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Outputs (76)

The Acceptability of Intraoral Imaging in Children with Caries (2024)
Presentation / Conference Contribution
Allen, N., Farmer, N., Young, S., Dawett, B., Leighton, P., Blake, H., …Marshman, Z. (2024, July). The Acceptability of Intraoral Imaging in Children with Caries. Presented at 71st Congress ORCA 2024, Crete, Greece

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology (2024)
Journal Article
Shariff, Z., Harvey, J., Leighton, P., Boyd, M., Ridd, M., Santer, M., …Maidment, I. (2024). Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology. Skin Health and Disease, Article e369. https://doi.org/10.1002/ski2.369

This research letter discusses the perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in this area. A mixed methods online survey was created, and a total of 174 commun... Read More about Perspectives of community pharmacy staff on commonly encountered skin conditions and the key challenges towards enhancing their role in dermatology.

Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people (2024)
Journal Article
Sach, T. H., Onoja, M., Clarke, H., Santer, M., Muller, I., Becque, T., …Thomas, K. S. (2024). Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people. European Journal of Health Economics, https://doi.org/10.1007/s10198-023-01649-9

Objective: To estimate the cost-effectiveness of online behavioral interventions (EczemaCareOnline.org.uk) designed to support eczema self-care management for parents/carers and young people from an NHS perspective. Methods: Two within-trial economic... Read More about Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people.

How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise (2024)
Journal Article
Harvey, J., Shariff, Z., Anderson, C., Boyd, M. J., Ridd, M. J., Santer, M., …Leighton, P. (2024). How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise. BMJ Open, 14(1), Article e071863. https://doi.org/10.1136/bmjopen-2023-071863

Objective: To establish research priorities which will support the development and delivery of community pharmacy initiatives for the management of skin conditions. Design: An iterative, multistage stakeholder consultation consisting of online survey... Read More about How can community pharmacists be supported to manage skin conditions? A multistage stakeholder research prioritisation exercise.

Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study (2023)
Journal Article
Ingram, J. R., Bates, J., Cannings-John, R., Collier, F., Gibbons, A., Harris, C., …Thomas-Jones, E. (2023). Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study. Health Technology Assessment, 27(30), https://doi.org/10.3310/HWNM2189

Background Hidradenitis suppurativa is a chronic inflammatory skin disease characterised by recurrent inflammatory lesions and skin tunnels in flexural sites such as the axilla. Deroofing of skin tunnels and laser treatment are standard hidradenit... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study.

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study (2023)
Journal Article
Ingram, J. R., Thomas, K. S., Cannings-John, R., Evans, J., Gibbons, A., Howes, R., …Leighton, P. (2024). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study. British Journal of Dermatology, 190(3), 382-391. https://doi.org/10.1093/bjd/ljad388

Background Hidradenitis suppurativa (HS) is a chronic, painful disease affecting flexures and other skin regions, producing nodules, abscesses and skin tunnels. Laser treatment targeting hair follicles and deroofing of skin tunnels are standard HS in... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study.

Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach. (2023)
Journal Article
Owen, R., Ashton, R. E. M., Ferraro, F. V., Skipper, L., Bewick, T., Leighton, P., …Faghy, M. A. (2023). Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach. eClinicalMedicine, 62, Article 102145. https://doi.org/10.1016/j.eclinm.2023.102145

Background: Current approaches to support patients living with post-COVID condition, also known as Long COVID, are highly disparate with limited success in managing or resolving a well-documented and long-standing symptom burden. With approximately 2... Read More about Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach..

Research priorities in the management of hidradenitis suppurativa (2023)
Journal Article
Leighton, P., Howells, L., Bates, J., Gibbons, A., Cannings-John, R., Collier, F., …Ingram, J. R. (2023). Research priorities in the management of hidradenitis suppurativa. British Journal of Dermatology, 189(3), 343–345. https://doi.org/10.1093/bjd/ljad152

There is a need for high-quality research to support the management of hidradenitis suppurativa. This letter offers suggestions for priority research topics derived from a stakeholder consensus meeting. Investigation of laser hair removal treatment,... Read More about Research priorities in the management of hidradenitis suppurativa.

Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study. (2023)
Journal Article
Radford, S., Leighton, P., Coad, J., & Moran, G. (2023). Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study. BMJ Open, 13(6), Article e067528. https://doi.org/10.1136/bmjopen-2022-067528

The study sought to explore and better understand the perceptions and experiences of stakeholders in relation to the use of ultrasound for the assessment of inflammatory bowel disease (IBD) in adults in the UK. A qualitative semistructured interview... Read More about Stakeholder-identified barriers and enablers to ultrasound implementation in inflammatory bowel disease services in the UK: a qualitative interview study..

‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study (2023)
Journal Article
Mousoulis, C., Karantana, A., Trickett, R. W., Thomas, K. S., & Leighton, P. (2023). ‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study. BMJ Open, 13(5), Article e065185. https://doi.org/10.1136/bmjopen-2022-065185

Objectives: To (1) generate detailed, person-centred data about the experience of finger injury and treatment and (2) understand the patients’ perspectives of research involvement with a view to informing better designed future studies in hand injury... Read More about ‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study.

'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema (2022)
Journal Article
Greenwell, K., Sivyer, K., Howells, L., Steele, M., Ridd, M. J., Roberts, A., …Muller, I. (2023). 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema. British Journal of Dermatology, 188(4), 506-513. https://doi.org/10.1093/bjd/ljac115

Background There is a lack of well-conducted randomized controlled trials evaluating the effectiveness of theory-based online interventions for eczema. To address these deficiencies, we previously developed and demonstrated the effectiveness of two o... Read More about 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema.

Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials (2022)
Journal Article
Santer, M., Muller, I., Becque, T., Stuart, B., Hooper, J., Steele, M., …Thomas, K. S. (2022). Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials. BMJ, 379, Article e072007. https://doi.org/10.1136/bmj-2022-072007

Objective: To determine the effectiveness of two online behavioural interventions, one for parents and carers and one for young people, to support eczema self-management. Design: Two independent, pragmatic, parallel group, unmasked, randomised contro... Read More about Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials.

A realist evaluation of a multifactorial falls prevention programme in care homes (2022)
Journal Article
Leighton, P. A., Darby, J., Allen, F., Cook, M., Evley, R., Fox, C., …Logan, P. (2022). A realist evaluation of a multifactorial falls prevention programme in care homes. Age and Ageing, 51(12), Article afac263. https://doi.org/10.1093/ageing/afac263

BACKGROUND: falls in care homes are common, costly and hard to prevent.Multifactorial falls programmes demonstrate clinical and cost-effectiveness, but the heterogeneity of the care home sector is a barrier to their implementation. A fuller appreciat... Read More about A realist evaluation of a multifactorial falls prevention programme in care homes.

Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation (2022)
Journal Article
Leighton, P. A., Dias, J., & Brearley, S. (2022). Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation. Bone & Joint Open, 3(8), 641-647. https://doi.org/10.1302/2633-1462.38.BJO-2022-0042.R1

Aims To explore individuals’ experience of a scaphoid waist fracture and its subsequent treatment. Methods A purposive sample was created, consisting of 49 participants in the Scaphoid Waist Internal Fixation for Fractures Trial of initial surgery co... Read More about Patient experiences of scaphoid waist fractures and their treatment a qualitative investigation.

Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial (2022)
Journal Article
Topcu, G., Smith, L., Mhizha-Murira, J. R., Goulden, N., Hoare, Z., Drummond, A., …On behalf of the NEuRoMS Collective. (2022). Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies, 8(1), Article 123. https://doi.org/10.1186/s40814-022-01073-5

Background: Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability to work, and quality of life. Addressing cognitive problems is a top 10 research priority for people with MS. Our ongoin... Read More about Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial.

Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial (2022)
Journal Article
Leighton, P., Chalmers, J. R., Batchelor, J., Rogers, A., Akram, P., Haines, R. H., …Thomas, K. S. (2022). Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial. Clinical and Experimental Dermatology, 47(8), 1480-1489. https://doi.org/10.1111/ced.15193

Background: The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better treatment response than potent TCS alone. However, it... Read More about Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial.

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., …Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people (2022)
Journal Article
Ong, T., Suazo Di Paola, A., Brookes, C., Drummond, A., Hendrick, P., Leighton, P., …Sahota, O. (2022). ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people. BMJ Open, 12(5), Article e050535. https://doi.org/10.1136/bmjopen-2021-050535

Objective To determine the feasibility of designing and conducting a definitive trial to evaluate the effectiveness of sacral fracture fixation compared with non-surgical management among older people admitted with a lateral compression pelvic fragil... Read More about ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people.

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study (2022)
Journal Article
Bates, J., Stanton, H., Cannings-John, R., Thomas, K. S., Leighton, P., Howells, L. M., …Ingram, J. R. (2022). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study. BMJ Open, 12(4), Article e060815. https://doi.org/10.1136/bmjopen-2022-060815

Background Hidradenitis suppurativa (HS) is a chronic, painful, inflammatory skin disease with estimates of prevalence in the European population of 1%–2%. Despite being a relatively common condition, the evidence base for management of HS is limited... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): protocol for a prospective cohort study.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article
Gordon, A. L., Rick, C., Juszczak, E., Montgomery, A., Howard, R., Guthrie, B., …Tate, V. (2022). The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age and Ageing, 51(3), Article afac052. https://doi.org/10.1093/ageing/afac052

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.

Working in partnership with the patient community to develop outline trial designs in CF (2021)
Journal Article
Rowbotham, N. J., Smith, S., Davies, G., Leighton, P., Rayner, O., Elliott, Z., …Smyth, A. R. (2022). Working in partnership with the patient community to develop outline trial designs in CF. Journal of Cystic Fibrosis, 21(2), 300-301. https://doi.org/10.1016/j.jcf.2021.12.008

In a collaboration between health professionals and the patient community, we previously identified the Top 10 priorities for clinical research in CF [ [1] ]. Here, we have used a similar approach to explore four of these priorities further and sugge... Read More about Working in partnership with the patient community to develop outline trial designs in CF.

Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs (2021)
Journal Article
Collier, F., Howes, R., Rodrigues, J., Thomas, K. S., Leighton, P., & Ingram, J. R. (2021). Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs. BJGP Open, 5(5), 1-8. https://doi.org/10.3399/BJGPO.2021.0051

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes painful discharging nodules and skin tunnels. HS has associations with several systemic diseases, including cardiovascular disease (CVD), anxiety, and depress... Read More about Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs.

Exploring the challenges of accessing medication for patients with cystic fibrosis (2021)
Journal Article
Herbert, S., Rowbotham, N., Smith, S., Wilson, P., Elliott, Z., Leighton, P., …Smyth, A. R. (2022). Exploring the challenges of accessing medication for patients with cystic fibrosis. Thorax, 77(3), 295-297. https://doi.org/10.1136/thoraxjnl-2021-217140

Reducing treatment burden in cystic fibrosis (CF) is the top research priority for patients and clinicians. Difficulty accessing medication is one aspect of treatment burden. We investigated this with an online survey available globally for patients... Read More about Exploring the challenges of accessing medication for patients with cystic fibrosis.

What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic? (2021)
Journal Article
Kulkarni, K., Shah, R., Armaou, M., Leighton, P., Mangwani, J., & Dias, J. (2021). What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic?. Bone & Joint Open, 2(8), 583-593. https://doi.org/10.1302/2633-1462.28.bjo-2021-0056.r1

COVID-19 has compounded a growing waiting list problem, with over 4.5 million patients now waiting for planned elective care in the UK. Views of patients on waiting lists are rarely considered in prioritization. Our primary aim was to understand how... Read More about What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic?.

Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review (2021)
Journal Article
Radford, S. J., Clarke, C. G., Shinkins, B., Leighton, P., Taylor, S. A., & Moran, G. W. (2022). Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review. Frontline Gastroenterology, 13(4), 280-286. https://doi.org/10.1136/flgastro-2021-101897

Background: Ultrasound is an alternative to Magnetic Resonance Enterography, and has the potential to significantly reduce waiting times, expedite clinical decision making and improve patient experience. Point of care ultrasound is an advantage of th... Read More about Clinical Utility of small bowel ultrasound assessment of Crohn’s Disease in Adults: A systematic scoping review.

Thematic synthesis of the experiences of people with hidradenitis suppurativa: a systematic review* (2021)
Journal Article
Howells, L., Lancasterm, N., McPheem, M., Bundy, C., Ingram, J. R., Leighton, P., …Thomas, K. S. (2021). Thematic synthesis of the experiences of people with hidradenitis suppurativa: a systematic review*. British Journal of Dermatology, 185(5), 921-934. https://doi.org/10.1111/bjd.20523

Background: Although hidradenitis suppurativa (HS) is known to affect quality of life, little summative knowledge exists on how HS impacts people living with the condition. Objectives: To synthesize experiences of people with HS within published qual... Read More about Thematic synthesis of the experiences of people with hidradenitis suppurativa: a systematic review*.

Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Muller, I., Stuart, B., Sach, T., Hooper, J., Wilczynska, S., Steele, M., …Santer, M. (2021). Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers. BMJ Open, 11(2), Article e045583. https://doi.org/10.1136/bmjopen-2020-045583

Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.

Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review (2021)
Journal Article
Deshmukh, S. R., Mousoulis, C., Marson, B. A., Grindlay, D., Karantana, A., the Core Outcome Set for Hand Fractures and Joint Injuries in Adults Group, …Montgomery, A. A. (2021). Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review. Journal of Hand Surgery (European Volume), 46(5), 488-495. https://doi.org/10.1177/1753193420983719

© The Author(s) 2021. This study identifies the treatment outcome domains used in recently published studies on the treatment of hand fractures and joint injuries with the aim to inform development of a core outcome set. Seven databases were searched... Read More about Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review.

Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma (2020)
Journal Article
Lakhani, B. K., Giannouladis, K., Leighton, P., Spry, P. G. D., Harper, R. A., & King, A. J. (2021). Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma. Eye, 35(9), 2524-2534. https://doi.org/10.1038/s41433-020-01251-w

Background Increasing demand on hospital services has led to the development of alternative community-based services, often run by optometrists for monitoring ‘stable’ and low-risk glaucoma patients. Methods An online Delphi exercise was underta... Read More about Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma.

Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT (2020)
Journal Article
Dias, J., Brealey, S., Cook, L., Fairhurst, C., Hinde, S., Leighton, P., …Torgerson, D. (2020). Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT. Health Technology Assessment, 24(52), a-234. https://doi.org/10.3310/hta24520

Background: Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. Immediate surgical fixation of this fracture has increased. Objective: To compare the clinical effectiveness and cost-effectiveness of surgical f... Read More about Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT.

An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK (2020)
Journal Article
Patel, M., Lee, S., Levell, N., Smart, P., Kai, J., Thomas, K., & Leighton, P. (2020). An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK. BMJ Open, 10, Article e034692. https://doi.org/10.1136/bmjopen-2019-034692

Objectives: To explore health care professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis. Setting: UK nationwide. Participants: 20 qualified HCPs, who had a minimum of two years clinical experience as a... Read More about An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK.

An interview study of the experiences of cellulitis diagnosis amongst health care professionals (2020)
Journal Article
Patel, M., Ing Lee, S., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). An interview study of the experiences of cellulitis diagnosis amongst health care professionals. BMJ Open, 10(10), Article e034692. https://doi.org/10.1136/+bmjopen-2019-034692

Objectives: To explore healthcare professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis. Setting: UK nationwide. Participants: 20 qualified HCPs, who had a minimum of 2 years clinical experience as an HCP... Read More about An interview study of the experiences of cellulitis diagnosis amongst health care professionals.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., …Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics. We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial (2020)
Journal Article
Dias, J. J., Brealey, S. D., Fairhurst, C., Amirfeyz, R., Bhowal, B., Blewitt, N., …Warwick, D. (2020). Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial. Lancet, 396(10248), 390-401. https://doi.org/10.1016/S0140-6736%2820%2930931-4

Background Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. Immediate surgical fixation of this fracture has increased, in spite of insufficient evidence of improved outcomes over non-surgical management.... Read More about Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial.

Outcome domains in lichen sclerosus (2020)
Journal Article
Goodrum, C., Leighton, P., & Simpson, R. (2020). Outcome domains in lichen sclerosus. British Journal of Dermatology, 183(5), 966-968. https://doi.org/10.1111/bjd.19253

Lichen Sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the genitals. It can affect men, women and children. LS affecting female genitalia typically presents with itchy patches that impact on physical and psychosocial‐sexua... Read More about Outcome domains in lichen sclerosus.

Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study (2019)
Journal Article
Patel, M., Lee, S. I., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study. British Journal of General Practice, 70(691), e130-e137. https://doi.org/10.3399/bjgp19X707909

© British Journal of General Practice 2020. BACKGROUND: Cellulitis can sometimes be challenging for healthcare professionals to diagnose, with no validated diagnostic criteria available. Supporting healthcare professionals to make a more accurate dia... Read More about Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study.

Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials (2019)
Journal Article
Davies, G., Rowbotham, N. J., Smith, S., Elliot, Z. C., Gathercole, K., Rayner, O., …Smyth, A. R. (2020). Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials. Journal of Cystic Fibrosis, 19(3), 499-502. https://doi.org/10.1016/j.jcf.2019.10.025

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: “What are effective ways of simplifying the treatment burden of people with CF?” We aimed to summarise the lived exp... Read More about Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials.

SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus (2019)
Presentation / Conference Contribution
Blake, H., Knox, E., Randell, T., Leighton, P., Guo, B., Greening, J., …Glazebrook, C. (2019). SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus. In 5th International Clinical Trials Methodology Conference (ICTMC 2019) Book of Abstracts

Introduction: Physical activity is important for children with type 1 diabetes mellitus (T1DM) but it is unclear whether interventions delivered online are feasible, acceptable to patients and efficacious. The aim was to assess the feasibility and ac... Read More about SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus.

Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis (2019)
Journal Article
Rowbotham, N. J., Smith, S. J., Elliott, Z. C., Leighton, P. A., Rayner, O. C., Morley, R., & Smyth, A. R. (2019). Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis. Research Involvement and Engagement, 5(1), Article 24. https://doi.org/10.1186/s40900-019-0159-x

Background The James Lind Alliance (JLA) method is well recognised for setting research priorities. The JLA approach involves a combination of surveys and workshop interactions between patients, carers and health care professionals to identify and... Read More about Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis.

Seeking a practical definition of stable glaucoma: a Delphi consensus survey of UK glaucoma consultants (2019)
Journal Article
Lakhani, B. K., Giannouladis, K., Leighton, P., & King, A. J. (2019). Seeking a practical definition of stable glaucoma: a Delphi consensus survey of UK glaucoma consultants. Eye, https://doi.org/10.1038/s41433-019-0540-x

© 2019, The Author(s), under exclusive licence to The Royal College of Ophthalmologists. Background: To generate a practical and clinically useful consensus definition of ‘stable glaucoma’ to aid provision of glaucoma services in the UK and to provid... Read More about Seeking a practical definition of stable glaucoma: a Delphi consensus survey of UK glaucoma consultants.

Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials (2019)
Journal Article
Mousoulis, C., Thomas, K., Leighton, P., Deshmukh, S., Grindlay, D., & Karantana, A. (2020). Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials. Journal of Hand Surgery (European Volume), 45(2), 111-118. https://doi.org/10.1177/1753193419865897

The aim of this study was to identify and assess all existing randomized studies on treatment interventions for hand fractures and joint injuries, to inform practice and plan future research. PubMed, Cochrane CENTRAL, MEDLINE and Embase were searche... Read More about Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials.

Exploring patients' expectations and preferences of glaucoma surgery outcomes to facilitate healthcare delivery and inform future glaucoma research (2019)
Journal Article
King, A. J., Kulkarni, B. B., & Leighton, P. (2019). Exploring patients' expectations and preferences of glaucoma surgery outcomes to facilitate healthcare delivery and inform future glaucoma research. British Journal of Ophthalmology, bjophthalmol-2018-313401. https://doi.org/10.1136/bjophthalmol-2018-313401

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Introduction: Glaucoma is a lifelong condition often requiring surgical intervention. To allow us to inform patients' expectations of surgery... Read More about Exploring patients' expectations and preferences of glaucoma surgery outcomes to facilitate healthcare delivery and inform future glaucoma research.

Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study (2019)
Journal Article
Johnson, N., Leighton, P., Pailthorpe, C., Dias, J., & Distal Radius Fracture Delphi Study Group. (2019). Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study. PLoS ONE, 14(1), 1-12. https://doi.org/10.1371/journal.pone.0210462

Distal radius fractures are very common yet controversy exists regarding which require treatment and is reflected by significant variation in surgical intervention rate. Evidence regarding which fractures would benefit from intervention is varied and... Read More about Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study.

Chair based exercise in community settings: a cluster randomised feasibility study (2018)
Journal Article
Robinson, K., Long, A., Leighton, P., Armstrong, S., Pulikottill-Jacob, R., Gladman, J., …Masud, T. (2018). Chair based exercise in community settings: a cluster randomised feasibility study. BMC Geriatrics, 18(1), Article 82. https://doi.org/10.1186/s12877-018-0769-4

Background: Some older people who find standard exercise programmes too strenuous may be encouraged to exercise while remaining seated - chair based exercises (CBE). We previously developed a consensus CBE programme (CCBE) following a modified Delphi... Read More about Chair based exercise in community settings: a cluster randomised feasibility study.

Interventions to improve retention in a surgical, clinical trial: a pragmatic, stakeholder driven approach (2018)
Journal Article
Leighton, P., Brealey, S. D., & Dias, J. J. (in press). Interventions to improve retention in a surgical, clinical trial: a pragmatic, stakeholder driven approach. Journal of Evidence-Based Medicine, https://doi.org/10.1111/jebm.12271

Objective To explore stakeholder perspectives upon participant retention in clinical trials, and to generate strategies to support retention in a surgical, clinical trial. Study Design & Setting The SWIFFT trial is a multi-centre study com... Read More about Interventions to improve retention in a surgical, clinical trial: a pragmatic, stakeholder driven approach.

The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and health care providers (2017)
Journal Article
Rowbotham, N. J., Smith, S., Leighton, P., Rayner, O. C., Gathercole, K., Elliott, Z., …Smyth, A. R. (2018). The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and health care providers. Thorax, 73(4), 388-390. https://doi.org/10.1136/thoraxjnl-2017-210473

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Researc... Read More about The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and health care providers.

Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial (2016)
Journal Article
Blake, H., Quirk, H., Leighton, P., Randell, T., Greening, J., Guo, B., & Glazebrook, C. (2016). Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial. Trials, 17(283), https://doi.org/10.1186/s13063-016-1719-0

Background: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multi... Read More about Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial.

Supporting Kids with diabetes In Physical activity (SKIP): protocol for a randomized feasibility trial of an online intervention to promote physical activity in children with type 1 diabetes (2016)
Presentation / Conference Contribution
Blake, H., Quirk, H., Leighton, P., Randell, T., Greening, J., Knox, E., …Glazebrook, C. (2016, December). Supporting Kids with diabetes In Physical activity (SKIP): protocol for a randomized feasibility trial of an online intervention to promote physical activity in children with type 1 diabetes. Paper presented at UK Society for Behavioural Medicine 12th Annual Scientific Meeting

Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT) protocol: a pragmatic multi-centre randomised controlled trial of cast treatment versus surgical fixation for the treatment of bi-cortical, minimally displaced fractures of the scaphoid waist in adults (2016)
Journal Article
Dias, J., Brealey, S., Choudhary, S., Cook, L., Costa, M., Fairhurst, C., …Torgerson, D. (2016). Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT) protocol: a pragmatic multi-centre randomised controlled trial of cast treatment versus surgical fixation for the treatment of bi-cortical, minimally displaced fractures of the scaphoid waist in adults. BMC Musculoskeletal Disorders, 17(1), Article 248. https://doi.org/10.1186/s12891-016-1107-7

Background: A scaphoid fracture is the most common type of carpal fracture affecting young active people. The optimal management of this fracture is uncertain. When treated with a cast, 88 to 90 % of these fractures unite; however, for the remaining... Read More about Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT) protocol: a pragmatic multi-centre randomised controlled trial of cast treatment versus surgical fixation for the treatment of bi-cortical, minimally displaced fractures of the scaphoid waist in adults.

Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial (2016)
Journal Article
das Nair, R., Anderson, P., Clarke, S. P., Leighton, P., Lincoln, N., Mhizha-Murira, J. R., …Walsh, D. A. (2016). Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial. Trials, 17(54), 1-11. https://doi.org/10.1186/s13063-016-1165-z

Background: Knee replacement surgery reduces pain for many people with osteoarthritis (OA). However, surgical outcomes are partly dependent on patients’ moods, and those with depression or anxiety have worse outcomes. Approximately one-third of peopl... Read More about Home-administered pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): study protocol for a randomised controlled trial.

Prescribing opioid analgesics for chronic non-malignant pain in general practice - a survey of attitudes and practice (2015)
Journal Article
Blake, H., Leighton, P., van der Walt, G., & Ravenscroft, A. (2015). Prescribing opioid analgesics for chronic non-malignant pain in general practice - a survey of attitudes and practice. British Journal of Pain, 9(4), https://doi.org/10.1177/2049463715579284

Background: This study replicates a previous postal survey of general practitioners (GPs) to explore whether attitudes to opioid prescribing have changed at a time when the number of opioid prescriptions issued in primary care has increased. Metho... Read More about Prescribing opioid analgesics for chronic non-malignant pain in general practice - a survey of attitudes and practice.

Assessment of the feasibility and clinical value of further research to evaluate the management options for children with Down syndrome and otitis media (2014)
Journal Article

Background There is clinical uncertainty of the benefits and costs of different treatment options for children with Down syndrome who have glue ear. This study was designed to assess the extent of this lack of knowledge and determine if pursuing fur... Read More about Assessment of the feasibility and clinical value of further research to evaluate the management options for children with Down syndrome and otitis media.

Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise (2013)
Journal Article
Simpson, R. C., Thomas, K., Leighton, P., & Murphy, R. (in press). Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. British Journal of Dermatology, 169(2), https://doi.org/10.1111/bjd.12334

Background: There is no defined set of criteria for diagnosing erosive lichen planus affecting the vulva (ELPV) and there is geographical variation in management. Objectives: To reach consensus on clinicopathological diagnostic criteria for ELPV.... Read More about Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise.

Does oral health knowledge and behaviour improve following brief dental care professional (DCP) delivered educational intervention in schools? (2011)
Presentation / Conference Contribution
Blake, H., Brady, L., Leighton, P., Younis, F., Deery, C., & Dawett, B. (2011, December). Does oral health knowledge and behaviour improve following brief dental care professional (DCP) delivered educational intervention in schools?. Poster presented at UK Society for Behavioural Medicine 7th Annual Scientific Meeting

Salivary diagnostics in primary dental care (2011)
Presentation / Conference Contribution
Dawlett, B., Pope, L., Blake, H., Leighton, P., & Deery, C. (2011, September). Salivary diagnostics in primary dental care. Presented at BSODR Meeting, Sheffield, UK

Presented on 13 September 2011.