All Outputs (3307)

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials (2023)
Journal Article

OBJECTIVE: Clinical guidelines recommend exercise as a core treatment for knee or hip osteoarthritis (OA). However, how its analgesic effect compares to analgesics, for example, oral non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol-the... Read More about Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials.

Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology (2023)
Journal Article

Abstract: With the development of Artificial Intelligence techniques, smart health monitoring is becoming more popular. In this study, we investigate the trend of wearable sensors being adopted and developed in neonatal cardiorespiratory monitoring.... Read More about Artificial intelligence-driven wearable technologies for neonatal cardiorespiratory monitoring: Part 1 wearable technology.

‘Getting to know you through music.’ Music therapists’ unique ways of ‘knowing’ their clients and our collective responsibilities to articulate our implicit knowledge (2023)
Journal Article

“How do you get to know your client’s inner-world so well?” I am often amazed by the depth of insight music therapy colleagues share about their clients during clinical peer-supervision. Of course, colleagues from other disciplines I closely work wit... Read More about ‘Getting to know you through music.’ Music therapists’ unique ways of ‘knowing’ their clients and our collective responsibilities to articulate our implicit knowledge.

Concept and Demonstration of a Coaxial Magnetic Coupling with Electromagnetic Disconnection for Aircraft Permanent Magnet Generators (2023)
Journal Article

The application of more electrified systems in aircraft is required to achieve the target of a more sustainable aviation industry. This in turn relies on the development of new electro-mechanical devices to ensure reliability of critical aircraft fun... Read More about Concept and Demonstration of a Coaxial Magnetic Coupling with Electromagnetic Disconnection for Aircraft Permanent Magnet Generators.

Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design (2023)
Journal Article

Nanopore sequencers can select which DNA molecules to sequence, rejecting a molecule after analysis of a small initial part. Currently, selection is based on predetermined regions of interest that remain constant throughout an experiment. Sequencing... Read More about Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design.

Towards Shaping the Future of Responsible AI in Africa (2023)
Book Chapter

Artificial Intelligence (AI) presents unprecedented opportunities for Africa. Increasingly, AI and other emerging technologies are being deployed in African contexts—healthcare, agriculture, sociopolitical processes, businesses and education—in ways... Read More about Towards Shaping the Future of Responsible AI in Africa.

Reproducible microbiome composition signatures of anxiety and depressive symptoms (2023)
Journal Article

The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diag... Read More about Reproducible microbiome composition signatures of anxiety and depressive symptoms.

Environmental and farming practice controls of productivity of Cyrtosperma merkusii (giant swamp taro), an underutilised wetland and potential paludiculture crop (2023)
Journal Article

Growing recognition of the potential vulnerabilities of major crop systems has spurred a growing interest in the potential of alternative crops which may be resilient to climate change and also help mitigate its effects. In Indonesia, such issues are... Read More about Environmental and farming practice controls of productivity of Cyrtosperma merkusii (giant swamp taro), an underutilised wetland and potential paludiculture crop.

Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations (2023)
Journal Article

Base editors are recent multiplex gene editing tools derived from the Cas9 nuclease of Streptomyces pyogenes. They can target and modify a single nucleotide in the genome without inducing double-strand breaks (DSB) of the DNA helix. As such, they hol... Read More about Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations.

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics (2023)
Journal Article

A new generation of dual-target μ opioid receptor (MOR) agonist/dopamine D3 receptor (D3R) antagonist/partial agonists with optimized physicochemical properties was designed and synthesized. Combining in vitro cell-based on-target/off-target affinity... Read More about Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers (2023)
Journal Article

Introduction: Characterization of the tumour immune infiltrate (notably CD8+ T-cells) has strong predictive survival value for cancer patients. Quantification of CD8 T-cells alone cannot determine antigenic experience, as not all infiltrating T-cells... Read More about Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers.

Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules (2023)
Journal Article

Ecogeographical habitat heterogeneity in wild endotherm species results in morphological variability associated with physiological mechanisms for maintaining their body temperature at a thermoneutral state in different environments. This habitat-indu... Read More about Morphological and osteological characterization of indigenous domestic chickens (Gallus gallus domesticus): validation of Rensch’s, Bergmann’s and Allen’s rules.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Numerical validation of novel scaling laws for air–water flows including compressibility and heat transfer (2023)
Journal Article

Air–water flows are among the most important flow types in hydraulic engineering. Their experimental modelling at reduced size using Froude scaling laws introduces scale effects. This study introduces novel scaling laws for compressible air–water flo... Read More about Numerical validation of novel scaling laws for air–water flows including compressibility and heat transfer.

Anaphoric reference to mereological entities (2023)
Journal Article

Corpus evidence suggests that in contexts in which the presence of multiple antecedents might favor plural reference, the disadvantage observed for singular reference may disappear if the potential antecedents are combined in a group-like plural enti... Read More about Anaphoric reference to mereological entities.

Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data (2023)
Journal Article

Purpose: Osteoarthritis (OA) is a chronic painful condition that often affects large joints such as the knee. Treatment guidelines recommend paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. Antidepressants and anti-epileptic d... Read More about Analgesic utilization in people with knee osteoarthritis: A population-based study using primary care data.

Higher education student motivations for extracurricular activities: evidence from UK universities (2023)
Journal Article

Higher education students are required to demonstrate value beyond their curricula achievements to secure jobs in increasingly competitive labour markets. Focusing on extracurricular activities as one-way students can do so, this paper uses a motivat... Read More about Higher education student motivations for extracurricular activities: evidence from UK universities.

Angry politics fails the climate (2023)
Journal Article

Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials (2023)
Journal Article

Background and Aims: Observational studies have shown an association between statin or aspirin use and a decreased risk of HCC, but the effects of a well-defined treatment strategy remain unknown. We emulated trials of the effects of continuous stati... Read More about Effects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials.

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (2023)
Journal Article

Improving the tumor reoxygenation to sensitize the tumor to radiation therapy is a cornerstone in radiation oncology. Here, the pre‐clinical development of a clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC... Read More about Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.