Skip to main content

Research Repository

Advanced Search

Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort

Schuil, Hugo; Derks, Marloes; Liefers, Gerrit-Jan; Portielje, Johanneke; van de Velde, Cornelis; Syed, Binafsha; Green, Andrew; Ellis, Ian; Cheung, Kwok-Leung; Bastiaannet, Esther

Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort Thumbnail


Authors

Hugo Schuil

Marloes Derks

Gerrit-Jan Liefers

Johanneke Portielje

Cornelis van de Velde

Binafsha Syed

Esther Bastiaannet



Abstract

Objective: Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort.
Materials and Methods: Women aged 70 years and older diagnosed with breast cancer after 1990 with a T0-T2 tumor stage and no evidence of metastatic disease were included from a population-based cohort in the Netherlands and a British hospital-based cohort in Nottingham. Main outcomes were proportions of local and systemic treatment, ten-year overall survival and ten-year relative survival for each cohort.
Results: 1439 patients from Nottingham and 2180 patients from the Netherlands were included. Median follow-up was 12.4 years (IQR 11.0–14.0) in the FOCUS cohort and 6.4 years (IQR 6.2–6.8) in the Nottingham cohort. British patients were more likely to receive primary endocrine therapy (50.0% vs 7.5%, P 

Citation

Schuil, H., Derks, M., Liefers, G., Portielje, J., van de Velde, C., Syed, B., …Bastiaannet, E. (in press). Treatment strategies and survival outcomes in older women with breast cancer: a comparative study between the FOCUS cohort and Nottingham cohort. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2018.05.004

Journal Article Type Article
Acceptance Date May 4, 2018
Online Publication Date May 18, 2018
Deposit Date Jul 17, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Geriatric Oncology
Print ISSN 1879-4068
Electronic ISSN 1879-4068
Publisher Elsevier
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1016/j.jgo.2018.05.004
Keywords breast cancer, geriatric oncology, age, treatment, mortality, surgical therapy
Public URL https://nottingham-repository.worktribe.com/output/933003
Publisher URL https://www.sciencedirect.com/science/article/pii/S1879406817302862?via%3Dihub

Files






You might also like



Downloadable Citations