All Outputs (1294)

A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition (2013)
Journal Article

Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is believed to be the basis of lea... Read More about A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition.

Linear bosonic and fermionic quantum gauge theories on curved spacetimes (2013)
Journal Article

We develop a general setting for the quantization of linear bosonic and fermionic field theories subject to local gauge invariance and show how standard examples such as linearized Yang-Mills theory and linearized general relativity fit into this fra... Read More about Linear bosonic and fermionic quantum gauge theories on curved spacetimes.

Chaste: An Open Source C++ Library for Computational Physiology and Biology (2013)
Journal Article

Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac ele... Read More about Chaste: An Open Source C++ Library for Computational Physiology and Biology.

Association between somatic cell count early in the first lactation and the lifetime milk yield of cows in Irish dairy herds (2013)
Journal Article

Change in lifetime milk yield is an important component of the cost of diseases in dairy cows. Knowledge of the likelihood and scale of potential savings through disease prevention measures is important to evaluate how much expenditure on control mea... Read More about Association between somatic cell count early in the first lactation and the lifetime milk yield of cows in Irish dairy herds.

Handwriting automaticity: the search for performance thresholds (2013)
Journal Article

Although handwriting has a fairly low status in literacy education, evidence is accumulating that it has an important role in written composition. In particular, handwriting automaticity appears to relate to success in composition. This relationship... Read More about Handwriting automaticity: the search for performance thresholds.

Complexity and specificity of experimentally-induced expectations in motion perception (2013)
Journal Article

Our perceptions are fundamentally altered by our expectations, i.e., priors about the world. In previous statistical learning experiments (Chalk, Seitz, & Seriès, 2010), we investigated how such priors are formed by presenting subjects with white low... Read More about Complexity and specificity of experimentally-induced expectations in motion perception.

Fallow deer (Dama dama dama) management in Roman South-East Britain (2013)
Journal Article

This paper presents new carbon, nitrogen and sulphur isotope data for European fallow deer (Dama dama dama) in Roman Britain and discusses results in light of evidence from classical texts, landscape archaeology, zooarchaeology and the limited availa... Read More about Fallow deer (Dama dama dama) management in Roman South-East Britain.

Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes (2013)
Journal Article

Background and Purpose: Chondrocytes exist within cartilage and serve to maintain the extracellular matrix. It has been postulated that osteoarthritic (OA) chondrocytes lose the ability to regulate their volume, affecting extracellular matrix product... Read More about Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes.

Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi (2013)
Journal Article

Selenium (Se) is an essential human micronutrient with critical roles in immune functioning and antioxidant defence. Estimates of dietary Se intakes and status are scarce for Africa although crop surveys indicate deficiency is probably widespread in... Read More about Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi.

Detection of porcine circovirus type 2 and viral replication by in situ hybridization in primary lymphoid organs from naturally and experimentally infected pigs (2013)
Journal Article

Porcine circovirus type 2 (PCV2) infection is the cause of postweaning multisystemic wasting syndrome (PMWS). It has been speculated whether cell types permissive of replication are found in the primary lymphoid organs and whether infection of these... Read More about Detection of porcine circovirus type 2 and viral replication by in situ hybridization in primary lymphoid organs from naturally and experimentally infected pigs.

Lateral root morphogenesis is dependent on the mechanical properties of the overlaying tissues (2013)
Journal Article

In Arabidopsis, lateral root primordia (LRPs) originate from pericycle cells located deep within the parental root and have to emerge through endodermal, cortical, and epidermal tissues. These overlaying tissues place biomechanical constraints on the... Read More about Lateral root morphogenesis is dependent on the mechanical properties of the overlaying tissues.

Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD) (2013)
Journal Article

Background:CD8+ T-lymphocytes, natural killer T-like cells (NKT-like cells, CD56+CD3+) and natural killer cells (NK cells, CD56+CD3?) are the three main classes of human killer cells and they are implicated in the pathogenesis of chronic obstructive... Read More about Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD).

Tobacco imagery on prime time UK television (2013)
Journal Article

Background: Smoking in ?lms is a common and well documented cause of youth smoking experimentation and uptake and hence a signi?cant health hazard. The extent of exposure of young people to tobacco imagery in television programming has to date be... Read More about Tobacco imagery on prime time UK television.

Trifluoromethylation of Allylsilanes under Photoredox Catalysis (2013)
Journal Article

A new catalytic method to access allylic secondary CF3 products is described. These reactions use the visible light excited Ru(bpy)3Cl2·6H2O catalyst and the Togni or Umemoto reagent as the CF3 source. The photoredox catalytic manifold delivers enant... Read More about Trifluoromethylation of Allylsilanes under Photoredox Catalysis.

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes (2013)
Journal Article

Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to use cardiomyocytes derived from human-induced pluripotency stem cells (hiPSCs... Read More about Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences (2013)
Journal Article

Background There is little research on the process of transition between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS). More recently, there is growing recognition that Attention Deficit/Hyperactivity Di... Read More about Transition to adult mental health services for young people with Attention Deficit/Hyperactivity Disorder (ADHD): A qualitative analysis of their experiences.

Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice (2013)
Journal Article

A lifestyle rich in physical and mental activities protects against Alzheimer's disease (AD) but the underlying mechanisms are unclear. We have proposed that this is mediated by a stress response and have shown that repeated exposure to novelty stres... Read More about Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice.

What promotes greater use of the corporate bond market? A study of the issuance behaviour of firms in Asia (2013)
Journal Article

This paper investigates bond market development in Asia by exploring the determinants of firms’ decisions to issue public debt in a range of Asian economies. Using a novel database covering the period 1995 to 2007, we use comparable micro level panel... Read More about What promotes greater use of the corporate bond market? A study of the issuance behaviour of firms in Asia.

Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial (2013)
Journal Article

Background The Single combination budesonide–formoterol inhaler Maintenance And Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but whether the high doses of corticosteroid and β agonist increase the risk of adverse... Read More about Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.

Structural reorganisation of cellulose fibrils in hydrothermally deconstructed lignocellulosic biomass and relationships with enzyme digestibility (2013)
Journal Article

Background: The investigation of structural organisation in lignocellulose materials is important to understand changes in cellulase accessibility and reactivity resulting from hydrothermal deconstruction, to allow development of strategies to maxi... Read More about Structural reorganisation of cellulose fibrils in hydrothermally deconstructed lignocellulosic biomass and relationships with enzyme digestibility.