All Outputs (4338)

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors (2016)
Journal Article
Torchia, J., Golbourn, B., Feng, S., Ching Ho, K., Sin-Chan, P., Vasiljevic, A., …Huang, A. (2016). Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell, 30(6), 891-908. https://doi.org/10.1016/j.ccell.2016.11.003

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we anal... Read More about Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples (2016)
Journal Article
Zaky, A. S., Pensupa, N., Andrade-Eiroa, Á., Tucker, G. A., & Du, C. (2017). A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples. Journal of Food Composition and Analysis, 56, https://doi.org/10.1016/j.jfca.2016.12.010

This paper introduces an original, rapid, efficient and reliable HPLC method for the accurate and simultaneous quantification (g/L) of chloride in samples containing sugars, organic acids and alcohols. Separation was achieved using a HI-Plex H column... Read More about A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples.

An enhanced dq-based vector control system for modular multilevel converters feeding variable speed drives (2016)
Journal Article
Espinoza, M., Cardenas, R., Diaz, M., & Clare, J. C. (2017). An enhanced dq-based vector control system for modular multilevel converters feeding variable speed drives. IEEE Transactions on Industrial Electronics, 64(4), 2620-2630. https://doi.org/10.1109/TIE.2016.2637894

Modular multilevel converters (M2C) are considered an attractive solution for high power drive applications. However, energy balancing within the converter is complex to achieve, particularly when the machine is operating at low rotational speeds. In... Read More about An enhanced dq-based vector control system for modular multilevel converters feeding variable speed drives.

The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover (2016)
Journal Article
Zhou, L., Zhang, L.-H., Cámara, M., & He, Y.-W. (2017). The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends in Microbiology, 25(4), https://doi.org/10.1016/j.tim.2016.11.013

The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regul... Read More about The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover.

Client Abuse to Public Welfare Workers: Theoretical Framework and Critical Incident Case Study (2016)
Journal Article
Stroebeak, P. S., & Korczynski, M. (2018). Client Abuse to Public Welfare Workers: Theoretical Framework and Critical Incident Case Study. Sociology, 52(4), 762-777. https://doi.org/10.1177/0038038516672626

© The Author(s) 2016. We analyse a case study of workers’ experience of client abuse in a Danish public welfare organisation. We make an original contribution by putting forward two different theoretical expectations of the case. One expectation is t... Read More about Client Abuse to Public Welfare Workers: Theoretical Framework and Critical Incident Case Study.

Personal data management with the Databox: What’s inside the box? (2016)
Presentation / Conference Contribution
Mortier, R., Zhao, J., Crowcroft, J., Wang, L., Qi, L., Haddadi, H., …Greenhalgh, C. (2016). Personal data management with the Databox: What’s inside the box?. In CAN 2016 - Proceedings of the 2016 ACM Workshop on Cloud-Assisted Networking (49-54). https://doi.org/10.1145/3010079.3010082

We are all increasingly the subjects of data collection and processing systems that use data generated both about and by us to provide and optimise a wide range of services. Means for others to collect and process data that concerns each of us – ofte... Read More about Personal data management with the Databox: What’s inside the box?.

X-Y converter family: A new breed of buck boost converter for high step-up renewable energy applications (2016)
Presentation / Conference Contribution
Mahajan, S., Sanjeevikumar, P., Wheeler, P., Blaabjerg, F., Rivera, M., & Kulkarni, R. (in press). X-Y converter family: A new breed of buck boost converter for high step-up renewable energy applications.

A new breed of a buck boost converter, named as the XY converter family is proposed in this article. In the XY family, 16 topologies are presented which are highly suitable for renewable energy applications which require a high ratio of DC-DC convert... Read More about X-Y converter family: A new breed of buck boost converter for high step-up renewable energy applications.

Anti-confocal assessment of middle ear inflammation (2016)
Journal Article
Jung, D. S., Crowe, J. A., Birchall, J. P., Somekh, M. G., & See, C. W. (2016). Anti-confocal assessment of middle ear inflammation. Biomedical Optics Express, 8(1), https://doi.org/10.1364/BOE.8.000230

To improve the diagnostic prediction of recurrence of otitis media with effusion after surgery, an anti-confocal system combined with spectroscopic measurements is proposed to reject unwanted signals from the eardrum and assess the blood content. The... Read More about Anti-confocal assessment of middle ear inflammation.

A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease (2016)
Journal Article
Barron, M., Gartlon, J., Dawson, L. A., Atkinson, P. J., & Pardon, M.-C. (2017). A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease. Experimental Gerontology, 94, 103-107. https://doi.org/10.1016/j.exger.2016.12.006

Alzheimer's disease (AD), the predominant form of dementia, is highly correlated with the abnormal hyperphosphorylation and aggregation of tau. Immune responses are key drivers of AD and how they contribute to tau pathology in human disease remains l... Read More about A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease.

Planck intermediate results. XLIX. Parity-violation constraints from polarization data (2016)
Journal Article
Aghanim, N., Ashdown, M., Aumont, J., Baccigalupi, C., Ballardini, M., Banday, A., …Zonca, A. (in press). Planck intermediate results. XLIX. Parity-violation constraints from polarization data. Astronomy and Astrophysics, 596, Article A110. https://doi.org/10.1051/0004-6361/201629018

Parity-violating extensions of the standard electromagnetic theory cause in vacuo rotation of the plane of polarization of propagating photons. This effect, also known as cosmic birefringence, has an impact on the cosmic microwave background (CMB) an... Read More about Planck intermediate results. XLIX. Parity-violation constraints from polarization data.

Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies (2016)
Journal Article
Planck Collaboration, Aghanim, N., Ashdown, M., Aumont, J., Baccigalupi, C., Ballardini, M., …Zonca, A. (2016). Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies. Astronomy and Astrophysics, 596, Article A109. https://doi.org/10.1051/0004-6361/201629022

Using the Planck 2015 data release (PR2) temperature maps, we separate Galactic thermal dust emission from cosmic infrared background (CIB) anisotropies. For this purpose, we implement a specifically tailored component-separation method, the so-calle... Read More about Planck intermediate results. XLVIII. Disentangling Galactic dust emission and cosmic infrared background anisotropies.

Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth (2016)
Journal Article
Planck Collaboration, Aghanim, N., Ashdown, M., Aumont, J., Baccigalupi, C., Ballardini, M., …Zonca, A. (2016). Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth. Astronomy and Astrophysics, 596, Article A107. https://doi.org/10.1051/0004-6361/201628890

This paper describes the identification, modelling, and removal of previously unexplained systematic effects in the polarization data of the Planck High Frequency Instrument (HFI) on large angular scales, including new mapmaking and calibration proce... Read More about Planck intermediate results. XLVI. Reduction of large-scale systematic effects in HFI polarization maps and estimation of the reionization optical depth.

Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap (2016)
Journal Article
Planck Collaboration, Aghanim, N., Alves, M. I. R., Arzoumanian, D., Aumont, J., Baccigalupi, C., …Zonca, A. (2016). Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap. Astronomy and Astrophysics, 596, Article A105. https://doi.org/10.1051/0004-6361/201628636

Using data from the Planck satellite, we study the statistical properties of interstellar dust polarization at high Galactic latitudes around the south pole (b < −60°). Our aim is to advance the understanding of the magnetized interstellar medium (IS... Read More about Planck intermediate results. XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap.

Planck intermediate results. XLVII. Planck constraints on reionization history (2016)
Journal Article
Planck Collaboration, Adam, R., Aghanim, N., Ashdown, M., Aumont, J., Baccigalupi, C., …Zonca, A. (2016). Planck intermediate results. XLVII. Planck constraints on reionization history. Astronomy and Astrophysics, 596, Article A108. https://doi.org/10.1051/0004-6361/201628897

We investigate constraints on cosmic reionization extracted from the Planck cosmic microwave background (CMB) data. We combine the Planck CMB anisotropy data in temperature with the low-multipole polarization data to fit ΛCDM models with various para... Read More about Planck intermediate results. XLVII. Planck constraints on reionization history.

Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study (2016)
Journal Article
Abhishek, A., Jenkins, W., La-Crette, J., Fernandes, G. S., & Doherty, M. (2016). Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study. Rheumatology, 56(4), https://doi.org/10.1093/rheumatology/kew395

Objectives: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout.

Methods: One hundred gout patients initiated on up-titrated ULT between March and July 20... Read More about Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study.

Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability (2016)
Journal Article
Karimi, M., Ignasiak, M. T., Chan, B., Croft, A. K., Radom, L., Schiesser, C. H., …Davies, M. J. (2016). Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability. Scientific Reports, 6(1), Article 38572. https://doi.org/10.1038/srep38572

© 2016 The Author(s). Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly associated with loss of protein function and activity. Previous data have suggested that disulfides show only modest reactivity with oxi... Read More about Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability.

Small fish in a big pond: an architectural approach to users privacy, rights and security in the age of big data (2016)
Presentation / Conference Contribution
Angelopoulos, S., McAuley, D., Merali, Y., Mortier, R., & Price, D. (2016). Small fish in a big pond: an architectural approach to users privacy, rights and security in the age of big data.

We focus on the challenges and issues associated with Big Data, and propose a novel architecture that uses the principles of Separation of Concerns and distributed computing to overcome many of the challenges associated with storage, analysis and int... Read More about Small fish in a big pond: an architectural approach to users privacy, rights and security in the age of big data.

A novel index for the study of synergistic effects during the co-processing of coal and biomass (2016)
Journal Article
Oladejo, J. M., Adegbite, S., Pang, C. H., Hao, L., Parvez, A. M., & Wu, T. (2017). A novel index for the study of synergistic effects during the co-processing of coal and biomass. Applied Energy, 188, https://doi.org/10.1016/j.apenergy.2016.12.005

In this study, synergistic interaction between coal and biomass and its intensity were investigated systematically using a low rank coal and its blends with different biomass samples at various blending ratios. The catalytic effects of minerals origi... Read More about A novel index for the study of synergistic effects during the co-processing of coal and biomass.

The effect of like-charge attraction on aerosol growth in the atmosphere of Titan (2016)
Journal Article
Lindgren, E. B., Stamm, B., Chan, H.-K., Maday, Y., Stace, A. J., & Besley, E. (2017). The effect of like-charge attraction on aerosol growth in the atmosphere of Titan. Icarus, 291, 245-253. https://doi.org/10.1016/j.icarus.2016.12.013

The formation of aerosols in the atmosphere of Titan is based extensively onion-neutral chemistry and physical condensation processes. Herein it is shown that the formation of aerosols may also occur through an alternative pathway that involves the p... Read More about The effect of like-charge attraction on aerosol growth in the atmosphere of Titan.

Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review (2016)
Journal Article
Hollis, C., Falconer, C. J., Martin, J. L., Whittington, C., Stockton, S., Glazebrook, C., & Davies, E. B. (in press). Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review. Journal of Child Psychology and Psychiatry, https://doi.org/10.1111/jcpp.12663

Digital health interventions (DHIs), including computer-assisted therapy, smartphone apps and wearable technologies, are heralded as having enormous potential to improve uptake and accessibility, efficiency, clinical effectiveness and personalisation... Read More about Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review.