All Outputs (4)

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition (2021)
Journal Article
Steketee, P. C., Dickie, E. A., Iremonger, J., Crouch, K., Paxton, E., Jayaraman, S., …Morrison, L. J. (2021). Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), Article e1009734. https://doi.org/10.1371/journal.ppat.1009734

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit... Read More about Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex (2021)
Journal Article
Brusini, L., D’Archivio, S., McDonald, J., & Wickstead, B. (2021). Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex. Frontiers in Cellular and Infection Microbiology, 11, Article 641174. https://doi.org/10.3389/fcimb.2021.641174

Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules. In spite o... Read More about Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei (2021)
Journal Article
Davies, C., Ooi, C. P., Sioutas, G., Hall, B. S., Sidhu, H., Butter, F., …Rudenko, G. (2021). TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei. Nucleic Acids Research, 49(6), 3242-3262. https://doi.org/10.1093/nar/gkab109

The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian host. A single trypanosome has >2000 VSG genes and pseudogenes of which only one... Read More about TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo (2021)
Journal Article
Awuah-Mensah, G., McDonald, J., Steketee, P. C., Autheman, D., Whipple, S., D'Archivio, S., …Wickstead, B. (2021). Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo. PLoS Pathogens, 17(1), Article e1009224. https://doi.org/10.1371/journal.ppat.1009224

Copyright: © 2021 Awuah-Mensah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author a... Read More about Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo.