All Outputs (2)

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences (2015)
Journal Article
Kerr, I., Haider, A. J., Cox, M. H., Jones, N., Goode, A. J., Bridge, K. S., …Briggs, D. (2015). Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences. Bioscience Reports, 35(4), Article e00241. https://doi.org/10.1042/BSR20150150

ABCG2 is an ABC (ATP-binding cassette) transporter with a physiological role in urate transport in the kidney and is also implicated in multi-drug efflux from a number of organs in the body. The trafficking of the protein and the mechanism by which i... Read More about Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

Autophagy receptor defects and ALS-FTLD (2015)
Journal Article
Majchera, V., Goode, A., James, V., & Layfield, R. (2015). Autophagy receptor defects and ALS-FTLD. Molecular and Cellular Neuroscience, 66(A), 43-52. doi:10.1016/j.mcn.2015.01.002

Various pathophysiological mechanisms have been implicated in the ALS-FTLD clinicopathological spectrum of neurodegenerative disorders. Here we focus on the role of autophagy, an intracellular catabolic pathway, in these conditions. Growing evidence... Read More about Autophagy receptor defects and ALS-FTLD.