Hugo Schuil
Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort
Schuil, Hugo; Derks, Marloes; Liefers, Gerrit-Jan; Portielje, Johanneke; van de Velde, Cornelis; Syed, Binafsha; Green, Andrew; Ellis, Ian; Cheung, Kwok-Leung; Bastiaannet, Esther
Authors
Marloes Derks
Gerrit-Jan Liefers
Johanneke Portielje
Cornelis van de Velde
Binafsha Syed
ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor
Professor IAN ELLIS IAN.ELLIS@NOTTINGHAM.AC.UK
Professor of Cancer Pathology
Professor KWOK_LEUNG CHEUNG KWOK_LEUNG.CHEUNG@NOTTINGHAM.AC.UK
Deputy Head of Education & Director of The Bmbs Medicine Programmes
Esther Bastiaannet
Abstract
Objective: Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort.
Materials and Methods: Women aged 70 years and older diagnosed with breast cancer after 1990 with a T0-T2 tumor stage and no evidence of metastatic disease were included from a population-based cohort in the Netherlands and a British hospital-based cohort in Nottingham. Main outcomes were proportions of local and systemic treatment, ten-year overall survival and ten-year relative survival for each cohort.
Results: 1439 patients from Nottingham and 2180 patients from the Netherlands were included. Median follow-up was 12.4 years (IQR 11.0–14.0) in the FOCUS cohort and 6.4 years (IQR 6.2–6.8) in the Nottingham cohort. British patients were more likely to receive primary endocrine therapy (50.0% vs 7.5%, P
Citation
Schuil, H., Derks, M., Liefers, G., Portielje, J., van de Velde, C., Syed, B., …Bastiaannet, E. (in press). Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2018.05.004
Journal Article Type | Article |
---|---|
Acceptance Date | May 4, 2018 |
Online Publication Date | May 18, 2018 |
Deposit Date | Jul 17, 2018 |
Publicly Available Date | Mar 28, 2024 |
Journal | Journal of Geriatric Oncology |
Print ISSN | 1879-4068 |
Electronic ISSN | 1879-4068 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1016/j.jgo.2018.05.004 |
Keywords | breast cancer, geriatric oncology, age, treatment, mortality, surgical therapy |
Public URL | https://nottingham-repository.worktribe.com/output/933003 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S1879406817302862?via%3Dihub |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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