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Does trajectory matter? A study looking into the relationship of trajectory with target engagement and error accommodation in subthalamic nucleus deep brain stimulation (2017)
Journal Article
Steel, D. A., & Basu, S. (in press). Does trajectory matter? A study looking into the relationship of trajectory with target engagement and error accommodation in subthalamic nucleus deep brain stimulation. Acta Neurochirurgica, https://doi.org/10.1007/s00701-017-3151-y

Background: STN-DBS is now a key treatment choice for advanced Parkinson’s disease. The optimum target area within the STN is well established. However, no emphasis on the impact of trajectory exists. The ellipsoid shape of the STN and the off-centre... Read More about Does trajectory matter? A study looking into the relationship of trajectory with target engagement and error accommodation in subthalamic nucleus deep brain stimulation.

Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial (2017)
Journal Article
Deave, T., Hawkins, A., Kumar, A., Hayes, M., Cooper, N., Watson, M., …Kendrick, D. (2017). Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial. PLoS ONE, 12(3), Article e0172584. https://doi.org/10.1371/journal.pone.0172584

Background: Many developed countries have high mortality rates for fire-related deaths in children aged 0–14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a rang... Read More about Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial.

Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women (2017)
Journal Article
Alshammari, G., Khan, R., Brameld, J. M., Amer, S. A., & Lomax, M. A. (2017). Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21(5),

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory m... Read More about Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women.

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells (2017)
Journal Article
Sampaziotis, F., de Brito, M. C., Geti, I., Bertero, A., Hannan, N. R., & Vallier, L. (2017). Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nature Protocols, 12(4), 814-827. https://doi.org/10.1038/nprot.2017.011

The difficulty in isolating and propagating functional primary cholangiocytes is a major limitation in the study of biliary disorders and the testing of novel therapeutic agents. To overcome this problem, we have developed a platform for the differen... Read More about Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Mosad, S. M., Khan, R., & Amer, S. (2017). Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells. Toxicology Letters, 272, https://doi.org/10.1016/j.toxlet.2017.03.018

Background Antipsychotics (APs) are widely prescribed drugs, which are well known to cause reproductive adverse effects through mechanisms yet to be determined. The purpose of this study was to investigate the effect of antipsychotics on mitochond... Read More about Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells.

Eating symptomatology and general psychopathology in patients with anorexia nervosa from China, UK and Spain: a cross-cultural study examining the role of social attitudes (2017)
Journal Article
Aguera, Z., Brewin, N., Chen, J., Granero, R., Kang, Q., Fernandez-Aranda, F., & Arcelus, J. (in press). Eating symptomatology and general psychopathology in patients with anorexia nervosa from China, UK and Spain: a cross-cultural study examining the role of social attitudes. PLoS ONE, 12(3), Article e0173781. https://doi.org/10.1371/journal.pone.0173781

Cultural studies exploring differences in the manifestation of anorexia nervosa (AN) have primarily focus on Western and non-Western cultures. However, no study so far has considered the role that social attitudes (i.e. Collectivist vs. Individualist... Read More about Eating symptomatology and general psychopathology in patients with anorexia nervosa from China, UK and Spain: a cross-cultural study examining the role of social attitudes.

Challenges and opportunities in understanding dementia and delirium in the acute hospital (2017)
Journal Article
Jackson, T. A., Gladman, J. R., Harwood, R. H., MacLullich, A. M., Sampson, E. L., Sheehan, B., & Davis, D. H. (2017). Challenges and opportunities in understanding dementia and delirium in the acute hospital. PLoS Medicine, 14(3), Article e1002247. https://doi.org/10.1371/journal.pmed.1002247

What is the problem? Dementia in general hospitals Dementia is very common in patients admitted to acute hospitals, affecting one in four patients, with 6% of people living with dementia being inpatients in acute hospitals at any given time [1,... Read More about Challenges and opportunities in understanding dementia and delirium in the acute hospital.

Everyday sadism, dark triad, personality and disgust sensitivity (2017)
Journal Article
Meere, M., & Egan, V. (2017). Everyday sadism, dark triad, personality and disgust sensitivity. Personality and Individual Differences, 112, https://doi.org/10.1016/j.paid.2017.02.056

Research into dark personalities has advocated for the addition of sadism due to its close relationship with other dark traits (Book et al., 2016). Lower disgust for atavistic and animalistic tendencies may provide an objective marker of the greater... Read More about Everyday sadism, dark triad, personality and disgust sensitivity.

Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI (2017)
Journal Article
Dyke, K., Pépés, S. E., Chen, C., Kim, S., Sigurdsson, H. P., Draper, A., …Jackson, S. R. (2017). Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI. NeuroImage, 152, 360-370. https://doi.org/10.1016/j.neuroimage.2017.03.011

Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain networks are thought to underlie many brain and mental health disorders, and for this reason there is considerable interest in investigating how individual var... Read More about Comparing GABA-­dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-­high-­field MRI.

The effect of tonsillectomy on the morbidity from recurrent tonsillitis (2017)
Journal Article
Douglas, C. M., Lang, K., Whitmer, W. M., Wilson, J. A., & Mackenzie, K. (2017). The effect of tonsillectomy on the morbidity from recurrent tonsillitis. Clinical Otolaryngology, 42(6), 1206-1210. https://doi.org/10.1111/coa.12850

Background Tonsillitis is a common condition with an incidence in UK general practice of 37 per 1000 population a year.1 Recurrent tonsillitis results in significant morbidity and impacts on individuals’ quality of life. This study assesses the mo... Read More about The effect of tonsillectomy on the morbidity from recurrent tonsillitis.

Axillary reverse mapping in N0 patients requiring sentinel lymph node biopsy: a systematic review of the literature and necessity of a randomised study (2017)
Journal Article
Parks, R., & Cheung, K. (2017). Axillary reverse mapping in N0 patients requiring sentinel lymph node biopsy: a systematic review of the literature and necessity of a randomised study. Breast, 33, https://doi.org/10.1016/j.breast.2017.02.019

Objectives: Axillary reverse mapping (ARM) is a technique to map and preserve arm lymphatics which may be damaged during surgery, resulting in lymphoedema. This work systematically reviews the incidence of lymphoedema following sentinel lymph node bi... Read More about Axillary reverse mapping in N0 patients requiring sentinel lymph node biopsy: a systematic review of the literature and necessity of a randomised study.

Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015) (2017)
Journal Article
England, T. J., Hedstrom, A., O'Sullivan, S., Donnelly, R., Barrett, D. A., Sarmad, S., …Bath, P. M. (2017). Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015). Stroke, 48(5), https://doi.org/10.1161/STROKEAHA.116.016429

Background: Repeated episodes of limb ischaemia and reperfusion (remote ischaemic conditioning, RIC) may improve outcome after acute stroke. Methods: We performed a pilot blinded placebo-controlled trial in patients with acute ischaemic stroke, ra... Read More about Remote Ischaemic Conditioning after Stroke Trial (RECAST): a pilot randomised placebo controlled phase II trial in acute ischaemic stroke (ISRCTN 86672015).

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial (2017)
Journal Article
Williams, H. C., Wojnarowska, F., Kirtschig, G., Mason, J., Godec, T. R., Schmidt, E., …Nunn, A. J. (in press). Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial. Lancet, 389(10079), https://doi.org/10.1016/S0140-6736%2817%2930560-3

Background: Bullous pemphigoid (BP) is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline conveys acceptable short-term blister control whilst conferring long-term safety advantage... Read More about Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial.

Immunoprofile of metaplastic carcinomas of the breast (2017)
Journal Article
Rakha, E. A., Coimbra, N. D., Hodi, Z., Juneinah, E., Ellis, I. O., & Lee, A. H. (2017). Immunoprofile of metaplastic carcinomas of the breast. Histopathology, 70(6), (975-985). doi:10.1111/his.13159. ISSN 0309-0167

Aims Metaplastic breast carcinoma (MBC) is a rare type of breast cancer; its diagnosis in routine practice can be challenging, and may require immunohistochemical (IHC) characterization if no conventional invasive or in‐situ carcinoma is present. Pr... Read More about Immunoprofile of metaplastic carcinomas of the breast.

Three-year outcomes after acute kidney injury: results of a prospective parallel group cohort study (2017)
Journal Article
Horne, K. L., Packington, R., Monaghan, J., Reilly, T., & Selby, N. M. (2017). Three-year outcomes after acute kidney injury: results of a prospective parallel group cohort study. BMJ Open, 7(3), Article e015316. https://doi.org/10.1136/bmjopen-2016-015316

Objectives Using a prospective study design, we aimed to characterise the effect of acute kidney injury (AKI) on long-term changes in renal function in a general hospital population. Participants Hospitalised patients with AKI (exposed) and hospit... Read More about Three-year outcomes after acute kidney injury: results of a prospective parallel group cohort study.

Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study (2017)
Journal Article
Barratt, E. L., Tewarie, P. K., Clarke, M. A., Hall, E. L., Gowland, P. A., Morris, P. G., …Brookes, M. J. (2017). Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study. Human Brain Mapping, 38(5), 2441-2453. https://doi.org/10.1002/hbm.23531

Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observ... Read More about Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study.

Skin diseases affecting the vulva (2017)
Journal Article
Simpson, R., & Nunns, D. (2017). Skin diseases affecting the vulva. Obstetrics, Gynaecology and Reproductive Medicine, 27(3), 77-85. https://doi.org/10.1016/j.ogrm.2016.12.007

Vulval skin disease is common in gynaecological practice. This article aims to enhance clinical skills in patient assessment, vulval examination and treatment of common benign vulval skin disease. Basic treatments are often of benefit the patient (e.... Read More about Skin diseases affecting the vulva.

Lung cancer diagnosed following an emergency admission: exploring patient and carer perspectives on delay in seeking help (2017)
Journal Article
Caswell, G., Seymour, J., Crosby, V., Hussain, A., Manderson, C., Farnan, S., …Wilcock, A. (2017). Lung cancer diagnosed following an emergency admission: exploring patient and carer perspectives on delay in seeking help. Supportive Care in Cancer, 25(7), 2259-2266. https://doi.org/10.1007/s00520-017-3633-8

Purpose Compared to others, patients diagnosed with lung cancer following an emergency, unplanned admission to hospital (DFEA) have more advanced disease and poorer prognosis. Little is known about DFEA patients’ beliefs about cancer and its sympt... Read More about Lung cancer diagnosed following an emergency admission: exploring patient and carer perspectives on delay in seeking help.