All Outputs (2)

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., …Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms (2012)
Journal Article
Tan, T. C., Rahman, R., Jaber-Hijazi, F., Felix, D. A., Chen, C., Louis, E. J., & Aboobaker, A. (2012). Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Proceedings of the National Academy of Sciences, 109(11), https://doi.org/10.1073/pnas.1118885109

In most sexually reproducing animals, replication and maintenance of telomeres occurs in the germ line and during early development in embryogenesis through the use of telomerase. Somatic cells generally do not maintain telomere sequences, and these... Read More about Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms.