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Using Raman spectroscopy to improve hyperpolarized noble gas production for clinical lung imaging techniques (2017)
Book Chapter
Birchall, J., Whiting, N., Skinner, J., Barlow, M. J., & Goodson, B. M. (2017). Using Raman spectroscopy to improve hyperpolarized noble gas production for clinical lung imaging techniques. In Raman spectroscopy and applications (247-268). London: InTech. https://doi.org/10.5772/65114

Spin-exchange optical pumping (SEOP) can be used to “hyperpolarize” 129Xe for human lung MRI. SEOP involves transfer of angular momentum from light to an alkali metal (Rb) vapor, and then onto 129Xe nuclear spins during collisions; collisions between... Read More about Using Raman spectroscopy to improve hyperpolarized noble gas production for clinical lung imaging techniques.

XeNA: An automated ‘open-source’ 129Xe hyperpolarizer for clinical use (2014)
Journal Article
Nikolaou, P., Coffey, A. M., Walkup, L. L., Gust, B. M., Whiting, N., Newton, H., …Goodson, B. M. (2014). XeNA: An automated ‘open-source’ 129Xe hyperpolarizer for clinical use. Magnetic Resonance Imaging, 32(5), 541-550. https://doi.org/10.1016/j.mri.2014.02.002

Here we provide a full report on the construction, components, and capabilities of our consortium’s “open-source” large-scale (~ 1 L/h) 129Xe hyperpolarizer for clinical, pre-clinical, and materials NMR/MRI (Nikolaou et al., Proc. Natl. Acad. Sci. US... Read More about XeNA: An automated ‘open-source’ 129Xe hyperpolarizer for clinical use.

Comparative study of in situ N2 rotational Raman spectroscopy methods for probing energy thermalisation processes during spin-exchange optical pumping (2013)
Journal Article
Newton, H., Walkup, L. L., Whiting, N., West, L., Carriere, J., Havermeyer, F., …Barlow, M. J. (2014). Comparative study of in situ N2 rotational Raman spectroscopy methods for probing energy thermalisation processes during spin-exchange optical pumping. Applied Physics B, 115(2), 167-172. https://doi.org/10.1007/s00340-013-5588-x

Spin-exchange optical pumping (SEOP) has been widely used to produce enhancements in nuclear spin polarisation for hyperpolarised noble gases. However, some key fundamental physical processes underlying SEOP remain poorly understood, particularly in... Read More about Comparative study of in situ N2 rotational Raman spectroscopy methods for probing energy thermalisation processes during spin-exchange optical pumping.