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Characterisation of the developing heart in a pressure overloaded model utilising RNA sequencing to direct functional analysis (2019)
Journal Article
Parnall, M., Perdios, C., Pang, K. L., Rochette, S., & Loughna, S. (2020). Characterisation of the developing heart in a pressure overloaded model utilising RNA sequencing to direct functional analysis. Journal of Anatomy, 236(3), 549-563. https://doi.org/10.1111/joa.13112

Cardiogenesis is influenced by both environmental and genetic factors, with blood flow playing a critical role in cardiac remodelling. Perturbation of any of these factors could lead to abnormal heart development and hence the formation of congenital... Read More about Characterisation of the developing heart in a pressure overloaded model utilising RNA sequencing to direct functional analysis.

Altered haemodynamics cause aberrations in the epicardium (2019)
Journal Article
Perdios, C., Parnall, M., Pang, K. L., & Loughna, S. (2019). Altered haemodynamics cause aberrations in the epicardium. Journal of Anatomy, 234(6), 800-814. https://doi.org/10.1111/joa.12977

During embryo development, the heart is the first functioning organ. Although quiescent in the adult, the epicardium is essential during development to form a normal four‐chambered heart. Epicardial‐derived cells contribute to the heart as it develop... Read More about Altered haemodynamics cause aberrations in the epicardium.