AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity
(2010)
Journal Article
McKee, A. G., Loscher, J. S., O'Sullivan, N. C., Chadderton, N., Palfi, A., Batti, L., Sheridan, G. K., O'Shea, S., Moran, M., McCabe, O., Fernández, A. B., Pangalos, M. N., O'Connor, J. J., Regan, C. M., O'Connor, W. T., Humphries, P., Farrar, G. J., & Murphy, K. J. (2010). AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity. Journal of Neurochemistry, 112(4), 991-1004. https://doi.org/10.1111/j.1471-4159.2009.06516.x
Long-term memory is formed by alterations in glutamate-dependent excitatory synaptic transmission, which is in turn regulated by synaptosomal protein of 25 kDa (SNAP-25), a key component of the soluble N-ethylmaleimide-sensitive factor attachment pro... Read More about AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity.