Dr PAUL LEIGHTON's Outputs (11)

Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation (2024)
Journal Article
Dias, J., Tharmanathan, P., Arundel, C., Welch, C., Wu, Q., Leighton, P., Armaou, M., Corbacho, B., Johnson, N., James, S., Cooke, J., Bainbridge, C., Craigen, M., Warwick, D., Brady, S., Flett, L., Jones, J., Knowlson, C., Watson, M., Keding, A., …Torgerson, D. (2024). Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation. Health Technology Assessment, 28(78), 1-262. https://doi.org/10.3310/kgxd8528

Background: Dupuytren's contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence comparing l... Read More about Collagenase injection versus limited fasciectomy surgery to treat Dupuytren's contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation.

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2024)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (in press). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment,

Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture (2024)
Journal Article
Dias, J., Tharmanathan, P., Arundel, C., Welch, C., Math, M., Wu, Q., Leighton, P., Armaou, M., Johnson, N., James, S., Cooke, J., Bainbridge, L., Craigen, M., Warwick, D., Brady, S., Flett, L. G., Jones, J., Knowlson, C. N., Watson, M., Keding, A., …Torgerson, D. (2024). Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture. New England Journal of Medicine, 391(16), 1499-1510. https://doi.org/10.1056/NEJMoa2312631

Background
Treatments for Dupuytren’s contracture include limited fasciectomy and collagenase injection. Comparisons of the effectiveness of these treatments have been limited.

Methods
We performed an unblinded, multicenter, pragmatic, two-group... Read More about Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture.

‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study (2024)
Journal Article
Carter, H. M., Beard, D. J., Leighton, P., Moffatt, F., Smith, B. E., Webster, K. E., & Logan, P. (2024). ‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study. BMJ Open, 14(9), Article e079468. https://doi.org/10.1136/bmjopen-2023-079468

Objectives: This study aimed to understand the lived experiences of patients on the anterior cruciate ligament reconstruction (ACLR) pathway up to 3 months before, 3 months after and 1 year after surgery. Study objectives were to explore (1) patient... Read More about ‘Going through the motions’; a rich account of the complexity of the anterior cruciate ligament reconstruction pathway, a UK qualitative study.

improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review [version 1; peer review: 2 approved with reservations] (2024)
Journal Article
Nicholls, G., Eaton, G., Ortega, M., Sumera, K., Baliousis, M., Hodgson, J., Laparidou, D., Siriwardena, A. N., Leighton, P., Redsell, S., Lord, B., Bujor, T., & Whitley, G. A. (2024). improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review [version 1; peer review: 2 approved with reservations]. NIHR Open Research, 4, Article 42. https://doi.org/10.3310/nihropenres.13627.1

Background
Each year in England, 450,000 children and young people (CYP) under 18 years of age are transported by ambulance to emergency departments. Approximately 20% of these suffer acute pain caused by illness or injury. Pain is a highly complex... Read More about improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review [version 1; peer review: 2 approved with reservations].

The Acceptability of Intraoral Imaging in Children with Caries (2024)
Journal Article
Young, S., Allen, N., Farmer, N., Dawett, B., Leighton, P., Blake, H., Deery, C., & Marshman, Z. (2024). The Acceptability of Intraoral Imaging in Children with Caries. Caries Research, 58(3), 353. https://doi.org/10.1159/000539768

A multifaceted and standardised approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals (2024)
Journal Article
Masterson, N., Burden-Teh, E., Healy, E., Hepburn, T., Layfield, C., Layton, A., Leighton, P., Leng, S., Mitchell, E., Northover, G., Penzer-Hick, R., Price, W., Radley, K., Ramesh, G., Ravenscroft, J. C., Sach, T., Sadiq, S., Santer, M., Thomas, K. S., Thompson, A., …the Acne-ID Trial Development Team. (2025). A multifaceted and standardised approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals. Clinical and Experimental Dermatology, 50(1), 158-160. https://doi.org/10.1093/ced/llae180

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology (2024)
Journal Article
Shariff, Z., Harvey, J., Leighton, P., Boyd, M., Ridd, M., Santer, M., Tucker, R., & Maidment, I. (2024). Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology. Skin Health and Disease, Article e369. https://doi.org/10.1002/ski2.369

This research letter discusses the perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in this area. A mixed methods online survey was created, and a total of 174 commun... Read More about Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology.

Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people (2024)
Journal Article
Sach, T. H., Onoja, M., Clarke, H., Santer, M., Muller, I., Becque, T., Stuart, B., Hooper, J., Steele, M., Wilczynska, S., Ridd, M. J., Roberts, A., Ahmed, A., Yardley, L., Little, P., Greenwell, K., Sivyer, K., Nuttall, J., Griffiths, G., Lawton, S., …Thomas, K. S. (2024). Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people. European Journal of Health Economics, 25(7), 1165–1176. https://doi.org/10.1007/s10198-023-01649-9

Objective: To estimate the cost-effectiveness of online behavioral interventions (EczemaCareOnline.org.uk) designed to support eczema self-care management for parents/carers and young people from an NHS perspective. Methods: Two within-trial economic... Read More about Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people.

How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise (2024)
Journal Article
Harvey, J., Shariff, Z., Anderson, C., Boyd, M. J., Ridd, M. J., Santer, M., Thomas, K. S., Maidment, I., & Leighton, P. (2024). How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise. BMJ Open, 14(1), Article e071863. https://doi.org/10.1136/bmjopen-2023-071863

Objective: To establish research priorities which will support the development and delivery of community pharmacy initiatives for the management of skin conditions. Design: An iterative, multistage stakeholder consultation consisting of online survey... Read More about How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise.