The peptide PnPP-19, a spider toxin derivative, activates ?-opioid receptors and modulates calcium channels
(2018)
Journal Article
Freitas, A. C., Peigneur, S., Macedo, F. H., Menezes-Filho, J. E., Millns, P., Medeiros, L. F., …de Lima, M. E. (2018). The peptide PnPP-19, a spider toxin derivative, activates μ-opioid receptors and modulates calcium channels. Toxins, 10(1), 1-12. https://doi.org/10.3390/toxins10010043
The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin ?-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19... Read More about The peptide PnPP-19, a spider toxin derivative, activates ?-opioid receptors and modulates calcium channels.