All Outputs (3)

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy (2020)
Journal Article
Shaw, J., Gosain, R., Kalita, M. M., Foster, T. L., Kankanala, J., Mahato, D. R., …Griffin, S. (2020). Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy. eLife, 9, Article e52555. https://doi.org/10.7554/eLife.52555

© 2020, Shaw et al. Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or 'viroporins', contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these pro... Read More about Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza (2020)
Journal Article
Scott, C., Kankanala, J., Foster, T. L., Goldhill, D. H., Bao, P., Simmons, K., …Griffin, S. (2020). Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. PLoS Pathogens, 16(8), Article e1008716. https://doi.org/10.1371/journal.ppat.1008716

Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alt... Read More about Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.

Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins (2020)
Journal Article
Stott, R. J., Strecker, T., & Foster, T. L. (2020). Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins. Viruses, 12(7), Article 784. https://doi.org/10.3390/v12070784

Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The incre... Read More about Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins.