Professor TRICIA MCKEEVER's Outputs (88)

Respiratory muscle specific warm-up and elite swimming performance (2014)
Journal Article
Wilson, E. E., McKeever, T. M., Lobb, C., Sherriff, T., Gupta, L., Hearson, G., Martin, N., Lindley, M. R., & Shaw, D. E. (2014). Respiratory muscle specific warm-up and elite swimming performance. British Journal of Sports Medicine, 48(9), https://doi.org/10.1136/bjsports-2013-092523

Background: Inspiratory muscle training has been shown to improve performance in elite swimmers, when used as part of routine training, but its use as a respiratory warm-up has yet to be investigated.
Aim: To determine the influence of inspiratory m... Read More about Respiratory muscle specific warm-up and elite swimming performance.

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction (2014)
Journal Article
Wain, L. V., Sayers, I., Soler Artigas, M., Portelli, M. A., Zeggini, E., Obeidat, M., Sin, D. D., Bossé, Y., Nickle, D. C., Brandsma, C.-A., Malarstig, A., Vangjeli, C., Jelingsky, S. A., John, S., Kilty, I., McKeever, T. M., Shrine, N., Cook, J. P., Patel, S., Spector, T. D., …Tobin, M. D. (2014). Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction. PLoS Genetics, 10(5), Article e1004314. https://doi.org/10.1371/journal.pgen.1004314

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with l... Read More about Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction.

Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study (2014)
Journal Article
Hurley, M., McKeever, T. M., Prayle, A. P., Smyth, A. R., & Fogarty, A. W. (2014). Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study. Journal of Cystic Fibrosis, 13(4), https://doi.org/10.1016/j.jcf.2013.12.002

Background: It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement.
Method: Death registration data analysis (US, England & Wa... Read More about Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study.

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma (2014)
Journal Article
Wain, L. V., Odenthal-Hesse, L., Abujaber, R., Sayers, I., Beardsmore, C., Gaillard, E. A., Chappell, S., Dogaru, C. M., McKeever, T. M., Guetta-Baranes, T., Kalsheker, N., Kuehni, C. E., Hall, I. P., Tobin, M. D., & Hollox, E. J. (2014). Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma. PLoS ONE, 9(1), Article e84192. https://doi.org/10.1371/journal.pone.0084192

Lung function measures are heritable, predict mortality and are relevant in diagnosis of chronic obstructive pulmonary disease (COPD). COPD and asthma are diseases of the airways with major public health impacts and each have a heritable component. G... Read More about Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma.

Inhaled corticosteroids and the risk of pneumonia in people with asthma (2013)
Journal Article
McKeever, T. M., Harrison, T. W., Hubbard, R., & Shaw, D. E. (2013). Inhaled corticosteroids and the risk of pneumonia in people with asthma. Chest, 144(6), https://doi.org/10.1378/chest.13-0871

Background

In clinical trials, the use of inhaled corticosteroids is associated with an increased risk of pneumonia in people with COPD, but whether the same is true for people with asthma is not known.
Methods

With the use of primary care dat... Read More about Inhaled corticosteroids and the risk of pneumonia in people with asthma.

The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study (2013)
Journal Article
Donaldson, J. W., McKeever, T. M., Hall, I. P., Hubbard, R., & Fogarty, A. W. (2014). The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study. Thorax, 69(2), 161-167. https://doi.org/10.1136/thoraxjnl-2013-203720

Background Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of aberrant blood vessel development characterised by arteriovenous malformations. HHT is associated with significant morbidity due to complications inc... Read More about The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study.

Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study (2013)
Journal Article
Navaratnam, V., Fogarty, A. W., McKeever, T. M., Thompson, N., Jenkins, G., Johnson, S. R., Dolan, G., Kumaran, M., Pointon, K., & Hubbard, R. B. (2014). Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study. Thorax, 69(3), 207-215. https://doi.org/10.1136/thoraxjnl-2013-203740

BACKGROUND: Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary in their tendency to clot due to a variety of inherited or acquired defects, we investigated whether a prothrombotic state increases th... Read More about Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study.

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study (2013)
Journal Article
Enocson, A., Hubbard, R., McKeever, T. M., Russell, N., Byrne, J., Das-Gupta, E., Watson, L., & Fogarty, A. W. (2013). The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study. BMC Pulmonary Medicine, 13(Januar), Article 6. https://doi.org/10.1186/1471-2466-13-2

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function.

Methods: Using a prospective study design, we quantified the changes in... Read More about The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study.