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Mammalian cell-driven polymerisation of pyrrole

Sherman, Harry G.; Jain, Akhil; Stolnik, Snow; Alexander, Cameron; Rawson, Frankie James; Hicks, Jacqueline

Mammalian cell-driven polymerisation of pyrrole Thumbnail


Authors

Harry G. Sherman

Akhil Jain

Snow Stolnik



Abstract

A model cancer cell line was used to initiate polymerisation of pyrrole to form the conducting material polypyrrole. The polymerisation was shown to occur via cytosolic exudates rather than via membrane redox sites which normally control the oxidation state of iron as ferricyanide or ferrocyanide.. The data demonstrate for the first time that mammalian cells can be used to initiate synthesis of conducting polymers, and suggest a possible route to detection of cell damage and/or transcellular processes via an in?situ and amplifiable signal generation.

Journal Article Type Article
Acceptance Date Dec 20, 2018
Online Publication Date Dec 20, 2018
Publication Date Dec 20, 2018
Deposit Date Jan 31, 2019
Publicly Available Date Jan 31, 2019
Journal ChemBioChem
Print ISSN 1439-4227
Electronic ISSN 1439-7633
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 20
Issue 8
Pages 1008-1013
DOI https://doi.org/10.1002/cbic.201800630
Keywords Organic Chemistry; Molecular Medicine; Biochemistry; Molecular Biology
Public URL https://nottingham-repository.worktribe.com/output/1509912
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800630