All Outputs (28)

Evaluation of an enhanced training package to support clinical trials training in low and middle income countries (LMICs): experiences from the Born Too Soon Optimising Nutrition study (2021)
Working Paper

Training is essential before working on a clinical trial, yet there is limited evidence on effective training methods. In low and middle income countries (LMICs), training of research staff was considered the second highest priority in a global healt... Read More about Evaluation of an enhanced training package to support clinical trials training in low and middle income countries (LMICs): experiences from the Born Too Soon Optimising Nutrition study.

Investigating Spatio-temporal Changes in Groundwater Quality for London Between 2000-2020 (2021)
Working Paper

The groundwater is relatively a pure natural resource as compared to the surface water, but anthropogenic activities pose a threat to its purity and suitability for drinking purpose. Thus, monitoring of spatial and temporal variation of groundwater q... Read More about Investigating Spatio-temporal Changes in Groundwater Quality for London Between 2000-2020.

Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol (2021)
Working Paper

East Midlands Research into Ageing Network (EMRAN) is a research collaboration across the East Midlands to facilitate collaborative applied clinical research into ageing and the care of older people. EMRAN was set up by NIHR CLAHRC East Midlands and... Read More about Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol.

Development and Validation of Quality of Life Measurement Tools Used in Older Peoples’ Care Homes: a scoping review protocol (2021)
Working Paper

Introduction There is a high prevalence of frailty and cognitive impairment within care home population. These wide-ranging experiences and needs impact on residents’ quality of life. Therefore, measuring Quality of Life (QOL) in residents as part... Read More about Development and Validation of Quality of Life Measurement Tools Used in Older Peoples’ Care Homes: a scoping review protocol.

Schengen-pathway controls spatially separated and chemically distinct lignin deposition in the endodermis (2021)
Working Paper

Lignin is a complex polymer precisely deposited in the cell wall of specialised plant cells, where it provides essential cellular functions. Plants coordinate timing, location, abundance and composition of lignin deposition in response to endogenous... Read More about Schengen-pathway controls spatially separated and chemically distinct lignin deposition in the endodermis.

Mainstreaming Climate Change Education in UK Higher Education Institutions (2021)
Working Paper

Key messages • Mainstreaming Climate Change Education (CCE) across all learning and operational activities enables Higher Education Institutions (HEIs) to better serve their core purpose of preparing learners for their roles in work and wider societ... Read More about Mainstreaming Climate Change Education in UK Higher Education Institutions.

Effects of neuromuscular electrical stimulation (NMES) in acutely hospitalised adult patients -protocol for a systematic review of randomised controlled trials (RCTs) (2021)
Working Paper

Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review (2021)
Working Paper

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis (2021)
Working Paper

Background Most people with cystic fibrosis (pwCF) suffer from gastrointestinal symptoms and are at risk of gut complications. Gut microbiota dysbiosis is apparent within the CF population across all age groups, with evidence linking dysbiosis to int... Read More about Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis.

The Extent of User Involvement in the Design of Self-Tracking Technology for Bipolar Disorder: Literature Review (2021)
Working Paper

Background: Self-monitoring applications for bipolar disorder are increasing in numbers. The application of user-centred design (UCD) is becoming standardised to optimise the reach, adoption and sustained use of this type of technology. Objectiv... Read More about The Extent of User Involvement in the Design of Self-Tracking Technology for Bipolar Disorder: Literature Review.

Prospective examination of mental health in university students during the COVID-19 pandemic (2021)
Working Paper

Background The impact of changing social restrictions on the mental health of students during the COVID-19 pandemic warrants exploration. Aims To prospectively examine changes to university students’ mental health during the pandemic. Methods S... Read More about Prospective examination of mental health in university students during the COVID-19 pandemic.

Disentangling Age and Schooling Effects on Inhibitory Control Development: An fNIRS Investigation (2021)
Working Paper

FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study (2021)
Working Paper

Background: Point-of-care (POC) tests for COVID-19 could relieve pressure on isolation resource, support infection prevention and control, and help commence more timely and appropriate treatment. We aimed to undertake a systematic review and pooled d... Read More about FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study.

Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers (2021)
Working Paper

Accurate assessment of SARS-CoV-2 immunity in the population is critical to evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T cell respon... Read More about Whole blood-based measurement of SARS-CoV-2-specific T cell responses reveals asymptomatic infection and vaccine efficacy in healthy subjects and patients with solid organ cancers.

Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Working Paper

Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.

A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data (2021)
Working Paper

We assessed the validity of coded health care data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013-2018 using ICD-10 codes D76.1, D76.2 and D76.3.... Read More about A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data.

Point of Care Testing using rapid automated Antigen Testing for SARS- COV-2 in Care Homes -an exploratory safety, usability and diagnostic agreement evaluation (2021)
Working Paper

The Effectiveness of Mobile Phone Messaging–Based Interventions to Promote Physical Activity in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis (Preprint) (2021)
Working Paper

Background: Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide. Physical activity (PA) is an important aspect of self-care and first-line management for T2DM. Mobile text messages (SMS) can be used to support self-management in pe... Read More about The Effectiveness of Mobile Phone Messaging–Based Interventions to Promote Physical Activity in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis (Preprint).

Public Adoption of and Trust in the NHS COVID-19 Contact Tracing App in the United Kingdom: Quantitative Online Survey Study (2021)
Working Paper

Background: Digital contact tracing is employed to monitor and manage the spread of COVID-19. However, to be effective the system must be adopted by a substantial proportion of the population. Studies of mostly hypothetical contact tracing apps show... Read More about Public Adoption of and Trust in the NHS COVID-19 Contact Tracing App in the United Kingdom: Quantitative Online Survey Study.

Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study (2021)
Working Paper

Background: Clinical trials that assess the benefits and harms of an intervention do so by measuring and reporting outcomes. Inconsistent selection and diversity in the choice of outcomes makes it challenging to directly compare interventions. To... Read More about Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study.