A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutL? during crossover formation in meiotic prophase I
(2019)
Journal Article
Toledo, M., Sun, X., Brieño-Enríquez, M. A., Raghavan, V., Gray, S., Pea, J., …Cohen, P. E. (2019). A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I. PLoS Genetics, 15(6), 1-28. https://doi.org/10.1371/journal.pgen.1008177
During meiotic prophase I, double-strand breaks (DSBs) initiate homologous recombination leading to non-crossovers (NCOs) and crossovers (COs). In mouse, 10% of DSBs are designated to become COs, primarily through a pathway dependent on the MLH1-MLH3... Read More about A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutL? during crossover formation in meiotic prophase I.