All Outputs (105)

The development of a protocol for diagnosing hand dermatitis from photographic images (2018)
Journal Article
Parsons, V., Williams, H., English, J., Llewellyn, J., Ntani, G., & Madan, I. (2018). The development of a protocol for diagnosing hand dermatitis from photographic images. Contact Dermatitis, 79(5), 270-275. https://doi.org/10.1111/cod.13053

Background: A hand photography protocol was needed to ascertain the presence and severity of dermatitis in a trial testing the effectiveness of a behaviour change intervention to prevent hand dermatitis in nurses.
Methods: We developed the protocol... Read More about The development of a protocol for diagnosing hand dermatitis from photographic images.

Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls (2018)
Journal Article
Piasecki, J., McPhee, J., Hannam, K., Deere, K., Elhakeem, A., Piasecki, M., …Ireland, A. (2018). Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls. Archives of Osteoporosis, 13, https://doi.org/10.1007/s11657-018-0486-9

Summary: We examined bone density in older athletes and controls. Sprinters had greater hip and spine bone density than endurance athletes and controls, whereas values were similar in the latter two groups. These results could not be explained by dif... Read More about Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls.

Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials (2018)
Journal Article
Sasso, L., Purdie, L., Grabowska, A. M., Jones, A. T., & Alexander, C. (2018). Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials. Journal of Interdisciplinary Nanomedicine, 3(2), https://doi.org/10.1002/jin2.39

Endocytosis is an essential function of cells, with key roles in the internalisation of nutrients, signal molecules and also drugs. Endocytic processes are therefore widely investigated in the context of drug delivery, and inhibitors of endocytic pat... Read More about Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials.

Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions (2018)
Journal Article
Bestall, S. M., Hulse, R. P., Blackley, Z., Swift, M., Ved, N., Paton, K., …Donaldson, L. F. (in press). Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions. Journal of Cell Science, Article jcs.215939. https://doi.org/10.1242/jcs.215939

Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility group protein B1 (HMGB1) is a RAGE agonist, increased in diabetes, that contributes to pain by modulating periph... Read More about Sensory neuronal sensitisation occurs through HMGB-1/RAGE and TRPV1 in high glucose conditions.

Handgrip strength cannot be assumed a proxy for overall muscle strength (2018)
Journal Article
Yeung, S. S., Reijnierse, E. M., Trappenburg, M. C., Hogrel, J.-Y., McPhee, J. S., Piasecki, M., Sipila, S., Salpakoski, A., Butler-Browne, G., Pääsuke, M., Gapeyeva, H., Narici, M. V., Meskers, C. G., & Maier, A. B. (2018). Handgrip strength cannot be assumed a proxy for overall muscle strength. Journal of the American Medical Directors Association, 19(8), 703-709. https://doi.org/10.1016/j.jamda.2018.04.019

Objectives: Dynapenia, low muscle strength, is predictive for negative health outcomes and is usually expressed as handgrip strength (HGS). Whether HGS can be a proxy for overall muscle strength and whether this depends on age and health status is co... Read More about Handgrip strength cannot be assumed a proxy for overall muscle strength.

Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques (2018)
Journal Article
Eithne, H., David, M., Johanna, B., & Melanie, F. (2019). Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques. Ear and Hearing, 40(2), 328-339. https://doi.org/10.1097/AUD.0000000000000618

Objectives: The primary aim of this research was to refine and validate the Social Participation Restrictions Questionnaire (SPaRQ). The SPaRQ is a hearing-specific, patient-reported outcome measure that was originally developed through consultation... Read More about Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques.

Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants (2018)
Journal Article
Stocks, J., Tang, N. K., Walsh, D. A., Warner, S. C., Harvey, H., Jenkins, W., Abhishek, A., Doherty, M., & Valdes, A. M. (2018). Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018(11), 1087—1093. https://doi.org/10.2147/JPR.S149830

Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic pain-like symptoms. 423 individuals who had undergone total joint... Read More about Bidirectional association between disturbed sleep and neuropathic pain symptoms: a prospective cohort study in post-total joint replacement participants.

Clinical evidence synopsis: hearing aids and health-related quality of life in adults with hearing loss (2018)
Journal Article
Kitterick, P. T., & Ferguson, M. A. (2018). Clinical evidence synopsis: hearing aids and health-related quality of life in adults with hearing loss. Journal of the American Medical Association, 319(21), https://doi.org/10.1001/jama.2018.5567

Clinical Question

Are hearing aids associated with improved health-related quality of life in adults with mild to moderate hearing loss?

Bottom Line


Compared with no hearing aids, the provision of hearing aids was associated with improveme... Read More about Clinical evidence synopsis: hearing aids and health-related quality of life in adults with hearing loss.

Cellular patterning of Arabidopsis roots under low phosphate conditions (2018)
Journal Article
Janes, G., von Wangenheim, D., Cowling, S., Kerr, I. D., Band, L. R., French, A. P., & Bishopp, A. (2018). Cellular patterning of Arabidopsis roots under low phosphate conditions. Frontiers in Plant Science, 9, Article 735. https://doi.org/10.3389/fpls.2018.00735

Phosphorus is a crucial macronutrient for plants playing a critical role in many cellular signaling and energy cycling processes. In light of this, phosphorus acquisition efficiency is an important target trait for crop improvement, but it also provi... Read More about Cellular patterning of Arabidopsis roots under low phosphate conditions.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency (2018)
Journal Article
Segeritz, C., Rashid, S. T., de Brito, M. C., Serra, M. P., Ordonez, A., Morell, C. M., …Vallier, L. (2018). hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency. Journal of Hepatology, 69(4), 851-860. https://doi.org/10.1016/j.jhep.2018.05.028

© 2018 The Authors Background & Aims: α1-Antitrypsin deficiency (A1ATD) is an autosomal recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant (Gly342Lys) retain polymerised protein in the endoplasmic reticulum (E... Read More about hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial (2018)
Journal Article
Varlet, P., Mackay, A., Burford, A., Molinari, V., Jones, D. T., Izquierdo, E., …Jones, C. (2018). Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. Cancer Cell, 33(5), 829-842.e5. https://doi.org/10.1016/j.ccell.2018.04.004

The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years.... Read More about Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer (2018)
Journal Article
Wilcock, A., Koon, S., Manderson, C., Taylor, V., & Maddocks, M. (2018). Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer. Respiratory Medicine, 140, https://doi.org/10.1016/j.rmed.2018.05.018

Background:
Breathlessness is common in patients with thoracic cancer but difficult to manage. The Incremental Shuttle Walking Test (ISWT) can help assess new treatments, but its repeatability has not been described in this group.

Aim:
To examin... Read More about Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer.

Relapse after treatment withdrawal of antiepileptic drugs for juvenile absence epilepsy and juvenile myoclonic epilepsy (2018)
Journal Article
Healy, L., Moran, M., Singhal, S., O'Donoghue, M. F., Alzoubidi, R., & Whitehouse, W. P. (2018). Relapse after treatment withdrawal of antiepileptic drugs for juvenile absence epilepsy and juvenile myoclonic epilepsy. Seizure - European Journal of Epilepsy, 59, https://doi.org/10.1016/j.seizure.2018.05.015

Purpose
Conventional teaching is that juvenile myoclonic epilepsy (JME) and juvenile absence epilepsy (JAE) require lifelong antiepileptic drug (AED) treatment. We therefore wanted to determine how many patients attending our epilepsy service with J... Read More about Relapse after treatment withdrawal of antiepileptic drugs for juvenile absence epilepsy and juvenile myoclonic epilepsy.

Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort (2018)
Journal Article
Schuil, H., Derks, M., Liefers, G.-J., Portielje, J., van de Velde, C., Syed, B., Green, A., Ellis, I., Cheung, K.-L., & Bastiaannet, E. (in press). Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2018.05.004

Objective: Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational c... Read More about Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort.

Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol (2018)
Journal Article
Stocks, J., & Valdes, A. M. (2018). Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol. BMJ Open, 8(5), Article e021344. https://doi.org/10.1136/bmjopen-2017-021344

Introduction: The beneficial effect of dietary omega-3 supplementation in younger adults or older people with acute or chronic disease is established. Knowledge is now needed about the effect in medically stable older people. The objective of this st... Read More about Effect of dietary omega-3 fatty acid supplementation on frailty related phenotypes in older adults: a systematic review and meta-analysis protocol.

Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress (2018)
Journal Article
Nwidu, L. L., Oboma, Y. I., Elmorsy, E., & Carter, W. G. (2018). Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress. Journal of Taibah University Medical Sciences, 13(4), https://doi.org/10.1016/j.jtumed.2018.04.006

Objective: Natural antioxidant products are gaining popularity as treatments for various pathological liver injuries. Musanga cecropioides (Urticaceae) leaf extract is used in ethnomedicine for the management of jaundice and other hepatic ailments in... Read More about Hepatoprotective effect of hydromethanolic leaf extract of Musanga cecropioides (Urticaceae) on carbon tetrachloride-induced liver injury and oxidative stress.

The pattern of penetration and aspiration in acute stroke survivors (2018)
Presentation / Conference Contribution
Everton, L., Benfield, J., Michou, E., Hamdy, S., & Bath, P. M. The pattern of penetration and aspiration in acute stroke survivors. Presented at 4th European Stroke Organisation Conference ​(ESOC 2018)

Background and Aims: Aspiration is common in acute stroke survivors with dysphagia, is associated with increased pneumonia rates, and is an independent predictor of mortality. However, studies evaluating the nature and pattern of penetration and aspi... Read More about The pattern of penetration and aspiration in acute stroke survivors.

Fulvestrant for the treatment of advanced breast cancer (2018)
Journal Article
Blackburn, S. A., Parks, R. M., & Cheung, K.-L. (2018). Fulvestrant for the treatment of advanced breast cancer. Expert Review of Anticancer Therapy, 18(7), 619-628. https://doi.org/10.1080/14737140.2018.1473038

Introduction: The current issues with endocrine therapy for treatment of advanced breast cancer include balance of efficacy of therapy versus tolerability as well as hormone resistance. The efficacy of fulvestrant, a selective oestrogen receptor degr... Read More about Fulvestrant for the treatment of advanced breast cancer.

A systematic review of the literature describing the outcomes of near-peer mentoring programs for first year medical students (2018)
Journal Article
Akinla, O., Hagan, P., & Atiomo, W. (2018). A systematic review of the literature describing the outcomes of near-peer mentoring programs for first year medical students. BMC Medical Education, 18, Article 98. https://doi.org/10.1186/s12909-018-1195-1

Background
Transition into higher education has been identified as one of the most stressful periods for learners. Interventions targeting the transition phase such as near- peer mentoring might help address some of these challenges. We were however... Read More about A systematic review of the literature describing the outcomes of near-peer mentoring programs for first year medical students.

Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study (2018)
Journal Article
Palaniyappan, L., Hodgson, O., Balain, V., Iwabuchi, S., Gowland, P., & Liddle, P. (2019). Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study. Psychological Medicine, 49(3), 412-420. https://doi.org/10.1017/S0033291718001010

Background: In patients with schizophrenia, distributed abnormalities are observed in grey matter volume. A recent hypothesis posits that these distributed changes are indicative of a plastic reorganization process occurring in response to a function... Read More about Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study.