Cell death pathologies: targeting death pathways and the immune system for cancer therapy

Pentimalli, Francesca; Grelli, Sandro; Di Daniele, Nicola; Melino, Gerry; Amelio, Ivano

doi:10.1038/s41435-018-0052-x

All Outputs (4605)

The Role of Discourse Analysis in Researching Severe Labour Exploitation (2018)
Book Chapter

Investigating severe forms of labour exploitation presents a series of particular methodological challenges to researchers in the field, including access to respondents, credibility of data, reliability of measures, researcher ethics and the practica... Read More about The Role of Discourse Analysis in Researching Severe Labour Exploitation.

Spectacle and adventure philanthropy (2018)
Journal Article

While humanitarian tourism is increasingly examined from critical theory perspectives (see Ingram, 2011; Mostafanezhad, 2013, 2104; Simpson, 2004), less attention has been given to the role of media and spectacle in the enactment of this type of tour... Read More about Spectacle and adventure philanthropy.

Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION2 (2018)
Journal Article

The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukaryotes. Mechanisms controlling its developmental specificity and signal-responsiveness are poorly understood. Here, we identify an oxygen-sensitive N-terminal (N-) d... Read More about Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION2.

Roots branch towards water by post-translational modification of transcription factor ARF7 (2018)
Journal Article

Plants adapt to heterogeneous soil conditions by altering their root architecture. For example, roots branch when in contact with water using the hydropatterning response. We report that hydropatterning is dependent on auxin response factor ARF7. Thi... Read More about Roots branch towards water by post-translational modification of transcription factor ARF7.

Resolution enhancement for topography measurement of high-dynamic-range surfaces via image fusion (2018)
Journal Article

In this paper, we introduce a method and algorithm for resolution enhancement of low-resolution surface topography data by fusing it with corresponding high-resolution intensity images. This fusion is carried out by linking the three-dimensional topo... Read More about Resolution enhancement for topography measurement of high-dynamic-range surfaces via image fusion.

Confronting Bias in NGO Research on Modern Slavery (2018)
Book Chapter
Okyere, S. (2018). Confronting Bias in NGO Research on Modern Slavery. In G. LeBaron (Ed.), Researching Forced Labour in the Global Economy: Methodological Challenges and Advances (94-110). Oxford University Press (OUP). https://doi.org/10.5871/bacad/9780197266472.003.0006

This chapter explores the extent to which efforts to attain more reliable, comprehensive data and knowledge on forced labour could be impeded by a lack of critical reflexivity in the use of mainstream conventional definitional and conceptual framewor... Read More about Confronting Bias in NGO Research on Modern Slavery.

Centrifuge and Real-Time Hybrid Testing of Tunneling beneath Piles and Piled Buildings (2018)
Journal Article
Andrea, F., & Alec M., M. (2019). Centrifuge and Real-Time Hybrid Testing of Tunneling beneath Piles and Piled Buildings. Journal of Geotechnical and Geoenvironmental Engineering, 145(3), Article 04018110. https://doi.org/10.1061/%28ASCE%29GT.1943-5606.0002003

Tunnels are constructed increasingly close to existing buried structures, including pile foundations. This poses a serious concern, especially for tunnels built beneath piles. Current understanding of the global tunnel-soil-pile-building interaction... Read More about Centrifuge and Real-Time Hybrid Testing of Tunneling beneath Piles and Piled Buildings.

Variable Switching Frequency ON–OFF Control for Class E DC–DC Converter (2018)
Journal Article

The efficiency improvement of the on-off controlled Class E dc-dc converter operated at 20 MHz switching frequency is investigated in this paper. It is found that with the on-off control, the input power of the converter during the on mode increases... Read More about Variable Switching Frequency ON–OFF Control for Class E DC–DC Converter.

All the protestors fit to count: using geospatial affordances to estimate protest event size (2018)
Journal Article

Protest events are a hallmark of social movement tactics. Large crowds in public spaces send a clear message to those in authority. Consequently, estimating crowd size is important for clarifying how much support a particular movement has been able t... Read More about All the protestors fit to count: using geospatial affordances to estimate protest event size.

"Friends Of Dorothy": Queerness In and Beyond the MGM Film (2018)
Book Chapter

Artificial Intelligence Aided Automated Design for Reliability of Power Electronic Systems (2018)
Journal Article

© 1986-2012 IEEE. This paper proposes a new methodology for automated design of power electronic systems realized through the use of artificial intelligence. Existing approaches do not consider the system's reliability as a performance metric or are... Read More about Artificial Intelligence Aided Automated Design for Reliability of Power Electronic Systems.

Mammalian cell-driven polymerisation of pyrrole (2018)
Journal Article

A model cancer cell line was used to initiate polymerisation of pyrrole to form the conducting material polypyrrole. The polymerisation was shown to occur via cytosolic exudates rather than via membrane redox sites which normally control the oxidatio... Read More about Mammalian cell-driven polymerisation of pyrrole.

Metal–organic frameworks constructed from Group 1 metals (Li, Na) and silicon-centered linkers (2018)
Journal Article

A series of “light metal” metal–organic frameworks containing secondary building units (SBUs) based on Li+ and Na+ cations have been prepared using the silicon-centered linkers MexSi(p-C6H4CO2H)4-x (x = 2, 1, 0). The unipositive charge, small size, a... Read More about Metal–organic frameworks constructed from Group 1 metals (Li, Na) and silicon-centered linkers.

The benefits of international volunteering in a low-resource setting: development of a core outcome set (2018)
Journal Article

Background: Qualitative narrative analysis and case studies form the majority of the current peer-reviewed literature about the benefits of professional volunteering or international placements for healthcare professionals. These often describe gener... Read More about The benefits of international volunteering in a low-resource setting: development of a core outcome set.

Tensions within the Ministry of Provenance: reflections on co-creating a research game together with artists (2018)
Journal Article

Background: Research games are challenging to design as they seek to fulfil a research agenda as well as work as a game. We have successfully collaborated with a group of artists in a research game about people’s perception of provenance called The A... Read More about Tensions within the Ministry of Provenance: reflections on co-creating a research game together with artists.

Local asymptotic equivalence of pure states ensembles and quantum Gaussian white noise (2018)
Journal Article

Quantum technology is increasingly relying on specialised statistical inference methods for analysing quantum measurement data. This motivates the development of “quantum statistics”, a field that is shaping up at the overlap of quantum physics and “... Read More about Local asymptotic equivalence of pure states ensembles and quantum Gaussian white noise.

Healthcare utilisation, morbidities and alcohol use monitoring prior to alcoholic psychosis diagnosis (2018)
Journal Article

Aims: This study aimed to describe healthcare utilisation, morbidities and monitoring of alcohol use in patients prior to a diagnosis of alcoholic psychosis in order to inform the early identification of patients at risk. Method: Using linked gene... Read More about Healthcare utilisation, morbidities and alcohol use monitoring prior to alcoholic psychosis diagnosis.

Reading Muirchú’s Life of St Patrick as a 'sacred narration' (2018)
Journal Article

Testing explosive bubbles with time-varying volatility (2018)
Journal Article
Harvey, D. I., Leybourne, S. J., & Zu, Y. (2019). Testing explosive bubbles with time-varying volatility. Econometric Reviews, 38(10), 1131-1151. https://doi.org/10.1080/07474938.2018.1536099

This paper considers the problem of testing for an explosive bubble in financial data in the presence of time-varying volatility. We propose a weighted least squares-based variant of the Phillips, Wu and Yu (2011) test for explosive autoregressive be... Read More about Testing explosive bubbles with time-varying volatility.

Cell death pathologies: targeting death pathways and the immune system for cancer therapy (2018)
Journal Article

Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse... Read More about Cell death pathologies: targeting death pathways and the immune system for cancer therapy.