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A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows (2023)
Journal Article
Thomas, M., Green, M., Kypraios, T., & Kaler, J. (2023). A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows. Journal of Dairy Science, https://doi.org/10.3168/jds.2021-21749

Claw horn disruption lesions (CHDL) are a leading cause of lameness in dairy cattle, and the development, effect, and pathology of these lesions remains an open area of interest within dairy cattle health. Current literature typically attempts to mea... Read More about A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows.

Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent (2023)
Dataset
Martini, R., Delpe, P., Chu, T. R., Arora, K., Lord, B., Verma, A., …Davis, M. B. (2023). Data from African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. [Dataset]. https://doi.org/10.1158/2159-8290.c.6549760.v1

Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers (2023)
Journal Article
Algethami, M., Toss, M. S., Woodcock, C. L., Jaipal, C., Brownlie, J., Shoqafi, A., …Madhusudan, S. (2023). Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers. npj Breast Cancer, 9, Article 18. https://doi.org/10.1038/s41523-023-00524-3

Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have evaluated RPA... Read More about Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers.

Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection (2023)
Journal Article
Zou, Y., Zheng, W. B., Elsheikha, H. M., He, J. J., Lu, Y. X., Wang, S., …Zhu, X. Q. (2023). Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection. Parasites and Vectors, 16, Article 114. https://doi.org/10.1186/s13071-023-05738-9

Background Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in regulating various physiological and pathological processes. However, the role of lncRNAs and mRNAs in mediating the liver response during Toxocara canis infec... Read More about Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection.

Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks (2023)
Journal Article
Davies, P. L., Hyde, R. M., & Lovatt, F. M. (2023). Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks. Veterinary Record, 193(2), Article e2786. https://doi.org/10.1002/vetr.2786

Background: The aim of the study was to describe the longitudinal dynamics of antimicrobial use (AMU) on sheep farms and explore associations between AMU and management factors, vaccination strategies, reproductive performance and prevalence of lamen... Read More about Longitudinal study of antimicrobial use patterns, vaccination and disease prevalence in British sheep flocks.

Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions (2023)
Journal Article
Russell, A. L., Randall, L. V., Kaler, J., Eyre, N., & Green, M. J. (2023). Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions. Frontiers in Veterinary Science, 10, Article 1099170. https://doi.org/10.3389/fvets.2023.1099170

In addition to the reduction of suboptimal welfare, there is now a need to provide farmed animals with positive opportunities to provide confidence that they have experienced a life worth living. Diversification of the environment through environment... Read More about Use of qualitative behavioural assessment to investigate affective states of housed dairy cows under different environmental conditions.

Topographic anatomy and vascularization of the glandula thyroidea in rats (2023)
Journal Article
Nur, I. H., Pérez, W., & Rutland, C. S. (2023). Topographic anatomy and vascularization of the glandula thyroidea in rats. Anatomia, Histologia, Embryologia, 52(4), 571-582. https://doi.org/10.1111/ahe.12916

Topographical anatomy and detailed measurements of the glandula thyroidea (thyroid gland) and the glandula parathyroidea (parathyroid gland) were determined in rats, with significant differences identified between the sexes. In the rats (N=10 male, 1... Read More about Topographic anatomy and vascularization of the glandula thyroidea in rats.

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2023)
Working Paper
Kovac, M., Aliev, R., Berestov, I., Aimaletdinov, A., Rutland, C., Rizvanov, A., & Zakirova, E. Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows (2023)
Journal Article
Barden, M., Phelan, M. M., Hyde, R., Anagnostopoulos, A., Griffiths, B. E., Bedford, C., …Oikonomou, G. (2023). Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows. Journal of Dairy Science, 106(4), 2667-2684. https://doi.org/10.3168/jds.2022-22681

Sole hemorrhage and sole ulcers, referred to as sole lesions, are important causes of lameness in dairy cattle. We aimed to compare the serum metabolome of dairy cows that developed sole lesions in early lactation with that of cows that remained unaf... Read More about Serum 1H nuclear magnetic resonance–based metabolomics of sole lesion development in Holstein cows.

Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation (2023)
Journal Article
Kopycka, K., Maddison, B. C., & Gough, K. C. (2023). Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation. Scientific Reports, 13(1), Article 3452. https://doi.org/10.1038/s41598-023-30202-0

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrPC into PrPSc and its accumulation in the central nervous system. Previous st... Read More about Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation.

Zinc, Copper, and Manganese Homeostasis and Potential Trace Metal Accumulation in Dairy Cows: Longitudinal Study from Late Lactation to Subsequent Mid-Lactation (2023)
Journal Article
Daniel, J. B., Brugger, D., van der Drift, S., van der Merwe, D., Kendall, N., Windisch, W., …Martín-Tereso, J. (2023). Zinc, Copper, and Manganese Homeostasis and Potential Trace Metal Accumulation in Dairy Cows: Longitudinal Study from Late Lactation to Subsequent Mid-Lactation. Journal of Nutrition, 153(4), 1008-1018. https://doi.org/10.1016/j.tjnut.2023.02.022

Background: Trace metals are supplemented in cattle to prevent nutrient deficiencies. Levels supplemented to mitigate worst-case basal supply and availability scenarios can, however, result in trace metal intakes far above the nutritional requirement... Read More about Zinc, Copper, and Manganese Homeostasis and Potential Trace Metal Accumulation in Dairy Cows: Longitudinal Study from Late Lactation to Subsequent Mid-Lactation.

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode (2023)
Journal Article
Baron, F., Zhang, M., Archer, N., Bellows, E., Knight, H. M., Welham, S., …Bodi, Z. (2023). The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode. RNA, 29(6), 777-789. https://doi.org/10.1261/rna.079615.123

N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g... Read More about The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode.

Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock (2023)
Journal Article
Davies, P., Jones, S., Dunham, S., & Tarlinton, R. E. (2023). Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock. Veterinary Record, 192(11), Article e2731. https://doi.org/10.1002/vetr.2731

Background Small ruminant lentiviruses (SRLVs) are lentiviruses of sheep and goats, formerly known as maedi–visna (MV) in sheep and caprine encephalitis and arthritis in goats. In sheep, SRLVs commonly cause progressive pneumonia, wasting and indura... Read More about Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock.

Familiarity, age, weaning and health status impact social proximity networks in dairy calves (2023)
Journal Article
Vázquez-Diosdado, J. A., Occhiuto, F., Carslake, C., & Kaler, J. (2023). Familiarity, age, weaning and health status impact social proximity networks in dairy calves. Scientific Reports, 13, Article 2275. https://doi.org/10.1038/s41598-023-29309-1

Social network analysis in dairy calves has not been widely studied, with previous studies limited by the short study duration, and low number of animals and replicates. In this study, we investigated social proximity interactions of 79 Holstein–Frie... Read More about Familiarity, age, weaning and health status impact social proximity networks in dairy calves.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article
James, J. R., Curd, J., Ashworth, J. C., Abuhantash, M., Grundy, M., Seedhouse, C. H., …Thompson, A. (2023). Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. International Journal of Molecular Sciences, 24(4), Article 4235. https://doi.org/10.3390/ijms24044235

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.

NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma (2023)
Journal Article
Kubala, J. M., Laursen, K. B., Schreiner, R., Williams, R. M., van der Mijn, J. C., Crowley, M. J., …Gudas, L. J. (2023). NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Cancer Biology and Therapy, 24(1), Article 2170669. https://doi.org/10.1080/15384047.2023.2170669

In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression. Over 90% of ccRCCs exhibit overexpression of NDUFA4L2, which we previously showed... Read More about NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.

Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells (2023)
Journal Article
Soliman, S. A., Abd-Elhafeez, H. H., Mohamed, N., Al-Rashdi, B. M., Alghamdi, A. A., Elmansi, A., …Massoud, D. (2023). Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells. Microscopy Research and Technique, 86(5), 600-613. https://doi.org/10.1002/jemt.24298

Varanus niloticus is a lizard residing within the Varanidae family. To date no studies detailing its blood morphology and characteristics have been conducted. This study used histologically stained blood and bone marrow samples to visualize the cells... Read More about Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells.

Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances (2023)
Journal Article
Kembou-Ringert, J. E., Steinhagen, D., Readman, J., Daly, J. M., & Adamek, M. (2023). Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances. Vaccines, 11(2), Article 251. https://doi.org/10.3390/vaccines11020251

Tilapia tilapinevirus (or tilapia lake virus, TiLV) is a recently emerging virus associated with a novel disease affecting and decimating tilapia populations around the world. Since its initial identification, TiLV has been reported in 17 countries,... Read More about Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances.

Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape (2023)
Journal Article
Sartorius, A., Cahoon, M., Corbetta, D., Grau-Roma, L., Johnson, M. F., Sandoval Barron, E., …Bennett, M. (2023). Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape. Science of the Total Environment, 869, Article 161684. https://doi.org/10.1016/j.scitotenv.2023.161684

Understanding the links between environmental and wildlife elemental concentrations is key to help assess ecosystem functions and the potential effects of legacy pollutants. In this study, livers from 448 European badgers (Meles meles) collected acro... Read More about Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape.