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Professor JOE KAI's Outputs (62)

Opportunities and challenges for identifying undiagnosed Rare Disease patients through analysis of primary care records: long QT syndrome as a test case (2024)
Journal Article
Evans, W., Akyea, R. K., Simms, A., Kai, J., & Qureshi, N. (2024). Opportunities and challenges for identifying undiagnosed Rare Disease patients through analysis of primary care records: long QT syndrome as a test case. Journal of Community Genetics, https://doi.org/10.1007/s12687-024-00742-7

Background: Patients with rare genetic diseases frequently experience significant diagnostic delays. Routinely collected data in the electronic health record (EHR) may be used to help identify patients at risk of undiagnosed conditions. Long QT syndr... Read More about Opportunities and challenges for identifying undiagnosed Rare Disease patients through analysis of primary care records: long QT syndrome as a test case.

Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial (2024)
Journal Article
Husain, N., Lunat, F., Lovell, K., Miah, J., Chew-Graham, C. A., Bee, P., Waqas, A., Pierce, M., Sharma, D., Atif, N., Aseem, S., Bhui, K., Bower, P., Brugha, T., Chaudhry, N., Ullah, A., Davies, L., Gire, N., Kai, J., Morrison, J., …Morriss, R. (2024). Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial. Lancet, 404(10461), 1430-1443. https://doi.org/10.1016/s0140-6736%2824%2901612-x

Background: Postnatal depression necessitates timely and effective interventions to mitigate adverse maternal and child outcomes in the short term and over the life course. British south Asian women with depression are often underserved and undertrea... Read More about Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial.

A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD (2024)
Preprint / Working Paper
Vinogradova, Y., Iyen, B., Masud, T., Taylor, L., & Kai, J. A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD

Menopausal hormone therapy (MHT) is prescribed to women with severe symptoms of menopause. Various studies have demonstrated increased bone density and decreased fracture risk in women using MHT. The randomised controlled trials were, however, run ov... Read More about A protocol to assess risk of fractures associated with use of menopausal hormone therapy: nested case-control study using CPRD.

Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care (2024)
Journal Article
Evans, W., Meslin, E. M., Kai, J., & Qureshi, N. (2024). Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care. Journal of Personalized Medicine, 14(4), Article 418. https://doi.org/10.3390/jpm14040418

Precision medicine (PM), also termed stratified, individualised, targeted, or personalised medicine, embraces a rapidly expanding area of research, knowledge, and practice. It brings together two emerging health technologies to deliver better individ... Read More about Precision Medicine—Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care.

Experiences of coordinated care for people in the UK affected by rare diseases: cross-sectional survey of patients, carers, and healthcare professionals (2023)
Journal Article
Walton, H., Ng, P. L., Simpson, A., Bloom, L., Chitty, L. S., Fulop, N. J., …Morris, S. (2023). Experiences of coordinated care for people in the UK affected by rare diseases: cross-sectional survey of patients, carers, and healthcare professionals. Orphanet Journal of Rare Diseases, 18(1), Article 364. https://doi.org/10.1186/s13023-023-02934-9

Background
Poorly coordinated care can have major impacts on patients and families affected by rare conditions, with negative physical health, psychosocial and financial consequences. This study aimed to understand how care is coordinated for rare d... Read More about Experiences of coordinated care for people in the UK affected by rare diseases: cross-sectional survey of patients, carers, and healthcare professionals.

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis (2023)
Journal Article
Qureshi, N., Woods, B., Neves de Faria, R., Saramago Goncalves, P., Cox, E., Leonardi Bee, J., …Kai, J. (2023). Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis. Health Technology Assessment, 27(16), https://doi.org/10.3310/CTMD0148

Background
Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia. The cascade-testing protocol starts with identifying an index patient with familial hyperc... Read More about Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis.

Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study (2023)
Journal Article
Kai, J., Dutton, B., Vinogradova, Y., Hilken, N., Gupta, J., & Daniels, J. (2023). Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study. Health Technology Assessment, 27(17), https://doi.org/10.3310/jhsw0174

Background: Heavy menstrual bleeding is a common problem that can significantly affect women’s lives until menopause. There is a lack of evidence on longer-term outcomes after seeking health care and treatment for heavy menstrual bleeding. Objectives... Read More about Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study.

A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach (2023)
Journal Article
Akyea, R. K., Ntaios, G., Kontopantelis, E., Georgiopoulos, G., Soria, D., Asselbergs, F. W., …Qureshi, N. (2023). A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach. PLOS Digital Health, 2(9), Article e0000334. https://doi.org/10.1371/journal.pdig.0000334

Individuals developing stroke have varying clinical characteristics, demographic, and biochemical profiles. This heterogeneity in phenotypic characteristics can impact on cardiovascular disease (CVD) morbidity and mortality outcomes. This study uses... Read More about A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach.

Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region (2023)
Journal Article
Chan, A. Y., Chan, V. K., Bahmanyar, S., Beyene, K., Bushnell, G., Carleton, B., …Wong, I. C. K. Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region. Manuscript submitted for publication

Implementation of a diabetes prevention programme in a multi-ethnic community in primary care in England: An evaluation using constructs from the RE-AIM Framework (2023)
Journal Article
Dallosso, H., Khunti, K., Gray, L. J., Hulley, K., Ghaly, M., Patel, N., …Yates, T. (2023). Implementation of a diabetes prevention programme in a multi-ethnic community in primary care in England: An evaluation using constructs from the RE-AIM Framework. Primary Care Diabetes, 17(4), 309-313. https://doi.org/10.1016/j.pcd.2023.05.001

Aims: To implement a diabetes prevention programme in primary care Methods: The programme was implemented for 12 months in two neighbouring towns, served by eight general practices. Practices requested a referral pathway involving an external adminis... Read More about Implementation of a diabetes prevention programme in a multi-ethnic community in primary care in England: An evaluation using constructs from the RE-AIM Framework.

Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history (2022)
Journal Article
Akyea, R. K., Iyen, B., Georgiopoulos, G., Kai, J., Qureshi, N., & Ntaios, G. (2023). Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history. European Journal of Internal Medicine, 109, 50-57. https://doi.org/10.1016/j.ejim.2022.12.006

Background: Up to 10% of patients with ischaemic stroke have comorbid cancer and stroke in these patients is thought to have a poor short-term prognosis. There is little known about the long-term cardiovascular morbidity and mortality outcomes after... Read More about Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history.

Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial (2022)
Journal Article
Kai, J., Dutton, B., Vinogradova, Y., Hilken, N., Gupta, J., & Daniels, J. (2022). Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial. British Journal of General Practice, 72(725), e857-e864. https://doi.org/10.3399/bjgp.2022.0260

Background Heavy menstrual bleeding (HMB) is a common problem that can significantly affect women's lives. There is a lack of evidence on long-term outcomes after seeking treatment. Aim To assess continuation rates of medical treatments and rates of... Read More about Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial.

Identifying Patients with Bicuspid Aortic Valve Disease in UK Primary Care: A Case–Control Study and Prediction Model (2022)
Journal Article
Evans, W., Akyea, R. K., Weng, S., Kai, J., & Qureshi, N. (2022). Identifying Patients with Bicuspid Aortic Valve Disease in UK Primary Care: A Case–Control Study and Prediction Model. Journal of Personalized Medicine, 12(8), Article 1290. https://doi.org/10.3390/jpm12081290

Bicuspid aortic valve disease (BAV) is the most common congenital heart condition, and early detection can improve outcomes for patients. In this case–control study, patients with a diagnosis of BAV were identified from their electronic primary-care... Read More about Identifying Patients with Bicuspid Aortic Valve Disease in UK Primary Care: A Case–Control Study and Prediction Model.

Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study (2022)
Journal Article
Akyea, R. K., Georgiopoulos, G., Iyen, B., Kai, J., Qureshi, N., & Ntaios, G. (2022). Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study. Thrombosis and Haemostasis, 122(11), 1921-1931. https://doi.org/10.1055/a-1873-9092

Background Patients with ischemic stroke are considered a very high risk population for subsequent cardiovascular events and guidelines recommend intensive preventive strategies. However, there is no clear recommendation that patients with hemorrhagi... Read More about Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study.

Developing a taxonomy of care coordination for people living with rare conditions: a qualitative study (2022)
Journal Article
Walton, H., Simpson, A., Ramsay, A. I., Hudson, E., Hunter, A., Jones, J., …Fulop, N. J. (2022). Developing a taxonomy of care coordination for people living with rare conditions: a qualitative study. Orphanet Journal of Rare Diseases, 17, Article 171. https://doi.org/10.1186/s13023-022-02321-w

Background: Improving care coordination is particularly important for individuals with rare conditions (who may experience multiple inputs into their care, across different providers and settings). To develop and evaluate strategies to potentially im... Read More about Developing a taxonomy of care coordination for people living with rare conditions: a qualitative study.

A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial) (2022)
Journal Article
Patel, S., Boutry, C., Patel, P., Craven, M. P., Guo, B., Zafar, A., …Morriss, R. (2022). A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial). Trials, 23(1), Article 250. https://doi.org/10.1186/s13063-022-06192-1

Background: Major depression is the second leading cause of years lost to disability worldwide and is a leading contributor to suicide. However, first-line antidepressants are only fully effective for 33%, and only 40% of those offered psychological... Read More about A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial).

Co-ordinated care for people affected by rare diseases: the CONCORD mixed-methods study (2022)
Journal Article
Morris, S., Hudson, E., Bloom, L., Chitty, L. S., Fulop, N. J., Hunter, A., …Walton, H. (2022). Co-ordinated care for people affected by rare diseases: the CONCORD mixed-methods study. Health and Social Care Delivery Research, 10(5), 1-220. https://doi.org/10.3310/lnzz5321

This study found evidence of a lack of co-ordinated care for people affected by rare diseases, which could have negative impacts on the physical and mental health of patients and families.

Development of models of care coordination for rare conditions: A qualitative study (2022)
Journal Article
Walton, H., Simpson, A., Ramsay, A. I., Hunter, A., Jones, J., Ng, P. L., …Fulop, N. J. (2022). Development of models of care coordination for rare conditions: A qualitative study. Orphanet Journal of Rare Diseases, 17, Article 49. https://doi.org/10.1101/2021.11.16.21266395

Introduction: Improving care coordination for people with rare conditions may help to reduce burden on patients and carers and improve the care that patients receive. We recently developed a taxonomy of different ways of coordinating care for rare co... Read More about Development of models of care coordination for rare conditions: A qualitative study.

Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis (2021)
Journal Article
Qureshi, S., Latif, A., Condon, L., Akyea, R. K., Kai, J., & Qureshi, N. (2022). Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis. Pharmacogenomics, 23(2), 135-154. https://doi.org/10.2217/pgs-2021-0131

Introduction: Pharmacogenomic testing can indicate which drugs may have limited therapeutic action or lead to adverse effects, hence guiding rational and safe prescribing. However, in the UK and other countries, there are still significant barriers t... Read More about Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis.

Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease (2021)
Journal Article
Weng, S. F., Akyea, R. K., Man, K. K., Lau, W. C. Y., Iyen, B., Blais, J. E., …Kai, J. (2021). Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease. PLoS ONE, 16(12), Article e0260839. https://doi.org/10.1371/journal.pone.0260839

Background: Variability in low-density lipoprotein cholesterol (LDL-C) response to statins is underappreciated. We characterised patients by their statin response (SR), baseline risk of cardiovascular disease (CVD) and 10-year CVD outcomes.

Method... Read More about Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease.

Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol (2021)
Journal Article
Husain, N., Lovell, K., Chew-Graham, C. A., Lunat, F., McPhillips, R., Atif, N., …Morriss, R. (2022). Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol. BJPsych Open, 8(1), Article E2. https://doi.org/10.1192/bjo.2021.1032

Background In the UK, postnatal depression is more common in British South Asian women than White Caucasion women. Cognitive-behavioural therapy (CBT) is recommended as a first-line treatment, but there is little evidence for the adaptation of CBT fo... Read More about Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol.

Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care (2021)
Journal Article
Iyen, B., Akyea, R. K., Weng, S., Kai, J., & Qureshi, N. (2021). Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care. Open Heart, 8(2), Article e001817. https://doi.org/10.1136/openhrt-2021-001817

Objectives: Guidance recommends statin treatment in Familial Hypercholesterolaemia (FH) achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). We assessed statin prescribing rates and LDL-cholesterol treatment goal attainmen... Read More about Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care.

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2021)
Journal Article
Hussein, N., Henneman, L., Kai, J., & Qureshi, N. (2021). Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease. Cochrane Database of Systematic Reviews, 2021(10), Article CCD010849. https://doi.org/10.1002/14651858.cd010849.pub4

Background: Globally, about 6% of children are born with a serious birth defect of genetic or partially genetic origin. Carrier screening or testing is one way to identify couples at increased risk of having a child with an autosomal recessive condit... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Strategies for screening for familial hypercholesterolaemia in primary care and other community settings (2021)
Journal Article
Qureshi, N., Da Silva, M. L. R., Abdul-Hamid, H., Weng, S. F., Kai, J., & Leonardi-Bee, J. (2021). Strategies for screening for familial hypercholesterolaemia in primary care and other community settings. Cochrane Database of Systematic Reviews, 2021(10), Article CD012985. https://doi.org/10.1002/14651858.cd012985.pub2

Background: Familial hypercholesterolaemia is a common inherited condition that is associated with premature cardiovascular disease. The increased cardiovascular morbidity and mortality, resulting from high levels of cholesterol since birth, can be p... Read More about Strategies for screening for familial hypercholesterolaemia in primary care and other community settings.

Case-finding and genetic testing for familial hypercholesterolaemia in primary care (2021)
Journal Article
Qureshi, N., Akyea, R. K., Dutton, B., Leonardi-Bee, J., Humphries, S. E., Weng, S., & Kai, J. (2021). Case-finding and genetic testing for familial hypercholesterolaemia in primary care. Heart, 107(24), 1956-1961. https://doi.org/10.1136/heartjnl-2021-319742

Objective: Familial Hypercholesterolaemia (FH) is a common inherited disorder causing premature heart disease and death. We have developed novel case-finding algorithms (FAMCAT version 1 & 2) for application in primary care, to improve detection of... Read More about Case-finding and genetic testing for familial hypercholesterolaemia in primary care.

Sex disparity in subsequent outcomes in survivors of coronary heart disease (2021)
Journal Article
Akyea, R. K., Kontopantelis, E., Kai, J., Weng, S. F., Patel, R. S., Asselbergs, F. W., & Qureshi, N. (2022). Sex disparity in subsequent outcomes in survivors of coronary heart disease. Heart, 108(1), 37-45. https://doi.org/10.1136/heartjnl-2021-319566

Objective: Evidence on sex differences in outcomes after developing coronary heart disease (CHD) has focused on recurrent CHD, all-cause mortality or revascularisation. We assessed sex disparities in subsequent major adverse cardiovascular events (M... Read More about Sex disparity in subsequent outcomes in survivors of coronary heart disease.

Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK (2021)
Journal Article
Iyen, B., Weng, S., Vinogradova, Y., Akyea, R. K., Qureshi, N., & Kai, J. (2021). Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK. BMC Public Health, 21, Article 576. https://doi.org/10.1186/s12889-021-10606-1

Background: Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantifi... Read More about Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.

Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study (2020)
Journal Article
Akyea, R. K., Qureshi, N., Kai, J., de Lusignan, S., Sherlock, J., McGee, C., & Weng, S. (2020). Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study. BJGP Open, 4(5), 1-10. https://doi.org/10.3399/bjgpopen20X101114

Background: Familial hypercholesterolaemia (FH) is an inherited lipid disorder causing premature heart disease, which is severely underdiagnosed. Improving the identification of people with FH in primary care settings would help to reduce avoidable h... Read More about Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study.

Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records (2020)
Journal Article
Iyen, B., Qureshi, N., Weng, S., Roderick, P., Kai, J., Capps, N., …Humphries, S. E. (2020). Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records. Atherosclerosis, 315, 131-137. https://doi.org/10.1016/j.atherosclerosis.2020.10.895

Background and aims: The UK Simon Broome (SB) familial hypercholesterolaemia (FH) register previously reported 3-fold higher standardised mortality ratio for cardiovascular disease (CVD) in women compared to men from 2009 to 2015. Here we examined se... Read More about Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records.

An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK (2020)
Journal Article
Patel, M., Lee, S., Levell, N., Smart, P., Kai, J., Thomas, K., & Leighton, P. (2020). An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK. BMJ Open, 10, Article e034692. https://doi.org/10.1136/bmjopen-2019-034692

Objectives: To explore health care professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis.

Setting: UK nationwide.

Participants: 20 qualified HCPs, who had a minimum of two years clinical experience as a... Read More about An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK.

An interview study of the experiences of cellulitis diagnosis amongst health care professionals (2020)
Journal Article
Patel, M., Ing Lee, S., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). An interview study of the experiences of cellulitis diagnosis amongst health care professionals. BMJ Open, 10(10), Article e034692. https://doi.org/10.1136/+bmjopen-2019-034692

Objectives: To explore healthcare professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis.

Setting: UK nationwide.

Participants: 20 qualified HCPs, who had a minimum of 2 years clinical experience as an HCP... Read More about An interview study of the experiences of cellulitis diagnosis amongst health care professionals.

Evidence generated from a realist synthesis of trials on educational weight loss interventions in type 2 diabetes mellitus (2020)
Journal Article
Maula, A., Kendrick, D., Kai, J., & Griffiths, F. (2021). Evidence generated from a realist synthesis of trials on educational weight loss interventions in type 2 diabetes mellitus. Diabetic Medicine, 38(1), Article e14394. https://doi.org/10.1111/dme.14394

Background: Obesity and diabetes are major public health problems. Current approaches to weight loss show varying success. Complex community‐based interventions work through several interconnected stages. An individual’s actions in response to an int... Read More about Evidence generated from a realist synthesis of trials on educational weight loss interventions in type 2 diabetes mellitus.

Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models (2020)
Journal Article
Akyea, R. K., Leonardi-Bee, J., Asselbergs, F. W., Patel, R. S., Durrington, P., Wierzbicki, A. S., …Weng, S. F. (2020). Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models. BMJ Open, 10(7), Article e034564. https://doi.org/10.1136/bmjopen-2019-034564

Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. With advances in early diagnosis and treatment of CVD and increasing life expectancy, more people are surviving initial CVD events. However, models t... Read More about Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models.

Defining Coordinated Care for People with Rare Conditions: A Scoping Review (2020)
Journal Article
Walton, H., Hudson, E., Simpson, A., Ramsay, A. I. G., Kai, J., Morris, S., …Sutcliffe, A. G. (2020). Defining Coordinated Care for People with Rare Conditions: A Scoping Review. International Journal of Integrated Care, 20(2), Article 14. https://doi.org/10.5334/ijic.5464

Introduction: To coordinate care effectively for rare conditions, we need to understand what coordinated care means. This review aimed to define coordinated care and identify components of coordinated care within the context of rare diseases; by draw... Read More about Defining Coordinated Care for People with Rare Conditions: A Scoping Review.

Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care (2020)
Journal Article
Lee, S. I., Kai, J., Qureshi, N., Dutton, B., & Weng, S. (2020). Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care. Journal of Community Genetics, 11, 331–338. https://doi.org/10.1007/s12687-020-00452-w

© 2020, The Author(s). Family history of breast and related cancers can indicate increased breast cancer (BC) risk. In national familial breast cancer (FBC) guidelines, the risk is stratified to guide referral decisions. We aimed to identify characte... Read More about Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.

Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study (2019)
Journal Article
Patel, M., Lee, S. I., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study. British Journal of General Practice, 70(691), e130-e137. https://doi.org/10.3399/bjgp19X707909

© British Journal of General Practice 2020. BACKGROUND: Cellulitis can sometimes be challenging for healthcare professionals to diagnose, with no validated diagnostic criteria available. Supporting healthcare professionals to make a more accurate dia... Read More about Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study.

Users’ experiences of a pragmatic diabetes prevention intervention implemented in primary care: Qualitative study (2019)
Journal Article
Aujla, N., Yates, T., Dallosso, H., & Kai, J. (2019). Users’ experiences of a pragmatic diabetes prevention intervention implemented in primary care: Qualitative study. BMJ Open, 9(8), Article e028491. https://doi.org/10.1136/bmjopen-2018-028491

Objectives: To explore service-user and provider experience of the acceptability and feasibility of the Let’s Prevent Diabetes programme, a pragmatic six-hour behavioural intervention using structured group education, introduced into primary care pra... Read More about Users’ experiences of a pragmatic diabetes prevention intervention implemented in primary care: Qualitative study.

Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach (2019)
Journal Article
Cabral, C., Horwood, J., Symonds, J., Ingram, J., Lucas, P. J., Redmond, N. M., …Barnes, R. K. (2019). Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach. BMC Family Practice, 20(1), Article 102. https://doi.org/10.1186/s12875-019-0993-9

Background: Acute respiratory tract infections (RTI) in children are a common reason for antibiotic prescribing. Clinicians’ prescribing decisions are influenced by perceived parental expectations for antibiotics, however there is evidence that paren... Read More about Understanding the influence of parent-clinician communication on antibiotic prescribing for children with respiratory tract infections in primary care: a qualitative observational study using a conversation analysis approach.

Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study (2019)
Journal Article
Iyen, B., Qureshi, N., Leonardi-Bee, J., Kai, J., Akyea, R. K., Roderick, P., …Weng, S. (2019). Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study. Atherosclerosis, 287, 8-15. https://doi.org/10.1016/j.atherosclerosis.2019.05.017

Background and aims: Familial hypercholesterolaemia (FH) is a known major cause of premature heart disease. However, the risks of atherosclerotic disease in other vascular regions are less known. We determined the risk of major cardiovascular disease... Read More about Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Akyea, R., Kai, J., Qureshi, N., Iyen, B., & Weng, S. (2019). Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease. Heart, 105(13), 975-981. https://doi.org/10.1136/heartjnl-2018-314253

Objective:
To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD.

Method:
Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More about Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.

The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis (2018)
Journal Article
Patel, M., Kai, J., Lee, S., & Thomas, K. (2019). The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis. British Journal of Dermatology, 180(5), 993-1000. https://doi.org/10.1111/bjd.17415

Background: Suspected lower limb cellulitis presentations are commonly misdiagnoses, resulting in avoidable antibiotic prescribing or hospital admissions. Understanding the challenges posed in diagnosing cellulitis may help enhance future care.

Ob... Read More about The red leg dilemma: a scoping review of the challenges of diagnosing lower limb cellulitis.

Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study (2018)
Journal Article
Weng, S., Kai, J., Tranter, J., Leonardi-Bee, J., & Qureshi, N. (2018). Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study. Atherosclerosis, 274, 54-60. https://doi.org/10.1016/j.atherosclerosis.2018.04.037

Background and Aims: Familial hypercholesterolaemia (FH) is a major cause of premature heart disease but remains unrecognised in most patients. This study investigated if a systematic primary care-based approach to identify and manage possible FH imp... Read More about Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study.

Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings (2018)
Journal Article
Qureshi, N., Weng, S. F., Tranter, J. A., Da Silva, M. L., Kai, J., & Leonardi-Bee, J. (2018). Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings. Cochrane Database of Systematic Reviews, 3, https://doi.org/10.1002/14651858.CD012985

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The purpose of this review is to assess the effectiveness of interventions to systematically improve identification of FH in non-specialist settings compared t... Read More about Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings.

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2018)
Journal Article
Hussein, N., Weng, S. F., Kai, J., Kleijnen, J., & Qureshi, N. (2018). Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease. Cochrane Database of Systematic Reviews, 2015(8), https://doi.org/10.1002/14651858.CD010849.pub3

Background: Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rate... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article
Little, I., Vinogradova, Y., Orton, E., Kai, J., & Qureshi, N. (2017). Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis. BMJ Open, 7(3), Article e012665. https://doi.org/10.1136/bmjopen-2016-012665

Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE).


Design: Cohort study with nested case-control analysis.
Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.

Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care (2016)
Journal Article
Kai, J., Middleton, L., Daniels, J., Pattison, H., Tryposkiadis, K., & Gupta, J. (in press). Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care. British Journal of General Practice, 66(653), Article e861-e870. https://doi.org/10.3399/bjgp16X687577

Background: Heavy menstrual bleeding (HMB) is a common, chronic problem burdening women and health services. However long-term evidence on treatment in primary care is lacking.

Aim: To assess the effectiveness of commencing levonorgestrel intra-ut... Read More about Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care.

Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study (2016)
Journal Article
Malins, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. K. (2016). Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study. British Journal of General Practice, 66(651), e729-e736. https://doi.org/10.3399/bjgp16X686569

Background: Most frequent attendance in primary care is temporary. Long-term frequent attendance may be suitable for psychological intervention to address health management and service use.

Aim: To explore the feasibility and acceptability of cog... Read More about Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study.

Sensitivity to scale of willingness-to-pay within the context of menorrhagia (2016)
Journal Article
Sanghera, S., Frew, E., Gupta, J. K., Kai, J., & Roberts, T. E. (2017). Sensitivity to scale of willingness-to-pay within the context of menorrhagia. Health Expectations, 20(2), https://doi.org/10.1111/hex.12452

Objectives: Willingness-to-pay (WTP) provides a broad assessment of well-being, capturing benefits beyond health. However, the validity of the approach has been questioned and the evidence relating to the sensitivity of WTP to changes in health statu... Read More about Sensitivity to scale of willingness-to-pay within the context of menorrhagia.

Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial (2016)
Journal Article
Patel, S., Malins, S., Guo, B., James, M., Kai, J., Kaylor-Hughes, C., …Morriss, R. K. (2016). Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial. BJPsych Open, 2, https://doi.org/10.1192/bjpo.bp.115.002220

Background
Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues s... Read More about Protocol investigating the clinical outcomes and cost-effectiveness of cognitive–behavioural therapy delivered remotely for unscheduled care users with health anxiety: randomised controlled trial.

Clinical characteristics of persistent frequent attenders in primary care: case–control study (2015)
Journal Article
Patel, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. (2015). Clinical characteristics of persistent frequent attenders in primary care: case–control study. Family Practice, cmv076. https://doi.org/10.1093/fampra/cmv076

Background. Most frequent attendance in primary care is temporary, but persistent frequent attendance is expensive and may be suitable for psychological intervention. To plan appropriate intervention and service delivery, there is a need for research... Read More about Clinical characteristics of persistent frequent attenders in primary care: case–control study.

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial (2015)
Journal Article
Gupta, J. K., Daniels, J. P., Middleton, L. J., Pattison, H. M., Prileszky, G., Roberts, T. E., Sanghera, S., Barton, P., Gray, R., & Kai, J. (2015). A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial. Health Technology Assessment, 19(88), 1-118. https://doi.org/10.3310/hta19880

Background: Heavy menstrual bleeding (HMB) is a common problem, yet evidence to inform decisions about initial medical treatment is limited.

Objectives: To assess the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing in... Read More about A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial.

Exploring the use of cost-benefit analysis to compare pharmaceutical treatments for menorrhagia (2015)
Journal Article
Sanghera, S., Frew, E., Gupta, J. K., Kai, J., & Roberts, T. E. (2015). Exploring the use of cost-benefit analysis to compare pharmaceutical treatments for menorrhagia. PharmacoEconomics, 33(9), https://doi.org/10.1007/s40273-015-0280-0

Background: The extra-welfarist theoretical framework tends to focus on health-related quality of life, whilst the welfarist framework captures a wider notion of well-being. EQ-5D and SF-6D are commonly used to value outcomes in chronic conditions wi... Read More about Exploring the use of cost-benefit analysis to compare pharmaceutical treatments for menorrhagia.

Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study (2015)
Journal Article
Qureshi, N., Kai, J., Middlemass, J., Dhiman, P., Cross-Bardell, L., Acharya, J., …Standen, P. (2015). Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study. Primary Health Care Research and Development, 16(6), 607-617. https://doi.org/10.1017/S1463423615000122

Aim: This study assesses the feasibility of collecting genetic samples and self-reported outcome measures after cardiovascular risk assessment, and presenting the genetic test results to participants.
Background: Coronary heart disease (CHD) genetic... Read More about Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study.

Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study (2015)
Journal Article
Cross-Bardell, L., George, T., Bhoday, M., Tuomainen, H., Qureshi, N., & Kai, J. (2015). Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study. BMJ Open, 5(2), Article e007317. https://doi.org/10.1136/bmjopen-2014-007317

Objectives

To explore perspectives on enhancing physical activity and diet among South Asians in urban deprived communities at high risk of chronic disease and to inform development of culturally appropriate health promotion intervention.

Des... Read More about Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study.

Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening (2014)
Journal Article
Qureshi, N., Ulph, F., Cullinan, T., & Kai, J. (2015). Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening. European Journal of Human Genetics, 23(4), 459–465. https://doi.org/10.1038/ejhg.2014.126

Universal newborn screening for sickle cell disorders and cystic fibrosis aims to enable the early identification and treatment of affected babies. Screening can also identify infants who are healthy carriers, with carrier results being the commonest... Read More about Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening.

Introducing genetic testing for cardiovascular disease in primary care: a qualitative study (2014)
Journal Article
Middlemass, J., Yazdani, M., Kai, J., Standen, P., & Qureshi, N. (2014). Introducing genetic testing for cardiovascular disease in primary care: a qualitative study. British Journal of General Practice, 64(622), Article e282-e289. https://doi.org/10.3399/bjgp14X679714

Background: While primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these n... Read More about Introducing genetic testing for cardiovascular disease in primary care: a qualitative study.

Levonorgestrel-releasing intrauterine system vs. usual medical treatment for menorrhagia: an economic evaluation alongside a randomised controlled trial (2014)
Journal Article
Sanghera, S., Roberts, T. E., Barton, P., Frew, E., Daniels, J., Middleton, L., …Gupta, J. K. (2014). Levonorgestrel-releasing intrauterine system vs. usual medical treatment for menorrhagia: an economic evaluation alongside a randomised controlled trial. PLoS ONE, 9(3), Article e91891. https://doi.org/10.1371/journal.pone.0091891

Objective: To undertake an economic evaluation alongside the largest randomised controlled trial comparing Levonorgestrel-releasing intrauterine device (‘LNG-IUS’) and usual medical treatment for women with menorrhagia in primary care; and compare th... Read More about Levonorgestrel-releasing intrauterine system vs. usual medical treatment for menorrhagia: an economic evaluation alongside a randomised controlled trial.

Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention (2012)
Journal Article
Morriss, R. K., Kai, J., Atha, C., Avery, A., Bayes, S., Franklin, M., …Yang, M. (2012). Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention. BMC Family Practice, 13(39), https://doi.org/10.1186/1471-2296-13-39

Background:

The top 3% of frequent attendance in primary care is associated with 15% of all appointments in primary care, a fivefold increase in hospital expenditure, and more mental disorder and functional somatic symptoms compared to normal atte... Read More about Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention.