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A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development (2012)
Journal Article
Guttery, D. S., Ferguson, D. J. P., Poulin, B., Xu, Z., Straschil, U., Klop, O., Solyakov, L., Sandrini, S. M., Brady, D., Nieduszynski, C. A., Janse, C. J., Holder, A. A., Tobin, A. B., & Tewari, R. (2012). A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathogens, 8(2), Article e1002554. https://doi.org/10.1371/journal.ppat.1002554

Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC... Read More about A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

Automating the packing heuristic design process with genetic programming (2012)
Journal Article
Burke, E. K., Hyde, M. R., Kendall, G., & Woodward, J. (in press). Automating the packing heuristic design process with genetic programming. Evolutionary Computation, 20(1), https://doi.org/10.1162/EVCO_a_00044

The literature shows that one-, two-, and three-dimensional bin packing and knapsack packing are difficult problems in operational research. Many techniques, including exact, heuristic, and metaheuristic approaches, have been investigated to solve th... Read More about Automating the packing heuristic design process with genetic programming.

Dynamical simulations of electroweak baryogenesis with fermions (2012)
Journal Article
Saffin, P. M., & Tranberg, A. (2012). Dynamical simulations of electroweak baryogenesis with fermions. Journal of High Energy Physics, 2012(2), Article 102. https://doi.org/10.1007/JHEP02%282012%29102

We perform real-time numerical lattice simulations of a one-family version of the Standard Model. We model the quantum fermions using the ensemble method and treat the bosonic scalar and non-abelian gauge fields classically. Our main interest is elec... Read More about Dynamical simulations of electroweak baryogenesis with fermions.

Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts (2012)
Journal Article
Heeg, D., Burns, D. A., Cartman, S. T., & Minton, N. P. (2012). Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts. PLoS ONE, 7(2), Article e32381. https://doi.org/10.1371/journal.pone.0032381

Clostridium difficile spores play a pivotal role in the transmission of infectious diarrhoea, but in order to cause disease spores must complete germination and return to vegetative cell growth. While the mechanisms of spore germination are well unde... Read More about Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts.

Unhappy working with men? Workplace gender diversity and employee job- related well-being in Britain: a WERS2004 based analysis (2012)
Journal Article
Haile, G. A. (2012). Unhappy working with men? Workplace gender diversity and employee job- related well-being in Britain: a WERS2004 based analysis. Labour Economics, 19(3), 329-350. https://doi.org/10.1016/j.labeco.2012.02.002

This paper attempts to establish empirically the link between workplace gender diversity and employee job-related well-being in Britain. Using nationally representative linked employer-employee data and accounting for unobserved workplace heterogenei... Read More about Unhappy working with men? Workplace gender diversity and employee job- related well-being in Britain: a WERS2004 based analysis.

The need for operational reasoning in data-driven rating curve prediction of suspended sediment (2012)
Journal Article
Mount, N. J., Abrahart, R., Dawson, C., & Ab Ghani, N. (2012). The need for operational reasoning in data-driven rating curve prediction of suspended sediment. Hydrological Processes, 26(26), https://doi.org/10.1002/hyp.8439

The use of data-driven modelling techniques to deliver improved suspended sediment rating curves has received considerable interest in recent years. Studies indicate an increased level of performance over traditional approaches when such techniques a... Read More about The need for operational reasoning in data-driven rating curve prediction of suspended sediment.

The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments (2012)
Journal Article
Hirt, B. V., Wattis, J. A., Preston, S. P., & Laughton, C. A. (2012). The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments. Journal of Theoretical Biology, 295, https://doi.org/10.1016/j.jtbi.2011.10.038

The pentacyclic acridinium salt RHPS4 displays anti-tumour properties in vitro as well as in vivo and is potentially cell-cycle specific. We have collected experimental data and formulated a compartmental model using ordinary differential equations t... Read More about The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments.

Dorsal hippocampal involvement in appetitive trace conditioning and interval timing (2012)
Journal Article
Tam, S. K. E., & Bonardi, C. (2012). Dorsal hippocampal involvement in appetitive trace conditioning and interval timing. Behavioral Neuroscience, 126(2), 258-269. https://doi.org/10.1037/a0027164

Involvement of the dorsal hippocampus (DHPC) in acquisition of Pavlovian trace conditioning and interval timing was examined in an appetitive preparation in which presentations of one conditioned stimulus (CS) were immediately followed by food (delay... Read More about Dorsal hippocampal involvement in appetitive trace conditioning and interval timing.

Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing (2012)
Journal Article
Tam, S. K., & Bonardi, C. (2012). Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing. Behavioural Brain Research, 230(1), 259-267. https://doi.org/10.1016/j.bbr.2012.02.016

The involvement of the rat dorsal hippocampus (dhpc) in Pavlovian conditioning and timing of conditioned responding was examined in an appetitive preparation in which presentation of a relatively long, 40-s auditory conditioned stimulus (CS) was foll... Read More about Dorsal hippocampal lesions disrupt Pavlovian delay conditioning and conditioned-response timing.

Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite (2012)
Journal Article
Emara, M., Royer, P.-J., Mahdavi, J., Shakib, F., & Ghaemmaghami, A. M. (2012). Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. Journal of Biological Chemistry, 287(8), https://doi.org/10.1074/jbc.M111.312520

Dendritic cells (DCs) have been shown to play a key role in the initiation and maintenance of immune responses to microbial pathogens as well as to allergens, but the exact mechanisms of their involvement in allergic responses and Th2 cell differenti... Read More about Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite.

A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor (2012)
Journal Article
Lane, J. R., Klein Herenbrink, C., van Westen, G. J. P., Spoorendonk, J. A., Hoffmann, C., & Ijzerman, A. P. (2012). A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor. Molecular Pharmacology, 81(3), 475-487. https://doi.org/10.1124/mol.111.075937

The recent publication of both the antagonist- and agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a ligand may bind to a receptor and cause the conformational changes associated with agonist-mediated activation.... Read More about A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor.

Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring (2012)
Journal Article
Allen, H. A., & Payne, H. (2012). Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring. NeuroImage, 59(4), https://doi.org/10.1016/j.neuroimage.2011.10.070

We measured behavioural performance and fMRI activity whilst old and young adults performed a temporal
segmentation task (‘preview search’). Being able to select parts of the visual world to be attended or ignored
is a critical visual skill. Both o... Read More about Similar behaviour, different brain patterns: age-related changes in neural signatures of ignoring.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., Savio, A. M., Graña, M., & Behrens, T. E. (2012). Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic Resonance in Medicine, 68(6), https://doi.org/10.1002/mrm.24204

In this article, we highlight an issue that arises when using multiple b‐values in a model‐based analysis of diffusion MR data for tractography. The non‐monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion (2012)
Journal Article
Munro, R. J. (in press). The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion. Physics of Fluids, 24(2), https://doi.org/10.1063/1.3683555

Experiments were performed to analyse the interaction between a vortex ring and a sloped sediment layer. Attention focussed on interactions under “critical” conditions, in which sediment motion was only just induced by the ring's flow field. Both hyd... Read More about The interaction of a vortex ring with a sloped sediment layer: critical criteria for incipient grain motion.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG (2012)
Journal Article
Jonsson, M. K., Vos, M. A., Mirams, G. R., Duker, G., Sartipy, P., De Boer, T. P., & Van Veen, T. A. (2012). Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. Journal of Molecular and Cellular Cardiology, 52(5), 998-1008. https://doi.org/10.1016/j.yjmcc.2012.02.002

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overal... Read More about Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Associations between udder health and reproductive performance in United Kingdom dairy cows (2012)
Journal Article
Hudson, C., Bradley, A. J., Breen, J., & Green, M. J. (2012). Associations between udder health and reproductive performance in United Kingdom dairy cows. Journal of Dairy Science, 95(7), https://doi.org/10.3168/jds.2011-4629

The objective of this research was to evaluate the relationship between udder health and reproductive performance in UK dairy cows. Data from 80 herds were restructured such that each unit of data represented a 2-d period during lactation where a cow... Read More about Associations between udder health and reproductive performance in United Kingdom dairy cows.

Collaborative knowledge building with shared video representations: Special Issue on supporting shared representations in collaborative activities (2012)
Journal Article
BARTHEL, R., AINSWORTH, S., & SHARPLES, M. (2013). Collaborative knowledge building with shared video representations: Special Issue on supporting shared representations in collaborative activities. International Journal of Human-Computer Studies, 71(1), 59--75. https://doi.org/10.1016/j.ijhcs.2012.02.006

Online video has become established as a fundamental part of the fabric of the web; widely used by people for information sharing, learning and entertainment. We report results from a design study that explored how people interact to create shared mu... Read More about Collaborative knowledge building with shared video representations: Special Issue on supporting shared representations in collaborative activities.

Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling (2012)
Journal Article
Li, J., Davies, G., Kendall, G., Soane, E., Bai, R., Rocks, S., & Pollard, S. (2012). Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling. Expert Systems with Applications, 39(10), https://doi.org/10.1016/j.eswa.2012.01.193

Recent changes in the assessment and management of risks has had the effect that greater importance has been placed on relationships between individuals and within groups to inform decision making. In this paper, we provide the theoretical underpinni... Read More about Evidence and belief in regulatory decisions – incorporating expected utility into decision modelling.