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Professor Lucy Fairclough's Outputs (59)

Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study (2025)
Journal Article
Ayling, K., Jackson, H., Jia, R., Royal, S., Fairclough, L., & Vedhara, K. (2025). Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study. Brain, Behavior, and Immunity, 127, 103-109. https://doi.org/10.1016/j.bbi.2025.03.011

Background
Vaccines fundamentally changed the course of the COVID-19 pandemic, saving > 14 million lives within a year. However, vaccine-conferred protection showed inter-individual variability, with many identified correlates of protection (e.g., a... Read More about Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study.

Measuring Vaccine Responses in the Multiplex Era (2024)
Book Chapter
Ayling, K., Vedhara, K., & Fairclough, L. (2024). Measuring Vaccine Responses in the Multiplex Era. In Q. Yan (Ed.), Psychoneuroimmunology: Methods and Protocols (149-162). Springer US. https://doi.org/10.1007/978-1-0716-4200-9_9

Vaccine studies in psychoneuroimmunology (PNI) provide insight into biopsychosocial interactions and their role in infectious diseases. Methodologies to measure vaccine responses are therefore of critical importance for PNI researchers. In this chapt... Read More about Measuring Vaccine Responses in the Multiplex Era.

Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort) (2024)
Journal Article
Hopkins, G., Gomez, N., Tucis, D., Bartlett, L., Steers, G., Burns, E., Brown, M., Harvey-Cowlishaw, T., Santos, R., Lauder, S. N., Scurr, M., Capitani, L., Burnell, S., Rees, T., Smart, K., Somerville, M., Gallimore, A., Perera, M., Potts, M., Metaxaki, M., …Fairclough, L. (2024). Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort). Journal of Clinical Immunology, 44(6), Article 147. https://doi.org/10.1007/s10875-024-01739-0

Purpose
Asymptomatic SARS-CoV-2 infections were widely reported during the COVID-19 pandemic, acting as a hidden source of infection. Many existing studies investigating asymptomatic immunity failed to recruit true asymptomatic individuals. Thus, we... Read More about Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort).

The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review (2024)
Journal Article
Tucis, D., Hopkins, G., Browne, W., James, V., Onion, D., & Fairclough, L. C. (2024). The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review. International Journal of Molecular Sciences, 25(8), Article 4492. https://doi.org/10.3390/ijms25084492

Allergies affect approximately 10–30% of people worldwide, with an increasing number of cases each year; however, the underlying mechanisms are still poorly understood. In recent years, extracellular vesicles (EVs) have been suggested to play a role... Read More about The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review.

The Role of Extracellular Vesicles in Atopic Dermatitis (2024)
Journal Article
Harvey-Seutcheu, C., Hopkins, G., & Fairclough, L. C. (2024). The Role of Extracellular Vesicles in Atopic Dermatitis. International Journal of Molecular Sciences, 25(6), Article 3255. https://doi.org/10.3390/ijms25063255

Atopic dermatitis, or eczema, is the most common chronic skin disorder, characterized by red and pruritic lesions. Its etiology is multifaceted, involving an interplay of factors, such as the allergic immune response, skin barrier dysfunction, and dy... Read More about The Role of Extracellular Vesicles in Atopic Dermatitis.

Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk (2024)
Journal Article
Granata, S., Vivarelli, F., Morosini, C., Canistro, D., Paolini, M., & Fairclough, L. C. (2024). Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk. International Journal of Molecular Sciences, 25(5), Article 2737. https://doi.org/10.3390/ijms25052737

Tobacco smoking remains one of the leading causes of premature death worldwide. Electronic Nicotine Delivery Systems (ENDSs) are proposed as a tool for smoking cessation. In the last few years, a growing number of different types of ENDSs were launch... Read More about Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk.

Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats (2024)
Journal Article
Granata, S., Morosini, C., Valerii, M. C., Fagiolino, I., Sangiorgi, S., Ghini, S., Spisni, E., Vivarelli, F., Fairclough, L. C., Paolini, M., & Canistro, D. (2024). Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats. Frontiers in Toxicology, 6, Article 1515850. https://doi.org/10.3389/ftox.2024.1515850

Introduction: Heating tobacco products (HTPs) are advanced electronic cigarette models. Classified by the FDA as a modified-risk tobacco product and can be used as part of efforts to quit smoking. Using heat-not-burn (HnB) technology, these devices h... Read More about Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats.

Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial (2023)
Journal Article
Ayling, K., Brown, M., Carlisle, S., Bennett, R., Buchanan, H., Dumbleton, J., Hawkey, C., Hoschler, K., Jack, R. H., Nguyen-Van-Tam, J., Royal, S., Turner, D., Zambon, M., Fairclough, L., & Vedhara, K. (2023). Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial. Health Psychology, 43(2), 77-88. https://doi.org/10.1037/hea0001267

Objective: This trial explored the psychological and immunological effects of two brief interventions, targeting improving positive mood, administered to older adults immediately prior to influenza vaccination. The primary aim was to examine whether... Read More about Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial.

Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study (2023)
Journal Article
Gumber, L., Jackson, H., Gomez, N., Hopkins, G., Tucis, D., Chakravorty, M., Tighe, P., Grainge, M. J., Rutter, M., Ferraro, A., Power, S., Pradère, M.-J., Lanyon, P. C., Pearce, F. A., & Fairclough, L. (2023). Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study. Rheumatology Advances in Practice, 7(3), Article rkad097. https://doi.org/10.1093/rap/rkad097

Objective: Antibody responses to coronavirus disease 2019 (COVID-19) vaccines are reduced among immunocompromised patients but are not well quantified among people with rare disease. We conducted an observational study to evaluate the antibody respon... Read More about Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study.

Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8 + iNKT cells are depleted after peanut oil exposure (2023)
Journal Article
Hopkins, G. V., Cochrane, S., Onion, D., & Fairclough, L. C. (in press). Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8 + iNKT cells are depleted after peanut oil exposure. Frontiers in Immunology, 14, Article 1293158. https://doi.org/10.3389/fimmu.2023.1293158

Introduction:

Peanut allergy is one of the most prevalent food allergies globally. Currently, most research into the mechanisms involved in protein allergy focuses on the protein allergens under investigation, and information on the function of a... Read More about Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8 + iNKT cells are depleted after peanut oil exposure.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination (2022)
Journal Article
Gumber, L., Gomez, N., Hopkins, G., Tucis, D., Bartlett, L., Ayling, K., Vedhara, K., Steers, G., Chakravorty, M., Rutter, M., Jackson, H., Tighe, P., Ferraro, A., Power, S., Pradère, M.-J., Onion, D., Lanyon, P. C., Pearce, F. A., & Fairclough, L. (2023). Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination. Rheumatology, 62(6), 2294-2303. https://doi.org/10.1093/rheumatology/keac574

Objectives: COVID-19 vaccine responses in rare autoimmune rheumatic diseases (RAIRD) remain poorly understood, in particular there is little known about whether people develop effective T-cell responses. We conducted a prospective cohort study to eva... Read More about Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

The Role of Lipids in Allergic Sensitization: A Systematic Review (2022)
Journal Article
Hopkins, G. V., Cochrane, S., Onion, D., & Fairclough, L. C. (2022). The Role of Lipids in Allergic Sensitization: A Systematic Review. Frontiers in Molecular Biosciences, 9, Article 832330. https://doi.org/10.3389/fmolb.2022.832330

Background: Immunoglobulin E (IgE)-mediated allergies are increasing in prevalence, with IgE-mediated food allergies currently affecting up to 10% of children and 6% of adults worldwide. The mechanisms underpinning the first phase of IgE-mediated all... Read More about The Role of Lipids in Allergic Sensitization: A Systematic Review.

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review (2022)
Journal Article
Gomez, N., James, V., Onion, D., & Fairclough, L. C. (2022). Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review. Respiratory Research, 23(1), Article 82. https://doi.org/10.1186/s12931-022-01984-0

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review.

Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept (2022)
Journal Article
Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J. K., Knight, H., Blake, H., Corner, J., Denning, C., Bolton, K., Jackson, H., Coupland, C., & Tighe, P. (2022). Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept. Journal of Infectious Diseases, 225(12), 2137-2141. https://doi.org/10.1093/infdis/jiac006

Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed mea... Read More about Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept.

Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers (2021)
Journal Article
Scurr, M. J., Zelek, W. M., Lippiatt, G., Somerville, M., Burnell, S. E., Capitani, L., Davies, K., Lawton, H., Tozer, T., Rees, T., Roberts, K., Evans, M., Jackson, A., Young, C., Fairclough, L., Tighe, P., Wills, M., Westwell, A. D., Morgan, B. P., Gallimore, A., & Godkin, A. (2022). Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers. Immunology, 165(2), 250-259. https://doi.org/10.1111/imm.13433

Accurate assessment of SARS-CoV-2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T-cell responses are a critical... Read More about Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers.

Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review (2021)
Preprint / Working Paper
Gomez, N., James, V., Onion, D., & Fairclough, L. Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity (2021)
Journal Article
Albogami, S., Todd, I., Negm, O., Fairclough, L. C., & Tighe, P. J. (2021). Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity. Immunology, 164(3), 637-654. https://doi.org/10.1111/imm.13400

The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p... Read More about Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity.

Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers (2021)
Preprint / Working Paper
Scurr, M. J., Zelek, W. M., Lippiatt, G., Somerville, M., Burnell, S. E. A., Capitani, L., Davies, K., Lawton, H., Tozer, T., Rees, T., Roberts, K., Evans, M., Jackson, A., Young, C., Fairclough, L., Wills, M., Westwell, A. D., Morgan, B. P., Gallimore, A., & Godkin, A. Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers

Accurate assessment of SARS-CoV-2 immunity in the population is critical to evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T cell respon... Read More about Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers.