Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China

Lin, Yi; Chattopadhyay, Kaushik; Yang, Xi; Li, Jia Lin; Chen, Yan Shu; Zhou, Ye; Li, Li

Abstract

Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycemic response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) levels in T2D patients. Methods: Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt intake was assessed through a standardized food frequency questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLMs) were used to examine the associations. Results: A total of 1145 eligible T2D patients with a mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2-hour postprandial plasma glucose and 2-hour postprandial insulin were significantly increased across dietary salt categories. The GLMs further showed that dietary salt intake >8 g/day was positively associated with FPG and HbA1c. Conclusion: Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion of salt reduction should be provided to T2D patients.

Citation

Lin, Y., Chattopadhyay, K., Yang, X., Li, J. L., Chen, Y. S., Zhou, Y., & Li, L. (2021). Association Between Dietary Salt and Plasma Glucose, Insulin and Hemoglobin A1c Levels Among Type 2 Diabetes Patients in Eastern China. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, 4811-4818. https://doi.org/10.2147/DMSO.S338915

• Journal Article Type: Article
• Acceptance Date: Nov 12, 2021
• Online Publication Date: Dec 19, 2021
• Publication Date: Dec 19, 2021
• Deposit Date: Nov 22, 2021
• Publicly Available Date: Dec 19, 2021
• Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
• Electronic ISSN: 1178-7007
• Publisher: Dove Press
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Pages: 4811-4818
• DOI: https://doi.org/10.2147/DMSO.S338915
• Keywords: dietary salt, type 2 diabetes, blood glucose, insulin, glycated hemoglobin A1c, China
• Public URL: https://nottingham-repository.worktribe.com/output/6784093
• Publisher URL: https://www.dovepress.com/association-between-dietary-salt-and-plasma-glucose-insulin-and-hemogl-peer-reviewed-fulltext-article-DMSO