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Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells

Salazar, Fabian; Ghaemmaghami, Amir M.

Authors

Fabian Salazar

Abstract

Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses. The allergic cascade starts with the recognition of allergens by antigen presenting cells, mainly dendritic cells (DCs), leading to Th2 polarization, switching to IgE production by B cells, culminating in mast cell sensitization and triggering. DCs have been demonstrated to play a crucial role in orchestrating allergic diseases. Using different C-type lectin receptors DCs are able to recognize and internalize a number of allergens from diverse sources leading to sensitization. Furthermore, there is increasing evidence highlighting the role of epithelial cells in triggering and modulating immune responses to allergens. As well as providing a physical barrier, epithelial cells can interact with allergens and influence DCs behavior through the release of a number of Th2 promoting cytokines. In this review we will summarize current understanding of how allergens are recognized by DCs and epithelial cells and what are the consequences of such interaction in the context of allergic sensitization and downstream events leading to allergic inflammation. Better understanding of the molecular mechanisms of allergen recognition and associated signaling pathways could enable developing more effective therapeutic strategies that target the initial steps of allergic sensitization hence hindering development or progression of allergic diseases.

Journal Article Type Article
Publication Date Nov 4, 2013
Journal Frontiers in Immunology
Electronic ISSN 1664-3224
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 4
Article Number 356
Institution Citation Salazar, F., & Ghaemmaghami, A. M. (2013). Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells. Frontiers in Immunology, 4, doi:10.3389/fimmu.2013.00356
DOI https://doi.org/10.3389/fimmu.2013.00356
Publisher URL http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00356/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0



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