The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations
(2023)
Journal Article
Musa, A., Ihmaid, S. K., Hughes, D. L., Said, M. A., Abulkhair, H. S., El-Ghorab, A. H., Abdelgawad, M. A., Shalaby, K., Shaker, M. E., Alharbi, K. S., Alotaibi, N. H., Kays, D. L., Taylor, L. J., Parambi, D. G. T., Alzarea, S. I., Al-Karmalawy, A. A., Ahmed, H. E., & El-Agrody, A. M. (2023). The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations. Journal of Biomolecular Structure and Dynamics, 41(21), 12411-12425. https://doi.org/10.1080/07391102.2023.2167000
Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often resulting in the recurrence of metastatic disorders. Cumulative evidence suggests that epid...
Read More about The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations.