All Outputs (3)

Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung (2019)
Journal Article
Nieto-Orellana, A., Li, H., Rosiere, R., Wauthoz, N., Williams, H., Monteiro, C., …Stolnik, S. (2019). Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung. Journal of Controlled Release, 316, 250-262. https://doi.org/10.1016/j.jconrel.2019.10.012

Pulmonary delivery is increasingly seen as an attractive, non-invasive route for the delivery of forthcoming protein therapeutics. In this context, here we describe protein complexes with a new ‘complexing excipient’ - vitamin B12-targeted poly(ethyl... Read More about Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung.

Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers (2019)
Journal Article
Madeira Do O, J., Foralosso, R., Yilmaz, G., Mastrotto, F., King, P. J. S., Xerri, R. M., …Mantovani, G. (2019). Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers. Nanoscale, 11(44), 21155-21166. https://doi.org/10.1039/C9NR05836B

Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with fine-tuned balance between hydrophilic sugar pendant units and relatively... Read More about Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers.

Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo (2019)
Journal Article
Francini, N., Cochrane, D., Illingworth, S., Purdie, L., Mantovani, G., Fisher, K., …Alexander, C. (2019). Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo. Bioconjugate Chemistry, 30(4), 1244-1257. https://doi.org/10.1021/acs.bioconjchem.9b00189

Oncolytic viruses offer many advantages for cancer therapy when administered directly to confined solid tumors. However, the systemic delivery of these viruses is problematic because of the host immune response, undesired interactions with blood comp... Read More about Polyvalent diazonium polymers provide efficient protection of oncolytic adenovirus Enadenotucirev from neutralizing antibodies while maintaining biological activity in vitro and in vivo.