All Outputs (44)

Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts (2017)
Journal Article
Carpenter, L., Norton, S., Nikiphorou, E., Jayakumar, K., McWilliams, D. F., Rennie, K. L., …Young, A. (2017). Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts. Arthritis Care and Research, 69(12), 1809-1817. https://doi.org/10.1002/acr.23217

Objectives: To assess 5-year progression of erosions and Joint Space Narrowing (JSN), and their associations with RF status in two large, multi-centre early-RA cohorts spanning 25-years. Methods: Radiographic joint damage was recorded using the Sh... Read More about Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts.

The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis (2017)
Journal Article
Morandi, E., Tanasescu, R., Tarlinton, R. E., Constantinescu, C. S., Zhang, W., Tench, C. R., & Gran, B. (2017). The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12(2), Article e0172415. https://doi.org/10.1371/journal.pone.0172415

Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.... Read More about The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis.

Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study (2017)
Journal Article
Abhishek, A., Doherty, M., Kuo, C., Mallen, C. D., Zhang, W., & Grainge, M. J. (2017). Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study. Rheumatology, 56(5), 736-744. https://doi.org/10.1093/rheumatology/kew468

Objectives: The objectives of this study were to examine changes in incidence and prevalence of RA between 1990 and 2014, and to explore if there is any geographic variation in incidence and prevalence of RA in the UK Methods: Design Prospective... Read More about Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study.

Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene (2017)
Journal Article
Warner, S. C., van Meurs, J. B., Schiphof, D., Bierma-Zeinstra, S. M., Hofman, A., Uitterlinden, A. G., …Valdes, A. M. (in press). Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene. European Journal of Human Genetics, https://doi.org/10.1038/ejhg.2016.196

Neuropathic pain-like joint symptoms (NP) are seen in a proportion of individuals diagnosed with osteoarthritis (OA) and post total joint replacement (TJR). In this study, we performed a genome-wide association study (GWAS) using NP as defined by the... Read More about Genome-wide association scan of neuropathic pain symptoms post total joint replacement highlights a variant in the protein-kinase C gene.