All Outputs (4)

Integrin-mediated interactions control macrophage polarization in 3D hydrogels (2017)
Journal Article
Cha, B., Shin, S. R., Leijten, J., Li, Y., Singh, S., Liu, J. C., …Khademhosseini, A. (2017). Integrin-mediated interactions control macrophage polarization in 3D hydrogels. Advanced Healthcare Materials, 6(21), Article 1700289. https://doi.org/10.1002/adhm.201700289

Adverse immune reactions prevent clinical translation of numerous implantable devices and materials. Although inflammation is an essential part of tissue regeneration, chronic inflammation ultimately leads to implant failure. In particular, macrophag... Read More about Integrin-mediated interactions control macrophage polarization in 3D hydrogels.

Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations (2017)
Journal Article
Dollinger, C., Ndreu-Halili, A., Uka, A., Singh, S., Sadam, H., Neuman, T., …Vrana, N. E. (2017). Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations. Advanced Biosystems, 1(6), Article 1700041. https://doi.org/10.1002/adbi.201700041

Adverse immune reactions to implanted devices can seriously hamper the efficacy of implants. Monocyte derived macrophages play a crucial role in both initiation and resolution of the inflammatory response toward foreign bodies. As the surface microt... Read More about Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations.

Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states (2017)
Journal Article
Singh, S., Awuah, D., Rostam, H., Emes, R., Kandola, N. K., Onion, D., …Ghaemmaghami, A. M. (in press). Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states. ACS Biomaterials Science and Engineering, https://doi.org/10.1021/acsbiomaterials.7b00104

Macrophages are master regulators of immune responses towards implanted biomaterials. The activation state adopted by macrophages in response to biomaterials determines their own phenotype and function as well as those of other resident and infiltrat... Read More about Unbiased analysis of the impact of micropatterned biomaterials on macrophage behaviour provides insights beyond pre-defined polarisation states.

Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures (2017)
Journal Article
Pokorny, M., Klemes, J., Zidek, O., Dollinger, C., Ozcebe, G., Singh, S., …Vrana, N. E. (in press). Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures. Biomedical Physics and Engineering Express, 3(1), https://doi.org/10.1088/2057-1976/3/1/015002

Metallic implants are widely used in orthopaedic and orthodontic applications. However, generally surface treatment of the metallic surfaces is necessary to render them more biologically active. Herein, we describe a direct write printing method to m... Read More about Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures.