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CAROL COUPLAND's Outputs (100)

Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study (2024)
Journal Article
Iyen, B., Coupland, C., Bell, B., Orrell, M., Dening, T., & Avery, T. (2024). Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study. BMJ Medicine, 3(1), Article e000799. https://doi.org/10.1136/bmjmed-2023-000799

Objective To investigate whether different anticholinergic drug treatments for overactive bladder have differential risks for incident dementia, in a large representative population of older adults in England.

Design Nested case-control study.... Read More about Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.

Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England (2024)
Journal Article
Tzu-Hsuan Chen, D., Hirst, J., Coupland, C. A., Liao, W., Baldwin, D. R., & Hippisley-Cox, J. (2025). Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England. The Lancet Regional Health Europe, 48, Article 101124. https://doi.org/10.1016/j.lanepe.2024.101124

Background: Lung cancer is a leading cause of mortality, yet disparities in lung cancer across different sociodemographic groups in the UK remain unclear. This study investigates ethnicity and sociodemographic disparities and differences in lung canc... Read More about Ethnic disparities in lung cancer incidence and differences in diagnostic characteristics: a population-based cohort study in England.

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2024). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., Marciani, L., Atkinson, D., Sansone, S., Zdanaviciene, A., Coupland, C., Knowles, C. H., Dinning, P., Taylor, S. A., Gowland, P., Hoad, C. L., Corsetti, M., & Spiller, R. C. (2024). Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut, https://doi.org/10.1136/gutjnl-2024-332755

Background: Colonic motility in constipation can be assessed non-invasively using MRI.

Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design: Part 1: 44 healthy volunteers (HVs), 43 pa... Read More about Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study.

Cost-effectiveness of the ‘Stay One Step Ahead’ Home Safety programme for the prevention of injuries among children under 5 years (2024)
Journal Article
Jones, M., Orton, E., Taylor, M. J., Timblin, C., Clarke, R., Watson, M. C., Hayes, M., Patel, T., Coupland, C., & Kendrick, D. (2024). Cost-effectiveness of the ‘Stay One Step Ahead’ Home Safety programme for the prevention of injuries among children under 5 years. Injury Prevention, https://doi.org/10.1136/ip-2024-045236

Background Unintentional injuries are a common cause of morbidity and mortality in the under-5s, but undertaking home safety practices can reduce injury risk. Stay One Step Ahead (SOSA) is an evidence-based standardised home safety programme. This st... Read More about Cost-effectiveness of the ‘Stay One Step Ahead’ Home Safety programme for the prevention of injuries among children under 5 years.

Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records (2024)
Journal Article
Cardwell, C. R., Ranger, T. A., Labeit, A. M., Coupland, C. A. C., Hicks, B., Hughes, C., …Hippisley-Cox, J. (in press). Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records. British Journal of Cancer, https://doi.org/10.1038/s41416-024-02767-8

Background: There is limited evidence on the safety of Hormone Replacement Therapy (HRT) in women with cancer. Therefore, we systematically examined HRT use and cancer-specific mortality in women with 17 site-specific cancers. Methods: Women newly di... Read More about Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records.

Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England (2024)
Journal Article
Chen, D. T.-H., Copland, E., Hirst, J. A., Mi, E., Dixon, S., Coupland, C., & Hippisley-Cox, J. (2024). Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England. BMC Medicine, 22(1), Article 237. https://doi.org/10.1186/s12916-024-03457-1

Background: Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 vaccination in this population. The lack of comprehensive real world data on vaccine uptake, effectiveness and safety... Read More about Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England.

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England (2024)
Journal Article
Copland, E., Patone, M., Saatci, D., Handunnetthi, L., Hirst, J., Hunt, D. P. J., …Hippisley-Cox, J. (2024). Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England. Nature Communications, 15(1), Article 3822. https://doi.org/10.1038/s41467-024-47745-z

The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes af... Read More about Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England.

Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study (2024)
Journal Article
Kalfas, M., Ayling, K., Jia, R., Coupland, C., Vedhara, K., & Chalder, T. (2024). Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study. Stress, 27(1), Article 2352117. https://doi.org/10.1080/10253890.2024.2352117

The COVID-19 pandemic and consequent lockdowns had a substantial impact on mental health. Distress and fatigue are highly correlated. However, little is known about the determinants of fatigue in the general population during the pandemic. This study... Read More about Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study.

Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model (2024)
Journal Article
Clift, A. K., Tan, P. S., Patone, M., Liao, W., Coupland, C., Bashford-Rogers, R., Sivakumar, S., & Hippisley-Cox, J. (2024). Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model. British Journal of Cancer, 130, 1969-1978. https://doi.org/10.1038/s41416-024-02693-9

Background: The National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight loss undergo abdominal imaging to assess for pancreatic cancer. More nuanced stratification could... Read More about Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model.

Development and validation of a new algorithm for improved cardiovascular risk prediction (2024)
Journal Article
Hippisley-Cox, J., Coupland, C. A. C., Bafadhel, M., Russell, R. E. K., Sheikh, A., Brindle, P., & Channon, K. M. (2024). Development and validation of a new algorithm for improved cardiovascular risk prediction. Nature Medicine, 30, 1440-1447. https://doi.org/10.1038/s41591-024-02905-y

QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which we have named QR4, that incorporates novel risk fac... Read More about Development and validation of a new algorithm for improved cardiovascular risk prediction.

Effectiveness and safety of COVID-19 vaccination in people with blood cancer (2024)
Journal Article
Copland, E., Hirst, J., Mi, E., Patone, M., Chen, D., Coupland, C., & Hippisley-Cox, J. (2024). Effectiveness and safety of COVID-19 vaccination in people with blood cancer. European Journal of Cancer, 201, Article 113603. https://doi.org/10.1016/j.ejca.2024.113603

Background
People with blood cancer have increased risk of severe COVID-19 outcomes and poor response to vaccination. We assessed the safety and effectiveness of COVID-19 vaccines in this vulnerable group compared to the general population.
Methods... Read More about Effectiveness and safety of COVID-19 vaccination in people with blood cancer.

Dynamic updating of clinical survival prediction models in a changing environment (2023)
Journal Article
Tanner, K. T., Keogh, R. H., Coupland, C. A. C., Hippisley-Cox, J., & Diaz-Ordaz, K. (2023). Dynamic updating of clinical survival prediction models in a changing environment. Diagnostic and Prognostic Research, 7, Article 24. https://doi.org/10.1186/s41512-023-00163-z

Background
Over time, the performance of clinical prediction models may deteriorate due to changes in clinical management, data quality, disease risk and/or patient mix. Such prediction models must be updated in order to remain useful. In this study... Read More about Dynamic updating of clinical survival prediction models in a changing environment.

Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study (2023)
Journal Article
Thompson, W., Swain, S., Zhao, S. S., Kamps, A., Coupland, C., Kuo, C., …Zhang, W. (2023). Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study. Osteoarthritis and Cartilage Open, 5(4), Article 100414. https://doi.org/10.1016/j.ocarto.2023.100414

Objective To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout.... Read More about Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study.

Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models (2023)
Journal Article
Hippisley-Cox, J., Mei, W., Fitzgerald, R., & Coupland, C. (2023). Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models. The Lancet Regional Health Europe, 32, Article 100700. https://doi.org/10.1016/j.lanepe.2023.100700

Background: Methods to identify patients at increased risk of oesophageal cancer are needed to better identify those for targeted screening. We aimed to derive and validate novel risk prediction algorithms (CanPredict) to estimate the 10-year risk of... Read More about Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models.

Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study (2023)
Journal Article
Hippisley-Cox, J., Khunti, K., Sheikh, A., Nguyen-Van-Tam, J. S., & Coupland, C. A. (2023). Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study. British Medical Journal, 381, Article e072976. https://doi.org/10.1136/bmj-2022-072976

Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was... Read More about Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database (2023)
Journal Article
Liao, W., Coupland, C. A., Innes, H., Jepsen, P., Matthews, P. C., Campbell, C., …Welberry, C. (2023). Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database. eClinicalMedicine, 59, Article 101969. https://doi.org/10.1016/j.eclinm.2023.101969

Background: Liver cancer has one of the fastest rising incidence and mortality rates among all cancers in the UK, but it receives little attention. This study aims to understand the disparities in epidemiology and clinical pathways of primary liver c... Read More about Disparities in care and outcomes for primary liver cancer in England during 2008–2018: a cohort study of 8.52 million primary care population using the QResearch database.

Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models (2023)
Journal Article
Liao, W., Coupland, C., Burchardt, J., Baldwin, D. R., Gleeson, F. V., Hippisley-Cox, J., & DART initiative. (2023). Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models. Lancet Respiratory Medicine, https://doi.org/10.1016/S2213-2600%2823%2900050-4

Background: Lung cancer is the second most common cancer in incidence and the leading cause of cancer deaths worldwide. Meanwhile, lung cancer screening with low-dose CT can reduce mortality. The UK National Screening Committee recommended targeted l... Read More about Predicting the future risk of lung cancer: development, and internal and external validation of the CanPredict (lung) model in 19·67 million people and evaluation of model performance against seven other risk prediction models.

Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada (2023)
Journal Article
Zaccardi, F., Tan, P. S., Shah, B. R., Everett, K., Clift, A. K., Patone, M., Saatci, D., Coupland, C., Griffin, S. J., Khunti, K., Dambha-Miller, H., & Hippisley-Cox, J. (2023). Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada. BMC Public Health, 23(1), Article 399. https://doi.org/10.1186/s12889-023-15223-8

Background: Heterogeneous studies have demonstrated ethnic inequalities in the risk of SARS-CoV-2 infection and adverse COVID-19 outcomes. This study evaluates the association between ethnicity and COVID-19 outcomes in two large population-based coho... Read More about Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada.

Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England (2023)
Journal Article
Hirst, J., Mi, E., Copland, E., Patone, M., Coupland, C., & Hippisley-Cox, J. (2023). Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England. European Journal of Cancer, 183, 162-170. https://doi.org/10.1016/j.ejca.2023.02.001

Background: People with blood cancers have increased risk of severe outcomes from COVID-19 and were prioritised for vaccination. Methods: Individuals in the QResearch database aged 12 years and above on 1st December 2020 were included in the analysis... Read More about Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England.

Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5 (2022)
Journal Article
Jones, M., Hill, T., Coupland, C., Kendrick, D., Akbari, A., Rodgers, S., …Orton, E. (2022). Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5. Injury Prevention, https://doi.org/10.1136/ip-2022-044698

Background: Injuries in children aged under 5 years most commonly occur in the home and disproportionately affect those living in the most disadvantaged communities. The 'Safe at Home' (SAH) national home safety equipment scheme, which ran in England... Read More about Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5.

Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections (2022)
Journal Article
Ranger, T. A., Clift, A. K., Patone, M., Coupland, C. A. C., Hatch, R., Thomas, K., …Hippisley-Cox, J. (2022). Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections. JAMA Psychiatry, 80(1), 57-65. https://doi.org/10.1001/jamapsychiatry.2022.3614

Importance Evidence indicates that preexisting neuropsychiatric conditions confer increased risks of severe outcomes from COVID-19 infection. It is unclear how this increased risk compares with risks associated with other severe acute respiratory inf... Read More about Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections.

Design decisions and data completeness for experience sampling methods used in psychosis: systematic review (2022)
Journal Article
Deakin, E., Ng, F., Young, E., Thorpe, N., Newby, C., Coupland, C., Craven, M., & Slade, M. (2022). Design decisions and data completeness for experience sampling methods used in psychosis: systematic review. BMC Psychiatry, 22, Article 669. https://doi.org/10.1186/s12888-022-04319-x

Background: The experience sampling method (ESM) is an intensive longitudinal research method. Participants complete questionnaires at multiple times about their current or very recent state. The design of ESM studies is complex. People with psychosi... Read More about Design decisions and data completeness for experience sampling methods used in psychosis: systematic review.

Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study (2022)
Journal Article
Piernas, C., Patone, M., Astbury, N. M., Gao, M., Sheikh, A., Khunti, K., …Jebb, S. A. (2022). Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study. Lancet Diabetes and Endocrinology, 10(8), 571-580. https://doi.org/10.1016/s2213-8587%2822%2900158-9

Background: A high BMI has been associated with a reduced immune response to vaccination against influenza. We aimed to investigate the association between BMI and COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes a... Read More about Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study.

Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study (2022)
Journal Article
Tan, P. S., Garriga, C., Clift, A., Liao, W., Patone, M., Coupland, C., …Hippisley-Cox, J. (2023). Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study. Gut, 72(3), 512-521. https://doi.org/10.1136/gutjnl-2021-326522

Objective Prior studies identified clinical factors associated with increased risk of pancreatic ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying nature, which could inform earlier diagnosis. This study assessed tem... Read More about Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study.

Common protocol for validation of the QCOVID algorithm across the four UK nations (2022)
Journal Article
Kerr, S., Robertson, C., Nafilyan, V., Lyons, R. A., Kee, F., Cardwell, C. R., …Sheikh, A. (2022). Common protocol for validation of the QCOVID algorithm across the four UK nations. BMJ Open, 12(6), Article e050994. https://doi.org/10.1136/bmjopen-2021-050994

Introduction The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it is being used in important policy-making decisions by the UK and devolved governments for com... Read More about Common protocol for validation of the QCOVID algorithm across the four UK nations.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries (2022)
Journal Article
Swain, S., Kamps, A., Runhaar, J., Dell ‘Isola, A., Turkiewicz, A., Robinson, D., …Zhang, W. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries. BMJ Open, 12(4), Article e052816. https://doi.org/10.1136/bmjopen-2021-052816

Introduction: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries.

Association between smoking, e-cigarette use and severe COVID-19: A cohort study (2022)
Journal Article
Gao, M., Aveyard, P., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., …Hippisley-Cox, J. (2022). Association between smoking, e-cigarette use and severe COVID-19: A cohort study. International Journal of Epidemiology, 51(4), 1062-1072. https://doi.org/10.1093/ije/dyac028

Background: Smoking is a risk factor for most respiratory infections, but it may protect against SARS-CoV-2 infection. The objective was to assess whether smoking and e-cigarette use were associated with severe COVID-19. Methods: This cohort ran from... Read More about Association between smoking, e-cigarette use and severe COVID-19: A cohort study.

‘It is designed for everybody to find their own level and to improve themselves’; views of older people and instructors of the Falls Management Exercise (FaME) programme (2022)
Journal Article
Gumber, L., Timmons, S., Coupland, C., Gladman, J., Lliffe, S., Kendrick, D., …Orton, E. (2022). ‘It is designed for everybody to find their own level and to improve themselves’; views of older people and instructors of the Falls Management Exercise (FaME) programme. Age and Ageing, 51(2), Article afac023. https://doi.org/10.1093/ageing/afac023

Background: Older adults are at increased risk of falls due to ageing, decreased muscle strength and impaired balance. Clinical trials have demonstrated the efficacy and effectiveness of the Falls Management Exercise (FaME) programme in improving fun... Read More about ‘It is designed for everybody to find their own level and to improve themselves’; views of older people and instructors of the Falls Management Exercise (FaME) programme.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study (2022)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C. F., Sarmanova, A., …Zhang, W. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, 30(5), 702-713. https://doi.org/10.1016/j.joca.2021.12.013

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.

Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets (2022)
Journal Article
Burchardt, J. M., Mei, X. W., Ranger, T., McDermott, C. J., Radunovic, A., Coupland, C., & Hippisley-Cox, J. (2022). Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 23(5-6), 363-371. https://doi.org/10.1080/21678421.2021.2016837

Objective: This study uses three linked datasets to provide an estimate of incidence of motor neuron disease (MND) in England from 1998 to 2019. Comparison is made to previous British studies. It examines age at diagnosis and ethnicity of those affec... Read More about Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets.

Psychological Predictors of Self-reported COVID-19 Outcomes: Results From a Prospective Cohort Study (2022)
Journal Article
Ayling, K., Jia, R., Coupland, C., Chalder, T., Massey, A., Broadbent, E., & Vedhara, K. (2022). Psychological Predictors of Self-reported COVID-19 Outcomes: Results From a Prospective Cohort Study. Annals of Behavioral Medicine, 56(5), 484-497. https://doi.org/10.1093/abm/kaab106

Background: Previous research has shown that psychological factors, such as stress and social support, are associated with greater susceptibility to viral respiratory illnesses and more severe symptoms. During the COVID-19 pandemic there has been a w... Read More about Psychological Predictors of Self-reported COVID-19 Outcomes: Results From a Prospective Cohort Study.

Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment (2022)
Journal Article
Abhishek, A., Fuller, A., Nakafero, G., Zhang, W., Dumbleton, J., Hawkey, C., …Doherty, M. (2022). Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment. Rheumatology Advances in Practice, 6(3), Article rkac086. https://doi.org/10.1093/rap/rkac086

Objective: The aim was to test the feasibility of a randomized controlled trial exploring whether omega-3 fatty acid supplementation limits gout flares during treat-to-target urate-lowering treatment (T2T-ULT). Methods: Adults with at least one gout... Read More about Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment.

Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort (2022)
Journal Article
Swain, S., Fernandes, G. S., Sarmanova, A., Valdes, A. M., Walsh, D. A., Coupland, C., …Zhang, W. (2022). Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatology Advances in Practice, 6(2), Article rkac049. https://doi.org/10.1093/rap/rkac049

Objectives: The aims were to examine the prevalence of comorbidities and role of oral analgesic use in people with knee pain (KP) compared with those without. Methods: The Knee Pain and related health In the Community (KPIC) cohort comprises communit... Read More about Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., …Hippisley-Cox, J. (2022). Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature Medicine, 28(2), 410-422. https://doi.org/10.1038/s41591-021-01630-0

Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination in the general population. We undertook a self-... Read More about Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.

Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases. British Medical Journal, 374, Article n2182. https://doi.org/10.1136/bmj.n2182

Objective To assess the risks of developing dementia associated with different types and durations of menopausal hormone therapy. Design Two nested case-control studies. Setting UK general practices contributing to QResearch or the Clinical Practice... Read More about Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases.

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study (2021)
Journal Article
Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., …Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study. BMJ, 374, Article n2244. https://doi.org/10.1136/bmj.n2244

Objectives To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination. Design Prospective, population based cohort study usin... Read More about Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study.

Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population (2021)
Journal Article
Liao, W., Clift, A. K., Patone, M., Coupland, C., González-Izquierdo, A., Pereira, S., & Cox, J. H. (2021). Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population. British Journal of General Practice, 71(712), e836-e845. https://doi.org/10.3399/bjgp.2021.0153

Background: Pancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients were diagnosed at Stage IV.

Aim: This study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (P... Read More about Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population.

Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study (2021)
Journal Article
Kellezi, B., Dhiman, P., Coupland, C., Whitehead, J., Morriss, R., Joseph, S., …Kendrick, D. (2022). Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study. Injury Prevention, 28(2), 131-140. https://doi.org/10.1136/injuryprev-2021-044311

Introduction: Mental health conditions are a major contributor to productivity loss and are common post-injury. This study quantifies post-injury productivity loss and its association with pre and post-injury mental health, injury, demographic, healt... Read More about Mental health and other factors associated with work productivity after injury in the UK: multicentre cohort study.

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study (2021)
Journal Article
Hippisley-Cox, J., Patone, M., Mei, X. W., Saatci, D., Dixon, S., Khunti, K., …Coupland, C. A. C. (2021). Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study. BMJ, 374, Article n1931. https://doi.org/10.1136/bmj.n1931

Objective: To assess the association between covid-19 vaccines and risk of thrombocytopenia and thromboembolic events in England among adults.

Design: Self-controlled case series study using national data on covid-19 vaccination and hospital adm... Read More about Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper (2021)
Journal Article
Ranger, T. A., Burchardt, J., Clift, A. K., Mei, W. X., Coupland, C., Tan, P. S., …Hippisley-Cox, J. (2021). Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper. BMJ Open, 11(8), Article e046701. https://doi.org/10.1136/bmjopen-2020-046701

Introduction Hormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean tha... Read More about Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.

Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study (2021)
Journal Article
Clift, A. K., Saatci, D., Coupland, C. A., Dambha-Miller, H., Hippisley-Cox, J., & International Investigator Group for Ethnicity and COVID-19. (2021). Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study. Annals of Internal Medicine, 174(10), 1483-1487. https://doi.org/10.7326/M21-1375

Background: Sickle cell disease is a collection of compound heterozygote hemoglobinopathies, including sickle cell anemia (1). The heterozygote hemoglobinopathies are characterized by erythrocyte deformation with hemolysis; immune and coagulation dys... Read More about Sickle Cell Disorders and Severe COVID-19 Outcomes: A Cohort Study.

Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity (2021)
Journal Article
Orton, E., Lafond, N., Skelton, D. A., Coupland, C., Gladman, J. R., Iliffe, S., …Kendrick, D. (2021). Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity. Public Health, 197, 11-18. https://doi.org/10.1016/j.puhe.2021.05.038

Objectives: Falls in older adults cause significant morbidity and mortality and incur cost to health and care services. The Falls Management Exercise (FaME) programme is a 24-week intervention for older adults that, in clinical trials, improves balan... Read More about Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity.

An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England (2021)
Journal Article
Nafilyan, V., Humberstone, B., Mehta, N., Diamond, I., Coupland, C., Lorenzi, L., …Hippisley-Cox, J. (2021). An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England. The Lancet. Digital Health, 3(7), E425-E433. https://doi.org/10.1016/S2589-7500%2821%2900080-7

Background: Public policy measures and clinical risk assessments relevant to COVID-19 need to be aided by risk prediction models that are rigorously developed and validated. We aimed to externally validate a risk prediction algorithm (QCovid) to esti... Read More about An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England.

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study (2021)
Journal Article
Patone, M., Thomas, K., Hatch, R., Tan, P. S., Coupland, C., Liao, W., …Hippisley-Cox, J. (2021). Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study. Lancet Infectious Diseases, 21(11), 1518-1528. https://doi.org/10.1016/s1473-3099%2821%2900318-2

Background: A more transmissible variant of SARS-CoV-2, the variant of concern 202012/01 or lineage B.1.1.7, has emerged in the UK. We aimed to estimate the risk of critical care admission, mortality in patients who are critically ill, and overall mo... Read More about Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study.

Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis (2021)
Journal Article
Hill, T., Coupland, C., Kendrick, D., Jones, M., Akbari, A., Rodgers, S., …Orton, E. (2022). Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis. Journal of Epidemiology and Community Health, 76(1), 53-59. https://doi.org/10.1136/jech-2021-216613

Background: Unintentional home injuries are a leading cause of preventable death in young children. Safety education and equipment provision improve home safety practices, but their impact on injuries is less clear. Between 2009 and 2011 a national h... Read More about Impact of the national home safety equipment scheme ‘Safe At Home’ on hospital admissions for unintentional injury in children under 5: controlled interrupted time series analysis.

Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England (2021)
Journal Article
Saatci, D., Ranger, T. A., Garriga, C., Clift, A. K., Zaccardi, F., Tan, P. S., …Hippisley-Cox, J. (2021). Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England. JAMA Pediatrics, 175(9), 928-938. https://doi.org/10.1001/jamapediatrics.2021.1685

Importance: Although children mainly experience mild COVID-19 disease, hospitalization rates are increasing, with limited understanding of underlying factors. There is an established association between race and severe COVID-19 outcomes in adults in... Read More about Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England.

Anticholinergic drugs and risk of dementia: Time for action? (2021)
Journal Article
Bell, B., Avery, A., Bishara, D., Coupland, C., Ashcroft, D., & Orrell, M. (2021). Anticholinergic drugs and risk of dementia: Time for action?. Pharmacology Research and Perspectives, 9(3), Article e00793. https://doi.org/10.1002/prp2.793

Evidence suggests that the prescription of bladder anticholinergics is increasing. Recent studies have accentuated concerns about whether certain prescribed medications could increase risk of dementia, including anticholinergic drugs, and specificall... Read More about Anticholinergic drugs and risk of dementia: Time for action?.

Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being (2021)
Journal Article
Gasteiger, N., Vedhara, K., Massey, A., Jia, R., Ayling, K., Chalder, T., …Broadbent, E. (2021). Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being. BMJ Open, 11(5), Article e045325. https://doi.org/10.1136/bmjopen-2020-045325

Objectives: The COVID-19 pandemic has caused unprecedented disruption to daily life. This study investigated depression, anxiety and stress in New Zealand (NZ) during the first ten weeks of the COVID-19 pandemic, and associated psychological and beha... Read More about Depression, anxiety and stress during the COVID-19 pandemic: results from a New Zealand cohort study on mental well-being.

Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm (2021)
Journal Article
Coupland, C., & Hippisley-Cox, J. (2021). Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm. British Journal of General Practice, 71(706), e364-e371. https://doi.org/10.3399/bjgp20x714137

Background: Diagnosis of prostate cancer at an early stage can potentially identify tumours when intervention may improve treatment options and survival.

Aim: To develop and validate an equation to predict absolute risk of prostate cancer in asymp... Read More about Predicting the risk of prostate cancer in asymptomatic men: a cohort study to develop and validate a novel algorithm.

Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol (2021)
Journal Article
Dambha-Miller, H., San Tan, P., Saatci, D., Kieran Clift, A., Zaccardi, F., Coupland, C., …Hippisley-Cox, J. (2021). Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol. BMJ Open, 11(4), Article e045286. https://doi.org/10.1136/bmjopen-2020-045286

Introduction: Recent evidence suggests that ethnic minority groups are disproportionately at increased risk of hospitalisation and death from SARS-CoV-2 infection. Population-based evidence on potential explanatory factors across minority groups and... Read More about Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.

Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study (2021)
Journal Article
Aveyard, P., Gao, M., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., …Hippisley-Cox, J. (2021). Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study. Lancet Respiratory Medicine, 9(8), 909-923. https://doi.org/10.1016/S2213-2600%2821%2900095-3

Background: The aim was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affect the risk of contracting severe COVID-19.

Methods: English general practice records from the QResearch database were linked to Public Hea... Read More about Association between pre-existing respiratory disease and its treatments and severe COVID-19: population cohort study.

Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales (2021)
Journal Article
McMenamin, Ú., Hicks, B., Hughes, C., Murchie, P., Hippisley-Cox, J., Ranger, T., …Cardwell, C. (in press). Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales. BMC Cancer, 21, Article 313. https://doi.org/10.1186/s12885-021-08065-3

Background: Hormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is uncl... Read More about Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: A protocol for a cohort study from Scotland and Wales.

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting (2021)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Bierma-Zeinstra, S. M., …Zhang, W. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 60(9), 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK.

METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched n... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting.

Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch. East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series, 38, 1-16

Introduction: Research from clinical trials of hormone replacement therapy (HRT) has produced conflicting findings about possible risks of dementia after receiving these treatments, and further research on HRT and dementia risk has been identified as... Read More about Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Preprint / Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study (2021)
Journal Article
Orton, E., Audsley, S., Coupland, C., Gladman, J. R., Iliffe, S., Lafond, N., …Kendrick, D. (2021). ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study. Age and Ageing, 50(4), 1290-1297. https://doi.org/10.1093/ageing/afaa288

Background
Falls incidence increases with age alongside declines in strength and balance. Clinical trials show that the Falls Management Exercise (FaME) programme improves strength and balance, which can reduce falls and improve physical functioning... Read More about ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study.

Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017 (2021)
Journal Article
Clift, A. K., Coupland, C. A., & Hippisley-Cox, J. (2021). Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017. British Journal of General Practice, 71(703), e157-e165. https://doi.org/10.3399/bjgp20X713957

Background: Prostate cancer is a leading cause of cancer-related death. Interpretation of results from trials of screening with prostate-specific antigen (PSA) are complex in terms of defining optimal prostate cancer screening policy.

Aims: Assess... Read More about Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017.

Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study (2020)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2021). Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study. British Journal of General Practice, 71(706), E364-E371. https://doi.org/10.3399/bjgp20X714137

Abstract Objective: To develop and validate a risk prediction equation to predict absolute risk of prostate cancer in asymptomatic men with prostate specific antigen (PSA) tests in primary care. Design: Open cohort study. Setting: Routine data from 1... Read More about Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study.

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases (2020)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2020). Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ, 371, Article m3873. https://doi.org/10.1136/bmj.m3873

Objective: To assess breast cancer risks associated with different types and durations of hormone replacement therapy

Design: Two nested case-control studies

Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases.

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (2020)
Journal Article
Clift, A. K., Coupland, C. A., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., …Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ, 371, Article m3731. https://doi.org/10.1136/bmj.m3731

Objective: To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults.

Design: Population based cohort study.

Setting and participants: QResearch d... Read More about Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study.

Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol (2020)
Journal Article
Orton, E., Watson, M., Hayes, M., Patel, T., Jones, M., Coupland, C., …Kendrick, D. (2020). Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol. Injury Prevention, 26(6), 573-580. https://doi.org/10.1136/injuryprev-2020-043877

Background: Unintentional injuries in children under the age of 5 years commonly occur in the home and disproportionately affect those living in disadvantaged circumstances. Targeted home safety promotion should be offered to families most at risk bu... Read More about Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol.

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people (2020)
Journal Article
Hippisley-Cox, J., Young, D., Coupland, C., Channon, K. M., Tan, P. S., Harrison, D. A., …Watkinson, P. J. (2020). Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people. Heart, 106(19), 1503-1511. https://doi.org/10.1136/heartjnl-2020-317393

Background: There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. We studied whether patients prescribed these drugs had altered risks of contracting sev... Read More about Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people.

The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge (2020)
Journal Article
Wilkinson-Smith, V., Menys, A., Bradley, C., Corsetti, M., Marciani, L., Atkinson, D., …Hoad, C. (2020). The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge. Neurogastroenterology and Motility, 32(11), Article e13942. https://doi.org/10.1111/nmo.13942

Background

Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intra-subject reproducibility of MRI measures of colonic funct... Read More about The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.

Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study (2020)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Butler, D., …Hippisley-Cox, J. (2020). Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study. PLoS Medicine, 17(7), Article e1003215. https://doi.org/10.1371/journal.pmed.1003215

BACKGROUND: The use of antidepressants in children and adolescents remains controversial. We examined trends over time and variation in antidepressant prescribing in children and young people in England and whether the drugs prescribed reflected UK l... Read More about Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.

Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study (2020)
Journal Article
De Crescenzo, F., Garriga, C., Tomlinson, A., Coupland, C., Efthimiou, O., Fazel, S., …Cipriani, A. (2020). Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study. Evidence-Based Mental Health, 23(3), 122-126. https://doi.org/10.1136/ebmental-2020-300149

Introduction: Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of antidepressants for depression,... Read More about Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study.

Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care. (2019)
Other
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care

Hormone replacement therapy (HRT) is used to help women suffering from menopausal symptoms and reduce risk of osteoporosis. Although effective, the therapy may lead to an increased risk of breast cancer. Previous studies have not been powerful enou... Read More about Protocol to assess risk of breast cancer associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care..

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets (2019)
Journal Article
Jack, R. H., Hollis, C., Coupland, C., Morriss, R., Knaggs, R. D., Cipriani, A., …Hippisley-Cox, J. (2019). Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets. Evidence-Based Mental Health, 22(3), 129-133. https://doi.org/10.1136/ebmental-2019-300097

Introduction
Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and t... Read More about Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019)
Journal Article
Coupland, C. A., Hill, T., Dening, T., Morriss, R., Moore, M., & Hippisley-Cox, J. (2019). Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study. JAMA Internal Medicine, 179(8), 1084-1093. https://doi.org/10.1001/jamainternmed.2019.0677

IMPORTANCE Anticholinergic medicines have short-term cognitive adverse effects, but it
is uncertain whether long-term use of these drugs is associated with an increased risk of dementia.

OBJECTIVE To assess associations between anticholinergic dr... Read More about Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study.

Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases (2019)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2019). Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ, 364, Article k4810. https://doi.org/10.1136/bmj.k4810

Objectives: To assess risk of venous thromboembolism associated with different types of hormone replacement therapy.

Design: Two nested case-control studies.

Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases.

Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care (2018)
Journal Article
Vinogradova, Y., Coupland, C., Hill, T., & Hippisley-Cox, J. (2018). Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care. BMJ, 362, Article k2505. https://doi.org/10.1136/bmj.k2505

Objective: To investigate the associations between direct oral anticoagulants (DOACs) and risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality compared with warfarin.

Design: Prospective open cohort study.

Settin... Read More about Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care.

Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study (2018)
Journal Article
Kendrick, D., Baker, R., Hill, T., Beckett, K., Coupland, C., Kellezi, B., Joseph, S., Barnes, J., Sleney, J., Christie, N., & Morriss, R. (2018). Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study. Journal of Psychosomatic Research, 112, 15-24. https://doi.org/10.1016/j.jpsychores.2018.06.008

Objective: To quantify psychological morbidity and identify baseline factors associated with depression, anxiety and post-traumatic distress symptoms up to 12 months post-injury.

Methods: Multicentre cohort study of 668 adults, aged 16 to 70,... Read More about Early risk factors for depression, anxiety and post-traumatic distress after hospital admission for unintentional injury: multicentre cohort study.

Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets (2018)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2018). Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets. British Journal of General Practice, 68(suppl 1), Article bjgp18X696629. https://doi.org/10.3399/bjgp18X696629

Background: There is limited evidence on the safety of direct oral anticoagulants (DOACs) in real world settings.

Aim: To investigate risks of bleeding and all-cause mortality in DOACs compared to warfarin.

Method: Prospective cohorts of incide... Read More about Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets.

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database (2018)
Journal Article
Coupland, C., Hill, T., Morriss, R., Moore, M., Arthur, A., & Hippisley-Cox, J. (2018). Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database. BMC Medicine, 16(1), Article 36. https://doi.org/10.1186/s12916-018-1022-x

© 2018 The Author(s). Background: Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. Th... Read More about Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database.

Alcohol Misuse and Injury Outcomes in Young People Aged 10–24 (2017)
Journal Article
Lester, L., Baker, R., Coupland, C., & Orton, E. (2018). Alcohol Misuse and Injury Outcomes in Young People Aged 10–24. Journal of Adolescent Health, 62(4), 450-456. https://doi.org/10.1016/j.jadohealth.2017.10.003

Purpose: The burden of alcohol-attributable disease is a global problem. Young people often present to emergency health-care services with alcohol intoxication but little is known about how best to intervene at that point to improve future health out... Read More about Alcohol Misuse and Injury Outcomes in Young People Aged 10–24.

Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives (2017)
Journal Article
Kendrick, D., Ablewhite, J., Achana, F., Benford, P., Clacy, R., Coffey, F., …Zou, K. (2017). Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives. Programme Grants for Applied Research, 5(14), https://doi.org/10.3310/pgfar05140

Background: Unintentional injuries among 0- to 4-year-olds are a major public health problem incurring substantial NHS, individual and societal costs. However, evidence on the effectiveness and cost-effectiveness of preventative interventions is lack... Read More about Keeping children safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives.

Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial (2017)
Journal Article
Deave, T., Hawkins, A., Kumar, A., Hayes, M., Cooper, N., Watson, M., …Kendrick, D. (2017). Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial. PLoS ONE, 12(3), Article e0172584. https://doi.org/10.1371/journal.pone.0172584

Background: Many developed countries have high mortality rates for fire-related deaths in children aged 0–14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a rang... Read More about Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial.

Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study (2017)
Journal Article
Miller, P., Kendrick, D., Coupland, C., & Coffey, F. (in press). Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study. Journal of Transport and Health, 7(A), https://doi.org/10.1016/j.jth.2017.03.008

Background: Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may b... Read More about Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study.

Poison prevention practices and medically attended poisoning in young children: multicentre case-control study (2016)
Journal Article
Kendrick, D., Majsak-Newman, G., Benford, P., Coupland, C., Timblin, C., Hayes, M., …Reading, R. (2017). Poison prevention practices and medically attended poisoning in young children: multicentre case-control study. Injury Prevention, 23(2), 93-101. https://doi.org/10.1136/injuryprev-2015-041828

Introduction

Childhood poisonings are common, placing a substantial burden on health services. Case-control studies have found inconsistent evidence about modifiable risk factors for poisonings amongst 0-4 year olds. This study quantifies associat... Read More about Poison prevention practices and medically attended poisoning in young children: multicentre case-control study.

The impact of psychological factors on recovery from injury: a multicentre cohort study (2016)
Journal Article
Kellezi, B., Coupland, C., Morriss, R., Beckett, K., Joseph, S., Barnes, J., …Kendrick, D. (2016). The impact of psychological factors on recovery from injury: a multicentre cohort study. Social Psychiatry and Psychiatric Epidemiology, 52(7), https://doi.org/10.1007/s00127-016-1299-z

Purpose
Unintentional injuries have a significant long-term health impact in working age adults. Depression, anxiety and post-traumatic stress disorder are common post-injury, but their impact on self-reported recovery has not been investigated in g... Read More about The impact of psychological factors on recovery from injury: a multicentre cohort study.

Psychological morbidity and health related quality of life after injury: multicentre cohort study (2016)
Journal Article
Kendrick, D., Kellezi, B., Coupland, C., Maula, A., Beckett, K., Morriss, R. K., …Christie, N. (2017). Psychological morbidity and health related quality of life after injury: multicentre cohort study. Quality of Life Research, 26(5), 1233-1250. https://doi.org/10.1007/s11136-016-1439-7

Purpose: To demonstrate the impact of psychological morbidity one month post-injury on subsequent post-injury quality of life (HRQoL) in a general injury population in the UK to inform development of trauma care and rehabilitation services.

Method... Read More about Psychological morbidity and health related quality of life after injury: multicentre cohort study.

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database (2016)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (in press). Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. BMJ, 353, Article i3305. https://doi.org/10.1136/bmj.i3305

Objectives: To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting.

Design: Prospective open cohort study.

Setting: 664 general practices con... Read More about Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database.

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database (2016)
Journal Article
Coupland, C., Hill, T., Morriss, R. K., Moore, M., Arthur, A., & Hippisley-Cox, J. (2016). Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database. BMJ, 2016(352), Article i1350. https://doi.org/10.1136/bmj.i1350

© BMJ Publishing Group Ltd 2016. Objective To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depr... Read More about Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database.

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database (2015)
Journal Article
Hill, T., Coupland, C., Morriss, R. K., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry, 15, Article 315. https://doi.org/10.1186/s12888-015-0701-9

Background: Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepres... Read More about Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database.

Risk and protective factors for falls on stairs in young children: multicentre case–control study (2015)
Journal Article
Kendrick, D., Zou, K., Ablewhite, J., Watson, M., Coupland, C., Kay, B., Hawkins, A., & Reading, R. (2016). Risk and protective factors for falls on stairs in young children: multicentre case–control study. Archives of Disease in Childhood, 101(10), 909-916. https://doi.org/10.1136/archdischild-2015-308486

Aim: To investigate risk and protective factors for stair falls in children aged <5 years.

Methods: Multicentre case–control study at hospitals, minor injury units and general practices in and around four UK study centres. Cases were children with...

Patients who discontinued statin treatment: a protocol for cohort study using primary care data (2015)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (2015). Patients who discontinued statin treatment: a protocol for cohort study using primary care data. BMJ Open, 5(10), https://doi.org/10.1136/bmjopen-2015-008701

Introduction: Risk thresholds for using statins to prevent cardiovascular disease (CVD) have recently been lowered, so an increasing number of patients are now prescribed these drugs. Although the safety of long-term statin use has been generally est... Read More about Patients who discontinued statin treatment: a protocol for cohort study using primary care data.

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database (2015)
Journal Article
Coupland, C., Hill, T., Morriss, R., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database. BMJ, 350(7996), Article h517. https://doi.org/10.1136/BMJ.h517

© BMJ Publishing Group Ltd 2015. Objective To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. Design Cohort study. Setting Patients registered... Read More about Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database.

Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases (2013)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2013). Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases. British Journal of Cancer, 109, https://doi.org/10.1038/bjc.2013.383

Background: Bisphosphonates are the most commonly prescribed osteoporosis drugs but long-term effects are unclear, although antitumour properties are known from preclinical studies.
Methods: Nested case–control studies were conducted to investigate... Read More about Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases.

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database (2013)
Journal Article
Coupland, C., Morriss, R., Arthur, A., Moore, M., Hill, T., & Hippisley-Cox, J. (2013). Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry, 13(135), https://doi.org/10.1186/1471-244X-13-135

Background: Antidepressants are among the most commonly prescribed drugs in primary care in England and their use is increasing. This is largely due to longer durations of treatment of depression. Observational studies have shown some differences in... Read More about Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database.

Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database (2012)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2012). Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database. BMJ Open, 2(1), Article e000548. https://doi.org/10.1136/bmjopen-2011-000548

Introduction: Bisphosphonates are becoming
a common treatment for osteoporosis particularly after
discovery of the association between hormone
replacement therapy and increased risk of breast
cancer. As osteoporosis develops with age, treatment... Read More about Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database.

General practice characteristics associated with rates of testing and detection of hepatitis C: Cross-sectional study in Nottingham and Derbyshire (2006)
Journal Article
Coupland, C., Hippisley-Cox, J., Smith, S., Irving, W., Pringle, M., Ryder, S., …Bullock, D. (2006). General practice characteristics associated with rates of testing and detection of hepatitis C: Cross-sectional study in Nottingham and Derbyshire. British Journal of General Practice, 56(529), 620-623

The aim of this study was to determine general practice characteristics associated with testing rates for hepatitis C virus (HCV) and the proportion of tests with a positive result. The study included all patients tested for HCV from all general prac... Read More about General practice characteristics associated with rates of testing and detection of hepatitis C: Cross-sectional study in Nottingham and Derbyshire.

Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556] (2006)
Journal Article
Masud, T., Coupland, C., Drummond, A. E., Gladman, J. R., Kendrick, D., Sach, T., Harwood, R. H., Kumar, P., Morris, R., Taylor, R., Youde, J., & Conroy, S. (2006). Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556]. Trials, 7(1), Article 10. https://doi.org/10.1186/1745-6215-7-5

Falls in older people are a major public health concern in terms of morbidity, mortality and cost. Previous studies suggest that multifactorial interventions can reduce falls, and many geriatric day hospitals are now offering falls intervention progr... Read More about Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556].

Protocol to assess risk of venous thromboembolism associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care
Other
Vinogradova, Y., Coupland, C., Mustafa, M., & Hippisley-Cox, J. Protocol to assess risk of venous thromboembolism associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care

Hormone replacement therapy (HRT) is used to help women suffering from menopausal symptoms. Although effective, the therapy may have a rare but serious side effect – an increased risk of venous thromboembolism (VTE). Previous studies have not been... Read More about Protocol to assess risk of venous thromboembolism associated with use of hormone replacement therapy in real world settings: two nested case-control studies in primary care.