All Outputs (6)

Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice (2023)
Journal Article
Reolizo, L. M., Williams, H., Wadey, K., Frankow, A., Li, Z., Gaston, K., …George, S. J. (2023). Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(3), 456-473. https://doi.org/10.1161/ATVBAHA.122.318367

Background: Late vein graft failure is caused by intimal thickening resulting from endothelial cell (EC) damage and inflammation which promotes vascular smooth muscle cell (VSMC) dedifferentiation, migration, and proliferation. Nonphosphorylatable PR... Read More about Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice.

Targeting protein kinase CK2 in the treatment of cholangiocarcinoma (2021)
Journal Article
Jayaraman, P. S., & Gaston, K. (2021). Targeting protein kinase CK2 in the treatment of cholangiocarcinoma. Exploration of Targeted Anti-tumor Therapy, 2(5), 434-447. https://doi.org/10.37349/etat.2021.00055

Cholangiocarcinoma (CCA) is a disease with a very poor prognosis and limited treatment options. Although targeted therapies directed towards specific mutations found in CCA are becoming available and are showing great potential, many tumors do not ca... Read More about Targeting protein kinase CK2 in the treatment of cholangiocarcinoma.

A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition (2019)
Journal Article
Jayaraman, P., Kitchen, P., Gaston, K., Lee, K. Y., Afford, S., Clark, D., …Sawasdichai, A. (2020). A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition. Cancer Research, 80(4), 757-770. https://doi.org/10.1158/0008-5472.can-19-0942

Aberrant Notch and Wnt signalling are known drivers of cholangiocarcinoma (CCA) but the underlying factors that initiate and maintain these pathways are not known. Here we show that the PRH/HHEX transcription factor forms a positive transcriptional f... Read More about A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition.

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development (2018)
Journal Article
Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M. M., Marín-Juez, R., …Stainier, D. Y. R. (2018). HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature Communications, 9, Article 2704. https://doi.org/10.1038/s41467-018-05039-1

Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression (2016)
Journal Article
Stepanova, V., Jayaraman, P., Zaitsev, S. V., Lebedeva, T., Bdeir, K., Kershaw, R., …Cines, D. B. (2016). Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression. Journal of Biological Chemistry, 291(29), 15029-15045. https://doi.org/10.1074/jbc.m115.678490

Urokinase-type plasminogen activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uPAR/CD87 and other cell surface receptors.... Read More about Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.

The nirB promoter of Escherichia coli: location of nucleotide sequences essential for regulation by oxygen, the FNR protein and nitrite (1988)
Journal Article
Jayaraman, P., Gaston, K., Cole, J., & Busby, S. (1988). The nirB promoter of Escherichia coli: location of nucleotide sequences essential for regulation by oxygen, the FNR protein and nitrite. Molecular Microbiology, 2(4), 527-530. https://doi.org/10.1111/j.1365-2958.1988.tb00059.x

Using recombinant DNA techniques, nested deletions have been made upstream of the Escherichia coli nirB transcription start site and their effects on the regulation of nirB promoter activity have been measured. Nucleotide sequences downstream of ?73... Read More about The nirB promoter of Escherichia coli: location of nucleotide sequences essential for regulation by oxygen, the FNR protein and nitrite.