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Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China

Lin, Yi; Chattopadhyay, Kaushik; Yang, Xi; Li, Jia Lin; Chen, Yan Shu; Zhou, Ye; Li, Li

Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China Thumbnail


Authors

Yi Lin

Xi Yang

Jia Lin Li

Yan Shu Chen

Ye Zhou

LI LI li.li@nottingham.ac.uk
Senior Research Fellow



Abstract

Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycemic response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) levels in T2D patients. Methods: Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt intake was assessed through a standardized food frequency questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLMs) were used to examine the associations. Results: A total of 1145 eligible T2D patients with a mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2-hour postprandial plasma glucose and 2-hour postprandial insulin were significantly increased across dietary salt categories. The GLMs further showed that dietary salt intake >8 g/day was positively associated with FPG and HbA1c. Conclusion: Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion of salt reduction should be provided to T2D patients.

Journal Article Type Article
Acceptance Date Nov 12, 2021
Online Publication Date Dec 19, 2021
Publication Date Dec 19, 2021
Deposit Date Nov 22, 2021
Publicly Available Date Dec 19, 2021
Journal Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Electronic ISSN 1178-7007
Publisher Informa UK Limited
Peer Reviewed Peer Reviewed
Volume 14
Pages 4811-4818
DOI https://doi.org/10.2147/DMSO.S338915
Keywords dietary salt, type 2 diabetes, blood glucose, insulin, glycated hemoglobin A1c, China
Public URL https://nottingham-repository.worktribe.com/output/6784093
Publisher URL https://www.dovepress.com/association-between-dietary-salt-and-plasma-glucose-insulin-and-hemogl-peer-reviewed-fulltext-article-DMSO

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