Harry G. Sherman
Mammalian cell-driven polymerisation of pyrrole
Sherman, Harry G.; Jain, Akhil; Stolnik, Snow; Alexander, Cameron; Rawson, Frankie James; Hicks, Jacqueline
Authors
Akhil Jain
Snow Stolnik
Professor CAMERON ALEXANDER CAMERON.ALEXANDER@NOTTINGHAM.AC.UK
PROFESSOR OF POLYMER THERAPEUTICS
Dr Frankie Rawson Frankie.Rawson@nottingham.ac.uk
ASSOCIATE PROFESSOR
Jacqueline Hicks
Abstract
A model cancer cell line was used to initiate polymerisation of pyrrole to form the conducting material polypyrrole. The polymerisation was shown to occur via cytosolic exudates rather than via membrane redox sites which normally control the oxidation state of iron as ferricyanide or ferrocyanide.. The data demonstrate for the first time that mammalian cells can be used to initiate synthesis of conducting polymers, and suggest a possible route to detection of cell damage and/or transcellular processes via an in‐situ and amplifiable signal generation.
Citation
Sherman, H. G., Jain, A., Stolnik, S., Alexander, C., Rawson, F. J., & Hicks, J. (2018). Mammalian cell-driven polymerisation of pyrrole. ChemBioChem, 20(8), 1008-1013. https://doi.org/10.1002/cbic.201800630
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 20, 2018 |
Online Publication Date | Dec 20, 2018 |
Publication Date | Dec 20, 2018 |
Deposit Date | Jan 31, 2019 |
Publicly Available Date | Jan 31, 2019 |
Journal | ChemBioChem |
Print ISSN | 1439-4227 |
Electronic ISSN | 1439-7633 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 20 |
Issue | 8 |
Pages | 1008-1013 |
DOI | https://doi.org/10.1002/cbic.201800630 |
Keywords | Organic Chemistry; Molecular Medicine; Biochemistry; Molecular Biology |
Public URL | https://nottingham-repository.worktribe.com/output/1509912 |
Publisher URL | https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800630 |
Contract Date | Jan 31, 2019 |
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