Professor AMIR GHAEMMAGHAMI's Outputs (132)

Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering (2015)
Journal Article
Zhao, X., Lang, Q., Yildirimer, L., Lin, Z. Y., Cui, W., Annabi, N., Ng, K. W., Dokmeci, M. R., Ghaemmaghami, A. M., & Khademhosseini, A. (2016). Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering. Advanced Healthcare Materials, 5(1), 108-118. https://doi.org/10.1002/adhm.201500005

Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insu... Read More about Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering.

Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters (2015)
Journal Article
Khairalla, A. S., Omer, S. A., Mahdavi, J., Aslam, A., Dufailu, O. A., Self, T., Jonsson, A.-B., Geörg, M., Sjölinder, H., Royer, P.-J., Martinez-Pomares, L., Ghaemmaghami, A. M., Wooldridge, K. G., Oldfield, N. J., & Ala'Aldeen, D. A. (2015). Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. Cellular Microbiology, 17(7), 1008-1020. https://doi.org/10.1111/cmi.12417

Neisseria meningitidis, a major cause of bacterial meningitis and septicaemia, secretes multiple virulence factors, including the adhesion and penetration protein (App) and meningococcal serine protease A (MspA). Both are conserved, immunogenic, type... Read More about Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters.

Microfluidics for advanced drug delivery systems (2015)
Journal Article
Riahi, R., Tamayol, A., Shaegh, S. A. M., Ghaemmaghami, A. M., Dokmeci, M. R., & Khademshosseini, A. (2015). Microfluidics for advanced drug delivery systems. Current Opinion in Chemical Engineering, 7, 101-112. https://doi.org/10.1016/j.coche.2014.12.001

©2015 Elsevier Ltd. All rights reserved. Considerable efforts have been devoted toward developing effective drug delivery methods. Microfluidic systems, with their capability for precise handling and transport of small liquid quantities, have emerged... Read More about Microfluidics for advanced drug delivery systems.

Impact of surface chemistry and topography on the function of antigen presenting cells (2015)
Journal Article
Rostam, H. M., Singh, S., Vrana, N. E., Alexander, M. R., & Ghaemmaghami, A. M. (2015). Impact of surface chemistry and topography on the function of antigen presenting cells. Biomaterials Science, 3(3), 424-441. https://doi.org/10.1039/c4bm00375f

Antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs) play a crucial role in orchestrating immune responses against foreign materials. The activation status of APCs can determine the outcome of an immune response following imp... Read More about Impact of surface chemistry and topography on the function of antigen presenting cells.

Biomimetic Human Lung Models (2014)
Book Chapter
Harrington, H. C., Cato, P. A., & Ghaemmaghami, A. M. (2014). Biomimetic Human Lung Models. In Handbook of Biomimetics and Bioinspiration (1017-1036). World Scientific. https://doi.org/10.1142/9789814354936_0037

New strategies for the treatment of lung disease are being sought to combat the increased prevalence of lung disease within the developedworld.As researchmoves away from reliance upon the use of animal models in pre-clinical studies innovative method... Read More about Biomimetic Human Lung Models.

A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds (2014)
Presentation / Conference Contribution
Rahimi, R., Ochoa, M., Zhou, J., Tamayol, A., Dokmeci, M. R., Khademhosseini, A., Ghaemmaghami, A., & Ziaie, B. (2014, October). A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds. Presented at 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, Texas, USA

© 14CBMS. In this paper, we present a hybrid PDMS/paper-based passive pump for slow drug delivery in chronic wounds. The pump consists of a PDMS microfluidic network that is irreversibly bonded to the polyethylene-coated (hydrophobic) side of a comme... Read More about A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds.

Surgical materials: Current challenges and nano-enabled solutions (2014)
Journal Article
Annabi, N., Tamayol, A., Shin, S. R., Ghaemmaghami, A. M., Peppas, N. A., & Khademhosseini, A. (2014). Surgical materials: Current challenges and nano-enabled solutions. Nano Today, 9(5), 574-589. https://doi.org/10.1016/j.nantod.2014.09.006

© 2014 Elsevier Ltd. All rights reserved. Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been u... Read More about Surgical materials: Current challenges and nano-enabled solutions.

Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model (2014)
Book Chapter
Harrington, H. C., Rose, F. R., Ghaemmaghami, A. M., & Aylott, J. W. (2014). Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model. In J. Haycock, A. Ahluwalia, & J. M. Wilkinson (Eds.), Cellular In Vitro Testing (89-107). Jenny Stanford Publishing

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., Brightling, C., Ghaemmaghami, A., & Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells (2014)
Journal Article
Morris, G., Bridge, J., Brace, L., Knox, A., Aylott, J. W., Brightling, C., Ghaemmaghami, A. M., & Rose, F. R. (2014). A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells. Biofabrication, 6(3), Article 035014. https://doi.org/10.1088/1758-5082/6/3/035014

Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited three-dimensional (3D) models of the bronchial mucosa. Electrospinning offers an attractive method to pro... Read More about A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells.

A janus-paper PDMS platform for lab-on-a-chip applications (2014)
Presentation / Conference Contribution
Rahimi, R., Ochoa, M., Parupudi, T., Donaldson, A., Dokmeci, M. R., Khademhosseini, A., Ghaemmaghami, A., & Ziaie, B. (2014, June). A janus-paper PDMS platform for lab-on-a-chip applications. Presented at Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop, Hilton Head Island, South Carolina

© 2014TRF. A commercially available Janus paper with one hydrophobic (polyethylene-coated) face and a hygroscopic/hydrophilic one is irreversibly bonded to a PDMS substrate incorporating microfluidic channels via corona discharge surface treatment. T... Read More about A janus-paper PDMS platform for lab-on-a-chip applications.

Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems (2014)
Book
Jabbari, E., Kim, D. H., Lee, L. P., Ghaemmaghami, A., & Khademhosseini, A. (2014). Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems. World Scientific. https://doi.org/10.1142/8169

Global warming, pollution, food and water shortage, cyberspace insecurity, over-population, land erosion, and an overburdened health care system are major issues facing the human race and our planet. These challenges have presented a mandate to devel... Read More about Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems.

Front matter (2014)
Book Chapter
Jabbari, E., Kim, D. H., Lee, L. P., Ghaemmaghami, A., & Khademhosseini, A. (2014). Front matter. In E. Jabbari, D. Ho Kim, L. P. Lee, A. Ghaemmaghami, & A. Khademhosseini (Eds.), Handbook of Biomimetics and Bioinspiration: Biologically-driven Engineering of Materials, Processes, Devices, and Systems (i-lix). World Scientific. https://doi.org/10.1142/9789814354936_fmatter01

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels (2014)
Journal Article
Bertassoni, L. E., Cardoso, J. C., Manoharan, V., Cristino, A. L., Bhise, N. S., Araujo, W. A., Zorlutuna, P., Vrana, N. E., Ghaemmaghami, A. M., Dokmeci, M. R., & Khademhosseini, A. (2015). Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels. Biofabrication, 6(2), 1-11. https://doi.org/10.1088/1758-5082/6/2/024105

Fabrication of three dimensional (3D) organoids with controlled microarchitectures has been shown to enhance tissue functionality. Bioprinting can be used to precisely position cells and cell-laden materials to generate controlled tissue architecture... Read More about Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels.

Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation (2014)
Journal Article
Harrington, H., Cato, P., Salazar, F., Wilkinson, M., Knox, A., Haycock, J. W., Rose, F., Aylott, J. W., & Ghaemmaghami, A. M. (2014). Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation. Molecular Pharmaceutics, 11(7), 2082-2091. https://doi.org/10.1021/mp5000295

The development of more complex in vitro models for the assessment of novel drugs and chemicals is needed because of the limited biological relevance of animal models to humans as well as ethical considerations. Although some human-cell-based assays... Read More about Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article
Sharquie, I. K., Al-Ghouleh, A., Fitton, P., Clark, M. R., Armour, K. L., Sewell, H. F., Shakib, F., & Ghaemmaghami, A. M. (2013). An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14(Decemb), Article 12. https://doi.org/10.1186/1471-2172-14-54

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport (2013)
Journal Article
Watson, N. J., Johal, R. K., Glover, Z., Reinwald, Y., White, L. J., Ghaemmaghami, A. M., Morgan, S. P., Rose, F. R., Povey, M. J., & Parker, N. G. (2013). Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport. Materials Science and Engineering: C, 33(8), 4825-4832. https://doi.org/10.1016/j.msec.2013.07.046

The aimof this work is to demonstrate that the structural and fluidic properties of polymer foamtissue scaffolds, post-fabrication but prior to the introduction of cells, can be engineered via exposure to high power ultrasound. Our analysis is suppor... Read More about Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article
Harrington, H., Rose, F. R., Aylott, J. W., & Ghaemmaghami, A. M. (2013). Self-reporting Scaffolds for 3-Dimensional Cell Culture. Journal of Visualized Experiments, https://doi.org/10.3791/50608

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells (2013)
Journal Article
Salazar, F., & Ghaemmaghami, A. M. (2013). Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells. Frontiers in Immunology, 4, Article 356. https://doi.org/10.3389/fimmu.2013.00356

Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses. The allergic cascade starts with the recog... Read More about Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells.

Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution (2013)
Journal Article
Reinwald, Y., Johal, R. K., Ghaemmaghami, A. M., Rose, F. R., Howdle, S. M., & Shakesheff, K. M. (2014). Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution. Polymer, 55(1), 435-444. https://doi.org/10.1016/j.polymer.2013.09.041

This study aims to investigate interconnectivity and permeability of scCO2-foamed scaffolds and the influence of structural scaffold properties on cell distribution. Supercritical fluid technology was utilized to fabricated scaffolds from 37 kDa, 53... Read More about Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution.