All Outputs (475)

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN? (2011)
Journal Article

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN?.

The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles (2011)
Journal Article

The transcription factor p63 plays pivotal roles in epidermal barrier formation and in embryonic development. The protein structures of TAp63 and ΔNp63α isoforms include a C-terminal steril alpha-motif (SAM) involved in protein–protein interaction. I... Read More about The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris (2011)
Journal Article

We have investigated the relationship between the stability and secreted yield of a series of mutational variants of human lysozyme (HuL) in Pichia pastoris. We show that genes directly involved in the unfolded protein response (UPR), ER-associated d... Read More about Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Personality is of central concern to understand health: towards a theoretical model for health psychology (2011)
Journal Article

This paper sets out the case that personality traits are central to health psychology. To achieve this, three aims need to be addressed. First, it is necessary to show that personality influences a broad range of health outcomes and mechanisms. Secon... Read More about Personality is of central concern to understand health: towards a theoretical model for health psychology.

Efficacy, predictability, and safety of wavefront-guided refractive laser treatment: Metaanalysis (2011)
Journal Article

Symposium edition: Public sector reform in Central Asia (2011)
Journal Article

Electrochemical Detection (2011)
Book Chapter

Modelling electricity consumption in office buildings: an agent based approach (2011)
Journal Article

In this paper, we develop an agent-based model which integrates four important elements, i.e. organisational energy management policies/regulations, energy management technologies, electric appliances and equipment, and human behaviour, to simulate t... Read More about Modelling electricity consumption in office buildings: an agent based approach.

Real-time fermions for baryogenesis simulations (2011)
Journal Article

We study how to numerically simulate quantum fermions out of thermal equilibrium, in the context of electroweak baryogenesis. We find that by combining the lattice implementation of Aarts and Smit [1] with the "low cost" fermions of Borsanyi and Hind... Read More about Real-time fermions for baryogenesis simulations.

Widefield ultrastable heterodyne interferometry using a custom CMOS modulated light camera (2011)
Conference Proceeding

A method of detecting optical heterodyne interference fringes using a custom CMOS modulated light camera array has been developed. Widefield phase images are generated using quadrature demodulation and are kept stable using a feedback system. © 2011... Read More about Widefield ultrastable heterodyne interferometry using a custom CMOS modulated light camera.

CHOTs optical transducers (2011)
Journal Article

Laser ultrasonics conventionally use direct absorption in the sample to generate ultrasound and monitor the sample to detect the ultrasound. However, in some circumstances there are significant advantages to using an optical transducer - a device to... Read More about CHOTs optical transducers.

International trends in HRM in the public sector: Reform attempts in the Republic of Georgia (2011)
Journal Article

Purpose The overall purpose of this paper is to explore the limits of HRM in public sector organisations, within the context of international public management. The cultural basis of HRM, derived chiefly from North America and Western Europe continu... Read More about International trends in HRM in the public sector: Reform attempts in the Republic of Georgia.

Implementing Consumer Choice Long-term Care: The Impact of Individual Budgets on Social Care Providers England (2011)
Journal Article

common with many advanced welfare states, England has increasingly relied on consumerist principles to deliver both greater quality and improved efficiency the long-term care system. The Individual Budget (IB) pilots marked the next step this process... Read More about Implementing Consumer Choice Long-term Care: The Impact of Individual Budgets on Social Care Providers England.

The personalization of care services and the early impact on staff activity patterns (2011)
Journal Article

• Summary: This study examines the early impact on care coordinators' (care managers') work activity patterns of implementing the current personalization agenda within English local authorities. The Individual Budget (IB) pilots operated between 2005... Read More about The personalization of care services and the early impact on staff activity patterns.

Polymers with hydro-responsive topography identi?ed using high throughput AFM of an acrylate microarray (2011)
Journal Article

Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with disparate hydrophilicities that... Read More about Polymers with hydro-responsive topography identi?ed using high throughput AFM of an acrylate microarray.

Tinnitus referral pathways within the National Health Service in England: a survey of their perceived effectiveness among audiology staff (2011)
Journal Article

Background: In the UK, audiology services deliver the majority of tinnitus patient care, but not all patients experience the same level of service. In 2009, the Department of Health released a Good Practice Guide to inform commissioners about key asp... Read More about Tinnitus referral pathways within the National Health Service in England: a survey of their perceived effectiveness among audiology staff.

Personalizing the theme park: psychometric profiling and physiological monitoring (2011)
Book Chapter

Theme parks are important and complex forms of entertainment, with a broad user-base, and with a substantial economic impact. In this paper, we present a case study of an existing theme park, and use this to motivate two research challenges in relati... Read More about Personalizing the theme park: psychometric profiling and physiological monitoring.

Molecular dynamics simulations using graphics processing units (2011)
Journal Article

It is increasingly easy to develop software that exploits Graphics Processing Units (GPUs). The molecular dynamics simulation community has embraced this recent opportunity. Herein, we outline the current approaches that exploit this technology. In t... Read More about Molecular dynamics simulations using graphics processing units.

Development of a tissue engineered 3D immunocompetent model of the human upper respiratory tract (2011)
Journal Article

Revealing the genetic structure of a trait by sequencing a population under selection (2011)
Journal Article

One approach to understanding the genetic basis of traits is to study their pattern of inheritance among offspring of phenotypically different parents. Previously, such analysis has been limited by low mapping resolution, high labor costs, and large... Read More about Revealing the genetic structure of a trait by sequencing a population under selection.