read More about Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard.

Impact of postnatal dexamethasone timing on preterm mortality and bronchopulmonary dysplasia: a propensity score analysis (2023)
Journal Article
Kwok, T. C., Szatkowski, L., & Sharkey, D. (in press). Impact of postnatal dexamethasone timing on preterm mortality and bronchopulmonary dysplasia: a propensity score analysis. European Respiratory Journal, https://doi.org/10.1183/13993003.00825-2023

Introduction Postnatal dexamethasone (PND) is used in high-risk preterm infants after the first week of life to facilitate extubation and prevent bronchopulmonary dysplasia (BPD) but the optimal treatment timing remains unclear. Objective Explore... Read More about Impact of postnatal dexamethasone timing on preterm mortality and bronchopulmonary dysplasia: a propensity score analysis.

The Classification of Movement in Infants for the Autonomous Monitoring of Neurological Development (2023)
Journal Article
Turner, A., Hayes, S., & Sharkey, D. (2023). The Classification of Movement in Infants for the Autonomous Monitoring of Neurological Development. Sensors, 23(10), Article 4800. https://doi.org/10.3390/s23104800

Neurodevelopmental delay following extremely preterm birth or birth asphyxia is common but diagnosis is often delayed as early milder signs are not recognised by parents or clinicians. Early interventions have been shown to improve outcomes. Automati... Read More about The Classification of Movement in Infants for the Autonomous Monitoring of Neurological Development.

A modelling approach to studying variations in newborn life support procedure (2023)
Journal Article
Tan, A., Remenyte-Prescott, R., Valstar, M., & Sharkey, D. (2023). A modelling approach to studying variations in newborn life support procedure. Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability, https://doi.org/10.1177/1748006X231173595

Variations in clinical practice are common. However, some variations may cause undesired consequences. Careful consideration of their causes and effects is necessary to assure the quality of healthcare delivery. A modelling approach that could captur... Read More about A modelling approach to studying variations in newborn life support procedure.

Forehead monitoring of heart rate in neonatal intensive care (2023)
Journal Article
Stockwell, S. J., Kwok, T. C., Morgan, S. P., Sharkey, D., & Hayes-Gill, B. R. (2023). Forehead monitoring of heart rate in neonatal intensive care. Frontiers in Physiology, 14, Article 1127419. https://doi.org/10.3389/fphys.2023.1127419

Heart rate is an extremely important physiological parameter to measure in critically unwell infants, as it is the main physiological marker that changes in response to a change in infant condition. Heart rate is routinely measured peripherally on a... Read More about Forehead monitoring of heart rate in neonatal intensive care.

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia (2023)
Journal Article
Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296. https://doi.org/10.1152/ajplung.00106.2021

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from expo... Read More about Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia.

Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes (2023)
Journal Article
Szatkowski, L., Fateh, S., Abramson, J., Kwok, T. C., Sharkey, D., Budge, H., & Ojha, S. (2023). Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes. Archives of Disease in Childhood. Fetal and Neonatal Edition, 108(5), 505-510. https://doi.org/10.1136/archdischild-2022-324919

Objective: To quantify trends in caffeine use in infants born at

Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation (2023)
Journal Article
Kwok, T. C., Batey, N., Luu, K. L., Prayle, A., & Sharkey, D. (2023). Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation. Pediatric Research, 94, 43–54. https://doi.org/10.1038/s41390-022-02451-8

Abstract: Prediction models could identify infants at the greatest risk of bronchopulmonary dysplasia (BPD) and allow targeted preventative strategies. We performed a systematic review and meta-analysis with external validation of identified models.... Read More about Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation.

Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology (2023)
Journal Article
Grooby, E., Sitaula, C., Chang Kwok, T., Sharkey, D., Marzbanrad, F., & Malhotra, A. (2023). Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology. Pediatric Research, 93(2), 413-425. https://doi.org/10.1038/s41390-022-02416-x

Abstract: With the development of Artificial Intelligence techniques, smart health monitoring is becoming more popular. In this study, we investigate the trend of wearable sensors being adopted and developed in neonatal cardiorespiratory monitoring.... Read More about Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology.

Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring. Part 2: artificial intelligence (2022)
Journal Article
Sitaula, C., Grooby, E., Kwok, T. C., Sharkey, D., Marzbanrad, F., & Malhotra, A. (2023). Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring. Part 2: artificial intelligence. Pediatric Research, 93(2), 426-436. https://doi.org/10.1038/s41390-022-02417-w

Background: With the development of Artificial Intelligence (AI) techniques, smart health monitoring, particularly neonatal cardiorespiratory monitoring with wearable devices, is becoming more popular. To this end, it is crucial to investigate the tr... Read More about Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring. Part 2: artificial intelligence.

Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland (2022)
Journal Article
Kwok, T. C., Dineen, R. A., Whitehouse, W., Lynn, R. M., McSweeney, N., & Sharkey, D. (2022). Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland. Open Medicine, 17(1), 1417-1424. https://doi.org/10.1515/med-2022-0554

Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in olde... Read More about Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland.

Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets (2022)
Conference Proceeding
Leva, M. C., Patelli, E., Podofillini, L., Wilson, S., Tan, A., Remenyte-Prescott, R., …Sharkey, D. (2022). Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets. In M. Chiara Leva, E. Patelli, L. Podofillini, & S. Wilson (Eds.), Proceedings of the 32nd European Safety and Reliability Conference (ESREL 2022) (489-496). https://doi.org/10.3850/978-981-18-5183-4_R12-08-152-cd

This research is conducted to study variations in the Newborn Life Support procedure. This procedure follows an evidence-based protocol to resuscitate and stabilize newborn babies requiring assistance at birth. Errors and ineffective actions in this... Read More about Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets.

Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic (2022)
Journal Article
Hanley, S. J., Jones, A. B., Oberman, J., Baxter, E., Sharkey, D., Gray, J., & Walker, K. F. (2022). Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.018

Background: This study aimed to explore the successes and barriers to the implementation of Public Health England (PHE) infection prevention and control guidance in English maternity units during the COVID-19 pandemic. Methods: Qualitative semi-struc... Read More about Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic.

Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice (2022)
Journal Article
Hanley, S., Raybould, G., Baxter, E., Gray, J., Sharkey, D., & Walker, K. F. (2022). Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.019

Introduction: The rapidly evolving COVID-19 pandemic required systemic change in how healthcare was delivered to minimize virus transmission whilst maintaining safe service delivery. Deemed at ‘moderate-high risk’, maternity patients are an important... Read More about Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice.

Application and potential of artificial intelligence in neonatal medicine (2022)
Journal Article
Chang Kwok, T., Henry, C., Saffaran, S., Meeus, M., Bates, D., Van Laere, D., …Sharkey, D. (2022). Application and potential of artificial intelligence in neonatal medicine. Seminars in Fetal and Neonatal Medicine, 27(5), Article 101346. https://doi.org/10.1016/j.siny.2022.101346

Neonatal care is becoming increasingly complex with large amounts of rich, routinely recorded physiological, diagnostic and outcome data. Artificial intelligence (AI) has the potential to harness this vast quantity and range of information and become... Read More about Application and potential of artificial intelligence in neonatal medicine.

Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018 (2022)
Journal Article
Mistry, A., Shipley, L., Ojha, S., & Sharkey, D. (2022). Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(6), 597-602. https://doi.org/10.1136/archdischild-2021-322906

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.... Read More about Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants (2022)
Journal Article
Henry, C., Shipley, L., Morgan, S., Crowe, J. A., Carpenter, J., Hayes-Gill, B., & Sharkey, D. (2022). Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants. Neonatology, 119(2), 264-267. https://doi.org/10.1159/000521530

Background: International newborn resuscitation guidelines recommend electrocardiogram (ECG) heart rate (HR) monitoring at birth. We evaluated the application time of pre-set ECG electrodes fixed to a polyethene patch allowing adhesive-free attachmen... Read More about Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants.

Observational cohort study of changing trends in non-invasive ventilation in very preterm infants and associations with clinical outcomes (2021)
Journal Article
Sand, L., Szatkowski, L., Kwok, T. C., Sharkey, D., Todd, D. A., Budge, H., & Ojha, S. (2022). Observational cohort study of changing trends in non-invasive ventilation in very preterm infants and associations with clinical outcomes. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(2), 150-155. https://doi.org/10.1136/archdischild-2021-322390

Objective: To determine the change in non-invasive ventilation (NIV) use over time in infants born at

Temporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study (2021)
Journal Article
Shipley, L., Hyliger, G., & Sharkey, D. (2022). Temporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(2), 201-205. https://doi.org/10.1136/archdischild-2021-322195

Objective Early postnatal transfer (PNT) of extremely preterm infants is associated with adverse outcomes compared with in utero transfer (IUT). We aimed to explore recent national trends of IUT and early PNT. Design Observational cohort study... Read More about Temporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study.

Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis (2021)
Journal Article
Shipley, L., Mistry, A., & Sharkey, D. (2021). Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis. Archives of Disease in Childhood. Fetal and Neonatal Edition, Article fetalneonatal-2020-320966. https://doi.org/10.1136/archdischild-2020-320966

Airflow dispersion during common neonatal resuscitation procedures: A simulation study (2021)
Journal Article
Kwok, T. C., Swaby, R., & Sharkey, D. (2021). Airflow dispersion during common neonatal resuscitation procedures: A simulation study. Pediatric Pulmonology, 56(7), 2057-2066. https://doi.org/10.1002/ppul.25378

Background Aerosol generating medical procedures (AGMPs) are common during newborn resuscitation. Neonates with respiratory viruses such as severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) infection may pose a risk to healthcare workers.... Read More about Airflow dispersion during common neonatal resuscitation procedures: A simulation study.

Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study (2021)
Journal Article
Shipley, L., Gale, C., & Sharkey, D. (2021). Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 106(5), https://doi.org/10.1136/archdischild-2020-320902

Objective: Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of neonatal mortality and neurodisability. We aimed to determine the incidence of HIE and management patterns against national guidelines. Design: Retrospective cohort study... Read More about Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study.

Smartphone monitoring of in-ambulance vibration and noise (2021)
Journal Article
Partridge, T., Gherman, L., Morris, D., Light, R., Leslie, A., Sharkey, D., …Crowe, J. (2021). Smartphone monitoring of in-ambulance vibration and noise. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 235(4), 428-436. https://doi.org/10.1177/0954411920985994

Transferring sick premature infants between hospitals increases the risk of severe brain injury, potentially linked to the excessive exposure to noise, vibration and driving-related accelerations. One method of reducing these levels may be to travel... Read More about Smartphone monitoring of in-ambulance vibration and noise.

Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance (2020)
Journal Article
Gale, C., Quigley, M. A., Placzek, A., Knight, M., Ladhani, S., Draper, E. S., …Kurinczuk, J. J. (2021). Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. Lancet Child and Adolescent Health, 5(2), 113-121. https://doi.org/10.1016/S2352-4642%2820%2930342-4

Background: Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aime... Read More about Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Finding Comfortable Routes for Ambulance Transfers of Newborn Infants (2020)
Conference Proceeding
Partridge, T. J., Morris, D. E., Light, R. A., Leslie, A., Sharkey, D., Crowe, J. A., & McNally, D. S. (2020). Finding Comfortable Routes for Ambulance Transfers of Newborn Infants. In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). https://doi.org/10.1109/EMBC44109.2020.9175873

Early inter-hospital ambulance transport of premature babies is associated with more severe brain injury. The mechanism is unclear, but they are exposed to excessive noise and vibration. Smart-routing may help minimise these exposure levels and poten... Read More about Finding Comfortable Routes for Ambulance Transfers of Newborn Infants.

Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: A primary care population-based cohort study (2020)
Journal Article
Tan, S., Szatkowski, L., Moreton, W., Fiaschi, L., McKeever, T., Gibson, J., & Sharkey, D. (2020). Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: A primary care population-based cohort study. European Respiratory Journal, 56(1), https://doi.org/10.1183/13993003.00202-2020

Background Globally, bronchopulmonary dysplasia (BPD) continues to increase in preterm infants. Recent studies exploring subsequent early childhood respiratory morbidity have been small or focused on hospital admissions. Primary aim Examine early... Read More about Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: A primary care population-based cohort study.

Accurate neonatal heart rate monitoring using a new wireless, cap mounted device (2020)
Journal Article
Henry, C., Shipley, L., Ward, C., Mirahmadi, S., Liu, C., Morgan, S., …Sharkey, D. (2020). Accurate neonatal heart rate monitoring using a new wireless, cap mounted device. Acta Paediatrica, 110(1), 72-78. https://doi.org/10.1111/apa.15303

© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica Aim: A device for newborn heart rate (HR) monitoring at birth that is compatible with delayed cord clamping and minimises hypothermia r... Read More about Accurate neonatal heart rate monitoring using a new wireless, cap mounted device.

Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups (2020)
Journal Article
Taylor, C., Tan, S., McClaughry, R., & Sharkey, D. (2020). Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups. Neonatology, 117(4), 513–516. https://doi.org/10.1159/000506427

Background: Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as... Read More about Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups.

Clinical Scene Segmentation with Tiny Datasets (2019)
Conference Proceeding
Smith, T. J., Sharkey, D., Crowe, J., & Valstar, M. (2019). Clinical Scene Segmentation with Tiny Datasets. In 2019 IEEE/CVF International Conference on Computer Vision Workshop (ICCVW) (1637-1645). https://doi.org/10.1109/ICCVW.2019.00203

Many clinical procedures could benefit from automatic scene segmentation and subsequent action recognition. Using Convolutional Neural Networks to semantically segment meaningful parts of an image or video is still an unsolved problem. This becomes e... Read More about Clinical Scene Segmentation with Tiny Datasets.

Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements (2019)
Journal Article
Pickup, L., Lang, A., Shipley, L., Henry, C., Carpenter, J., McCartney, D., …Sharkey, D. (2019). Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements. JMIR Human Factors, 6(2), Article e12055. https://doi.org/10.2196/12055

Background: A novel medical device has been developed to address an unmet need of standardizing and facilitating heart rate recording during neonatal resuscitation. In a time-critical emergency resuscitation, where failure can mean death of an infant... Read More about Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements.

Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article
Shipley, L. J., Gyorkos, T., Jon, D., Tata, L. J., Lisa, S., & Sharkey, D. (2019). Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age. Pediatric Critical Care Medicine, 20(7), 638-644. https://doi.org/10.1097/PCC.0000000000001937

Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More about Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age.

Postnatal gestational age estimation of newborns using Small Sample Deep Learning (2018)
Journal Article
Torres Torres, M., Valstar, M., Henry, C., Ward, C., & Sharkey, D. (2019). Postnatal gestational age estimation of newborns using Small Sample Deep Learning. Image and Vision Computing, 83-84, 87-99. https://doi.org/10.1016/j.imavis.2018.09.003

© 2018 A baby's gestational age determines whether or not they are premature, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these are expensive, require traine... Read More about Postnatal gestational age estimation of newborns using Small Sample Deep Learning.

Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates (2018)
Journal Article
Szatkowski, L., McClaughry, R., Clarkson, M., & Sharkey, D. (2019). Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates. European Respiratory Journal, 53(3), Article 1801874. https://doi.org/10.1183/13993003.01874-2018

Restricting visitors on the neonatal intensive care unit to parents only during a worldwide pandemic resulted in a 39% reduction in nosocomial viral respiratory tract infections in neonatal patients. These findings need validating in a prospective tr... Read More about Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates.

The development of a clinical interface for a novel newborn resuscitation device; a Human Factors approach to understand cognitive user requirements (2018)
Working Paper
Pickup, L., Lang, A., Shipley, L., Henry, C., Carpenter, J., McCartney, D., …Sharkey, D. The development of a clinical interface for a novel newborn resuscitation device; a Human Factors approach to understand cognitive user requirements

Background: A novel medical device has been developed to address an unmet need of standardizing and facilitating heart rate recording during neonatal resuscitation. In a time-critical emergency resuscitation, where failure can mean death of an in... Read More about The development of a clinical interface for a novel newborn resuscitation device; a Human Factors approach to understand cognitive user requirements.

Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study (2018)
Journal Article
Bannister, J., Szatkowski, L., Sharkey, D., Tan, S., Fiaschi, L., & Ban, L. (2018). Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition, 67(5), 580–585. https://doi.org/10.1097/MPG.0000000000002045

Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of... Read More about Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study.

Variation in visiting and isolation policies in neonatal units: a UK nationwide survey (2017)
Journal Article
Tan, S., Clarkson, M., & Sharkey, D. (in press). Variation in visiting and isolation policies in neonatal units: a UK nationwide survey. Pediatric Infectious Disease Journal, https://doi.org/10.1097/INF.0000000000001820

Global pandemics, such as H1N1, are a major risk for neonatal patients. We surveyed UK tertiary and district neonatal units about visiting and infection control policies relating to viral respiratory infections. There was marked variation with visiti... Read More about Variation in visiting and isolation policies in neonatal units: a UK nationwide survey.

Small Sample Deep Learning for Newborn Gestational Age Estimation (2017)
Conference Proceeding
Torres Torres, M., Valstar, M. F., Henry, C., Ward, C., & Sharkey, D. (2017). Small Sample Deep Learning for Newborn Gestational Age Estimation. In Proceedings - 12th IEEE International Conference on Automatic Face and Gesture Recognition (FG 2017) (79-86). https://doi.org/10.1109/FG.2017.19

A baby’s gestational age determines whether or not they are preterm, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these machines are expensive, require traine... Read More about Small Sample Deep Learning for Newborn Gestational Age Estimation.

Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo (2017)
Journal Article
Scotney, H., Symonds, M. E., Law, J., Budge, H., Sharkey, D., & Manolopoulos, K. N. (2017). Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo. Metabolism, 70, 125-132. https://doi.org/10.1016/j.metabol.2017.01.024

© 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adre... Read More about Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.

Neonatal head and torso vibration exposure during inter-hospital transfer (2017)
Journal Article
Blaxter, L., Yeo, M., McNally, D., Crowe, J., Henry, C., Hill, S., …Sharkey, D. (2017). Neonatal head and torso vibration exposure during inter-hospital transfer. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 231(2), 99-113. https://doi.org/10.1177/0954411916680235

© Institution of Mechanical Engineers. Inter-hospital transport of premature infants is increasingly common, given the centralisation of neonatal intensive care. However, it is known to be associated with anomalously increased morbidity, most notably... Read More about Neonatal head and torso vibration exposure during inter-hospital transfer.

Outcomes of nosocomial viral respiratory infections in high-risk neonates (2016)
Journal Article
Zinna, S., Lakshmanan, A., Tan, S., McClaughry, R., Clarkson, M., Soo, S., …Sharkey, D. (2016). Outcomes of nosocomial viral respiratory infections in high-risk neonates. Pediatrics, 138(5), Article e20161675. https://doi.org/10.1542/peds.2016-1675

BACKGROUND AND OBJECTIVE: Neonatal respiratory disease, particularly bronchopulmonary dysplasia, remains one of the leading causes of morbidity and mortality in newborn infants. Recent evidence suggests nosocomially acquired viral respiratory tract... Read More about Outcomes of nosocomial viral respiratory infections in high-risk neonates.

An automated quasi-continuous capillary refill timing device (2015)
Journal Article
Blaxter, L., Morris, D. E., Crowe, J. A., Henry, C., Hill, S. J., Sharkey, D., …Hayes-Gill, B. R. (in press). An automated quasi-continuous capillary refill timing device. Physiological Measurement, 37(1), https://doi.org/10.1088/0967-3334/37/1/83

Capillary refill time (CRT) is a simple means of cardiovascular assessment which is widely used in clinical care. Currently, CRT is measured through manual assessment of the time taken for skin tone to return to normal colour following blanching of t... Read More about An automated quasi-continuous capillary refill timing device.

Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients (2014)
Journal Article
Grubb, M., Carpenter, J., Crowe, J. A., Teoh, J., Marlow, N., Ward, C., …Hayes-Gill, B. R. (2014). Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients. Physiological Measurement, 35(5), https://doi.org/10.1088/0967-3334/35/5/881

Around 5%–10% of newborn babies require some form of resuscitation at birth and heart rate (HR) is the best guide of efficacy. We report the development and first trial of a device that continuously monitors neonatal HR, with a view to deployment in... Read More about Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients.

Marked variation in newborn resuscitation practice: a national survey in the UK (2012)
Journal Article
Mann, C., Ward, C., Grubb, M., Hayes-Gill, B., Crowe, J., Marlow, N., & Sharkey, D. (2012). Marked variation in newborn resuscitation practice: a national survey in the UK. Resuscitation, 83(5), https://doi.org/10.1016/j.resuscitation.2012.01.002

Abstract Background Although international newborn resuscitation guidance has been in force for some time, there are no UK data on current newborn resuscitation practices. Objective Establish delivery room (DR) resuscitation practices in the UK... Read More about Marked variation in newborn resuscitation practice: a national survey in the UK.