All Outputs (2)

Alterations in neuronal metabolism contribute to the pathogenesis of prion disease (2018)
Journal Article
Bourgognon, J., Spiers, J. G., Scheiblich, H., Antonov, A., Bradley, S. J., Tobin, A. B., & Steinert, J. R. (2018). Alterations in neuronal metabolism contribute to the pathogenesis of prion disease. Cell Death and Differentiation, 25(8), 1408-1425. https://doi.org/10.1038/s41418-018-0148-x

Neurodegenerative conditions are characterised by a progressive loss of neurons, which is believed to be initiated by misfolded protein aggregations. During this time period, many physiological and metabolomic alterations and changes in gene expressi... Read More about Alterations in neuronal metabolism contribute to the pathogenesis of prion disease.

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability (2018)
Journal Article
Butcher, A., Robinson, S. W., Bourgognon, J., Spiers, J. G., Breda, C., Morone, N., …Steinert, J. R. (2018). Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability. PLoS Biology, 16(4), Article e2003611. https://doi.org/10.1371/journal.pbio.2003611

Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantl... Read More about Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.