Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats

Pannucci, Patrizia; Van Daele, Marieke; Cooper, Samantha L.; Wragg, Edward S.; March, Julie; Groenen, Marleen; Hill, Stephen J.; Woolard, Jeanette

doi:10.1016/j.bcp.2023.116007

All Outputs (3344)

Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke (2023)
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BACKGROUND: Dual antiplatelet treatment has been shown to lower the risk of recurrent stroke as compared with aspirin alone when treatment is initiated early (≤24 hours) after an acute mild stroke. The effect of clopidogrel plus aspirin as compared w... Read More about Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke.

The effects of neuromuscular electrical stimulation on hospitalised adults: systematic review and meta-analysis of randomised controlled trials (2023)
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Introduction Neuromuscular electrical stimulation (NMES) is a treatment to prevent or reverse acquired disability in hospitalised adults. We conducted a systematic review and meta-analysis of its effectiveness. Method We searched MEDLINE, EMBASE, Cum... Read More about The effects of neuromuscular electrical stimulation on hospitalised adults: systematic review and meta-analysis of randomised controlled trials.

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Language and History in the Late-Roman and Post-Imperial West (2023)
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In the context of growing concerns over energy consumption and sustainability, accurate modelling of occupancy patterns within residential buildings is critical. In this study, a novel stochastic occupancy model is introduced for simulating human beh... Read More about Introducing a novel method for simulating stochastic movement and occupancy in residential spaces using time-use survey data.

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Both acute and chronic pancreatitis are frequent diseases of the pancreas, which, despite being of benign nature, are related to a significant risk of malnutrition and may require nutritional support. Acute necrotizing pancreatitis is encountered in... Read More about ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis.

CapMatch: Semi-Supervised Contrastive Transformer Capsule With Feature-Based Knowledge Distillation for Human Activity Recognition (2023)
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This article proposes a semi-supervised contrastive capsule transformer method with feature-based knowledge distillation (KD) that simplifies the existing semisupervised learning (SSL) techniques for wearable human activity recognition (HAR), called... Read More about CapMatch: Semi-Supervised Contrastive Transformer Capsule With Feature-Based Knowledge Distillation for Human Activity Recognition.

COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning (2023)
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During the pandemic, nursing homes in the Netherlands were heavily affected by COVID-19. This study assesses the impact of COVID-19 on infection rate, survival rate, and daily functioning over the course of two years among residents of a nursing home... Read More about COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning.

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Throughout its history, Operational Research has evolved to include a variety of methods, models and algorithms that have been applied to a diverse and wide range of contexts. This encyclopedic article consists of two main sections: methods and appli... Read More about Operational Research: Methods and Applications.

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Pangenomes exhibit remarkable variability in many prokaryotic species, much of which is maintained through the processes of horizontal gene transfer and gene loss. Repeated acquisitions of near-identical homologs can easily be observed across pangeno... Read More about Contingency, repeatability, and predictability in the evolution of a prokaryotic pangenome.

Against received opinion: Recovering the original meaning of ‘paradox’ for populism and liberal democracy (2023)
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In philosophy and political theory, the term paradox is often used synonymously with antinomy, contradiction and aporia. This article clarifies the meaning of these terms through tracing their respective etymology. We see that antinomy denotes a deep... Read More about Against received opinion: Recovering the original meaning of ‘paradox’ for populism and liberal democracy.

Against received ppinion: recovering the original meaning of ‘paradox’ for an analysis of populism and liberal democracy (2023)
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In philosophy and political theory, the term paradox is often used synonymously with antinomy, contradiction, and aporia. This paper clarifies the meaning of these terms through tracing their respective etymology. We see that antinomy denotes a deep-... Read More about Against received ppinion: recovering the original meaning of ‘paradox’ for an analysis of populism and liberal democracy.

Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years (2023)
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Background While opioid analgesics are often necessary for the management of acute postoperative pain, appropriate prescribing practices are crucial to avoid harm. The aim was to investigate the changes in the proportion of people receiving initial... Read More about Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years.

Investigating ApoE4‐mediated metabolic alteration of H4 neuroglioma cells of Alzheimer’s disease (2023)
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Background Metabolites and proteins in ApoE4‐carried H4 neuroglioma cells were analyzed to investigate the potential mechanism of the risk gene ApoE4 involved in Alzheimer’s disease (AD). Method Metabolomics of ApoE4‐carried and wild‐type H4 cel... Read More about Investigating ApoE4‐mediated metabolic alteration of H4 neuroglioma cells of Alzheimer’s disease.

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Symmetry provides a powerful machinery to classify, interpret, and understand quantum-mechanical theories and results. However, most contemporary quantum chemistry packages lack the ability to handle degeneracy and symmetry breaking effects, especial... Read More about QSym2: A Quantum Symbolic Symmetry Analysis Program for Electronic Structure.

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Symmetry provides a powerful machinery to classify, interpret, and understand quantum-mechanical theories and results. However, most contemporary quantum chemistry packages lack the ability to handle degeneracy and symmetry breaking effects, especial... Read More about QSym²: A Quantum Symbolic Symmetry Analysis Program for Electronic Structure.

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The increasing demand for personalized products and cost-effectiveness has highlighted the necessity of integrating intelligence into production systems. This integration is crucial for enabling intelligent control that can adapt to variations in fea... Read More about A modular artificial intelligence and asset administration shell approach to streamline testing processes in manufacturing services.

Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats (2023)
Journal Article

Receptor tyrosine kinase inhibitors (RTKIs) suppress tumour growth by targeting vascular endothelial growth factor receptor 2 (VEGFR-2) which is an important mediator of angiogenesis. Here, we demonstrate that two potent RTKIs, axitinib and lenvatini... Read More about Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats.