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The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats (2007)
Journal Article
O’Neill, M., & Brown, V. J. (2007). The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats. Neurobiology of Learning and Memory, 88(1), 75-81. https://doi.org/10.1016/j.nlm.2007.03.003

This study assessed whether dopamine in the dorsomedial striatum is necessary for flexible adaptation to changes in stimulus–response contingencies. As KW-6002 (Istradefylline), an adenosine A2A antagonist, improves motor deficits resulting from stri... Read More about The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats.

Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials (2007)
Journal Article
Bath, P. M., & Optimising Analysis of Stroke Trials Collaboration, O. (2007). Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials. Stroke, 38(6), https://doi.org/10.1161/STROKEAHA.106.474080

Background and Purpose—Most large acute stroke trials have been neutral. Functional outcome is usually analyzed usinga yes or no answer, eg, death or dependency versus independence. We assessed which statistical approaches are mostefficient in analyz... Read More about Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials.

Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3 (2007)
Journal Article
Lane, J. R., Powney, B., Wise, A., Rees, S., & Milligan, G. (2007). Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3. Molecular Pharmacology, 71(5), 1349-1359. https://doi.org/10.1124/mol.106.032722

A range of ligands displayed agonism at the long isoform of the human dopamine D(2) receptor, whether using receptor-G protein fusions or membranes of cells in which pertussis toxin-resistant mutants of individual Galpha(i)-family G proteins could be... Read More about Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3.

Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' views. (2007)
Journal Article
Avis, M., Bulman, D., & Leighton, P. (2007). Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' views. Health and Social Care in the Community, 15(3), 203-211. https://doi.org/10.1111/j.1365-2524.2006.00673.x

The objectives of the present study were to examine the factors that parents identify as promoting or hindering participation in Sure Start programmes, and to identify methods for enhancing parents’ engagement with Sure Start. A qualitative, in-depth... Read More about Factors affecting participation in Sure Start programmes: a qualitative investigation of parents' views..

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis (2007)
Journal Article
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., …Brant, S. R. (2007). Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature Genetics, 39(5), 596-604. https://doi.org/10.1038/ng2032

We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R asso... Read More about Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Liquid film dynamics in horizontal and tilted tubes: dry spots and sliding drops (2007)
Journal Article
King, A. A., Cummings, L. J., Naire, S., & Jensen, O. E. (2007). Liquid film dynamics in horizontal and tilted tubes: dry spots and sliding drops. Physics of Fluids, 19(4), Article 042102. https://doi.org/10.1063/1.2714569

Using a model derived from lubrication theory, we consider the evolution of a thin viscous film coating the interior or exterior of a cylindrical tube. The flow is driven by surface tension and gravity and the liquid is assumed to wet the cylinder p... Read More about Liquid film dynamics in horizontal and tilted tubes: dry spots and sliding drops.

Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway (2007)
Journal Article
Anand-Ivell, R., Heng, K., Bartsch, O., & Ivell, R. (2007). Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway. Molecular and Cellular Endocrinology, 272(1-2), 1-13. https://doi.org/10.1016/j.mce.2007.04.001

The heterodimeric peptide hormone relaxin acts through the novel G-protein coupled receptor LGR7 to elicit the production of cAMP in the human monocyte cell line THP-1. The very small number of receptors on the cell surface, and the lack of response... Read More about Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway.

Clinical trials: the viewpoint of children (2007)
Journal Article
Cherrill, J., Hudson, H., Cocking, C., Unsworth, V., Franck, L., McIntyre, J., & Choonara, I. (2007). Clinical trials: the viewpoint of children. Archives of Disease in Childhood, 92(8), 712-713. https://doi.org/10.1136/adc.2006.114207

The views of 30 children (8–16 years old) attending paediatric medical clinics on paediatric clinical trials were determined by semi-structured interviews. Nineteen children recognised that there were risks involved with taking part in clinical trial... Read More about Clinical trials: the viewpoint of children.

China's oil diplomacy: is it a global security threat? (2007)
Journal Article
Lai, H. (2007). China's oil diplomacy: is it a global security threat?. Third World Quarterly, 28(3), https://doi.org/10.1080/01436590701192645

China is now the world's second largest oil consuming nation. China's external quest for oil has thus generated much attention and is believed by many to destabilise the world order. This article attempts to provide an overview of China's external in... Read More about China's oil diplomacy: is it a global security threat?.

Tele-branding in TVIII: the network as brand and the programme as brand (2007)
Journal Article
Johnson, C. (2007). Tele-branding in TVIII: the network as brand and the programme as brand. New Review of Film and Television Studies, 5(1), https://doi.org/10.1080/17400300601140126

In the era of TVIII, characterized by deregulation, multimedia conglomeration, expansion and increased competition, branding has emerged as a central industrial practice. Focusing on the case of HBO, a particularly successful brand in TVIII, this art... Read More about Tele-branding in TVIII: the network as brand and the programme as brand.

Open Access through the Depot (2007)
Journal Article
Hubbard, B. (2007). Open Access through the Depot. Aliss Quarterly, 2(3),

The mission of "the Depot" is to provide a service that enables all UK academics to share in the benefits of open access exposure for their post-print research outputs. It does this by providing a national intake and storage facility - the Depot - fo... Read More about Open Access through the Depot.

Branching dendrites with resonant membrane: a "sum-over-trips" approach (2007)
Journal Article
Coombes, S., Timofeeva, Y., Svennson, C.-M., Lord, G., Josic, K., Cox, S. J., & Colbert, C. (2007). Branching dendrites with resonant membrane: a "sum-over-trips" approach. Biological Cybernetics, 97(2), https://doi.org/10.1007/s00422-007-0161-5

Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dend... Read More about Branching dendrites with resonant membrane: a "sum-over-trips" approach.

The Role of Football in Everyday Life (2007)
Journal Article
Stone, C. (2007). The Role of Football in Everyday Life. Soccer and Society, 8(2-3), 169-184. https://doi.org/10.1080/14660970701224319

Research on the nature of sports audiences has been predominantly concerned with those attending live events and overlooks how sport is consumed within people’s everyday lives. Recent research into the nature of football fandom has offered ethnograph... Read More about The Role of Football in Everyday Life.

Global molecular phylogeography reveals persistent Arctic circumpolar isolation in a marine planktonic protist (2007)
Journal Article
Darling, K. F., Kucera, M., & Wade, C. M. (2007). Global molecular phylogeography reveals persistent Arctic circumpolar isolation in a marine planktonic protist. Proceedings of the National Academy of Sciences, 104(12), 5002-5007. https://doi.org/10.1073/pnas.0700520104

The high-latitude planktonic foraminifera have proved to be particularly useful model organisms for the study of global patterns of vicariance and gene flow in the oceans. Such studies demonstrate that gene flow can occur over enormous distances in t... Read More about Global molecular phylogeography reveals persistent Arctic circumpolar isolation in a marine planktonic protist.

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2007)
Journal Article
Sprigg, N., Gray, L. J., Bath, P. M., Lindenstrom, E., Boysen, G., De Deyn, P. P., Friis, P., Leys, D., Marttila, R., Olsson, J.-E., O'Neill, D., & Ringelstein, B. (2007). Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Journal of the Neurological Sciences, 254(1-2),

Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST) to assess the relation... Read More about Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Look who's talking: Communication and quorum sensing in the bacterial world (2007)
Journal Article
Williams, P., Winzer, K., Chan, W. C., & Cámara, M. (2007). Look who's talking: Communication and quorum sensing in the bacterial world. Philosophical Transactions B: Biological Sciences, 362(1483), 1119-1134. https://doi.org/10.1098/rstb.2007.2039

For many years bacteria were considered primarily as autonomous unicellular organisms with little capacity for collective behaviour. However, we now appreciate that bacterial cells are in fact, highly communicative. The generic term 'quorum sensing'... Read More about Look who's talking: Communication and quorum sensing in the bacterial world.

Media, metaphors and modeling: how the UK newspapers reported the epidemiological modelling controversy during the 2001 foot and mouth outbreak (2007)
Journal Article
Nerlich, B. (2007). Media, metaphors and modeling: how the UK newspapers reported the epidemiological modelling controversy during the 2001 foot and mouth outbreak. Science, Technology, and Human Values, 32(4), https://doi.org/10.1177/0162243907301003

The relation between theoretical models and metaphors has been studied since at least the 1950s. The relation between metaphors and mathematical modelling is less well researched. This article takes the media coverage of the foot and mouth modelling... Read More about Media, metaphors and modeling: how the UK newspapers reported the epidemiological modelling controversy during the 2001 foot and mouth outbreak.

The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets (2007)
Journal Article
Richens, J., Fairclough, L., Ghaemmaghami, A. M., Mahdavi, J., Shakib, F., & Sewell, H. F. (2007). The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets. Immunobiology, 212(1), 29-38. https://doi.org/10.1016/j.imbio.2006.06.012

A disintegrin and metalloprotease (ADAM) proteins have wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion and intracellular signalling. Recent evidence suggests the involvement of ADAM8 in all... Read More about The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets.