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Constitutive regulation of the Insl3 gene in rat Leydig cells (2005)
Journal Article
Sadeghian, H., Anand-Ivell, R., Balvers, M., Relan, V., & Ivell, R. (2005). Constitutive regulation of the Insl3 gene in rat Leydig cells. Molecular and Cellular Endocrinology, 241(1-2), 10-20. https://doi.org/10.1016/j.mce.2005.03.017

Insulin-like factor 3 (Insl3) is a major new product of the Leydig cells in all mammalian species so far examined. The rat Insl3 gene is encoded by two exons in close juxtaposition to the Jak3 gene. Using RT-PCR analysis we now show that in the rat t... Read More about Constitutive regulation of the Insl3 gene in rat Leydig cells.

Xanthine Oxidase Activity in Vitro:  Effects of Food Extracts and Components (2005)
Journal Article
Dew, T. P., Day, A. J., & Morgan, M. R. A. (2005). Xanthine Oxidase Activity in Vitro:  Effects of Food Extracts and Components. Journal of Agricultural and Food Chemistry, 53(16), 6510-6515. https://doi.org/10.1021/jf050716j

There is significant interest in the direct antioxidant activities of dietary polyphenols, due to associations between consumption of polyphenol-rich foods, such as fruits and vegetables, and decreased incidence of oxidative-stress related disease. H... Read More about Xanthine Oxidase Activity in Vitro:  Effects of Food Extracts and Components.

The geochemistry of fluids from an active shallow submarine hydrothermal system: Milos island, Hellenic Volcanic Arc (2005)
Journal Article
Valsami-Jones, E., Baltatzis, E., Bailey, E. H., Boyce, A. J., Alexander, J. L., Magganas, A., …Ragnarsdottir, K. V. (2005). The geochemistry of fluids from an active shallow submarine hydrothermal system: Milos island, Hellenic Volcanic Arc. Journal of Volcanology and Geothermal Research, 148(1-2), 130-151. https://doi.org/10.1016/j.jvolgeores.2005.03.018

Geothermal activity in the Aegean island of Milos (Greece), associated with island-arc volcanism, is abundant both on-and off-shore. Hydrothermal fluids venting from several sites, mainly shallow submarine (up to 10 m), but also just above seawater l... Read More about The geochemistry of fluids from an active shallow submarine hydrothermal system: Milos island, Hellenic Volcanic Arc.

Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection (2005)
Journal Article
Brown, R. J., Juttla, V. S., Tarr, A. W., Finnis, R., Irving, W. L., Hemsley, S., …Ball, J. K. (2005). Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection. Journal of General Virology, 86(7), 1931-1942. https://doi.org/10.1099/vir.0.80957-0

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are important targets for the host immune response. The genes encoding these proteins exhibit a high degree of variability that gives rise to differing phenotypic traits, including alterations... Read More about Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.

Atopic Dermatitis (2005)
Journal Article
Williams, H. C. (2005). Atopic Dermatitis

A 10-year-old girl with atopic dermatitis reports itching that has recently become relentless, resulting in sleep loss. Her mother has been reluctant to treat the girl with topical corticosteroids, because she was told that they damage the skin, bu... Read More about Atopic Dermatitis.

Natural and waste materials as metal sorbents in permeable reactive barriers (PRBs) (2005)
Journal Article
Wantanaphong, J., Mooney, S. J., & Bailey, E. H. (2005). Natural and waste materials as metal sorbents in permeable reactive barriers (PRBs). Environmental Chemistry Letters, 3(1), 19-23. https://doi.org/10.1007/s10311-005-0106-y

A range of waste products and natural materials including chitin, fly ash, clay soil, cocoa shell, calcified seaweed and the natural zeolite clinoptilolite were tested in batch experiments to assess their ability to remove metals from a synthetic gro... Read More about Natural and waste materials as metal sorbents in permeable reactive barriers (PRBs).

The bacterial helicase-primase interaction: a common structural/functional module (2005)
Journal Article
Soultanas, P. (2005). The bacterial helicase-primase interaction: a common structural/functional module. Structure, 13(6), https://doi.org/10.1016/j.str.2005.04.006

The lack of a high-resolution structure for the bacterial helicase-primase complex and the fragmented structural information for the individual proteins have been hindering our detailed understanding of this crucial binary protein interaction. Two ne... Read More about The bacterial helicase-primase interaction: a common structural/functional module.

Report on BCTCS 2005 (2005)
Journal Article
Hutton, G. (2005). Report on BCTCS 2005

This report contains edited abstracts from BCTCS 2005, which was held on 22nd to 24th March 2005 in Nottingham, England.

Insulin-like factor 3: Where are we now? (2005)
Journal Article
Ivell, R., Hartung, S., & Anand-Ivell, R. (2005). Insulin-like factor 3: Where are we now?. Annals of the New York Academy of Sciences, 1041(1), 486-496. https://doi.org/10.1196/annals.1282.073

Insulin-like factor 3 (INSL3), previously known as the relaxin-like factor (RLF), is a major peptide hormone secreted from the testicular Leydig cells of adult men and circulating in the blood at a concentration of approximately 1 ng/mL. Women also p... Read More about Insulin-like factor 3: Where are we now?.

A high fidelity tissue-based cardiac surgical simulator (2005)
Journal Article
Ramphal, P. S., Coore, D. N., Craven, M. P., Forbes, N. F., Newman, S. M., Coye, A. A., …Silvera, B. C. (2005). A high fidelity tissue-based cardiac surgical simulator. European Journal of Cardio-Thoracic Surgery, 27(5), 910-916. doi:10.1016/j.ejcts.2004.12.049

Issues concerning the training and certification of surgical specialists have taken on great significance in the last decade. A realistic computer-assisted, tissue-based simulator developed for use in the training of cardiac surgical residents in the... Read More about A high fidelity tissue-based cardiac surgical simulator.

Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid (2005)
Journal Article
Gardiner, L., Coyle, B. J., Chan, W. C., & Soultanas, P. (2005). Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid. Cell Chemistry Biology, 12(5), 595-604. https://doi.org/10.1016/j.chembiol.2005.04.007

Developing small-molecule antagonists against protein-protein interactions will provide powerful tools for mechanistic/functional studies and the discovery of new antibacterials. We have developed a reverse yeast three-hybrid approach that allows hig... Read More about Discovery of antagonist peptides against bacterial helicase-primase interaction in B. stearothermophilus by reverse yeast three-hybrid.

Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer (2005)
Journal Article
Seville, L. L., Shah, N., Westwell, A. D., & Chan, W. C. (2005). Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer. Current Cancer Drug Targets, 5(3), 159-170. https://doi.org/10.2174/1568009053765816

Cell proliferation is regulated by the cell cycle, and in order to divide the cell must enter a mitotic state. Prior to mitosis the cell is required to pass through a number of checkpoints, including the critical G1/S restriction point governed by th... Read More about Modulation of pRb/E2F functions in the regulation of cell cycle and in cancer.

Mode locking in a periodically forced "ghostbursting" neuron model (2005)
Journal Article
Laing, C. R., & Coombes, S. (2005). Mode locking in a periodically forced "ghostbursting" neuron model. International Journal of Bifurcation and Chaos, 15(4), 1433-1444. https://doi.org/10.1142/S0218127405012557

We study a minimal integrate-and-fire based model of a " ghostbursting" neuron under periodic stimulation. These neurons are involved in sensory processing in weakly electric fish. There exist regions in parameter space in which the model neuron is m... Read More about Mode locking in a periodically forced "ghostbursting" neuron model.

Introducing the National Library for Health Skin Conditions Specialist Library (2005)
Journal Article
Grindlay, D. J., Kamel Boulos, M. N., & Williams, H. C. (2005). Introducing the National Library for Health Skin Conditions Specialist Library. BMC Dermatology, 5(4),

Background: This paper introduces the new National Library for Health Skin Conditions Specialist Library http://www.library.nhs.uk/skin. Description: The aims, scope and audience of the new NLH Skin Conditions Specialist Library, and the compositi... Read More about Introducing the National Library for Health Skin Conditions Specialist Library.

Bumps, breathers, and waves in a neural network with spike frequency adaptation (2005)
Journal Article
Coombes, S., & Owen, M. R. (2005). Bumps, breathers, and waves in a neural network with spike frequency adaptation. Physical Review Letters, 94(14), https://doi.org/10.1103/PhysRevLett.94.148102

In this Letter we introduce a continuum model of neural tissue that include the effects of so-called spike frequency adaptation (SFA). The basic model is an integral equation for synaptic activity that depends upon the non-local network connectivity... Read More about Bumps, breathers, and waves in a neural network with spike frequency adaptation.

Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of haemophilus influenzae and its role in bacterial resistance to complement-mediated killing (2005)
Journal Article
Griffin, R., Cox, A. D., Makepeace, K., Richards, J., Moxon, E. R., & Hood, D. W. (2005). Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of haemophilus influenzae and its role in bacterial resistance to complement-mediated killing. Infection and Immunity, 73(4), https://doi.org/10.1128/IAI.73.4.2213-2221.2005

The phase-variable locus lex2 is required for expression of a Haemophilus influenzae lipopolysaccharide (LPS) epitope of previously unknown structure. This epitope, which is reactive with monoclonal antibody (MAb) 5G8, has been associated with virule... Read More about Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of haemophilus influenzae and its role in bacterial resistance to complement-mediated killing.