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Professor CAROL COUPLAND's Outputs (148)

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database (2016)
Journal Article
Coupland, C., Hill, T., Morriss, R. K., Moore, M., Arthur, A., & Hippisley-Cox, J. (2016). Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database. BMJ, 2016(352), Article i1350. https://doi.org/10.1136/bmj.i1350

© BMJ Publishing Group Ltd 2016. Objective To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depr... Read More about Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database.

Missed opportunities to keep children safe? National survey of injury prevention activities of children’s centres (2016)
Journal Article
Watson, M. C., Mulvaney, C. A., Timblin, C., Stewart, J., Coupland, C., Deave, T., Hayes, M., & Kendrick, D. (in press). Missed opportunities to keep children safe? National survey of injury prevention activities of children’s centres. Health Education Journal, 75(7), https://doi.org/10.1177/0017896916629816

Objective: To ascertain the activities undertaken by children’s centres to prevent unintentional injuries in the under-fives and, in particular, the prevention of falls, poisoning and scalds.
Design: A questionnaire was posted to managers of 851 chi... Read More about Missed opportunities to keep children safe? National survey of injury prevention activities of children’s centres.

The NHS Health Check in England: an evaluation of the first 4 years (2016)
Journal Article
Robson, J., Dostal, I., Sheikh, A., Eldridge, S., Madurasinghe, V., Griffiths, C., Coupland, C., & Hippisley-Cox, J. (2016). The NHS Health Check in England: an evaluation of the first 4 years. BMJ Open, 6(1), Article e008840. https://doi.org/10.1136/bmjopen-2015-008840

Objectives: To describe implementation of a new national preventive programme to reduce cardiovascular morbidity.

Design: Observational study over 4 years (April 2009—March 2013).

Setting: 655 general practices across England from the QResear... Read More about The NHS Health Check in England: an evaluation of the first 4 years.

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database (2015)
Journal Article
Hill, T., Coupland, C., Morriss, R. K., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry, 15, Article 315. https://doi.org/10.1186/s12888-015-0701-9

Background: Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepres... Read More about Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database.

Cycling infrastructure for reducing cycling injuries in cyclists (2015)
Journal Article
Mulvaney, C. A., Smith, S., Watson, M. C., Parkin, J., Coupland, C., Miller, P., Kendrick, D., & McClintock, H. (2015). Cycling infrastructure for reducing cycling injuries in cyclists. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD010415.pub2

Background: Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual’s daily routine, such as for cycling to work and to the shops, than other physical... Read More about Cycling infrastructure for reducing cycling injuries in cyclists.

Risk and protective factors for falls on stairs in young children: multicentre case–control study (2015)
Journal Article
Kendrick, D., Zou, K., Ablewhite, J., Watson, M., Coupland, C., Kay, B., Hawkins, A., & Reading, R. (2016). Risk and protective factors for falls on stairs in young children: multicentre case–control study. Archives of Disease in Childhood, 101(10), 909-916. https://doi.org/10.1136/archdischild-2015-308486

Aim: To investigate risk and protective factors for stair falls in children aged <5 years.

Methods: Multicentre case–control study at hospitals, minor injury units and general practices in and around four UK study centres. Cases were children with...

Risk and protective factors for falls on one level in young children: multicentre case-control study (2015)
Journal Article
Benford, P., Young, B., Coupland, C., Watson, M., Hindmarch, P., Hayes, M., Goodenough, T., Majsak-Newman, G., & Kendrick, D. (2015). Risk and protective factors for falls on one level in young children: multicentre case-control study. Injury Prevention, 21(6), https://doi.org/10.1136/injuryprev-2015-041581

Background: Childhood falls are an important global public health problem, but there is a lack of evidence about their prevention. Falls on one level result in considerable morbidity and they are costly to health services.

Objective: To estimate o... Read More about Risk and protective factors for falls on one level in young children: multicentre case-control study.

Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study (2015)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2015). Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study. BMJ, 351, Article h5441. https://doi.org/10.1136/bmj.h5441

Study question: Is it possible to develop and externally validate risk prediction equations to estimate the 10 year risk of blindness and lower limb amputation in patients with diabetes aged 25-84 years?

Methods: This was a prospective cohort stud... Read More about Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study.

Patients who discontinued statin treatment: a protocol for cohort study using primary care data (2015)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (2015). Patients who discontinued statin treatment: a protocol for cohort study using primary care data. BMJ Open, 5(10), https://doi.org/10.1136/bmjopen-2015-008701

Introduction: Risk thresholds for using statins to prevent cardiovascular disease (CVD) have recently been lowered, so an increasing number of patients are now prescribed these drugs. Although the safety of long-term statin use has been generally est... Read More about Patients who discontinued statin treatment: a protocol for cohort study using primary care data.

Development and validation of risk prediction equations to estimate future risk of heart failure in patients with diabetes: a prospective cohort study (2015)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2015). Development and validation of risk prediction equations to estimate future risk of heart failure in patients with diabetes: a prospective cohort study. BMJ Open, 5(9), Article e008503. https://doi.org/10.1136/bmjopen-2015-008503

Objective: To develop and externally validate risk prediction equations to estimate the 10-year risk of heart failure in patients with diabetes, aged 25–84 years.

Design: Cohort study using routinely collected data from general practices in Englan... Read More about Development and validation of risk prediction equations to estimate future risk of heart failure in patients with diabetes: a prospective cohort study.

Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study (2015)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2015). Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study. BMJ Open, 5(3), Article e007825. https://doi.org/10.1136/bmjopen-2015-007825

Objective: To derive and validate a set of clinical risk prediction algorithm to estimate the 10-year risk of 11 common cancers.

Design: Prospective open cohort study using routinely collected data from 753 QResearch general practices in England.... Read More about Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study.

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database (2015)
Journal Article
Coupland, C., Hill, T., Morriss, R., Arthur, A., Moore, M., & Hippisley-Cox, J. (2015). Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database. BMJ, 350(7996), Article h517. https://doi.org/10.1136/BMJ.h517

© BMJ Publishing Group Ltd 2015. Objective To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. Design Cohort study. Setting Patients registered... Read More about Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database.

Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores (2014)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2014). Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores. BMJ, 349, Article g4606. https://doi.org/10.1136/bmj.g4606

Objective: To develop and validate risk algorithms (QBleed) for estimating the absolute risk of upper gastrointestinal and intracranial bleed for patients with and without anticoagulation aged 21-99 years in primary care.

Design: Open cohort study... Read More about Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores.

National survey of the injury prevention activities of children's centres (2014)
Journal Article
Watson, M., Mulvaney, C. A., Kendrick, D., Stewart, J., Coupland, C., Hayes, M., & Wynn, P. (2014). National survey of the injury prevention activities of children's centres. https://doi.org/10.1111/hsc.12059

Children's centres were established across England to provide a range of services including early education, social care and health to pre-school children and their families. We surveyed children's centres to ascertain the activities they were undert... Read More about National survey of the injury prevention activities of children's centres.

Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases (2013)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2013). Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases. British Journal of Cancer, 109, https://doi.org/10.1038/bjc.2013.383

Background: Bisphosphonates are the most commonly prescribed osteoporosis drugs but long-term effects are unclear, although antitumour properties are known from preclinical studies.
Methods: Nested case–control studies were conducted to investigate... Read More about Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case–control studies using two primary-care databases.

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database (2013)
Journal Article
Coupland, C., Morriss, R., Arthur, A., Moore, M., Hill, T., & Hippisley-Cox, J. (2013). Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry, 13(135), https://doi.org/10.1186/1471-244X-13-135

Background: Antidepressants are among the most commonly prescribed drugs in primary care in England and their use is increasing. This is largely due to longer durations of treatment of depression. Observational studies have shown some differences in... Read More about Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database.