Mrs LAURA HOWELLS's Outputs (39)

P125 Online survey of perspectives on lung imaging use in cystic fibrosis (2025)
Journal Article
Beever, D., Leighton, P., Howells, L., & Prayle, A. (2025). P125 Online survey of perspectives on lung imaging use in cystic fibrosis. Journal of Cystic Fibrosis, 24(Supplement 1), S106. https://doi.org/10.1016/j.jcf.2025.03.143

Objectives
As an emerging technology in cystic fibrosis (CF), there is potential for misunderstanding of lung magnetic resonance imaging (MRI) scan results. As the initial stage of a project to develop a results communication toolkit, we sought to e... Read More about P125 Online survey of perspectives on lung imaging use in cystic fibrosis.

Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach (2025)
Journal Article
Baker, A., Bonsu, N., Howells, L., Muller, I., Mitchell, E. J., Cowdell, F., Davies, F., Eddis-Finbow, M., Montgomery, A., Patel, D., Putrym, G., Ridd, M. J., Santer, M., Roberts, A., Thomas, K. S., the Rapid Eczema Trials team, Thomas, K. S., Roberts, A., Baker, A., Bonsu, N., …Skelding, S. (2025). Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach. Skin Health and Disease, 5(2), 130-139. https://doi.org/10.1093/skinhd/vzaf005

Background
Eczema is a prevalent, chronic, itchy skin condition that often persists into adulthood and significantly affects the quality of life of patients and their families. With no cure available at present, effective management is crucial. Alth... Read More about Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach.

Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs (2025)
Journal Article
Muller, I., Stuart, B., Sach, T., Yardley, L., Greenwell, K., Becque, T., Leighton, P., Howells, L., Harvey, J., Hooper, J., Steele, M., Sivyer, K., Ghio, D., Teasdale, E., Axon, E., Lax, S., Clarke, H., Onoja, M., Ahmed, A., Griffiths, G., …Santer, M. (2025). Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs. Programme Grants for Applied Research, 13(3), https://doi.org/10.3310/FNHD8546

Background
Eczema is a common condition with significant impact on quality of life. The main cause of treatment failure is non-use of prescribed treatments because treatments are time-consuming to apply; they may sting when first applied to inflamed... Read More about Supporting self-care for eczema in the community: the Eczema Care Online research programme including two RCTs.

A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK (2025)
Journal Article
Howells, L., Leighton, P., Thomas, K. S., Collier, F., Gibbons, A., Harris, C., Hood, K., Riaz, M., Rodrigues, J., Stanton, H., Thomas-Jones, E., & Ingram, J. R. (2025). A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK. British Journal of Dermatology, 193(1), 85-92. https://doi.org/10.1093/bjd/ljaf046

Background
Hidradenitis suppurativa (HS) is a long-term skin condition where evidence for management after first-line treatment fails is limited and practice varies across the UK. Medical and surgical treatment options are potential avenues of treat... Read More about A qualitative interview study exploring patients' views and experiences of treatment for hidradenitis suppurativa in the UK.

CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden (2025)
Journal Article
Calthorpe, R. J., Saumtally, H. A., Howells, L. M., Goodchild, N. J., Evans, B. C., Elliott, Z., Hayee, B. H., Carr, S. B., Elston, C. M., Horsley, A. A., Peckham, D. G., Barr, H. L., Major, G. A., Stewart, I. D., Thomas, K. S., & Smyth, A. R. (2025). CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden. Mayo Clinic Proceedings: Digital Health, 3(2), Article 100203. https://doi.org/10.1016/j.mcpdig.2025.100203

Objective
To develop a cystic fibrosis (CF)–specific patient-reported outcome measure (PROM) to measure the daily burden of gastrointestinal symptoms for people with cystic fibrosis (pwCF) aged 12 years and older and address the lack of validated ou... Read More about CF Tummy Tracker: A Cystic Fibrosis–Specific Patient-Reported Outcome Measure for Daily Gastrointestinal Symptom Burden.

Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online) (2025)
Journal Article
Howells, L., Thomas, K. S., Santer, M., Muller, I., Greenwell, K., Roberts, A., Williams, H. C., Harvey, J., Lax, S. J., Rogers, N. K., Sach, T. H., Lawton, S., Steele, M., Sivyer, K., Hooper, J., Ahmed, A., Wilczynska, S., Langan, S., & Leighton, P. (2025). Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online). BMC Health Services Research, 25(1), Article 187. https://doi.org/10.1186/s12913-024-12179-2

Background
Eczema Care Online (www.EczemaCareOnline.org.uk/) is an online self-management toolkit which includes tailored content for young people (13–25 years) and for parents of children that have eczema (0–12 years). Testing in two randomised con... Read More about Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online).

Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials (2024)
Journal Article
Baker, A., Stuart, B., Howells, L., J. Mitchell, E., & S. Thomas, K. (2024). Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials. Skin Health and Disease, 4(6), Article ski2.470. https://doi.org/10.1002/ski2.470

Background

The Recap of atopic eczema (RECAP) is a patient-reported instrument designed to assess eczema control. There is a lack of evidence on the interpretability of change scores in clinical trials.

Objectives

To calculate the smallest d... Read More about Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials.

Feasibility of Daily Pain Measurement Using Text Messages in Hidradenitis Suppurativa Clinical Trials; Data from THESEUS Study (2024)
Journal Article
Hasan, S. B., Bates, J., Cannings-John, R., Collier, F., Evans, J., Gibbons, A., Harris, C., Howells, L., Hood, K., Howes, R., Leighton, P., Riaz, M., Rodrigues, J., Stanton, H., Thomas, K. S., Thomas-Jones, E., & Ingram, J. R. (2024). Feasibility of Daily Pain Measurement Using Text Messages in Hidradenitis Suppurativa Clinical Trials; Data from THESEUS Study. British Journal of Dermatology, 90(5), 775–777. https://doi.org/10.1093/bjd/ljae057

Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people (2024)
Journal Article
Sach, T. H., Onoja, M., Clarke, H., Santer, M., Muller, I., Becque, T., Stuart, B., Hooper, J., Steele, M., Wilczynska, S., Ridd, M. J., Roberts, A., Ahmed, A., Yardley, L., Little, P., Greenwell, K., Sivyer, K., Nuttall, J., Griffiths, G., Lawton, S., …Thomas, K. S. (2024). Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people. European Journal of Health Economics, 25(7), 1165–1176. https://doi.org/10.1007/s10198-023-01649-9

Objective: To estimate the cost-effectiveness of online behavioral interventions (EczemaCareOnline.org.uk) designed to support eczema self-care management for parents/carers and young people from an NHS perspective. Methods: Two within-trial economic... Read More about Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people.

How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide (2023)
Journal Article
Thomas, K. S., Howells, L., Leshem, Y. A., Simpson, E. L., Apfelbacher, C., Spuls, P. I., Gerbens, L. A. A., Jacobson, M. E., Katoh, N., Williams, H. C., & Stuart, B. L. (2024). How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide. British Journal of Dermatology, 190(4), 527-535. https://doi.org/10.1093/bjd/ljad497

Background
The Harmonising Outcome Measures for Eczema (HOME) initiative has agreed upon the Core Outcome Set (COS) for use in atopic dermatitis (AD) clinical trials, but additional guidance is needed to maximize its uptake.

Objectives
To provid... Read More about How to use the Harmonising Outcome Measures for Eczema Core Outcome Set for atopic dermatitis trials: a users’ guide.

Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study (2023)
Journal Article
Ingram, J. R., Bates, J., Cannings-John, R., Collier, F., Gibbons, A., Harris, C., Hood, K., Howells, L., Howes, R., Leighton, P., Riaz, M., Rodrigues, J., Stanton, H., Thomas, K. S., & Thomas-Jones, E. (2023). Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study. Health Technology Assessment, 27(30), https://doi.org/10.3310/HWNM2189

Background

Hidradenitis suppurativa is a chronic inflammatory skin disease characterised by recurrent inflammatory lesions and skin tunnels in flexural sites such as the axilla. Deroofing of skin tunnels and laser treatment are standard hidradenit... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study.

Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT (2023)
Journal Article
Ridd, M. J., Wells, S., MacNeill, S. J., Sanderson, E., Webb, D., Banks, J., Sutton, E., Shaw, A. R., Wilkins, Z., Clayton, J., Roberts, A., Garfield, K., Liddiard, L., Barrett, T. J., Lane, J. A., Baxter, H., Howells, L., Taylor, J., Hay, A. D., Williams, H. C., …Santer, M. (2023). Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT. Health Technology Assessment, 27(19), 1-120. https://doi.org/10.3310/gzqw6681

Background: Emollients are recommended for children with eczema (atopic eczema/dermatitis). A lack of head-to-head comparisons of the effectiveness and acceptability of the different types of emollients has resulted in a 'trial and error' approach to... Read More about Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT.

Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study (2023)
Journal Article
Ingram, J. R., Thomas, K. S., Cannings-John, R., Evans, J., Gibbons, A., Howes, R., Riaz, M., Stanton, H., Hood, K., Thomas-Jones, E., Collier, F., Harris, C., Rodrigues, J., Bates, J., Howells, L., & Leighton, P. (2024). Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study. British Journal of Dermatology, 190(3), 382-391. https://doi.org/10.1093/bjd/ljad388

Background Hidradenitis suppurativa (HS) is a chronic, painful disease affecting flexures and other skin regions, producing nodules, abscesses and skin tunnels. Laser treatment targeting hair follicles and deroofing of skin tunnels are standard HS in... Read More about Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS): a prospective cohort study.

Developing evidence-based patient-focused learning materials to support health behaviour change for people living with psoriatic arthritis (2023)
Journal Article
Hailey, L., Howells, L., Bundy, C., Kirtley, S., Martin, S., O'Sullivan, D., Steinkoenig, I., Stepney, M., & Coates, L. C. (2023). Developing evidence-based patient-focused learning materials to support health behaviour change for people living with psoriatic arthritis. RMD Open, 9(3), Article e003190. https://doi.org/10.1136/rmdopen-2023-003190

Objectives: In psoriatic arthritis (PsA), self-management is important for patient function and quality of life. Behaviour change can be difficult, patients could benefit from high-quality support to initiate change. Our aim was to codesign the proje... Read More about Developing evidence-based patient-focused learning materials to support health behaviour change for people living with psoriatic arthritis.

The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap (2023)
Journal Article
Leshem, Y. A., Simpson, E., Apfelbacher, C., Spuls, P., Thomas, K. S., Schmitt, J., Howells, L., Gerbens, L., Jacobson, M. E., Katoh, N., & Williams, H. C. (2023). The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap. British Journal of Dermatology, 189(6), 710-718. https://doi.org/10.1093/bjd/ljad278

Background Core outcome sets (COS) are consensus-driven sets of minimum outcomes that should be measured and reported in all clinical trials. COS aim to reduce heterogeneity in outcome measurement and reporting, and selective outcome reporting. Imple... Read More about The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap.

Implementation of the HOME core outcome set for clinical trials of atopic eczema—barriers and opportunities: the HOME IX meeting report (2023)
Journal Article
Jacobson, M. E., Thomas, K. S., Apfelbacher, C. J., Leshem, Y. A., Williams, H. C., Gerbens, L. A. A., Spuls, P. I., Schmitt, J., Howells, L., Katoh, N., Simpson, E. L., & On behalf of the Harmonising Outcome Measures for Eczema (HOME) Initiative. (2023). Implementation of the HOME core outcome set for clinical trials of atopic eczema—barriers and opportunities: the HOME IX meeting report. Archives of Dermatological Research, 315, 2617-2622. https://doi.org/10.1007/s00403-023-02647-w

The Harmonising Outcome Measures for Eczema (HOME) initiative established a core outcome set (COS) for atopic eczema (AE) clinical trials in 2019. This set encompasses four core outcome domains and corresponding measurement instruments: clinical sign... Read More about Implementation of the HOME core outcome set for clinical trials of atopic eczema—barriers and opportunities: the HOME IX meeting report.

Research priorities in the management of hidradenitis suppurativa (2023)
Journal Article
Leighton, P., Howells, L., Bates, J., Gibbons, A., Cannings-John, R., Collier, F., Evans, J., Harris, C., Hood, K., Howes, R., Riaz, M., Rodrigues, J., Stanton, H., Thomas-Jones, E., Thomas, K., & Ingram, J. R. (2023). Research priorities in the management of hidradenitis suppurativa. British Journal of Dermatology, 189(3), 343–345. https://doi.org/10.1093/bjd/ljad152

There is a need for high-quality research to support the management of hidradenitis suppurativa. This letter offers suggestions for priority research topics derived from a stakeholder consensus meeting. Investigation of laser hair removal treatment,... Read More about Research priorities in the management of hidradenitis suppurativa.

'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema (2022)
Journal Article
Greenwell, K., Sivyer, K., Howells, L., Steele, M., Ridd, M. J., Roberts, A., Ahmed, A., Lawton, S., Langan, S. M., Hooper, J., Wilczynska, S., Leighton, P., Griffiths, G., Sach, T., Little, P., Williams, H. C., Thomas, K. S., Yardley, L., Santer, M., & Muller, I. (2023). 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema. British Journal of Dermatology, 188(4), 506-513. https://doi.org/10.1093/bjd/ljac115

Background There is a lack of well-conducted randomized controlled trials evaluating the effectiveness of theory-based online interventions for eczema. To address these deficiencies, we previously developed and demonstrated the effectiveness of two o... Read More about 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema.

Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials (2022)
Journal Article
Santer, M., Muller, I., Becque, T., Stuart, B., Hooper, J., Steele, M., Wilczynska, S., Sach, T. H., Ridd, M. J., Roberts, A., Ahmed, A., Yardley, L., Little, P., Greenwell, K., Sivyer, K., Nuttall, J., Griffiths, G., Lawton, S., Langan, S. M., Howells, L. M., …Thomas, K. S. (2022). Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials. BMJ, 379, Article e072007. https://doi.org/10.1136/bmj-2022-072007

Objective: To determine the effectiveness of two online behavioural interventions, one for parents and carers and one for young people, to support eczema self-management. Design: Two independent, pragmatic, parallel group, unmasked, randomised contro... Read More about Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials.

Topical corticosteroid withdrawal syndrome: the patient community call for high-quality research, clear definitions and diagnostic criteria (2022)
Journal Article
Howells, L., Broome, H., Burleigh, A., Hammond, H., Ismail, F., Proctor, A., Roberts, A., Thomas, K. S., & Leighton, P. (2022). Topical corticosteroid withdrawal syndrome: the patient community call for high-quality research, clear definitions and diagnostic criteria. British Journal of Dermatology, 188(2), 288-289. https://doi.org/10.1093/bjd/ljac067