Outputs (6)

Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing (2019)
Journal Article
Clark, E. A., Alexander, M. R., Irvine, D. J., Roberts, C. J., Wallace, M. J., Yoo, J., & Wildman, R. D. (2020). Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing. International Journal of Pharmaceutics, 578, Article 118805. https://doi.org/10.1016/j.ijpharm.2019.118805

© 2019 In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959... Read More about Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing.

Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation (2019)
Journal Article
Dundas, A. A., Sanni, O., Dubern, J.-F., Dimitrakis, G., Hook, A. L., Irvine, D. J., …Alexander, M. R. (2019). Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation. Advanced Materials, 31(49), Article 1903513. https://doi.org/10.1002/adma.201903513

ynthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The incidence rate for catheter‐associated urinary tract infections is between 3% and 7% for each day o... Read More about Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation.

Toward Interpretable Machine Learning Models for Materials Discovery (2019)
Journal Article
Mikulskis, P., Alexander, M. R., & Winkler, D. A. (2019). Toward Interpretable Machine Learning Models for Materials Discovery. Advanced Intelligent Systems, 1(8), Article 1900045. https://doi.org/10.1002/aisy.201900045

Machine learning (ML) and artificial intelligence (AI) methods for modeling useful materials properties are now important technologies for rational design and optimization of bespoke functional materials. Although these methods make good predictions... Read More about Toward Interpretable Machine Learning Models for Materials Discovery.

Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators (2019)
Journal Article
Dundas, A. A., Hook, A. L., Alexander, M. R., Kingman, S. W., Dimitrakis, G., & Irvine, D. J. (2019). Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators. Reaction Chemistry and Engineering, 4(8), 1472-1476. https://doi.org/10.1039/c9re00173e

© 2019 The Royal Society of Chemistry. A novel single-well prototype high throughput microwave reactor geometry has been produced and shown to be capable of synthesizing an array of non-commercially available methacrylate monomers. The reactor, which... Read More about Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators.

Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form (2019)
Journal Article
Cader, H. K., Rance, G. A., Alexander, M. R., Gonçalves, A. D., Roberts, C. J., Tuck, C. J., & Wildman, R. D. (2019). Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form. International Journal of Pharmaceutics, 564, 359-368. https://doi.org/10.1016/j.ijpharm.2019.04.026

Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or tablets, i... Read More about Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form.

Lipids and polymers in pharmaceutical technology: lifelong companions (2019)
Journal Article
Siepmann, J., Faham, A., Clas, S.-D., Boyd, B. J., Jannin, V., Bernkop-Schnürch, A., …Leroux, J.-C. (2019). Lipids and polymers in pharmaceutical technology: lifelong companions. International Journal of Pharmaceutics, 558, 128-142. https://doi.org/10.1016/j.ijpharm.2018.12.080

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, st... Read More about Lipids and polymers in pharmaceutical technology: lifelong companions.