Outputs (22)

Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats (2024)
Journal Article
Gonçalves, S. V., Woodhams, S. G., Li, L., Hathway, G. J., & Chapman, V. (2024). Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats. PAIN Reports, 9(2), Article e1145. https://doi.org/10.1097/pr9.0000000000001145

IntroductionSustained opioid use has long-term negative impacts on future pain experience, particularly in women. This study aimed to investigate the underlying spinal neurobiology of this clinical observation in an experimental model of joint pain.O... Read More about Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats.

Association Between Physical Activity and Arterial Stiffness in Patients with Type 2 Diabetes in Ningbo, China: A Cross-Sectional Study (2023)
Journal Article
Li, X., Chattopadhyay, K., Chen, X., Li, J., Xu, M., Chen, X., & Li, L. (2023). Association Between Physical Activity and Arterial Stiffness in Patients with Type 2 Diabetes in Ningbo, China: A Cross-Sectional Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 16, 4133-4141. https://doi.org/10.2147/dmso.s438344

Aim: The study aimed to investigate the association between physical activity and arterial stiffness in patients with type 2 diabetes mellitus (T2DM) in Ningbo, China. Methods: A cross-sectional study was conducted using the Metabolic Management Cent... Read More about Association Between Physical Activity and Arterial Stiffness in Patients with Type 2 Diabetes in Ningbo, China: A Cross-Sectional Study.

Factors associated with nonattendance at annual diabetes check-up in Ningbo, China: a case-control study (2023)
Journal Article
Li, L., Chattopadhyay, K., Li, X., Yu, J., Xu, M., Chen, X., …Li, J. (2023). Factors associated with nonattendance at annual diabetes check-up in Ningbo, China: a case-control study. Frontiers in Public Health, 11, Article 1247406. https://doi.org/10.3389/fpubh.2023.1247406

Background: Type 2 diabetes mellitus (T2DM) is a grave issue in China. The annual check-up is recommended in clinical guidelines on T2DM. It plays an important role in monitoring and managing the condition and detecting and managing any comorbidities... Read More about Factors associated with nonattendance at annual diabetes check-up in Ningbo, China: a case-control study.

Lifestyle behaviours and associated factors among people with type 2 diabetes attending a diabetes clinic in Ningbo, China: A crosssectional study (2023)
Journal Article
Carter, N., Li, J., Xu, M., Li, L., Xu, S., Fan, X., …Chattopadhyay, K. (2023). Lifestyle behaviours and associated factors among people with type 2 diabetes attending a diabetes clinic in Ningbo, China: A crosssectional study. PLoS ONE, 18(11), Article e0294245. https://doi.org/10.1371/journal.pone.0294245

The burden of type 2 diabetes (T2DM) in China is significant and growing, and this is reflected in high rates of T2DM in the city of Ningbo, China. Consequent impacts on morbidity, mortality, healthcare expenditure, and health-related quality of life... Read More about Lifestyle behaviours and associated factors among people with type 2 diabetes attending a diabetes clinic in Ningbo, China: A crosssectional study.

Health-related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross-sectional study (2022)
Journal Article
Carter, N., Li, J., Xu, M., Li, L., Fan, X., Zhu, S., …Chattopadhyay, K. (2022). Health-related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross-sectional study. Endocrinology, Diabetes and Metabolism, 5(5), Article e353. https://doi.org/10.1002/edm2.353

Introduction: The burden of type 2 diabetes (T2DM) in China is increasing, with potential impacts on the health-related quality of life (HRQoL) of those who develop the disease. Context-specific assessment of HRQoL and its associated factors informs... Read More about Health-related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross-sectional study.

Association Between Sleep Duration and Albuminuria in Patients with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China (2022)
Journal Article
Li, X., Chattopadhyay, K., Qian, X., Yu, J., Xu, M., Li, L., …Li, J. (2022). Association Between Sleep Duration and Albuminuria in Patients with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 15, 1667-1675. https://doi.org/10.2147/dmso.s366064

Purpose: Type 2 diabetes mellitus (T2DM) can lead to microvascular complications including diabetic kidney disease. Albuminuria is an important marker to diagnose kidney injury in T2DM patients and healthy sleep duration is important for maintaining... Read More about Association Between Sleep Duration and Albuminuria in Patients with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China.

Association Between Nocturnal Sleep Duration and Obesity Indicators Among People with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China (2022)
Journal Article
Xu, M., Chattopadhyay, K., Qian, X., Li, J., Li, X., Sun, J., & Li, L. (2022). Association Between Nocturnal Sleep Duration and Obesity Indicators Among People with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 15, 1357-1364. https://doi.org/10.2147/DMSO.S350347

Aim: The study aimed to investigate the association between the nocturnal sleep duration and five obesity indicators, namely, visceral fat area (VFA), subcutaneous fat area (SFA), bodyweight, body mass index (BMI) and waist circumference (WC), among... Read More about Association Between Nocturnal Sleep Duration and Obesity Indicators Among People with Type 2 Diabetes: A Cross-Sectional Study in Ningbo, China.

Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China (2021)
Journal Article
Lin, Y., Chattopadhyay, K., Yang, X., Li, J. L., Chen, Y. S., Zhou, Y., & Li, L. (2021). Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, 4811-4818. https://doi.org/10.2147/DMSO.S338915

Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycemic response of T2D are lacking in China. The aim was to investigate the association between the l... Read More about Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China.

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia (2021)
Journal Article
Lillywhite, A., Woodhams, S. G., Gonçalves, S. V., Watson, D. J. G., Li, L., Burston, J. J., …Chapman, V. (2021). Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. PAIN Reports, 6(4), Article e956. https://doi.org/10.1097/PR9.0000000000000956

Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.... Read More about Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

36-month evaluation of a weight management programme in Chinese overweight and obese adults (2021)
Journal Article
Yang, X., Chattopadhyay, K., Hubbard, R., Li, J., Li, L., & Lin, Y. (2021). 36-month evaluation of a weight management programme in Chinese overweight and obese adults. Frontiers in Public Health, 9, Article 749302

Background: Few comprehensive lifestyle intervention programmes have been investigated on overweight and obese adults in China. This study was to evaluate the effect of a 36-month weight management programme on weight loss and its maintenance among o... Read More about 36-month evaluation of a weight management programme in Chinese overweight and obese adults.

Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study (2021)
Journal Article
Li, X., Chattopadhyay, K., Xu, S., Chen, Y., Xu, M., Li, L., & Li, J. (2021). Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study. BMJ Open, 11(1), Article e040532. https://doi.org/10.1136/bmjopen-2020-040532

Objectives: To determine the prevalence of comorbidities in patients with type 2 diabetes (T2DM) and identify the factors independently associated with comorbidities in a tertiary care department in Ningbo, China. Design: A computerised medical re... Read More about Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study.

Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain (2020)
Journal Article
Gowler, P. R., Li, L., Woodhams, S. G., Bennett, A. J., Suzuki, R., Walsh, D. A., & Chapman, V. (2020). Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain. PAIN, 161(1), 61-73. https://doi.org/10.1097/j.pain.0000000000001694

Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evidence also... Read More about Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain.

Weight management programme for overweight and obese adults in Ningbo, China: a feasibility pre- and post-intervention study (2019)
Journal Article
Xu, M., Chattopadhyay, K., Li, J., Rai, N., Chen, Y., Hu, F., …Li, L. (2019). Weight management programme for overweight and obese adults in Ningbo, China: a feasibility pre- and post-intervention study. Frontiers in Public Health, 7, Article 388. https://doi.org/10.3389/fpubh.2019.00388

Objective: To investigate the feasibility of conducting a randomized controlled trial (RCT) of a weight management programme in Ningbo, China. Methods: A pre- and post-intervention study was conducted in Ningbo. The study duration was from 01 July... Read More about Weight management programme for overweight and obese adults in Ningbo, China: a feasibility pre- and post-intervention study.

Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study (2019)
Journal Article
Li, J., Chattopadhyay, K., Xu, M., Chen, Y., Hu, F., Wang, X., & Li, L. (2019). Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study. PLoS ONE, 14(7), Article e0220047. https://doi.org/10.1371/journal.pone.0220047

Objectives To determine the prevalence of polypharmacy prescription among type 2 diabetes (T2DM) patients at a tertiary care department in Ningbo, China, and to determine factors that independently predict this polypharmacy prescription. Methods... Read More about Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study.

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain (2018)
Journal Article
Nwosu, L. N., Gowler, P. R., Burston, J. J., Rizoska, B., Tunblad, K., Lindström, E., …Chapman, V. (2018). Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. PAIN Reports, 3(6), Article 685. https://doi.org/10.1097/PR9.0000000000000685

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to invest... Read More about Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.

Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures (2017)
Journal Article
Lourdusamy, A., Luo, L. Z., Storer, L. C., Cohen, K. J., Resar, L., & Grundy, R. G. (2017). Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures. Oncotarget, 8(70), https://doi.org/10.18632/oncotarget.23311

Pediatric spinal ependymomas (SEPN) are important albeit uncommon malignant central nervous system tumors with limited treatment options. Our current knowledge about the underlying biology of these tumors is limited due to their rarity. To begin to e... Read More about Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article
Huang, J., Burston, J. J., Li, L., Ashraf, S., Mapp, P. I., Bennett, A. J., …Chapman, V. (2017). Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis and Rheumatology, 69(5), 996-1008. https://doi.org/10.1002/art.40001

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain (2016)
Journal Article
Xu, L., Nwosu, L. N., Burston, J., Millns, P., Sagar, D. R., Mapp, P. I., …Chapman, V. (2016). The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain. Osteoarthritis and Cartilage, 24(9), 1587-1595. https://doi.org/10.1016/j.joca.2016.05.015

Objective: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this st... Read More about The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

Artificial bee colony algorithm with time-varying strategy (2015)
Journal Article
Qin, Q., Cheng, S., Zhang, Q., Li, L., & Shi, Y. (2015). Artificial bee colony algorithm with time-varying strategy. Discrete Dynamics in Nature and Society, 2015, https://doi.org/10.1155/2015/674595

Artificial bee colony (ABC) is one of the newest additions to the class of swarm intelligence. ABC algorithm has been shown to be competitive with some other population-based algorithms. However, there is still an insufficiency that ABC is good at ex... Read More about Artificial bee colony algorithm with time-varying strategy.

A novel hybrid algorithm for mean-CVaR portfolio selection with real-world constraints (2014)
Journal Article
Qin, Q., Li, L., & Cheng, S. (2014). A novel hybrid algorithm for mean-CVaR portfolio selection with real-world constraints. Lecture Notes in Artificial Intelligence, 8795, https://doi.org/10.1007/978-3-319-11897-0_38

In this paper, we employ the Conditional Value at Risk (CVaR) to measure the portfolio risk, and propose a mean-CVaR portfolio selection model. In addition, some real-world constraints are considered. The constructed model is a non-linear discrete op... Read More about A novel hybrid algorithm for mean-CVaR portfolio selection with real-world constraints.

Learning from each other: co-teaching Chinese to pre-service teachers (2014)
Book Chapter
Medwell, J., Richardson, K., & Li, L. (2014). Learning from each other: co-teaching Chinese to pre-service teachers. In S. Hsin (Ed.), Selected papers: 2nd International Conference on Chinese as a Second Language Research. CASLAR

This study presents a case study co-teaching of beginner level Chinese as part of initial teacher education in England. The study involved interviews with teachers and observations of planning and teaching. The teaching in this study aims to teach el... Read More about Learning from each other: co-teaching Chinese to pre-service teachers.

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1 (2013)
Journal Article
Galbraith, M. D., Saxton, J., Li, L., Shelton, S. J., Zhang, H., Espinosa, J. M., & Shaw, P. E. (2013). ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Research, 41(22), https://doi.org/10.1093/nar/gkt837

The ETS domain transcription factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens. These events require phosphorylation of Elk-1 by extracellular signal-regulated kinase (ERK) and phosphorylation-dependent intera... Read More about ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1.