All Outputs (2)

SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians (2012)
Journal Article
Gonzalez-Estevez, C., Felix, D. A., Smith, M. D., Paps, J., Morley, S. J., James, V., …Aboobaker, A. A. (2012). SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genetics, 8(3), Article e1002619. https://doi.org/10.1371/journal.pgen.1002619

Planarian flatworms are able to both regenerate their whole bodies and continuously adapt their size to nutrient status. Tight control of stem cell proliferation and differentiation during these processes is the key feature of planarian biology. Here... Read More about SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity (2012)
Journal Article
Foxler, D. E., Bridge, K. S., James, V., Webb, T. M., Mee, M., Wong, S. C. K., …Sharp, T. V. (2012). The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nature Cell Biology, 14(2), 201-208. https://doi.org/10.1038/ncb2424

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O2 tension1,2. In high O2 tension (normoxia) the PHDs hydroxylate t... Read More about The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.